text: O. J. Howard, former Tight End for the Alabama Crimson Tide. He was drafted 1st Round 19th Overall to the Tampa Bay Buccaneers
  Randy Hunt, former Major League Baseball catcher
  Charlie Lucas, sculptor
  Nick Perry, NFL player and coach
  Wilson Pickett, R&B and soul singer and songwriter "Rock and Roll Hall of Fame"
  Tommy Shaw, member of the band Styx
  Brandon Taylor, author
  Daniel Holcombe Thomas, chief judge of the U.S. District Court for the Southern District of Alabama from 1966 to 1971
  Trust Company, alternative rock/post-grunge band
  Kevin Turner, NFL player
  Ernie Wingard, pitcher for the St. Louis Browns from 1924 to 1927
  Zac Woodfin, NFL player.
  Popular culture
  Gabriel García Marquez mentions Prattville in his well-known work One Hundred Years of Solitude; Prattville is referred to as the original city of Jack Brown, the founder of the banana company.
  Folklore
  A popular ghost-story known as "The Black Lady," inspired by deaths caused by poor working conditions in the nearby factories of downtown Prattville, is a popular phenomenon described by most as a black, ghastly figure that goes across the nearby dam during the night hours of 1 am to 4 am and has been featured on the ghost hunting show, Deep South Paranormal.
  This story, and additional Prattville ghost stories are cited by Digital Alabama.