text: 2000–2019: Continued work Grier is a comedian and hosted the Comedy Central series Premium Blend in 2001. He made an appearance on the Dave, Shelley, and Chainsaw (DSC) Show (San Diego Jack 100.7 FM) on October 5, 2012, before doing performances at The Madhouse Comedy Club. In the interview, he debunked internet reports that he was involved in a musical based on the life of Louis Farrakhan. He took a leading role in DAG and had a cameo in the Robert De Niro and Edward Burns film 15 Minutes (2001) as a Central Park mugger. In a departure from the comedic roles he played on In Living Color, he portrayed an abusive father in Rusty Cundieff's anthology film Tales from the Hood. In 2002, Grier joined the cast of the improv-based ABC sitcom and Bonnie Hunt vehicle Life with Bonnie which ran for two seasons. During this time, he continued to appear in comedy films but also returned to drama in the films Baadasssss! (2003) and The Woodsman (2004). He starred in his own Comedy Central stand-up special The Book of David: The Cult Figure's Manifesto. He is also a frequent guest on the Comedy Central show Crank Yankers.
  Grier was the host of the NBC show Thank God You're Here. He starred in Gym Teacher: The Movie (2008) playing the villain, Shelly Bragg. He appeared as Uncle Henry in the ABC 2005 television film The Muppets' Wizard of Oz. Grier guest starred in Season 6 of Fox's Bones. He played Professor Bunsen Jude, the Science Dude, the host of a children's television program. This character was inspired by Bill Nye "the Science Guy". In May 2013, Grier appeared in Tyler Perry Presents Peeples, playing the role of Virgil Peeples, alongside Kerry Washington and Craig Robinson.  Also in 2013, Grier appeared in The Watsons Go To Birmingham, a Hallmark Channel adaptation of Christopher Paul Curtis' 1995 Newbery Honor-winning novel, The Watsons Go to Birmingham – 1963. He appeared on the CBS TV-adaptation of Bad Teacher, playing the role of principal Carl Gaines.