 Mole became known for his hip, droll comic stylings in the clubs on Hollywood's Sunset Strip in the 1970s. He had a small role in the Norman Lear-created TV series Mary Hartman, Mary Hartman, and became the star of its spinoff, the satirical talk show Fernwood Tonight. In the 1980s, he appeared in films including Mr. Mom and Clue, and in the 1990s was a regular on Roseanne.