text: Doctor Nefarious Dr. Nefarious, voiced by Armin Shimerman, is the most recurring antagonist of the series. Dr. Nefarious is a robotic mad scientist and supervillain with a deep, distinct hatred for organic lifeforms. He is depicted as the arch-nemesis of Captain Qwark and later of the duo Ratchet and Clank. Throughout the series, Nefarious is always accompanied by his loyal robotic butler, Lawrence, who often proves to be much more shrewd than his pompous master. He has a famous trademark gag of that whenever he loses his temper or is put under extreme stress, Nefarious instantly malfunctions and freezes up, while radio waves of episodes from the fictional soap opera series Lance and Janice are broadcast through his mind, until he is whacked behind the head by Lawrence or someone else.
  Emperor Percival Tachyon
  Tachyon was raised by Lombaxes, but when he discovered that the Lombaxes banned his race from the universe he eventually did the same to them, only Ratchet, Alister Azimuth, Kaden and his wife (these two killed by Tachyon), and apparently also Angela Cross, stayed behind. This makes Tachyon a personal enemy of Ratchet's. He also created the Space Pirates, at least those featured in Tools of Destruction and Quest for Booty, including Captains Romulus Slag and Angstrom Darkwater and also Rusty Pete.