Our objective was to determine whether women>or = age 35 are more likely to undergo invasive testing after risk adjustment as compared with younger women at similar adjusted risk. Results of first-trimester combined aneuploidy risk assessment of singleton pregnancies from 2007-2008 were reviewed. For each level of adjusted risk, the rate of invasive testing (CVS or amniocentesis) was compared for those<age 35 and those>or = age 35. Spearman correlation, Fisher's exact test, and chi2 for trend were used for statistical comparison. For all categories except adjusted risk of 1 in<or = 250, women>or = age 35 were significantly more likely to undergo invasive testing as compared with younger women of similar risk. In women>or = age 35 with low adjusted risk, we observed a trend towards lower rates of invasive testing over time.
The higher rate of invasive testing in those>or = 35 indicates that women are still being categorized based on age, though our data suggest this may be decreasing.
Are age cutoffs still used to identify candidates for invasive testing for chromosomal abnormalities?