MARCH5 [SEP] found in taxon
MARCH5
E3 ubiquitin-protein ligase MARCH5, also known as membrane-associated ring finger (C3HC4) 5, is an enzyme that, in humans, is encoded by the "MARCH5" gene. It is localized in the mitochondrial outer membrane and has four transmembrane domains.
Structure.
Structure Gene.
The human gene "MARCH5", also known as "MITOL" or " RNF153", has 7 Exons and locates at the chromosome band 10q23.32-q23.33.
Structure Protein.
The human E3 ubiquitin-protein ligase
MARCH5 protein, a member of the transmembrane RING‐finger protein family is 31 kDa in size and composed of 278 amino acids with a N-terminal Zinc-finger domain at amino acid sequence 6-75 and four C-terminal transmembrane spans. The theoretical PI of this protein is 9.00.
Function.
As a E3 ubiquitin ligases, enzyme MARCH 5 catalyzes the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to an identified protein substrate. MARCH5 was firstly identified as a mitofusin 2- and Drp1-binding protein. MARCH5 promotes