 It can cause renal impairment. You have to be very cautious with those drugs that lower your sugar. Yeah, with every prescription there is a side effect, so you have to be careful about that. The thing we love about nutraceuticals, natural supplementation, is you have a much better chance of not having any side effects whatsoever as long as you consult with your doctor and make sure that there are no contraindications with any of your prescription medications as well.