text: The alternative view which sees the sequence ending with Greece and the Diadochi, thus excluding Rome, is not without historical precedent however. The pagan critic of Christianity, Porphyry, suggested a variation of this interpretation in the third century CE. In the following centuries, several Eastern Christians espoused this view, including Ephrem the Syrian, Polychronius, and Cosmas Indicopleustes.
  During the Medieval ages the orthodox Christian interpretation followed the commentary by Jerome on the Book of Daniel. It tied the fourth monarchy and its end to the end of the Roman Empire, which was considered not to have yet come to pass (the Eastern Roman Empire persisted until 1453). This is the case for example in the tenth-century writer Adso, whose Libellus de Antichristo incorporated the characteristic medieval myth of the Last Roman Emperor. Otto of Freising used the principle of translatio imperii and took the Holy Roman Empire as the continuation of the Roman Empire (as fourth monarchy).
  Protestant Reformation
  A series of Protestant theologians, such as Jerome Zanchius (1516–1590), Joseph Mede (1586–1639), and John Lightfoot (1602–1675), particularly emphasized the eschatological theory of four monarchies. Mede and other writers (such as William Guild (1586–1657), Edward Haughton and Nathaniel Stephens ()) expected the imminent end of the fourth empire, and a new age. The early modern version of the four monarchies in universal history was subsequently often attributed to the chronologist and astrologer Johann Carion, based on his Chronika (1532). Developments of his Protestant world chronology were endorsed in an influential preface of Philipp Melanchthon (published 1557).