XBP1 [SEP] chromosome
XBP1
X-box binding protein 1, also known as XBP1, is a protein which in humans is encoded by the "XBP1" gene. The "XBP1" gene is located on chromosome 22 while a closely related pseudogene has been identified and localized to chromosome 5. The XBP1 protein is a transcription factor that regulates the expression of genes important to the proper functioning of the immune system and in the cellular stress response.
Discovery.
The X-box binding protein 1 (XBP1) is a transcription factor
are misregulated, and XBP1-lacking plasma cells fail to colonize their long-lived niches in the bone marrow and to sustain antibody secretion.
Function Eosinophil differentiation.
XBP1 is required for eosinophil differentiation. Eosinophils lacking XBP1 exhibit defects in granule proteins.
Function Angiogenesis.
XBP1 acts to regulate endothelial cell proliferation through growth factor pathways, leading to angiogenesis. Additionally, XBP1 protects endothelial cells from oxidative stress by interacting with HDAC3.
Function Viral replication.
This protein has also been identified as a cellular transcription factor that binds to an