 A bull's eye rash can be the first sign of Lyme disease, but not everyone will develop the rash. If you've been in areas where Lyme disease is common and develop fever, fatigue, facial paralysis, or joint and muscle pain, seek medical care. Reduce your chances of getting Lyme disease by wearing insect repellent, showering soon after coming indoors, and checking for ticks daily. To learn more, visit www.cdc.gov slash Lyme. A message from CDC.