将以下文本的中文部分翻译成英文，无需修改其他部分：
经回归与主成分分析，咪唑并吡啶类药物和2-取代咪唑类药物在其与EGFR蛋白结合的活性方面差异较大。
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After regression and principal component analysis, there is a significant difference in the binding activity of imidazopyridine drugs and 2-substituted imidazole drugs with the EGFR protein.
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