INSIG2 [SEP] found in taxon
INSIG2
Insulin induced gene 2, also known as INSIG2, is a protein which in humans is encoded by the "INSIG2" gene.
Regulation.
Insulin activates the human INSIG2 promoter in a process mediated by phosphorylated SAP1a.
Akt mediates suppression of Insig2a, a liver-specific transcript encoding the SREBP1c inhibitor INSIG2.
MCHR2 has been observed to significantly decrease INSIG2.
Insig2 is upregulated under hypoxic conditions and is associated with the malignant potential of pancreatic cancer.
A novel 1alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3] response
a novel colon cancer biomarker. Over-expression of Insig2 appeared to suppress chemotherapeutic drug treatment-induced Bcl2 associated X protein (Bax) expression and activation. Insig2 was also found to localize to the mitochondria/heavy membrane fraction and associate with conformationally changed Bax. Moreover, Insig2 altered the expression of several additional apoptosis genes located in mitochondria. In a study by Kumar et al., the common polymorphisms in INSIG2 gene was not found to be significant in Indian population.