MT-TS2 [SEP] found in taxon
MT-TS2
Mitochondrially encoded tRNA serine 2 (AGU/C) also known as MT-TS2 is a transfer RNA which in humans is encoded by the mitochondrial "MT-TS2" gene.
MT-TS2 is a small 59 nucleotide RNA (human mitochondrial map position 12207-12265) that transfers the amino acid serine to a growing polypeptide chain at the ribosome site of protein synthesis during translation.
point mutation disrupts the mitochondrial gene for tRNA-Lys, thus disrupting the synthesis of proteins essential for oxidative phosphorylation. The remaining mutations only account for 10% of cases, and the remaining 10% of he patients with MERRF did not have an identifiable mutation in the mitochondrial DNA.
Many genes are involved. These genes include:
- MT-TK
- MT-TL1
- MT-TH
- MT-TS1
- MT-TS2
- MT-TF
It involves the following characteristics