BRCA2 [SEP] found in taxon
BRCA2
BRCA2 and BRCA2 () are a human gene and its protein product, respectively. The official symbol (BRCA2, italic for the gene, nonitalic for the protein) and the official name (originally breast cancer 2; currently BRCA2, DNA repair associated) are maintained by the HUGO Gene Nomenclature Committee. One alternative symbol, FANCD1, recognizes its association with the FANC protein complex. Orthologs, styled "Brca2" and Brca2, are common in other vertebrate species. "BRCA2" is a human tumor suppressor gene
cells "in vitro", and they were found to indeed repress "RAD51". This repression was generally associated with decreased HR and increased sensitivity of the cells to DNA damaging agents.
Pathology.
This protein is also found to interact with PALB2 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis