HK3 [SEP] chromosome
HK3
Hexokinase 3 also known as HK3 is an enzyme which in humans is encoded by the "HK2" gene on chromosome 5. Hexokinases phosphorylate glucose to produce glucose-6-phosphate (G6P), the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]
Structure.
HK3 is one of four highly homologous hexokinase isoforms in mammalian cells. This protein has a molecular weight of
regulate HK3, and the double regulation may better suit its anabolic functions. By phosphorylating glucose, HK3 effectively prevents glucose from leaving the cell and, thus, commits glucose to energy metabolism. Compared to HK1 and HK2, HK3 possesses a higher affinity for glucose and will bind the substrate even at physiological levels, though this binding may be attenuated by intracellular ATP. Uniquely, HK3 can be inhibited by glucose at high concentrations. HK3 is also less sensitive to G6P inhibition.
Despite its lack of mitochondrial association, HK3 also