ATF5 [SEP] found in taxon
ATF5 expression is regulated at both the transcriptional and translational level.
ATF5 is expressed in VZ and SVZ during brain development.
The human ATF5 protein is made up of 282 amino acids.
ATF5 is a transcription factor that contains a bZip domain.
See also.
- Activating transcription factor
Interactions.
ATF5 has been shown to interact with DISC1 and TRIB3.
ability of DISC1 to form complexes with itself may be important in regulating its affinity for interacting partners such as NDEL1. In postmortem brain samples of Schizophrenia patients there is an increase in insoluble DISC1 oligomer aggregates, indicative of a common link with other neurological disorders characterised by protein aggregation, namely Alzheimer's disease, Parkinson's disease, and Huntington's disease.
Protein interactions ATF4/ATF5.
ATF4 and ATF5 are members of the leucine zipper activating transcription factor / CREB family. They are known to bind to and regulate the function