MLH1 [SEP] found in taxon
MLH1
MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) is a protein that in humans is encoded by the MLH1 gene located on chromosome 3. It is a gene commonly associated with hereditary nonpolyposis colorectal cancer. Orthologs of human MLH1 have also been studied in other organisms including mouse and the budding yeast "Saccharomyces cerevisiae".
Function.
This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer. It is a human homolog of the "E. coli" DNA mismatch repair
another example, Kitajima et al. found that immunoreactivity for MLH1 and MGMT expression was closely correlated in 135 specimens of gastric cancer and loss of MLH1 and MGMTappeared to be synchronously accelerated during tumor progression.
Deficient expression of multiple DNA repair genes are often found in cancers, and may contribute to the thousands of mutations usually found in cancers (see Mutation frequencies in cancers).
Meiosis.
In addition to its role in DNA mismatch repair, MLH1 protein is also involved in meiotic crossing over. MLH1 forms a heterodimer