text: Jeffrey Stubblefield - Jerome (2 episodes, season 3)
  Kevin Symons - Jack Pinkham (3 episodes, seasons 6-7)
  T
  Mark L. Taylor - Mr. Steinberg (2 episodes, season 1)
  Lee Tergesen - Peter McMillan (5 episodes, season 2)
  Lily Tomlin - Roberta Simmons (6 episodes, season 5)
  Nancy Travis - Mary Wagner (2 episodes, season 7)
  Stacey Travis - Jordana Geist (3 episodes, seasons 1 and 3)
  Steve Tyler - Minister (5 episodes, seasons 2 and 3 and 4 and 5)
  U
  V
  Joyce Van Patten - Carol Prudy (2 episodes, season 2)
  W
  Dale Waddington Horowitz - Nurse Voorhees (6 episodes, seasons 2-3 and 6-7)
  Melora Walters - Sylvia Greene (3 episodes, season 4)
  Kiersten Warren - Nora Huntington (9 episodes, seasons 2−3 and 8)
  Lesley Ann Warren - Sophie Bremmer (6 episodes, seasons 1−2, 7)
  Cheyenne Wilbur - Edwin Mullins (3 episodes, season 1)
  Matt Winston - Lazaro (2 episodes, season 8)
  Wendy Worthington - Nurse Parker (2 episodes, season 3)
  Becky Wu - Amy Yamada (4 episodes, season 8)
  X
  Y
  Gwendoline Yeo - Xiao-Mei (9 episodes, seasons 2–3)
  Kathleen York - Monique Polier (3 episodes, season 3)
  Z
  Josh Zuckerman - Eddie Orlofsky - (11 episodes, season 6)