Hot Stocks: ABNB downgrade; CAH, BCRX move on guidance; MRNA rises on a collaboration deal
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Online travel giant Airbnb (NASDAQ:ABNB) was among the spotlight stocks in Monday's midday trading, dropping on word of an analyst downgrade. Cardinal Health (NYSE:CAH) also lost ground, weighed down by a warning about the impact of inflation.

On the other side of the spectrum, Moderna (NASDAQ:MRNA) rose on a collaboration deal related to cancer drug development. At the same time, BioCryst (NASDAQ:BCRX) rallied after providing guidance for one of its key products.

Decliners

Airbnb (ABNB) dropped about 6% in midday trading after Piper Sandler cut its rating on the stock. Citing valuation, the firm downgraded ABNB from Overweight to Neutral.
Cardinal Health (CAH) was another midday decliner, dropping more than 7% on disappointing guidance. The company predicted that inflationary pressures and global supply chain bottlenecks would weigh on its results.


Gainers

Moderna (MRNA) got a lift in midday trading from news of a collaboration with Carisma Therapeutics. The strategy agreement is aimed at developing in vivo CAR-M therapeutics for the treatment of cancer. MRNA rose 8% on the news.
Meanwhile, a positive forecast gave a 20% boost to shares of BioCryst (BCRX). The rally came as the company predicted Q4 revenue of $45.6M for its Orladeyo product. For 2022, the company projected Orladeyo would reach at least $250M in revenues.
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