Simona Mafai De Pasquale (5 July 1928 – 16 June 2019) was an Italian politician. She was a member of the Communist Party (PCI). She was elected to the Senate of the Republic in 1976, serving until 1979. She was born in Rome and was the daughter of painters/sculptors Mario and Antonietta Raphael. Mafai De Pasquale was married to Pancrazio De Pasquale, future president of the Sicilian Regional Assembly, until his death in 1992.