Placental growth factor [SEP] found in taxon
human atherosclerotic lesions is associated with plaque inflammation and neovascular growth.
Serum levels of PGF and sFlt-1 (soluble fms-like tyrosine kinase-1, also known as soluble VEGF receptor-1) are altered in women with preeclampsia. Studies show that in both early and late onset preeclampsia, maternal serum levels of sFlt-1 are higher and PGF lower in women presenting with preeclampsia. In addition, placental sFlt-1 levels were significantly increased and PGF decreased in women with preeclampsia as compared to those with uncomplicated pregnancies. This suggests that placental concentrations of sFlt-1 and
as intrauterine growth restriction (IUGR) and placental abruptions are risk factors that lead to placental disease. Especially when these symptoms are evident at early stages of pregnancy. The abnormal invasion of the trophoblast cells, lack of important growth factors such as vascular endothelial growth factor (VEGF) and placental growth factor (PlGF), has an association with the onset of placental disease.
Causes Risk factors.
Risk factors associated with placental disease are as follows:
- Smoking cigarettes and use other forms of drugs such as cocaine.