COX5A [SEP] chromosome
COX5A
Cytochrome "c" oxidase subunit 5a is a protein that in humans is encoded by the COX5A gene. Cytochrome "c" oxidase 5A is a subunit of the cytochrome c oxidase complex, also known as Complex IV, the last enzyme in the mitochondrial electron transport chain.
Structure.
The COX5A gene, located on the q arm of chromosome 15 in position 24.1, is made up of 5 exons and is 17,880 base pairs in length. The COX5A protein weighs 17 kDa and is composed of 150 amino
The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex.
Summary reaction:
Clinical significance.
COX5A (this gene) and COX5B are involved in the regulation of cancer cell metabolism by Bcl-2. COX5A interacts specifically with Bcl-2, but not with other members of the Bcl-2 family, such as Bcl-xL, Bax or Bak.
The "Trans"-activator of transcription protein (Tat) of human immunodeficiency virus (HIV) inhibits cytochrome "c