CD99 [SEP] found in taxon
. Antibodies to CD99 are used in diagnostic immunohistochemistry to distinguish Ewing's sarcoma from other tumours of similar histological appearance, as well as for the identification of thymic tumours, and of spindle cell tumours, such as synovial sarcoma, haemangiopericytoma, and meningioma. EWS/FLI is thought to regulate CD99, but knockdown of EWS/FLI results in only a modest reduction in CD99. When CD99 expression is knocked down in human cells with Ewing's sarcoma and those cells are grafted onto mice, tumor and bone metastasis development is reduced
in different parts of a tissue. Proteins found in an ATeratoid/RT are:
- Vimentin-positive
- Cytokeratin-positive
- Neuron specific enolase-positive
- Epitelial membrane antigen-positive
- Glial fibrillary acidic protein- positive
- Synaptophysin
- Chromogranin
- Smooth muscle actin
- Desmin
- Carcinoembrionary antigen
- CD99 antigen;
- S-100
- neurofilaments
- AFP – not found
- HCG – negative
Pathology Immunohistochemistry Cytogenetic studies.
Cytogenetics is the study of a tumor’s