HOTAIR [SEP] found in taxon
HOTAIR
HOTAIR (for HOX transcript antisense RNA) is a human gene located on chromosome 12. It is the first example of an RNA expressed on one chromosome that has been found to influence transcription on another chromosome.
Gene and transcribed RNA product.
The HOTAIR gene contains 6,232 bp and encodes 2.2 kb long noncoding RNA molecule, which controls gene expression. Its source DNA is located within a HOXC gene cluster. It is shuttled from chromosome 12 to chromosome 2 by the Suz-Twelve protein.
Function.
respectively. LncRNAs are able to complementarily hybridize to DNA sequences in the genome, thus targeting sequences and localizing epigenetic changes. Oftentimes, lncRNAs are not free-floating in the nucleus and are attached to chromosomes.
Studies regarding HOX genes have found that lncRNAs are highly expressed in relation to the homeobox genes. Known antisense HOX lncRNAs, such as HOTAIR, are scaffolds where transcription factors bind, which makes them mediators of epigenetic regulation. Furthermore, this and other HOX lncRNAs are required for the normal development of the organism and