 Taken together, the presence of a spike having an extremely high affinity for human SARS receptors, the presence of a furin cleavage site inserted at the spike S1-S2 border, the genome sequence enabling assembly from six synthetic nucleic acid building blocks using the reagent BSM-B1, and the 1-4-1 match between these features and the features proposed in the 2018 NIH and DARPA proposals make an extremely strong case, a smoking gun for a research origin.