CXCL10 [SEP] found in taxon
CXCL10
C-X-C motif chemokine 10 (CXCL10) also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10 is an 8.7 kDa protein that in humans is encoded by the "CXCL10" gene. C-X-C motif chemokine 10 is a small cytokine belonging to the CXC chemokine family.
Gene.
The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines.
Function.
CXCL10 is secreted by several cell
3 different conditions to a resolution of up to 1.92 Å. The Protein Data Bank accession codes for the structures of CXCL10 are , , and .
Biomarkers.
CXCL9, CXCL10 and CXCL11 have proven to be valid biomarkers for the development of heart failure and left ventricular dysfunction, suggesting an underlining pathophysiological relation between levels of these chemokines and the development of adverse cardiac remodeling.
Clinical significance.
Baseline pre-treatment plasma levels of CXCL10 are elevated in patients chronically infected with hepatitis C virus (HCV) of genotypes 1