E-selectin [SEP] chromosome
selectin locus on chromosome 1.
Different from P-selectin, which is stored in vesicles called Weibel-Palade bodies, E-selectin is not stored in the cell and has to be transcribed, translated, and transported to the cell surface. The production of E-selectin is stimulated by the expression of P-selectin which in turn, is stimulated by tumor necrosis factor α (TNFα), interleukin-1 (IL-1) and lipopolysaccharide (LPS). It takes about two hours, after cytokine recognition, for E
133,189,767 to 133,192,979. Within this region, there is 1 intron and 2 exons.
Gene Gene neighborhood.
LOC101928193 is flanked by GBGT1 and 0BP2B on chromosome 9. GBGT1 encodes a member of the ABO gene family and also plays a role in synthesizing glycolipids that are involved in tropism and binding pathogens. 0BP2B is a gene that associates with E-Selectin Level in the ABO gene region.
mRNA.
In humans, the LOC101928193 gene produces 3 transcript variants, which produce 3 isoforms of the protein. The LOC101928193