MT-ATP6 [SEP] found in taxon
called protons, to flow across a specialized membrane inside mitochondria. Another segment of the enzyme uses the energy created by this proton flow to convert a molecule called adenosine diphosphate (ADP) to ATP. Mutations in the "MT-ATP6" gene have been found in approximately 10 to 20 percent of people with Leigh syndrome.
Structure.
The "MT-ATP6" gene provides information for making a protein that is essential for normal mitochondrial function. The human "MT-ATP6" gene, located in mitochondrial DNA
, is 681 base pairs in length. An unusual feature of "MT-ATP6" is the 46-nucleotide gene overlap of its first codons with the end of the "MT-ATP8" gene. With respect to the "MT-ATP6" reading frame (+3), the "MT-ATP8" gene ends in the +1 reading frame with a TAG stop codon.
The MT-ATP6 protein weighs 24.8 kDa and is composed of 226 amino acids. The protein is a subunit of the FF ATPase, also