Phosphofructokinase 2 [SEP] found in taxon
Phosphofructokinase 2
Phosphofructokinase-2 (6-phosphofructo-2-kinase, PFK-2) or fructose bisphosphatase-2 (FBPase-2), is an enzyme indirectly responsible for regulating the rates of glycolysis and gluconeogenesis in cells. It catalyzes formation and degradation of a significant allosteric regulator, fructose-2,6-bisphosphate (Fru-2,6-P) from substrate fructose-6-phosphate. Fru-2,6-P contributes to the rate-determining step of glycolysis as it activates enzyme phosphofructokinase 1 in the glycolysis pathway, and inhibits fructose-1,6-bisphosphatase 1 in gluconeogenesis. Since Fru-2,6-P differentially regulates glycolysis and gluconeogenesis, it can act as a key signal to switch between the opposing pathways
- Review, Isis, Sep., 1998, vol. 89, no. 3, p. 557
- Review, Taxon, Nov., 1996, vol. 45, no. 4, p. 726
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