 Serious side effects may include ketoacidosis that may be fatal, dehydration that can lead to sudden worsening of kidney function, and genital yeast or urinary tract infections. A rare life-threatening bacterial infection in the skin of the perineum could occur. Stop Jardiance and call your doctor right away if you have symptoms of this infection, ketoacidosis, or an allergic reaction. You may have increased risk for lower limb loss. Call your doctor right away if you have symptoms of infection in your legs or feet. Taking Jardiance with a sulfonylurea or insulin may cause low blood sugar.