TMEM106A [SEP] found in taxon
bacteria, plants, or fungi.
Expression.
"TMEM106A" is expressed in several human tissues. The tissues with highest expression are uterus, kidneys, small intestine, and stomach. EST profiles for orthologs show expression is conserved with greatest expression in kidneys and lesser expression in several other areas. Some tissues never show expression including: muscle, adipose tissue, and bone.
Gene neighborhood.
In "Homo sapiens", TMEM106A is located next to "NBR1", a gene identified as an ovarian tumor
which belongs to the DUF1356 superfamily. This family consists of several mammalian proteins that are around 250 amino acids in length. TMEM106B and TMEM106C are conserved in invertebrates to mammals.
Homology Orthologs.
The "TMEM106A" gene has been found in only the Chordate phylum. Of the three subphyla, "TMEM106A" is most commonly found in Vertebrata and has also been found in select members of Tunicata, which are invertebrate marine filter feeders. This phylum split occurred 722.5 million years ago. "TMEM106A" has not been seen in