LYK5 [SEP] found in taxon
LYK5
Protein kinase LYK5, also known as LYK5 or STRADα, is a human protein and also denotes the gene encoding it.
Function.
Endogenous LKB1 and STRADα form a complex in which STRADα activates LKB1, resulting in phosphorylation of both partners. Removal of endogenous LYK5 by small interfering RNA abrogates LKB1-induced G1 phase arrest. STRADα stabilizes LKB1 protein both in vivo and in vitro, and is capable of eliciting multiple axons in mouse embryonic cortical cultured neurons when overexpressed with LKB1. STRADα is highly spliced in vivo, and
MO25 .
Splice variants.
Alternate transcriptional splice variants of this gene have been observed and characterized. There are two main splice isoforms denoted LKB1 long (LKB1) and LKB1 short (LKB1). The short LKB1 variant is predominantly found in testes.
Interactions.
STK11 has been shown to interact with:
- CDC37,
- * Fyn
- HSP90AA1
- LYK5, and
- SMARCA4.
- ERalpha
External links.
- GeneReviews/NCBI/NIH/UW entry on Peutz