FAM135B [SEP] found in taxon
FAM135B
FAM135B is a human gene coding for a protein of unknown function. It is well conserved in primates, rodents, zebra fish. It has one paralog, FAM135A.
Gene.
FAM135B is located on the long arm of Chromosome 8 in humans on the anti-sense located at 24.23. The following genes are near FAM135B on the chromosome:
- COL22A1: Collagen producing gene that is a cell adhesion ligand for skin epithelial cells and fibroblast
- FLJ45972: Gene function is unknown
- KCNK9: Gene
that encodes for a two pore potassium channel
Expression.
FAM135B is expressed in the brain, ear, eye, pancreas and testis. Within the brain, expression is apparent within the motor nucleus of trigeminal In addition, it is mainly expressed in normal health states, although it has shown moderate expression in glioma, non-neoplasima as well as expression in germ cell tumors.
Interactions.
FAM135B has shown to interact with KAT5, a gene that encodes for a histone acetyltransferase through yeast two-hybrid experimentation.