<transcript><audio_10>will catheter-directed tpa prevent post-thrombotic syndrome you can see the population is patients with dvt the intervention is catheter-directed thrombolysis the comparison would be standard therapy and the outcome is post-thrombotic syndrome</transcript><video><caption><image_11>The image is a collage of two photographs. On the left side, there is a photograph of a woman's legs with the letter "P" on them. The photograph is a close-up of the woman's lower body, with her legs slightly bent at the knees and her feet slightly spread apart. The background is black, and the photographs are in white and gray tones.

On the right side of the image, there are two photographs side by side. The first photograph on the left shows the legs of the person, with their legs slightly curled and their toes pointing upwards. The second photograph in the middle shows the same legs, but with a black and white abstract design. The design appears to be a combination of lines and curves, creating a sense of movement and energy. The text on the image reads "Emergency Medicine" and "Medical Center".</caption><caption><image_12>The image is a collage of three different images. The first image on the top left shows a close-up of a person's legs with the letter "P" on them, indicating that they are in pain or discomfort. The second image in the top right shows a black and white abstract design with lines and curves. The third image is in the center of the collage and shows two syringes, one with a red cap and the other with a blue cap. The syringe on the bottom left has a label that reads "Lowenox 60.0.6mg/ml" and the label on the right has the logo of the company "Emergency Medicine". The background of the image is black.</caption><caption><image_13>The image is a collage of three pictures. The first picture on the top left shows a close-up of a person's legs with a red circle circled in the center. The second picture in the middle shows a pair of legs with varicose veins on them. The third picture on top right shows a closer view of the legs. The legs appear to be healthy and well-groomed.

In the center of the image, there is a label that reads "Covid-19" with the text "60-0.6" and "Emergency Medicine". Below the label, there are two syringes, one labeled "Lovendox" and the other labeled "60mg/ml". The label also mentions that the image is related to the treatment of the condition, as indicated by the red circle. The background is black, and the text is in white.</caption></video><transcript><audio_14>the second common characteristic is that these clinical questions fall into five general types therapy harm differential diagnosis diagnosis and prognosis what we have asked with our catheter directed tpa question is a therapy question and these questions are</transcript><transcript><audio_15>generally best answered by randomized control trials or meta-analyses of randomized control trials we could have looked at harm by asking in patients with dvt what's the rate of significant bleeding with low molecular weight heparin this type of question is usually</transcript> will catheter-directed tpa prevent post-thrombotic syndrome you can see the population is patients with dvt the intervention is catheter-directed thrombolysis the comparison would be standard therapy and the outcome is post-thrombotic syndrome the second common characteristic is that these clinical questions fall into five general types therapy harm differential diagnosis diagnosis and prognosis what we have asked with our catheter directed tpa question is a therapy question and these questions are generally best answered by randomized control trials or meta-analyses of randomized control trials we could have looked at harm by asking in patients with dvt what's the rate of significant bleeding with low molecular weight heparin this type of question is usually
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