 I'm Nicole Murray with your Money Now. GoodRxData said the cost of prescription medications in the U.S. has increased 37% since 2014, far surpassing the rate of inflation. Though the price increases have slowed this year in comparison to the past decade, the average American spends $16.26 out of pocket per prescription. On average, Americans pay two to three times more for prescription drugs than consumers in other developed countries, and that is according to the White House.