GPR113 [SEP] found in taxon
also known by the aliases PGR23 and HGPCR37.
Homology & Evolution.
The GPR113 has 5 human paralogs GPR110, GPR115, GPR128, GPR111, and GPR116. GPR113 is well conserved in mammals from primates to semi-aquatic species, as well as some amphibians. These include the Common Chimpanzee, the African Bush Elephant, the Platypus, and the Western Clawed Frog. Homologous domains that are well conserved throughout orthologs center in the 7 transmembrane receptor (Secretin family) region highlighted in purple in the figure.
Protein
), Hormone Receptor Domain (Blue), Latrophilin/CL-1-like GPS domain (Orange), and the 7-transmembrane receptor (Purple). Between the Hormone Receptor Domain and the GPS is a Domain of unknown function that is not highlighted.
Function.
GPR113 is a G protein-coupled receptor that is involved in a neuropeptide signaling pathway.
Expression & Disease.
GPR113 has been found to be expressed differentially under diseased conditions. Under the condition of Type 2 diabetes, the percentile rank relative to other transcripts decreases