Renalase [SEP] found in taxon
Renalase
Renalase, FAD-dependent amine oxidase is an enzyme that in humans is encoded by the RNLS gene. Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney.
Structure.
Structure Gene.
The gene encoding this protein is called RNLS (also known as C10orf59 or FLJ11218). The renalase gene has 9 exons spanning approximately 311,000 bp and resides on chromosome 10 at q23.33.
Structure Protein.
The renalase protein consists of a putative secretory signal peptide (SignalP
When catecholamines are released into the bloodstream however, renalase activity increases about tenfold within 30 seconds, and remains high for an hour or longer. Activation of circulating renalase is probably responsible for early activation, while secretion into the bloodstream occurs after 15 minutes.
polymorphisms in the renalase gene is a risk factor for essential hypertension.
Single nucleotide polymorphisms in the renalase gene are associated with type 1 diabetes. A genome-wide association study and meta-analysis found that approximately 42 loci affect the risk of diabetes The data confirmed