 Dr. Dorsey, let's start with maybe a bit of a primer for those who may not know everything there is to know about Parkinson's disease. Tell us a bit about the disease and the typical effects of it. Sure. So Parkinson's disease is now the world's fastest growing brain disorder, faster growing than even than Alzheimer's disease. Over the past 25 years, the number of individuals who've been affected by the disease worldwide has more than doubled. And absent change, it'll double again the coming 25 years.