 One pill a day, 24 hours, zero heartburn with Prilosec OTC. It's possible while taking Prilosec OTC. Use as directed for 14 days to treat frequent heartburn, not for immediate relief. I made Prilosec OTC part of my morning routine. 100.5 FM. We make you smile. We make you think. We make you mad. We make you happy. Every weeknight, 6 p.m., The Joe Pag Show on News Talk WLOB AM and FM.