FAM63A [SEP] found in taxon
FAM63A
Family with sequence similarity 63, member A is a protein that, in humans, is encoded by the FAM63A gene. It is located on the minus strand of chromosome 1 at locus 1q21.3.
Evolutionarily, FAM63A orthologs are found in most vertebrates, and distant homologs of FAM63A are found in invertebrates. FAM63A is ubiquitously expressed throughout human tissues, and it is present during every stage of development.
It has been linked to a biomarker in Chronic Kidney Disease and Alzheimer's Disease.
Gene.
Gene Locus
-403 and from amino acid 426-429, leading to an elevated glutamine composition at the C-terminus.
Protein Composition.
FAM63A is composed of 469 amino acids. There is an increased presence of glutamine found near the C terminus making FAM63A glutamine rich.
FAM63A contains a greater amount of negatively charged (acidic) amino acids than positively charged (basic) amino acids which makes FAM63A a slightly acidic protein. Acidic amino acids such as aspartic acid and glutamic acid are more prevalent than the basic amino acids such