TAAR1 [SEP] found in taxon
a high-affinity receptor for amphetamine, methamphetamine, dopamine, and trace amines which mediates some of their cellular effects in monoamine neurons within the central nervous system.
The primary endogenous ligands of the human TAAR1 (hTAAR1) receptor, by rank order of potency, are:tyramine  β-phenethylamine  dopamine = octopamine.
Discovery.
TAAR1 was discovered independently by Borowski "et al." and Bunzow "et al." in 2001. To find the genetic variants responsible for TAAR1 synthesis, they
receptor antagonist
- Pimavanserin (ACP-103, BVF-048; Nuplazid) – 5-HT receptor inverse agonist
- SEP-363856 (SEP-856) – 5-HT receptor and TAAR1 agonist
- SUVN-D4010 – 5-HT receptor partial agonist
- TAK-058 (ENV-8058) – 5-HT receptor antagonist
Receptor modulators Glutamate receptor modulators.
- Neboglamine (CR-2249, XY-2401; nebostinel) – NMDA receptor glycine-site positive allosteric modulator
- PF-4958242 – AMPA receptor positive allosteric modulator
- Pomaglumetad methionil (DB-103, LY-2140023, LY-2812223) – mGluR and mGluR agonist