TMEM18 [SEP] found in taxon
of human and plants. The gene seems to have been lost in two separate lineages, but is not found duplicated in any analyzed genomes. Hence, it is not essential for eukaryotic organisms, but there appears to be selection against multiple copies of the TMEM18 gene.
cellular function. In the mouse brain, it is found in the majority of all cells, but is more abundant in neurons than other cell types.
Clinical significance.
Genetic variants in the proximity of the TMEM18 gene are associated with obesity, insulin levels, and blood sugar levels 
Evolutionary history.
The TMEM18 gene has a long evolutionary history as it is present in both plants and animals. The TMEM18 protein's amino acid sequence is well conserved, which suggests that it has retained its function since the divergence