 Some antidepressants can make you gain more weight than others. A Harvard study of more than 183,000 patients finds that at six months, people on Lexapro, Paxil, and Cymbalta are 10 to 15% more likely to pack on at least 5% of their starting weights than people on Zoloft, the most popular antidepressant in the U.S. Wellbutrin users were 15% less likely