GLRX5 [SEP] chromosome
GLRX5
Glutaredoxin 5, also known as GLRX5, is a protein which in humans is encoded by the "GLRX5" gene located on chromosome 14. This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron- sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia.
Structure.
The GLRX5 gene contains 2 exons and encodes for a protein that is 13 kDa in size. The protein is
highly expressed in erythroid cells. Crystal structure of the GLRX5 protein reveals that the protein likely exists as a tetramer with two Fe-S clusters buried in the interior.
Function.
GLRX5 is a mitochondrial protein is conserved evolutionarily and plays a role in the formation of iron-sulfur clusters, which function to maintain iron homeostasis within the mitochondria and in the cell. GLRX5 is required for the steps in haem synthesis that involves mitochondrial enzymes, and is therefore involved in hematopoiesis. GLRX5 activity is required for normal regulation of