text: The effects of trimethoprim causes a backlog of dihydrofolate (DHF) and this backlog can work against the inhibitory effect the drug has on tetrahydrofolate biosynthesis. This is where the sulfamethoxazole comes in; its role is in depleting the excess DHF by preventing it from being synthesised in the first place.
  Co-trimoxazole was claimed to be more effective than either of its components individually in treating bacterial infections, although this was later disputed.
  Society and culture
  Legal status
  Brand names
  Trimethoprim/sulfamethoxazole may be abbreviated as SXT, SMZ-TMP, TMP-SMX, TMP-SMZ, or TMP-sulfa. The generic British Approved Name (BAN) Co-trimoxazole is used for trimethoprim/sulfamethoxazole manufactured and sold by many different companies.
  The following list of brand names is incomplete:
  Bactrim, Bactrimel (manufactured by Roche and distributed in Europe)
  Bactrom (Venezuela)
  Bibactin (manufactured by PPM and distributed in Cambodia and some African countries)
  Biseptol
  Sumetrolim
  Co-trimoxazole (used as generic UK name)
  Cotrim
  Deprim (AFT Pharmaceuticals)
  Diseptyl (Israel)
  Graprima Forte Kaplet (manufactured by PT Graha Farma and distributed in Indonesia)
  Infectrin, Bactrim (Brazil)
  Novo-Trimel
  Primotren (Lek in Slovenia and other countries)
  Resprim
  Sanprima (manufactured by PT Sanbe Farma and distributed in Indonesia)
  Septra (Aspen Pharmacare and formerly GlaxoSmithKline)
  Septram (Panama)
  Septran (GlaxoSmithKline)
  Septrin (Spain)
  Sulfatrim
  Teva-Trimel
  Trisul
  Vactrim (manufactured and distributed in Laos)
  Economics
  Trimethoprim/sulfamethoxazole is relatively inexpensive as of 2019.