text: Sedation In Germany, it is approved for the treatment of agitation and agitation associated with underlying psychiatric disorders with a maximum daily dose of 200 mg.
  For nausea and vomiting associated with anesthesia or chemotherapy. It is commonly used postoperatively as an antiemetic. The antiemetic activity increases with increased dosing; however, side effects also increase, which often limits maximal dosing.
  For moderate to severe morning sickness and hyperemesis gravidarum: In the UK, Promethazine is the drug of first choice. Promethazine is preferred during pregnancy because it is an older drug and there is more data regarding the use of it during pregnancy. Second choice medications, which are used if Promethazine isn't tolerated or the patient cannot take it, are metoclopramide or prochlorperazine.
  For allergies such as hay fever and together with other medications in anaphylaxis
  To aid with symptoms of the common cold
  Motion sickness, including space sickness
  Hemolytic disease of the newborn
  Anxiety before surgery
  Short-term insomnia
  Side effects
  Some documented side effects include:
  Tardive dyskinesia, pseudoparkinsonism, acute dystonia (effects due to dopamine D2 receptor antagonism)
  Confusion in the elderly
  Drowsiness, dizziness, fatigue, more rarely vertigo
  Known to have effects on serotonin and dopamine receptors.
  Dry mouth
  Nausea
  Respiratory depression in patients under age of two and in those with severely compromised pulmonary function