 Eliquis can cause serious and in rare cases fatal bleeding. Don't take Eliquis if you have an artificial heart valve, abnormal bleeding, or antiphospholipid syndrome. While taking, you may bruise more easily or take longer for bleeding to stop. A spinal injection while on Eliquis increases risk of blood clots, which may cause paralysis, the inability to move. Get medical help right away for unexpected bleeding, unusual bruising, or tingling, numbness, or muscle weakness. Medications such as aspirin products, NSAIDs, SSRIs, SNRIs, and blood thinners may increase bleeding risk.