text: [{"text_idx": "#000002", "text": "Serine is among the 20 naturally-occurring amino acids utilized by all organisms within the biosynthesis of proteins. Having a single chiral middle, serine can exist as both of two stereoisomers (L-Serine and D-Serine). Along with its function as a protein constructing block, L-Serine serves as a precursor to many very important biomolecules, together with phosphatidylserine, sphingomyelin and the amino acids glycine and cysteine."}, {"text_idx": "#000003", "text": "The non-proteogenic isomer D-Serine can also be synthesized from L-Serine within the mammalian mind. Whereas most D-amino acids are solely current in hint quantities in mammals, D-Serine is an important neurotransmitter that acts as a co-agonist of synaptic N-methyl-D-aspartate (NMDA) sort glutamate-gated ion channels. Impaired D-Serine metabolism might contribute to a number of neuropsychiatric problems, together with melancholy, schizophrenia, epilepsy and dementia. BioVision\u2019s DL-Serine Assay Package permits for quantification of each L- and D-Serine in organic fluids and tissues. The assay is predicated on the conversion of L-Serine to D-Serine, which is metabolized to an intermediate product that\u2019s subsequently oxidized and reacts with a probe to kind a steady fluorophore (Ex/Em = 539/587 nm). Samples could also be divided and assayed concurrently for quantification of each D-Serine and complete DL-Serine. The assay is just not affected by physiological concentrations of different amino acids, is high-throughput adaptable and may detect lower than 1 \u03bcM Serine"}, {"text_idx": "#000005", "text": "Your email address will not be published. Required fields are marked *"}, {"text_idx": "#000006", "text": "Save my name, email, and website in this browser for the next time I comment."}]