NKG2D [SEP] chromosome
NKG2D
NKG2D is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors. NKG2D is encoded by "KLRK1" gene which is located in the NK-gene complex (NKC) situated on chromosome 6 in mice and chromosome 12 in humans. In mice, it is expressed by NK cells, NK1.1 T cells, γδ T cells, activated CD8 αβ T cells and activated macrophages. In humans, it is expressed by NK cells, γδ T cells and CD8 αβ T cells
2, member D""). MICA is broadly recognized by NK cells, γδ T cells, and CD8 αβ T cells which carry NKG2D receptor on their cell surface and which are activated "via" this interaction.
Structure.
The MICA gene is highly polymorphic in humans with more than 50 defined alleles. It is located on chromosome 6 and the protein is expressed in two isoforms formed by alternative splicing: MICA1 and MICA2 which is lacking exon 3. MICA contains external α1α2α3 domain, transmembrane segment and C