Tissue plasminogen activator [SEP] chromosome
activator is a protein encoded by the "PLAT" gene, which is located on chromosome 8. The primary transcript produced by this gene undergoes alternative splicing, producing three distinct messenger RNAs.
See also.
- Ultrasound-enhanced systemic thrombolysis
External links.
- History of Discovery: The Tissue-Type Plasminogen Activator Story, Collen, D., Lijnen, H.R.
- Genentech Press Release 1982
- Tissue Plasminogen Activator from the American Heart Association
- Widening the Window : Strategies to buy time in treating
of tissue plasminogen activator and urokinase is plasminogen activator inhibitor-1 (PAI-1). Plasminogen activator inhibitor-1 is a serine protease, synthesized by endothelial cells, that specifically inhibits tissue plasminogen activator (tPA) and urokinase (uPA). Tissue plasminogen activator and urokinase are the activators of plasminogen and results in the breakdown of blood clots (fibrinolysis).
PAI-1 levels has also been studied in patients and how they influence certain diseases. Elevated serum levels of PAI-1 have been found in obese individuals. Elevated levels of PAI-1 also seem to increase