ROCK1 [SEP] found in taxon
kinase. ROCK1 is activated when bound to the GTP-bound form of RhoA. The human ROCK1 gene is located on human chromosome 18 with specific location of 18q11.1. The location of the base pair starts at 18,529,703 and ends at 18,691,812 bp and translates into 1354 amino acids.
ROCK1 has a ubiquitous tissue distribution, but subcellularly it is thought to colocalize with the centrosomes. This is consistent with its function as a key modulator of cell motility, tumor cell invasion, and actin cytoskeleton organization. In rats, ROCK1 is expressed
) during telophase initiates constriction of the actomyosin ring by creating a groove that migrates in an inward motion. Rho-kinases such as ROCK1 has been found to regulate actomyosin contraction through phosphorylation of the myosin light chain (MLC). This mechanism promotes cell-cell contacts and integrity leading to adhesion formation.
Variation between Kingdoms.
In animals, the ring forms along the cleavage furrow on the inside of the plasma membrane then splits by abscission. In fungi it forms at the mother-bud neck before mitosis. Septin