 "...of what advantage came to the Jews by the murder of their wise king, seeing that from that very time their kingdom was driven from them?" And what's he referring to there? He's referring to the destruction of Jerusalem in the year 70 AD, the great Jewish war with the Romans, which resulted in the destruction of the temple. It was a great disaster. And Meribah Serapion says that there's a link between that and the rejection of Jesus.