LSMEM1 [SEP] chromosome
LSMEM1
Leucine-Rich Single-Pass Membrane Protein 1 (LSMEM1) is a protein that, in humans, is encoded by the LSMEM1 gene.
Gene.
In humans, LSMEM1 is located on chromosome 7q31.1. LSMEM1 neighbors the gene IFRD1 in humans. Aliases for LSMEM1 include C7orf53, chromosome 7 open reading frame 53, and FLJ39575. The human mRNA is 1686 base pairs long and the gene contains 5 exons. The human mRNA also has a 5' UTR and a 3' UTR. The 5'
protein encoded by the gene LSMEM1 that were determined via two-hybrid screening (LSMEM2 and MAL) and reconstituted complex (APP) experiments. A reconstituted complex experiment detects interactions between purified proteins in vitro. The 3 proteins thought to interact with LSMEM1 are: MAL, APP, and LSMEM2. All three of these interacting proteins are integral membrane proteins, just as LSMEM1 is.
Clinical Significance.
LSMEM1 expression levels in humans are greatly decreased in septic skeletal muscle. For humans, the LSMEM1 protein has 17 SNP missense