CLRN1-AS1 [SEP] found in taxon
CLRN1-AS1
In molecular biology, CLRN1 antisense RNA 1 (CLRN1-AS1) (previously known as clarin 1 opposite strand, CLRN1OS or USH critical region pseudogene, UCRP) is a human gene encoding a long non-coding RNA. It was originally identified in a screen to identify the genes responsible for Usher syndrome type 3 and presumed to be an unprocessed pseudogene.
See also.
- Long non-coding RNA
of AS1/2 were used to rescue the ribozyme activity; the results confirms the inhibitory roles of AS1/2. Third, mutational analysis introduces single/double mutations outside the ribozyme to ensure the observed ribozyme activity is directly associated with the stability of the Alt1. The stability of AS1 is found to be inversely related to the self-cleavage activity[26].
The second permissive structure enables the HDV ribozyme to self-cleave co-transcriptionally and this structure further includes the -54/-18 nt portion of the RNA transcript. The upstream inhibitory -24/-15 stretch