text: Alkylating-like Platinum-based chemotherapeutic drugs (termed platinum analogues) act in a similar manner. These agents do not have an alkyl group, but nevertheless damage DNA. They permanently coordinate to DNA to interfere with DNA repair, so they are sometimes described as "alkylating-like".
  Platinum
  Cisplatin
  Carboplatin
  Dicycloplatin
  Eptaplatin
  Lobaplatin
  Miriplatin
  Nedaplatin
  Oxaliplatin
  Picoplatin
  Satraplatin
  Triplatin tetranitrate
  These agents also bind at N7 of guanine.
  Nonclassical
  Certain alkylating agents are sometimes described as "nonclassical". There is not a perfect consensus on which items are included in this category, but, in general, they include:
  Procarbazine
  Altretamine
  Some sources explicitly exclude the triazenes (dacarbazine, mitozolomide, temozolomide) from the nonclassical category. However, other sources list dacarbazine as nonclassical, and some include temozolomide.
  The platinum agents are also sometimes described as nonclassical.
  Limitations
  Alkylating antineoplastic agents have limitations. Their functionality has been found to be limited when in the presence of the DNA-repair enzyme O-6-methylguanine-DNA methyltransferase (MGMT). Cross-linking of double-stranded DNA by alkylating agents is inhibited by the cellular DNA-repair mechanism, MGMT. If the MGMT promoter region is methylated, the cells no longer produce MGMT, and are therefore more responsive to alkylating agents. Methylation of the MGMT promoter in gliomas is a useful predictor of the responsiveness of tumors to alkylating agents.