MNX1 [SEP] found in taxon
MNX1
Motor neuron and pancreas homeobox 1 (MNX1), also known as Homeobox HB9 (HLXB9), is a human protein encoded by the "MNX1" gene.
Clinical significance.
Mutations in the "MNX1" gene are associated with Currarino syndrome.
been shown to arise from the early expression of the gene Mnx1/Hlxb1 (Motor Neuron and pancreas homobox 1). Mnx1 expression has been shown to be important for the development of dorsal Pdx1, hence acting as a necessary transcription factor for the specification of foregut endoderm into Pdx1 expressing pancreatic progenitors. Similarly, another set of genes Gata4 (GATA binding protein 4) and Hnf1b/Tcf2 (HNF homobox B gene) is required for the development of the ventral bud of the developing pancreas. These genes regulates the expression of