PGRMC1 [SEP] found in taxon
, yeast cells lacking the DAP1 gene are highly sensitive to antifungal drugs This function is conserved between the unrelated fungi "S. cerevisiae" and "S. pombe". Dap1 also regulates the metabolism of iron in yeast.
In yeast and humans, PGRMC1 binds directly to P450 proteins, including CYP51A1, CYP3A4, CYP7A1 and CYP21A2. PGRMC1 also activates Cyp21 when the two proteins are co-expressed, indicating that PGRMC1 promotes progesterone turnover. Just as Dap1 is required for the action of Erg11 in the synthesis of ergosterol in yeast
Function.
The sigma-2 receptor takes part in a number of normal-function roles, including cell proliferation, non-neuronal, and neuronal signaling. Much of sigma-2 receptor function relies on signaling cascades. The receptor's interaction with EGFR and PGRMC1 proteins allow for sigma-2 receptors to play diverse roles within cell through Ras, PLC, and PI3K singaling.
Function Non-neuronal signaling.
Binding of a number of hormones and steroids, including testosterone, progesterone, and cholesterol, has been found to occur with sigma-2 receptors