PINX1 [SEP] found in taxon
PINX1
PIN2/TERF1"-interacting telomerase inhibitor 1, also known as PINX1", is a human gene. "PINX1" is also known as "PIN2" interacting protein 1. "PINX1" is a telomerase inhibitor and a possible tumor suppressor.
Interactions.
PINX1 has been shown to interact with MCRS1, TERF1 and telomerase reverse transcriptase.
Structure.
There are two known variants of PINX1. The second variant “lacks an exon in the 3’ coding region which results in a frameshift compared to variant 1
cell death due to radiation. “PINX1 resistance to radiotherapy (RT) was attributed to PINX1 maintaining telomere stability, reducing ESCC cell death by RT-induced mitosis catastrophe.” High levels of PINX1 is a predictor of short disease-specific survival.
PINX1 levels were found to be reduced in urothelial carcinoma of the bladder (UCB) compared to normal urothelial bladder epithelium. “PINX1 levels were inversely correlated with tumor multiplicity, advanced N classification, high proliferation index, and poor survival.” Over-expression of PINX1