text: Romus R.V. Burgin – Author of Islands of the Damned: A Marine at War in the Pacific who was portrayed in the HBO miniseries The Pacific (2010)
  Bob Burns – comedian
  Conrad Burns – U.S. Senator from Montana
  C
  Robert D. Cabana – NASA space shuttle astronaut, director of Stennis and Kennedy Space Centers
  Enrique Camarena – Mexican-American DEA agent murdered in 1985
  Philip Caputo – author, journalist
  Rod Carew – baseball Hall of Famer
  Drew Carey – Grammy Award-nominated comedian, actor, host of The Price Is Right (2007–present)
  Philip Carey – actor (One Life to Live)
  Timothy Carey – actor known for his roles in Stanley Kubrick and John Cassavetes films (The Killing, Paths of Glory, The Killing of a Chinese Bookie)
  Liz Carmouche – mixed martial arts fighter and Bellator Women's Flyweight World Champion
  Gerald P. Carr – NASA astronaut
  Paul Carr – actor (Executive Action, Akira)
  James Carville – political strategist and manager
  Francis H. Case – represented South Dakota in the U.S. House of Representatives (1937-1950) and the U.S. Senate (1951-1962)
  Ronald D. Castille – Chief Justice of the Supreme Court of Pennsylvania
  John Chafee – Governor of Rhode Island, Secretary of the Navy, U.S. Senator (R-RI)
  Lonny Chapman – actor (Norma Rae, Take the Money and Run)