SCNN1G [SEP] chromosome
coding sequence human γ subunit was reported by Saxena et al.
Gene structure.
While the human gene SCNN1A is located in chromosome 12p, the human genes encoding SCNN1B and SCNN1G are located in juxtoposition in the short arm of chromosome 16 (16p12-p13). The structures of the human and rat SCNN1G genes were first reported by Thomas et al. Later studies by Saxena et al. reported the complete coding sequence of the human SCNN1G gene establishing that it has 13 exons The positions of introns are conserved in
SCNN1G
The SCNN1G gene encodes for the γ subunit of the epithelial sodium channel ENaC in vertebrates. ENaC is assembled as a heterotrimer composed of three homologous subunits α, β, and γ or δ, β, and γ. The other ENAC subunits are encoded by SCNN1A, SCNN1B, and SCNN1D.
ENaC is expressed in epithelial cells and is different from the voltage-gated sodium channel that is involved in the generation of action potentials in neurons. The abbreviation for the genes encoding for voltage-gated sodium channel