USP18 [SEP] found in taxon
USP18
Ubiquitin specific peptidase 18 (USP18), also known as UBP43, is an isopeptidase that in human is encoded by the "USP18" gene. USP18 is a member of the deubiquitinating protease family of enzymes. It is thought to remove ISG15 adducts from a broad range of protein substrates, a process known as deISGylation. In mice, deletion of this enzyme results in increased inflammatory response to type I interferons, suggesting that USP18 may, in part, regulate interferon responsiveness.
of cytokine signaling 1 (SOCS1) and ubiquitin-specific peptidase 18 (USP18), are induced after 4 hours. SOCS1 inhibits type I IFN signaling by inhibiting JAKs and binding phosphorylated Tyk2. USP18 binds to the C terminus of IFNAR2. USP18 may regulate type I IFN signaling by interfering with ternary complex formation, not through its peptidase function. Loss of USP18 results in an inflammatory interferon-mediated CNS disease.
Clinical implications.
Type I IFN can provide both beneficial or deleterious effects in a variety of diseases.