CCL3L1 [SEP] found in taxon
(C-C motif) receptor 5 (CCR5).
CCR5 is a co-receptor for HIV, and binding of CCL3L1 to CCR5 inhibits HIV entry. Furthermore, the binding causes the receptor to be taken inside the cell by endocytosis, to eventually be reprocessed and re-expressed.
Gene organization.
The human genome reference assembly contains two full copies of the gene (CCL3L1 and CCL3L3) and an additional partial duplication, which is thought to result in a pseudogene, designated CCL3L2. This record represents
gene on HIV-1/AIDS susceptibility tested if the copy number of the CCL3L1 gene had any effect on an individual’s susceptibility to HIV-1/AIDS. They sampled several different individuals and populations for their CCL3L1 copy number and compared it to their HIV acquirement risk. They found that there is an association between higher amounts in the copy number of CCL3L1 and susceptibility to HIV and AIDS since individuals who were more prone to HIV had a low copy number of CCL3L1. This difference in copy number was shown to play a possibly significant role