The angel answered her, "The Holy Spirit will come on you, and the power of the Most High will overshadow you. Therefore also the holy one who is born from you will be called the Son of God.
Shall be called the Son of God - This is spoken in reference to the human nature of Christ, and this passage proves, beyond controversy, that “one” reason why Jesus was called the Son of God was because he was begotten in a supernatural manner. He is also called the “Son of God” on account of his resurrection, Romans 1:4; Acts 13:33, compared with Psalms 2:7.