HLA-E [SEP] found in taxon
HLA-E
HLA class I histocompatibility antigen, alpha chain E (HLA-E) also known as MHC class I antigen E is a protein that in humans is encoded by the "HLA-E" gene. The human HLA-E is a non-classical MHC class I molecule that is characterized by a limited polymorphism and a lower cell surface expression than its classical paralogues. The functional homolog in mice is called Qa-1b, officially known as H2-T23.
Structure.
Like other MHC class I molecules,
to destroy any infected or transformed cells.
Genes and isotypes.
- Very polymorphic
- (HLA-A)
- (HLA-B)
- (HLA-C)
- Less polymorphic
- (HLA-E)
- (HLA-F)
- (HLA-G)
- (pseudogene)
- (pseudogene)
Evolutionary history.
The MHC class I genes originated in the most recent common ancestor of all jawed vertebrates, and have been found in