C11orf52 [SEP] chromosome
C11orf52
C11orf52 is an uncharacterized protein that in homo sapiens is encoded by the "C11orf52" gene.
Gene.
Gene Location.
C11orf52 is located on chromosome 11 at 11q23.1, starting at 111908620 and ending at 112064278. C11orf52 spans 155658 base pairs and is orientated on the positive strand. Gene C11orf52 has a molecular weight of 14kDa and is a protein coding gene of 7,995 bp containing four exons. The coding region is made up of 1,168 bp.
Gene Gene neighborhood.
Genes HSPB2, CRYAB, OLAT,
can be found going back to Geospiza fortis - the most distantly related to "Homo Sapiens" C11orf52 sequence. Gene duplication first occurred approximately 324.5 million years ago in reptiles and birds. There are no paralogs for the C11orf52 gene.
Clinical significance.
Unusual DNA methylation in the C11orf52 gene in some children can be attributed to prenatal smoke exposure.
C11orf52 may also play a role in lung cancer. C11orf52 is expressed in the lungs and has been associated with increased phosphorylation in cell lung cancer tumors. There is evidence