OLIG2 [SEP] chromosome
in malignancies beyond glioma and leukemia, such as breast cancer, melanoma and non-small cell lung carcinoma cell lines. It also has been shown that up-regulation of OLIG2 together with LMO1 and Notch1 helps to provide proliferation signals.
Clinical Significance OLIG2 in Neural Diseases.
OLIG2 is also associated with Down syndrome, as it locates at chromosome 21 within or near the Down syndrome critical region on the long arm. This region is believed to contribute to the cognitive defects of Down syndrome. The substantial increase in the number
In a study using the U12-1 cell line for controlled expression of OLIG2, researchers showed that OLIG2 can suppress the proliferation of U12-1 by transactivating the "p27" gene and can inhibit the motility of the cell by activating RhoA.
Besides glioma, OLIG2 is also involved in leukemogenesis. The "Olig2" gene was actually first identified in a study in T-cell acute lymphoblastic leukemia, in which the expression of OLIG2 was found elevated after t(14;21)(q11.2;q22) chromosomal translocation. The overexpression of OLIG2 was later shown present