text: Brandin Knight (1999–2003) 1,440 Lamar Patterson (2009–2014) 1,392
  Jerry McCullough (1991–1996) 1,342
  Sean Miller (1987–1992) 1,282
  Bobby Martin (1987–1991) 1,282
  Chevon Troutman (2001–2005) 1,274
  Jaron Brown (2000–2004) 1,258
  Levance Fields (2005–2009) 1,247
  Jerome Lane (1985–1988) 1,217
  Curtis Aiken (1983–1987) 1,200
  Bob Lazor (1954–1957) 1,175
  John Riser (1954–1957) 1,164
  Kent Scott (1969–1972) 1,143
  Isaac Hawkins (1996–2001) 1,127
  Calvin Sheffield (1961–1964) 1,115
  Brian Generalovich (1961–1964) 1,114
  Aaron Gray (2003–2007) 1,109
  Tray Woodall (2008–2013) 1,108
  Donatas Zavackas (1999–2003) 1,099
  Ronald Ramon (2004–2008) 1,096
  Brad Wanamaker (2007–2011) 1,090
  Talib Zanna (2009–2014) 1,089
  Chris McNeal (1990–1993) 1,067
  Carlton Neverson (1978–1981) 1,057
  Julius Pegues (1955–1958) 1,050
  Rod Brookin (1986–1990) 1,047
  Gilbert Brown (2006–2011) 1,046
  Darelle Porter (1987–1991) 1,007
  NBA players
  Pittsburgh Panthers have been selected 28 times in the NBA draft, 3 times in the ABA draft (Billy Knight was drafted by both the NBA and ABA in 1974). In addition,  11 former Panthers were selected in the CBA draft.  Eight Panthers have been selected as first-round NBA draft picks with Bub Carrington being the most recent in 2024.
  In addition, 48 former Panthers have played professionally in international basketball leagues. Clyde Vaughan especially stands out in averaging 28 points per game over his decade-long basketball career in Europe.
  Overseas leagues players
  Marcus Carr (born 1999) – in the Israeli Basketball Premier League