MEFV [SEP] found in taxon
MEFV
MEFV (Mediterranean fever) is a human gene that provides instructions for making a protein called pyrin (also known as marenostrin). Pyrin is produced in certain white blood cells (neutrophils, eosinophils and monocytes) that play a role in inflammation and in fighting infection. Inside these white blood cells, pyrin is found with the cytoskeleton, the structural framework that helps to define the shape, size, and movement of a cell. Pyrin's protein structure also allows it to interact with other molecules involved in fighting infection
animals in medical research.
His main research interests are in the fields of autoimmunity, primary immune deficiencies and diabetes. Liston led the discovery of Pyrin-associated autoinflammation with neutrophilic dermatosis, a previously unknown auto-inflammatory disease caused by mutation in the gene MEFV. Liston is also known for identifying genetic fragility of pancreatic beta cells as a cause of diabetes. In 2016, Liston led a team that found that cohabitation modified the immune system, making partners more similar to each other. His research team has emphasized the role