Methylphenidate [SEP] time of discovery
Chemistry Detection in biological fluids.
The concentration of methylphenidate or ritalinic acid, its major metabolite, may be quantified in plasma, serum or whole blood in order to monitor compliance in those receiving the drug therapeutically, to confirm the diagnosis in potential poisoning victims or to assist in the forensic investigation in a case of fatal overdosage.
History.
Methylphenidate was first made in 1944, and was identified as a stimulant in 1954.
Methylphenidate was synthesized by Ciba (now Novartis) chemist Leandro Panizzon. He named the
to Brookefield", on March 29, 1688; "The Grove Landing", on July 10, 1688; "The Forrest", on Sep. 5, 1694; "Dan" on September 6, 1694; "Brookes Discovery", on Dec. 10, 1695; and "The Prospect", on Dec. 11, 1695. At the time of his death on January 7, 1730 at "Brookefield", Thomas had amassed over 7,000 acres (28 km²) of land, in which a majority was