ARPP-21 [SEP] found in taxon
ARPP-21
Cyclic AMP-regulated phosphoprotein, 21 kD, also known as ARPP-21, is a human gene.
leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32. DARPP-32 is critical for dopamine dependent striatal synaptic plasticity, possibly by serving as a dopamine-dependent gating mechanism for calcium/CaMKII signaling. It has been predicted that DARPP-32, in conjunction with ARPP-21, could also be involved in setting-up of eligibility trace-like temporal window for striatal postsynaptic signaling.
Clinical significance.
Clinical significance CNS.
This gene is also known as "DARPP-32", highlighting its