NEDD4 [SEP] found in taxon
adaptors. The catalytic HECT domain forms a thioester bond with activated ubiquitin transferred from an E2 ubiquitin conjugating enzyme, before transferring ubiquitin directly to a specific substrate.
Expression.
The human "NEDD4" gene is located on chromosome 15q21.3, and consists of 30 exons that transcribe five protein variants of NEDD4, all of which vary in the C2 domain but share 100% identity from the first WW domain through to the end of the protein. The mouse "Nedd4" gene is located on chromosome 9. NEDD4 is a
of neuropathic pain NEDD4-2 expression has been found to be downregulated. Also NEDD4-2-deficiency results in hyperexcitability of DRG neurons and contributes to pathological pain
Interactions.
NEDD4L has been shown to interact with SCNN1A.