text: The 6.7 Nielsen rating (8.48 million viewers) was the lowest in Monday Night Football history, however it was the highest rated cable program for the week. The decisive Game 4 of the National League Championship Series was played at the same time.
  Week 7: vs. San Francisco 49ers
  The Giants recorded their fifth straight victory with a convincing 33–15 win over the San Francisco 49ers at Giants Stadium. Things started off well as the Giants drove right down the field on their opening possession. The balanced, well-executed seven-minute drive was capped off by a 4-yard touchdown pass from Eli Manning to Amani Toomer. The extra point was missed by Lawrence Tynes. On their next possession, the Giants were driving for more, but a tipped ball resulted in an interception inside the red zone. The 49ers responded with a nice drive of their own, aided by a personal foul on linebacker Antonio Pierce and several third down conversions.  San Francisco cashed in with a touchdown from Trent Dilfer to Arnaz Battle.
  Following a Frank Gore fumble, the Giants took control. The running game, which accounted for 140 total yards helped the Giants move back in front. Brandon Jacobs scored on a five-yard run for a 13–7 lead. After an interception by Sam Madison, the Giants added a 30-yard field goal by Tynes. Tynes made it 19–7 at the half with another field goal, this time from 39 yards, inside the final minute.