ZFP91-CNTF [SEP] found in taxon
ZFP91-CNTF
Zinc finger protein 91 homolog (mouse), ciliary neurotrophic factor transcription unit, also known as ZFP91-CNTF, is a human gene.
The genes ZFP91 and CNTF are adjacent on chromosome 11. In addition to a monocistronic transcript from each locus, a co-transcribed transcript also exists. The co-transcribed mRNA encodes an isoform of ZFP91 but does not appear to encode a CNTF protein.
leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. In addition to the predominant monocistronic transcript originating from this locus, the gene is also cotranscribed with the upstream ZFP91 gene. Cotranscription from the two loci results in a transcript that contains a complete coding region for the zinc finger protein but lacks a complete coding region for ciliary neurotrophic factor.
CNTF has also been shown to be expressed by cells on the bone surface, and to reduce the activity of bone-forming cells (osteoblasts