Triadin [SEP] found in taxon
Triadin
Triadin, also known as TRDN, is a human gene associated with the release of calcium ions from the sarcoplasmic reticulum triggering muscular contraction through calcium-induced calcium release. Triadin is a multiprotein family, arising from different processing of the TRDN gene on chromosome 6. It is a transmembrane protein on the sarcoplasmic reticulum due to a well defined hydrophobic section and it forms a quaternary complex with the cardiac ryanodine receptor (RYR2), calsequestrin (CASQ2) and junctin proteins. The luminal (inner compartment of the sarcoplasmic reticulum
to a weakened interaction between CASQ2 and Triadin. This removes CASQ2’s ability to have an inhibitory effect on the RYR2 channel activity. As more Ca binding sites on CASQ2 become occupied, there is an increasing probability of the RYR2 channel being able to open. Eventually, CASQ2 completely dissociates from Triadin and the RYR2 channel becomes completely uninhibited, although Triadin remains bound to RYR2 at all luminal concentrations of Ca.
Relation to catecholaminergic polymorphic ventricular tachycardia.
Most mutations that result in CPVT are found in RYR2 or CASQ2 genes,