text: Eugene Sledge – author of With the Old Breed: At Peleliu and Okinawa, basis in part for Ken Burns' World War II documentary, The War (2007), and later portrayed in the HBO miniseries The Pacific (2010)
  Harold "Dutch" Smith – diver, representing the US in the Summer Olympics in 1928 and 1932 (1 gold, 1 silver medal)
  Frederick W. Smith – businessman, founder of FedEx
  W. Thomas Smith, Jr. – author, journalist
  John Philip Sousa – composer, conductor/orchestra leader
  Anthony Sowell  – Ohio serial murder suspect
  Thomas Sowell – economist, social commentator, and author
  Taylor Spadaccino – Fitness and glamour model
  Leon Spinks – world boxing champion
  Robert C. Springer – NASA astronaut.
  Scott H. Stalker – Command Senior Enlisted Leader of the United States Cyber Command, and the National Security Agency
  Laurence Stallings – playwright, screenwriter, literary critic, journalist, novelist and photographer best known for the 1924 play What Price Glory
  Brian Stann – World Extreme Cagefighting Light Heavyweight champion, Ultimate Fighting Championship fighter
  Ernie Stautner – NFL football player and coach
  Richard Steele – boxing referee
  Robert J. Stevens – Retired Chairman, President and chief executive officer of Lockheed Martin Corporation
  Tuffy Stone – chef and competitive barbecue master