Ube3a-ATS [SEP] found in taxon
Ube3a-ATS
UBE3A-ATS/Ube3a-ATS (human/mouse), otherwise known as ubiquitin ligase E3A-ATS, is the name for the antisense DNA strand that is transcribed as part of a larger transcript called "LNCAT" (large non-coding antisense transcript) at the "Ube3a" locus. The "Ube3a" locus is imprinted and in the central nervous system expressed only from the maternal allele. Silencing of "Ube3a" on the paternal allele is thought to occur through the "Ube3a-
ATS" part of "LNCAT", since non-coding antisense transcripts are often found at imprinted loci. The deletion and/or mutation of "Ube3a" on the maternal chromosome causes Angelman Syndrome (AS) and "Ube3a-ATS" may prove to be an important aspect in finding a therapy for this disease. While in patients with AS the maternal "Ube3a" allele is inactive, the paternal allele is intact but epigenetically silenced. If unsilenced, the paternal allele could be a source of active Ube3a protein in AS patients