text: Ernie Cheatham – former defensive tackle for the Pittsburgh Steelers and the Baltimore Colts who led troops during the Korean and Vietnam Wars, attaining the rank of Lieutenant General
  Jack Chevigny – American football player, coach, lawyer and Marine Corps officer who was killed in action on the first day of the Battle of Iwo Jima during World War II. He is best known for scoring the famous "that's one for Gipper" touchdown for Knute Rockne's Notre Dame football team on November 10, 1928, against Army at Yankee Stadium.
  Roberto Clemente – baseball Hall of Famer
  Stephen Cochran – country music singer and songwriter
  Mike Coffman – U.S. Congressman representing Colorado
  Eddie Collins – baseball Hall of Famer
  Jerry Coleman – baseball player, announcer
  Charles Colson – White House special counsel, Nixon staffer (Watergate), evangelist
  Charlie Conerly – pro football player and College Football Hall of Fame inductee
  Tommy Cook – actor (Panic in the Streets, Stalag 17)
  Gene L. Coon – writer, Star Trek; Coon also wrote under the pseudonym Lee Cronin.
  Courtney Ryley Cooper – writer
  Gordon Cooper – aerospace engineer, test pilot and astronaut (Mercury-Atlas 9, Gemini 5)
  Barry Corbin – actor (No Country for Old Men, WarGames)