 Over a three-year study, Eliquis Epixaban tablets reduced stroke risk better than Warfarin, and over 97% of Eliquis patients did not experience a stroke. A first stroke occurred in 2.9% of Warfarin patients versus 2.3% of Eliquis patients. Don't stop taking prescription Eliquis without asking your doctor. It may increase your stroke risk. Eliquis can cause serious and, in rare cases, fatal bleeding. Don't take Eliquis if you have an artificial heart valve, abnormal bleeding, or antiphospholipid syndrome.