 The genome of SARS-2 has eight features found in a synthetic virus that are not found in natural viruses. The probability that SARS-2 came from nature based on these features is one in a billion. These features are the backbone, the receptor binding domain, the furin cleavage site, the genetics of the furin cleavage site, the number, location, and pattern of cloning sites in SARS-2 that use the Baric cloning method and the ORF8 gene.