Bence Jones protein [SEP] named after
specimen (which causes the protein to precipitate) and now by electrophoresis of concentrated urine. More recently, serum free light chain assays have been utilised in a number of published studies which have indicated superiority over the urine tests, particularly for patients producing low levels of monoclonal free light chains, as seen in nonsecretory multiple myeloma and AL amyloidosis.
History.
The Bence Jones protein was described by the English physician Henry Bence Jones in 1847 and published in 1848.
(1852). The eponymous Dalrymple's sign is named after him, which is an abnormal wideness of the palpebral fissures in exophthalmic goiter.
External links.
- Ophthalmology Hall of Fame (biography of John Dalrymple)
- The Discovery of Bence Jones Protein