TPH1 [SEP] found in taxon
TPH1
Tryptophan hydroxylase 1 (TPH1) is an isoenzyme of tryptophan hydroxylase which in humans is encoded by the "TPH1" gene.
TPH1 was first discovered to synthesize serotonin in 1988 and was thought that there only was a single "TPH" gene until 2003, while a second form was found in the mouse ("Tph2"), rat and human brain (TPH2) and the original TPH was then renamed to TPH1.
Function.
Tryptophan hydroxylases catalyze the biopterin-dependent monooxygenation of tryptophan to 5-hydroxytryptophan
was found in the genes associated with schizophrenia. An example of a beneficial trait that has been selected for through positive selection is creativity. Three allelic variants of creativity genes that are also associated with schizophrenia include SLC6A4, TPH1 and DRD2. The high inheritance of creative and cognitive characteristics by these allelic variants in individuals expressing schizophrenia confirms evidence of positive selection within some schizophrenia genes. Additional studies conducted using SNP analysis on the SLC39A8 gene, a gene associated with Schizophrenia, found that the T-allele on the