DEPDC5 [SEP] found in taxon
DEPDC5
DEPDC5 (or DEP domain-containing 5) is a human protein of poorly understood function but has been associated with cancer in several studies. It is encoded by a gene of the same name, located on chromosome 22.
Function.
The function of DEPDC5 is not yet known, but it has been implicated in intracellular signal transduction based on homology between the DEP domains of DEPDC5 and Dishevelled-1 (DVL1).
Mutations in this gene have been associated to cases of focal epilepsy (doi:10.1038/ng.2601)
lysosome The Ragulator-Rag complex Regulation of the Ragulator-Rag complex.
Rag activity is regulated by at least two highly conserved complexes: the "GATOR1" complex containing DEPDC5, NPRL2 and NPRL3 and the ""GATOR2" complex containing Mios, WDR24, WDR59, Seh1L, Sec13. GATOR1 inhibits Rags (it is a GTPase-activating protein for Rag subunits A/B) and GATOR2 activates Rags by inhibiting DEPDC5.
Upstream signaling.
Upstream signaling Receptor tyrosine kinases.
Upstream signaling Receptor tyrosine kinases Akt/PKB pathway.