CYP2D6 [SEP] chromosome
function) will have an exaggerated response to the drug and stronger side-effects.
Genetic basis of variability.
The genetic basis for CYP2D6-mediated metabolic variability is the "CYP2D6" allele, located on chromosome 22. Subjects possessing certain allelic variants will show normal, decreased, or no CYP2D6 function, depending on the allele. Pharmacogenomic tests are now available to identify patients with variations in the CYP2D6 allele and have been shown to have widespread use in clinical practice.
Ethnic factors in variability.
Race is a factor
- Integrating fragmented software applications into holistic solutions: focus on drug discovery Yuryev A, Expert Opinion on Drug Discovery, April 2011, 6(4):383-392(10)
- Analysis and construction of pathogenicity island regulatory pathways in Salmonella enterica serovar Typhi Ong SY, Ng FL, Badai SS, Yuryev A, Alam M, J Integr Bioinform. 2010 Sep 23;7(1)
- Custom CGH array profiling of copy number variations (CNVs) on chromosome 6p21.32 (HLA locus) in patients with venous malformations associated with multiple sclerosis Ferlini A, Bovolenta