HLA-DQ6 [SEP] found in taxon
HLA-DQ6
HLA-DQ6 (DQ6) is a human leukocyte antigen serotype within HLA-DQ (DQ) serotype group. The serotype is determined by the antibody recognition of β subset of DQ β-chains. The β-chain of DQ isoforms are encoded by HLA-DQB1 locus and DQ6 are encoded by the HLA-DQB1 allele group. This group currently contains many common alleles, DQB1 is the most common. HLA-DQ6 and DQB1 are almost synonymous in meaning. DQ6 β-chains combine
a bias toward central and eastern Europe. Parts of the haplotype are spread into East Asia and even appear within the New world's indigeonous populations. DR15:DQ6 frequencies peak in central Asia, and it is suspect that this may be a point of Eurasian spread westward into Europe.
While there are some diseases associated with the haplotype, the frequency of association is less compared to A1B8.
Disease Associations.
HLA B7-DR15-DQ6 was found to have an association with postmenopausal osteoporosis in a Greek population.
DR2 (15