ADAM17 [SEP] found in taxon
possibility that ADAM17-mediated ectodomain shedding may also occur in the intracellular environment, in contrast with the conventional model.
Functional ADAM17 has been documented to be ubiquitously expressed in the human colon, with increased activity in the colonic mucosa of patients with ulcerative colitis, a main form of inflammatory bowel disease. Other experiments have also suggested that expression of ADAM17 may be inhibited by ethanol.
Model organisms.
Model organisms have been used in the study of ADAM17 function. A conditional knockout mouse line, called "Adam17" was generated
on rodents pre-exposed to chloroethyl ethyl sulfide, nitrogen mustard, and sulfur mustard and has shown a marked acceleration of wound healing. While NDH4338 has several mechanisms of action, a principle one is suppression of mast cell degranulation in skin.
Hydroxamate compounds developed by Heindel's lab have been found to enhance corneal wound healing after mustard exposure. Compounds studied include olvanil OH (NDH4409) and retro olvanil 8 (NDH4417). Hydroxamates reduced the activity of ADAM17 and matrix metalloproteinases (MMPs), and attenuated expression of EMMPRIN