CYR61 [SEP] found in taxon
are extracellular matrix proteins that play regulatory roles, particularly in the context of wound repair.
Gene structure and regulation.
CYR61 is located at human chromosome 1p22.3, whereas the mouse Cyr61 gene is located at chromosome 3, 72.9cM. The mouse CYR61 coding region spans ~3.2 Kb, containing 5 exons interspaced with 4 introns. The first exon encodes 5’-UTR sequence and the first several amino acids in the secretory signal peptide. The remaining four exons each encode a distinct CCN1 domain. The 5th exon also contains the 3’-UTR sequences, which
in mice, "Cyr61" is highly expressed in the cardiovascular, skeletal, and neuronal systems. Cyr61 knockout mice are embryonic lethal due to defects in cardiac septal morphogenesis, deficient blood vessel formation in placenta, and compromised vascular integrity. In "Xenopus laevis", Cyr61 is required for normal gastrulation and modulation of Wnt signaling.
Clinical relevance.
CYR61 is highly expressed at sites of inflammation and wound repair, and is associated with diseases involving chronic inflammation and tissue injury.
Clinical relevance Wound healing and fibrosis.