text: with chlorpromazine  and phenobarbital as Vegetamin.
  Recreational use
  The recreational drug lean, also known as purple drank among other names, often contains a combination of promethazine with codeine-containing cold medication.
  Product liability lawsuit
  In 2009, the US Supreme Court ruled on a product liability case involving promethazine.  Diana Levine, a woman with a migraine, was administered Wyeth's Phenergan via IV push.  The drug was injected improperly, resulting in gangrene and subsequent amputation of her right forearm below the elbow.  A state jury awarded her $6 million in punitive damages.
  The case was appealed to the Supreme Court on grounds of federal preemption and substantive due process.  The Supreme Court upheld the lower courts' rulings, stating that "Wyeth could have unilaterally added a stronger warning about IV-push administration" without acting in opposition to federal law. In effect, this means drug manufacturers can be held liable for injuries if warnings of potential adverse effects, approved by the US Food and Drug Administration (FDA), are deemed insufficient by state courts.
  In September 2009, the FDA required a boxed warning be put on promethazine for injection, stating the contraindication for subcutaneous administration. The preferred administrative route is intramuscular, which reduces risk of surrounding muscle and tissue damage.