 One pill a day, 24 hours, zero heartburn with Prilosec OTC. It's possible while taking Prilosec OTC. Use as directed for 14 days to treat frequent heartburn, not for immediate relief. I made Prilosec OTC part of my morning routine. Stay informed. Stay up to date with the latest political news and talk. Just say, Alexa, play WLOB Radio from 100.5 FM. Mark Twain said the best way to double your money is fold it over once and put it in your pocket.