text: On a crucial 3rd and seven late in the game, Romo hit backup wideout Sam Hurd for a 51-yard touchdown.  With Manning injuring his shoulder, backup Jared Lorenzen finished the game for the Giants at quarterback late in the fourth quarter. Amani Toomer in his return from a knee injury, notched 9 catches for 91 yards while Burress gained 144. Justin Tuck and Gibril Wilson recorded the Giants' only sack and interception of the night respectively in the 45–35 loss as the Giants began the season at 0–1.
  It would be the only road loss for the Giants in the season.
  Week 2: vs. Green Bay Packers
  The Giants played their Week 2 home opener against the Green Bay Packers.  After both teams missed a field goal to open the game, Green Bay got on the board first with a 6-yard run by rookie DeShawn Wynn. The Giants responded with a 26-yard scoring strike by Eli Manning to Plaxico Burress. The Giants got a Lawrence Tynes field goal and a 10–7 half time lead.
  In the second half, the Packers drove 51 yards to start the second half. Favre capped off the scoring drive with a 2-yard pass to Bubba Franks for a 14–10 lead the Packers would not relinquish. The Giants responded with another drive but once again, an unsportsmanlike conduct penalty, this one on Amani Toomer, hurt the Giants. Tynes kicked a second field goal, pulling the Giants to within one.