DUF1220 [SEP] found in taxon
DUF1220
DUF1220 is a protein domain that shows a striking human lineage-specific (HLS) increase in copy number and may be involved in human brain evolution. The protein domain has also been linked to several neurogenetic disorders such as schizophrenia and increased severity of autism. In 2018, the name of the DUF1220 domain was changed to the Olduvai domain based on data obtained since initial discovery of the domain.
The copy number of DUF1220 domains increases generally as a function of a species's evolutionary proximity to humans. The increase
is considered the ancestral exons, and the NBPF family has been linked to primate evolution.
Function.
The function of NBPF16 is not fully understood. It is a member of the NBPF family of proteins, which have been linked to possible roles in oncogenesis and tumor suppressor genes.
Protein.
The protein is composed of 670 amino acids. The gene contains five domains of unknown function, called DUF1220. DUF1220 domains are found in all members of the NBPF gene family, although the number differs between each member