Hsp27 [SEP] found in taxon
. In particular, overexpression of HSP72 has been linked to the development of some cancers, such as hepatocellular carcinoma, gastric cancers, colonic tumors, breast cancers, and lung cancers, which led to its use as a prognostic marker for these cancers. Notably, phosphorylated Hsp27 increases human prostate cancer (PCa) cell invasion, enhances cell proliferation, and suppresses Fas-induced apoptosis in human PCa cells. Unphosphorylated Hsp27 has been shown to act as an actin capping protein, preventing actin reorganization and, consequently, cell adhesion and
.
An affinity of high expression levels of different phosphorylated Hsp27 species and muscle/neurodegenerative diseases and various cancers was observed. High expression levels possibly are in inverse relation with cell proliferation, metastasis, and resistance to chemotherapy. High levels of Hsp27 were also found in sera of breast cancer patients; therefore Hsp27 could be a potential diagnostic marker.
Function.
The main function of Hsp27 is to provide thermotolerance "in vivo", cytoprotection, and support of cell survival under stress conditions. More specialized functions of Hsp27