 Bill, tell us about the findings in the journal Frontiers of Pharmacology. 1,000 milligrams of berberine per day significantly lowered total and LDL cholesterols and triglycerides while raising good cholesterol HDL. At the same time, berberine reduced insulin resistance to improve type 2 diabetes and lowered the risk of diabetic encephalopathy, a degradation of motor and brain functions caused by diabetes.