 One pill a day, 24 hours, zero heartburn with Prilosec OTC. It's possible while taking Prilosec OTC. Use as directed for 14 days to treat frequent heartburn, not for immediate relief. I made Prilosec OTC part of my morning routine. 100.5 FM's Ray Richardson. Coming up Monday morning, we'll check in with Todd Pyro from Fox & Friends First. We haven't spoken with him since the debate on air, and I want to hear what he thought about it. If you watch Fox & Friends, you certainly know.