C7orf43 [SEP] found in taxon
C7orf43
C7orf43 (Chromosome 7 Open reading frame 43) is a protein that in human is encoded by the gene "C7orf43". C7orf43 has no other human alias, but in mice can be found as BC037034.
Gene Locus.
In humans, "C7orf43" is located in the long arm of human chromosome 7 (7q22.1), and is on the negative (antisense) strand. Genes located around "C7orf43" include GAL3ST4, LAMTOR4, GPC2. In humans, "C7orf43" has 9 detected common
. A study using FLAG affinity purification mass spectrometry (AP-MS) to profile protein interactions in the Hippo signaling pathway identified C7orf43 as one of the interacting proteins. C7orf43 was found to interact with angiomotin-like protein 2 (AMOTL2), also known as Leman Coiled-Coil Protein (LCCP), a regulator of Hippo signaling. AMOTL2 is also known to be an inhibitor of Wnt signaling, a pathway with known associations to cancer development, and to be a factor for angiogenesis, a process essential to tumour maintenance