 So those do penetrate through your skin into your bloodstream, but that doesn't mean you feel high. It just means that you don't actually have to apply it only where it hurts. So with a transdermal product, you could apply it in venous parts of your body, the top of your foot, the inside of your wrist, the top of your hands, anywhere where you can see a high proliferation of veins, you can actually apply the product there and it will move to the site in your body that needs the relief.