 those who are over the age of 35 and are smokers or have hypertension, and those who have a history of blood clots in their lungs or their legs. Really, the only people who should not take OPIL are those who've had a history of breast cancer in the past. While we encourage you to discuss this with a physician, you don't have to because OPIL is over the counter and you do not need a prescription to buy it. Where can we go for more information?