FAM83A [SEP] found in taxon
and five beta sheets, with an isoelectric point of 8.964 There appears to be no signal peptide and is not a transmembrane protein. Using CBLAST, it was observed to share a common sequence with the protein 3H0G, however, not in the predicted functional region of FAM83A. This may still provide valuable information, though, on a possible partial structure for this protein.
Expression.
FAM83A is expressed in many different areas of the human body, and at very different levels. EST data suggests that this gene is expressed
FAM83A shows decreased expression when activating transcription factor 2 (ATF2) is knocked out. Since ATF2 was not predicted to bind in the promoter region, it suggests that there is an indirect relationship between FAM83A and ATF2. With increased expression to irritants and allergens along with an indirect relationship with ATF2, it suggests FAM83A may be in a signaling pathway.
Cancer.
There are multiple studies that link FAM83A overexpression to lung, prostate, and bladder cancers. Researchers believe that this gene might make a good candidate for early detection