 Oh, boy. I'll go with, in the sprinting category, the lion. Yes. Giraffes can run about, or up to, I should say, 35 miles per hour. The giraffe's main predator is the lion, which can accelerate to almost 50 miles per hour. However, the giraffe uses his great height and excellent eyesight to spot a predator like a lion as far as half a mile away, so he can get a head start on the run.