<transcript><audio_28>in the microfluidic channel is highly stressful so that it may be very difficult for a normal cell to survive under such a stressful condition but the cancer cell has excellent adaptability</transcript><transcript><audio_29>so that it can get easily transported through the micro capillaries and that is how metastasis can be sustained so a big outstanding question is what are the physical attributes of a cancer</transcript><transcript><audio_30>cell which uh gives them the capability of migrating successfully through the stressful condition of the micro fluidic capillaries in human bodies so understanding cancer progression is a</transcript><transcript><audio_31>very important and outstanding topic that can be uh discussed or that can be uh uh uh I should not say uh that is yet</transcript><transcript><audio_32>satisfactory resolved but that can be uh uh probed to some extent successfully by using micr fluidics now not only cancer Biology one has to understand that uh uh cells are</transcript><transcript><audio_33>typically of the length scales of uh let us say you talk about human bodies typical biological cells are of length scales of around around 10 microns or so so the length scale of a cell is very much compatible to the length scale of a</transcript><transcript><audio_34>microfluidic system or or a microf fluidic channel therefore you can capture cellular Len scales you can capture the Dynamics over cellular Len scales in a micr fluing micr fluidic</transcript><transcript><audio_35>platform not only that you can control the fluid flow in micrometers in precisely defined geometries of microfluidic cell culture that can mimic the invitro cellular environment and</transcript><transcript><audio_36>also can facilitate simultaneous manipulation and Analysis starting from a single cell level to tissues cultured on fully integrated and automated chips in diseased conditions different</transcript> in the microfluidic channel is highly stressful so that it may be very difficult for a normal cell to survive under such a stressful condition but the cancer cell has excellent adaptability so that it can get easily transported through the micro capillaries and that is how metastasis can be sustained so a big outstanding question is what are the physical attributes of a cancer cell which uh gives them the capability of migrating successfully through the stressful condition of the micro fluidic capillaries in human bodies so understanding cancer progression is a very important and outstanding topic that can be uh discussed or that can be uh uh uh I should not say uh that is yet satisfactory resolved but that can be uh uh probed to some extent successfully by using micr fluidics now not only cancer Biology one has to understand that uh uh cells are typically of the length scales of uh let us say you talk about human bodies typical biological cells are of length scales of around around 10 microns or so so the length scale of a cell is very much compatible to the length scale of a microfluidic system or or a microf fluidic channel therefore you can capture cellular Len scales you can capture the Dynamics over cellular Len scales in a micr fluing micr fluidic platform not only that you can control the fluid flow in micrometers in precisely defined geometries of microfluidic cell culture that can mimic the invitro cellular environment and also can facilitate simultaneous manipulation and Analysis starting from a single cell level to tissues cultured on fully integrated and automated chips in diseased conditions different
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