text: Quina bark was mentioned by Fray Antonio de La Calancha in 1638 as coming from a tree in Loja (Loxa). He noted that bark powder weighing about two coins was cast into water and drunk to cure fevers and "tertians". Jesuit Father Bernabé Cobo (1582–1657) also wrote on the "fever tree" in 1653. The legend was popularized in English literature by Markham, and in 1874, he also published a "plea for the correct spelling of the genus Chinchona". Spanish physician and botanist Nicolás Monardes wrote of a New World bark powder used in Spain in 1574, and another physician, Juan Fragoso, wrote of bark powder from an unknown tree in 1600 that was used for treating various ills. Both identify the sources as trees that do not bear fruit and have heart-shaped leaves; they were suggested to have been referring to Cinchona species.
  The name quina-quina or quinquina was suggested as an old name for Cinchona used in Europe and based on the native name used by the Quechua people. Italian sources spelt quina as "cina", which was a source of confusion with Smilax from China. Haggis argued that qina and Jesuit's bark actually referred to Myroxylon peruiferum, or Peruvian balsam, and that this was an item of importance in Spanish trade in the 1500s. Over time, the bark of Myroxylon may have been adulterated with the similar-looking bark of what is now known as Cinchona. Gradually, the adulterant became the main product that was the key therapeutic ingredient used in malarial therapy. The bark was included as Cortex Peruanus in the London Pharmacopoeia in 1677.