KIAA1841 [SEP] found in taxon
acids.
Gene Gene neighborhood.
Genes PEX13 and C2orf74 neighbor KIAA1841 on chromosome 2.
Gene Expression.
KIAA1841 is highly expressed in reproductive structures and nervous tissue. These include the brain, prostate, cervix, ear and nervous tissue. It is intermediately expressed in the lungs and spinal cord. KIAA1841 is expressed at low levels in a wide range of tissues throughout the human body.
Gene Transcript variants.
In humans, the KIAA1841 gene produces 18 alternatively spliced transcript variants as well as 3 unspliced. From the 18
domains.
Protein Post-translational modifications.
KIAA1841 is highly phosphorylated post modification. There are 37 predicted phosphorylated sites. There is one leucine-rich nuclear export signal toward the end of the protein. There is one sulfated tyrosine, which strengthens protein-protein interactions. Two motifs with high probability of post translational modification sumoylation sites were found. Sumoylation sites are involved in a number of cellular processes, including nuclear-cytosolic transport, transcriptional regulation and protein stability.
Protein Secondary structure.
KIAA1841 is primarily composed of alpha