text: Rothwell was expected to face Mirko Filipović on February 21, 2010, at UFC 110. However, Rothwell had to withdraw from the event, just days prior, due to an illness and was replaced by Anthony Perosh.
  Rothwell then fought Gilbert Yvel on June 15, 2010, at UFC 115 where he won by unanimous decision (30–27, 29–28, and 29–28). Rothwell tore his ACL during his first takedown attempt, which required post-fight surgery. Rothwell also suffered a deviated septum from a head kick during the first round.
  After an extended layoff, Rothwell fought Mark Hunt on September 24, 2011, at UFC 135. He lost the fight via unanimous decision.
  Rothwell then faced Brendan Schaub on April 21, 2012, at UFC 145. He won the fight via knockout in round one. Rothwell also earned Knockout of the Night honors for his performance.
  Rothwell was expected to face Travis Browne at UFC on Fox: Shogun vs. Vera, but pulled out due to an injury
  Rothwell faced Gabriel Gonzaga on January 19, 2013, at UFC on FX: Belfort vs. Bisping He lost the fight via submission in the second round.
  Rothwell faced Brandon Vera at UFC 164 on August 31, 2013. He won the fight via TKO by punches in round three. Subsequent to the bout, Rothwell tested positive for elevated testosterone levels. The UFC suspended Rothwell for nine months, despite the Wisconsin commission only issuing him with an administrative warning.