ELP4 [SEP] found in taxon
ELP4
Elongation protein 4 homolog (S. cerevisiae), also known as ELP4, is a protein which in humans is encoded by the "ELP4" gene.
Function.
This gene encodes a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation. The human gene can partially complement sensitivity phenotypes of yeast ELP4 deletion mutants. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.
electrical stimulation. The findings here showed that the onset of spike-and-wave discharged were followed by 5–9 Hz oscillations in these cortical regions as well.
Pathophysiology Genetic/developmental factors.
Elongator Protein Complex 4 (ELP4) has been identified as a key component in the transcription of genes known to regulate the actin cytoskeleton, cell motility and migration of neurons. Research on "ELP4" has been linked the gene to a centrotemporal sharp spike phenotype. Hypotheses have been made that a mutation in the non-coding