 And so there is clearly something going on. And many of the cancers, there's plenty of good research right now showing that early onset cancers are associated with obesity. So I think that's probably our leading hypothesis, but of course there are others. Okay, so we've seen obesity rise in all age groups in the United States. So help me understand a little bit more about, first of all, what it is about obesity that leads it to be a major risk factor