GAS6 [SEP] found in taxon
GAS6
Growth arrest-specific 6, also known as GAS6, is a human gene coding for the Gas6 protein. It is similar to the Protein S with the same domain organization and 43% amino acid identity. It was originally found as a gene upregulated by growth arrested fibroblasts.
Function.
Gas6 is a gamma-carboxyglutamic acid (Gla) domain-containing protein thought to be involved in the stimulation of cell proliferation.
Interactions.
Gas6 has been shown to interact with AXL receptor tyrosine kinase,
Gas6). The Gla domain is responsible for high-affinity binding of calcium ions (Ca to Gla proteins, which is often necessary for their conformation, and always necessary for their function.
Role in coagulation.
Gamma-carboxyglutamic acid residues play an important role in coagulation. The high-affinity calcium binding sites in the GLA domain of factor IX, which is a serine protease of the coagulation system, were found to partially mediate the binding of factor IXa to platelets and in factor-X activation. In