SOGA2 [SEP] found in taxon
SOGA2
SOGA2, also known as Suppressor of glucose autophagy associated 2 or CCDC165, is a protein that in humans is encoded by the "SOGA2" gene.
SOGA2 has two human paralogs, SOGA1 and SOGA3.
In humans, the gene coding sequence is 151,349 base pairs long, with an mRNA of 6092 base pairs, and a protein sequence of 1586 amino acids. The SOGA2 gene is conserved in gorilla, baboon, galago, rat, mouse, cat, and more. There is distant conservation seen in
include:
- Sumoylation at amino acids 87, 152, 235, 392, and 1379.
- Sulfination at tyrosines 14 and 1249.
- Phosphorylation at a number of sites, highlighted in the following graphic:
Protein Secondary structure.
The consensus of the prediction software PELE, GOR4, and SOSUICoil is that the secondary structure of SOGA2 is dominated by alpha helices with interspersed regions of random coil. GOR4 indicated that SOGA2 is dominated by alpha-helices; it predicted a mere 5.61% of
residues in