 That is until now, and I'm now convinced that the science behind Cali-Curb is so compelling that I can actually support it as a plausible alternative for curbing appetite and enhancing satiety and help you shed pounds. The active ingredient in Cali-Curb, which is called Amerisade, comes from a specific New Zealand-grown hops flower, which works by activating your body's own appetite-regulating chemical messengers, including the famous GLP-1.