SOD2 [SEP] chromosome
SOD2
Superoxide dismutase 2, mitochondrial (SOD2), also known as manganese-dependent superoxide dismutase (MnSOD), is an enzyme which in humans is encoded by the "SOD2" gene on chromosome 6. A related pseudogene has been identified on chromosome 1. Alternative splicing of this gene results in multiple transcript variants. This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts
species also increased with cellular age, but by a greater amount in SOD2 mutant cells than in wild-type cells. In the fission yeast "Schizosaccharomyces pombe", SOD2 deficiency, drastically increased cellular aging and decreased cell viability in the stationary phase of the growth cycle.
Role in invertebrates.
SOD2's significant role in oxidative stress management makes it an essential component of the mitochondria. As a result, SOD2 similarly to SOD1 and SOD3 is highly conserved in vertebrates as well as in invertebrates. In the study Multiple