	Carlton recruited Prespakis with their first selection and third overall in the 2018 AFL Women's draft. She made her AFL Women's debut in the opening round of the 2019 season against at North Hobart Oval. The following round, she was nominated for the 2019 AFL Women's Rising Star award after kicking one goal and amassing 20 disposals, seven clearances and nine contested possessions against . Prespakis went on to play in the 2019 AFL Women's Grand Final loss to Adelaide in front of a record AFL Women's crowd, and was among Carlton's best players. Following a debut season in which she averaged 19 disposals and kicked seven goals across nine games, Prespakis won the 2019 AFL Women's Rising Star award with 49 votes and was named in the 2019 AFL Women's All-Australian team. She also won the AFLW Players' best first-year player award and tied for the Carlton best and fairest award with captain Brianna Davey, capping off a memorable first season.