FAM46C [SEP] chromosome
FAM46C
Protein FAM46C also known as family with sequence similarity 46, member C is a protein that, in humans, is encoded by the "FAM46C" gene at locus 1p12 spanning base pairs from 118,148,556 to 118,171,011.
Summary.
FAM46C is a protein of unknown function consisting of 391 amino acid residues that are translated from an mRNA consisting of 5720 base pairs. FAM46C was initially sequenced as part of the Full-length long Japan genomic sequencing project. FAM46C is found on chromosome 1 at the locus 1p12 FAM46C contains
one domain of unknown function, DUF1693, and as such has been placed in the DUF1693 protein family. This protein family has been established as a part of the Nucleotidyltransferase superfamily and contains 4 nematode prion-like proteins. FAM46C was placed into group XXV of the nucleotidyltransferase superfamily along with 3 other "Homo sapiens" FAM46 proteins (A, B, D).
It has been suggested that FAM46C may be functionally involved with the Type 1 interferon response. Deletion and/ or mutation of FAM46C has been associated with impaired overall