Endothelin 1 [SEP] found in taxon
Endothelin 1
Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is a potent vasoconstrictor that in humans is encoded by the "EDN1" gene and produced by vascular endothelial cells. The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. Endothelin 1 is one of three isoforms of human endothelin.
Preproendothelin is precursor of the peptide ET-1. Endothelial cells convert preproendothelin to proendothelin and subsequently to mature endothelin, which the cells release.
Endothelin-1 receptor antagonists (Bosentan
responsible an excess local pulmonary production of vasoconstrictors that occurs while vasodilatation predominates systemically. Key here are imbalances between vasodilatory and vasoconstricting molecules; endogenous prostacyclin and thromboxane (from Kupffer Cells) or nitrous oxide (NO) and endothelin-1 (ET-1). ET-1 is the most potent vasoconstrictor under investigation and it has been found to be increased in both cirrhosis and pulmonary hypertension. Endothelin-1 has two receptors in the pulmonary arterial tree, ET-A which mediates vasoconstriction and ET-B which mediates vasodilation. Rat models have shown decreased ET-