 Don't take Sifovir if you have an infection or active swelling in or around your eye that may include pain and redness. Sifovir can cause serious side effects such as eye infection and retinal detachments, severe inflammation of vessels in the retina which may result in severe vision loss, wet AMD, eye inflammation, and an increase in eye pressure. Most common side effects are eye discomfort, wet AMD, small specks floating in vision, and blood in the white of the eye.