<transcript><audio_257>biology of the cell or the molecular behavior of the cell is influenced by fluid flow so this is a very interesting point where fluid mechanics is interfacing with molecular biology so</transcript><transcript><audio_258>you can see that like normally the EGF uh distribution or egfr activation that should not be ideally dependent on the fluid mechanics but by the traditional thoughts those are dependent</transcript><transcript><audio_259>on the biophysical or the biochemical features within the cell now we we have shown that how these can be tuned by altering the stress condition as well as the confinement effect so with the</transcript><transcript><audio_260>confinement effect you have both the Lian dependent and Lian independent Activation so you have the Lian dependent activation which is dependent on the EGF concentration and lion</transcript><transcript><audio_261>independent activation of egfr which is dependent on the fluid flow so egfr activation depends on EGF which is Lian dependent and also on fluid flow which depends on the confinement effect as</transcript> biology of the cell or the molecular behavior of the cell is influenced by fluid flow so this is a very interesting point where fluid mechanics is interfacing with molecular biology so you can see that like normally the EGF uh distribution or egfr activation that should not be ideally dependent on the fluid mechanics but by the traditional thoughts those are dependent on the biophysical or the biochemical features within the cell now we we have shown that how these can be tuned by altering the stress condition as well as the confinement effect so with the confinement effect you have both the Lian dependent and Lian independent Activation so you have the Lian dependent activation which is dependent on the EGF concentration and lion independent activation of egfr which is dependent on the fluid flow so egfr activation depends on EGF which is Lian dependent and also on fluid flow which depends on the confinement effect as
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