text: Organometallic chemistry The organometallic chemistry of titanium typically starts from . An important reaction involves sodium cyclopentadienyl to give titanocene dichloride, . This compound and many of its derivatives are precursors to Ziegler–Natta catalysts. Tebbe's reagent, useful in organic chemistry, is an aluminium-containing derivative of titanocene that arises from the reaction of titanocene dichloride with trimethylaluminium. It is used for the "olefination" reactions.
  Arenes, such as  react to give the piano-stool complexes  (R = H, ; see figure above). This reaction illustrates the high Lewis acidity of the  entity, which is generated by abstraction of chloride from  by .
  Reagent in organic synthesis
  finds occasional use in organic synthesis, capitalizing on its Lewis acidity, its oxophilicity, and the electron-transfer properties of its reduced titanium halides. It is used in the Lewis acid catalysed aldol addition Key to this application is the tendency of  to activate aldehydes (RCHO) by formation of adducts such as .
  Toxicity and safety considerations
  Hazards posed by titanium tetrachloride generally arise from its reaction with water that releases hydrochloric acid, which is severely corrosive itself and whose vapors are also extremely irritating.  is a strong Lewis acid, which exothermically forms adducts with even weak bases such as THF and water.