	Wyeth married Florence Nightingale Sims, the daughter of surgeon J. Marion Sims, on August 10, 1886. They had two sons and one daughter. One of their sons, Marion Sims Wyeth, became an architect who designed many mansions in Florida. Another son, John Allan Wyeth, Jr., was a poet. After his first wife died, Wyeth married Marguerite Chalifoux.