BRCA1 [SEP] chromosome
gene is located on the long (q) arm of chromosome 17 at region 2 band 1, from base pair 41,196,312 to base pair 41,277,500 (Build GRCh37/hg19) (map). "BRCA1" orthologs have been identified in most vertebrates for which complete genome data are available.
Protein structure.
The BRCA1 protein contains the following domains:
- Zinc finger, C3HC4 type (RING finger)
- BRCA1 C Terminus (BRCT) domain
This protein also contains nuclear localization signals and nuclear export signal
meiotic cells in which synapsis is defective. One such surveillance mechanism is meiotic silencing that involves the transcriptional silencing of genes on asynapsed chromosomes. Any chromosome region, either in males or females, that is asynapsed is subject to meiotic silencing. ATR, BRCA1 and gammaH2AX localize to unsynapsed chromosomes at the pachytene stage of meiosis in human oocytes and this may lead to chromosome silencing. The DNA damage response protein TOPBP1 has also been identified as a crucial factor in meiotic sex chromosome silencing. DNA double-strand breaks appear to be initiation