SCNN1A [SEP] found in taxon
fluid. Thus, ENaC plays a central role in the regulation of body fluid and electrolyte homeostasis and consequently affects blood pressure.
As ENaC is strongly inhibited by amiloride, it is also referred to as an "amiloride-sensitive sodium channel".
History.
The first mRNA encoding the alpha subunit of ENaC was isolated by two independent groups by screening a rat colon cDNA library.
Gene structure.
The human gene SCNN1A is located in the short arm of chromosome 12 (12p3).
Analysis of
of neuropathic pain NEDD4-2 expression has been found to be downregulated. Also NEDD4-2-deficiency results in hyperexcitability of DRG neurons and contributes to pathological pain
Interactions.
NEDD4L has been shown to interact with SCNN1A.