RAMP3 [SEP] found in taxon
RAMP3
Receptor activity modifying protein 3, also known as RAMP3, is a human gene.
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as
:
- with RAMP1: produces a CGRP receptor
- with RAMP2: produces an adrenomedullin (AM) receptor, designated AM
- with RAMP3: produces a dual CGRP/AM receptor designated AM
These receptors are linked to the G protein G, which activates adenylate cyclase and activation results in the generation of intracellular cyclic adenosine monophosphate (cAMP).
CGRP receptors are found throughout the body, suggesting that the protein may modulate a variety of physiological functions in all major systems (e.g., respiratory, endocrine,