 The two main types of scleroderma, localized, which only affects the skin and muscles and tissues under your skin, and the systemic disease, which affects many parts of the body and can damage blood vessels and internal organs, such as the heart, lung, and kidneys. About one-third of the people with the disease have the systemic type. Since scleroderma presents with symptoms similar to other autoimmune diseases, diagnosis can be difficult.