ITM2B [SEP] chromosome
ITM2B
Integral membrane protein 2B (ITM2B or BRI2) is a protein that in humans is encoded by the "ITM2B" gene.
"ITM2B" or "BRI2" is a gene located on chromosome 13. The gene is connected to familial Danish dementia and familial British dementia causing amyloid and pre-filbrillar effects similar to those seen in Alzheimer's.
mouse gene knock-out studies, the amount of ADAM7 secreted is directly linked to ADAM2 and ADAM3 protein levels. Complex formation between ADAM7, Calnexin, Hspa5, and Itm2b have been shown to act as a molecular chaperone after ADAM7 is incorporated into the membrane of sperm cells. Furthermore, complex formation with Itm2b is increased during sperm capacitation leading to a conformation change in ADAM7. As such, the ADAM7 protein plays an important function involved in sperm capacitation, although this function is not entirely understood.
Mechanism of secretion and