Thymidine kinase 1 [SEP] found in taxon
Thymidine kinase 1
Thymidine kinase 1, soluble (gene name TK1), is a human thymidine kinase.
Two forms of this protein have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells.
Interactions.
Thymidine kinase 1 has been shown to interact with P21.
Thymidine Kinase 1 in Cancer.
Thymidine kinase has been making
Thymidine kinase
Thymidine kinase is an enzyme, a phosphotransferase (a kinase): 2'-deoxythymidine kinase, ATP-thymidine 5'-phosphotransferase, EC 2.7.1.21. It can be found in most living cells. It is present in two forms in mammalian cells, TK1 and TK2. Certain viruses also have genetic information for expression of viral thymidine kinases.
Thymidine kinase catalyzes the reaction:
where Thd is (deoxy)thymidine, ATP is adenosine triphosphate, TMP is (deoxy)thymidine monophosphate and ADP is adenosine diphosphate.
Thymidine kinases have a key function