Medrano studied at the School of Visual Arts in New York and graduated in August 2014. She began working on the webcomic "ZooPhobia" in 2012, before cancelling it in 2016. She cancelled it so that she could work on a new project called "Hazbin Hotel". In 2019, the pilot for "Hazbin Hotel" was released. The pilot for "Helluva Boss" was also released in 2019, because she had been secretly working on it too.