 But don't just get any old, down-and-dirty B-complex vitamins. It's not going to work the same if you have that gene variant where you can't break down synthetic folic acid. That becomes toxic to you. You want to eat folate, which is the natural form you get in your food, but when you take it in in supplemental form, folic acid is synthetic, and one out of three people can't break it down. So that's why you want to get a methylated supplement. Bio-coenzimated folate.