Diablo homolog [SEP] chromosome
Diablo homolog
Diablo homolog (DIABLO) is a mitochondrial protein that in humans is encoded by the "DIABLO" (direct IAP binding protein with low pI) gene on chromosome 12. DIABLO is also referred to as second mitochondria-derived activator of caspases or SMAC. This protein binds inhibitor of apoptosis proteins (IAPs), thus freeing caspases to activate apoptosis. Due to its proapoptotic function, SMAC is implicated in a broad spectrum of tumors, and small molecule SMAC mimetics have been developed to enhance current cancer treatments.
by ZZ Top from "Tejas" (1976)
- "El Diablo", a song by Frankie Laine (1959)
- "El Diablo", a song by Grace Slick from "Dreams" (1980)
Other uses.
- Diablo homolog, a gene
- Diablo sandwich, a fast-food entree
- Diablo Data Systems, a division of Xerox
- Diablo 630, a daisy wheel printer
See also.
- Diabolo (disambiguation)
- Diabolos (disambiguation)