text: Airlines and destinations The airport connects 50 domestic and 64 international destinations in Latin America, North America, Europe and Asia. Aeromexico serves the largest number of cities from any Latin American hub (80), 46 domestic and 34 international. It also operates the most departures and most destinations from the airport followed by Volaris. The most prominent foreign airlines are United Airlines, American Airlines, Delta Air Lines and Avianca Holdings.
  Passenger
  Notes:
  : China Southern’s flights to Shenzhen make a refueling stop in Tijuana. However, the airline does not have traffic rights to transport passengers solely between Mexico City and Tijuana.
  : Hainan Airlines’s flights to Beijing–Capital make a stop in Tijuana. However, the airline does not have traffic rights to transport passengers solely between Mexico City and Tijuana.
  : Turkish Airlines’ flights to Istanbul make a stop in Cancun. However, the airline does not have traffic rights to transport passengers solely between Mexico City and Cancun.
  Other services
  Apart from the scheduled airlines mentioned earlier, Mexico City Airport is utilized by several other carriers for chartered flights, such as Sunwing Airlines.
  Cargo
  As of January 2022, Mexico City airport was served by 20 cargo airlines flying directly to Europe, Central, North and South America, the Middle East, Africa and East Asia.