text: After the defense stopped Atlanta again, the Giants took command as Manning hit Plaxico Burress for his eighth and league-lead-tying touchdown from 42 yards out and a 21–10 lead.  The Giants squandered several chances to add on more points as the team struggled moving at the end of the first half and Eli Manning threw a late interception.
  In the second half, the defense continued to dominate. Fred Robbins, Antonio Pierce and Justin Tuck notched sacks for Big Blue and rookie Aaron Ross added his third interception in two weeks. The Giants added a Lawrence Tynes field goal from 32 yards out for a 14-point lead, then capped off the win with a nine-yard touchdown run by Derrick Ward.  On the night, the Giants rushed for 188 yards, Eli Manning passed for 303 yards along with a pair of touchdowns and interceptions and the defense shut down Atlanta following the slow start.
  Burress led the Giants with 97 receiving yards and Amani Toomer became the Giants all-time reception leader, catching 7 passes for 89 yards including his early touchdown. The Giants improved to 4–2 and took a four-game winning streak into the next week's game against the 49ers.
  The Giants and Falcons series has now been won by the road team the last 12 meetings.
  The Giants notched their 600th franchise win.