 We really said to them, it's fine to keep the current endpoint, but what we need is to add in addition to it another endpoint that can actually suit the needs of the field and the patients better. Dr. Newell, I wonder, are you in agreement for the most part with what Bill is saying here? Would you like to add to that? Do you think that this is an issue with endpoints and there is work that needs to be done here? And how would you describe it, I wonder?