SLC24A5 [SEP] chromosome
humans, is located on the long (q) arm of chromosome 15 on position 21.1, from base pair 46,200,461 to base pair 46,221,881.
Protein.
NCKX5 is 43 kDa protein that is partially localized to the trans-Golgi network in melanocytes. Removal of the NCKX5 protein disrupts melanogenesis in human and mouse melanocytes, causing a significant reduction in melanin pigment production. Site-directed mutagenesis corresponding to a non-synonymous single nucleotide polymorphism in "SLC24A5" alters a residue in NCKX5 (A111T) that is important
like without cream. Only one horse has been tested to carry this genotype.br
TE1/n, TE2/n, or n/n: Dark eyes.
Molecular Genetics.
The gene involved codes for SLC24A5, a solute carrier known to be involved in pigmentation in other species. "SLC24A5" is found on equine chromosome 1 base pairs 141,657,837–141,678,329 and the protein is a potassium-dependent sodium–calcium ion exchanger involved in melanocyte maturation. The protein is believed to be located in the "trans"-golgi network of melanocytes