ERBB3 [SEP] chromosome
located on the long arm of chromosome 12 (12q13). It is encoded by 23,651 base pairs and translates into 1342 amino acids.
During human development, "ERBB3" is expressed in skin, bone, muscle, nervous system, heart, lungs, and intestinal epithelium. "ERBB3" is expressed in normal adult human gastrointestinal tract, reproductive system, skin, nervous system, urinary tract, and endocrine system.
Structure.
ErbB3, like the other members of the ErbB receptor tyrosine kinase family, consists
ERBB3
Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene.
ErbB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases. The kinase-impaired ErbB3 is known to form active heterodimers with other members of the ErbB family, most notably the ligand binding-impaired ErbB2.
Gene and expression.
The human "ERBB3" gene is