C10orf76 [SEP] chromosome
C10orf76
C10orf76 or chromosome 10 open reading frame 76, also known as UPF0668, is a protein that in humans is encoded by the "c10orf76" gene. Its function is not currently known, but experimental evidence has suggested that it may be involved in transcriptional regulation. The protein contains a conserved proline-rich motif, suggesting that it may participate in protein-protein interactions via an SH3-binding domain, although no such interactions have been experimentally verified. The well-conserved gene appears to have emerged in Fungi approximately 1.2 billion
Met416 of the largest protein variant).
Protein Structure.
The structure of the c10orf76 protein has not been experimentally explored. The secondary structure is predicted to be completely helical in nature, with intervening regions of protein disorder. The potential SH3-binding domain is located on a predicted region of disorder, further supporting a protein-protein binding function for c10orf76. A helical region between amino acids 610-655 was predicted to be a coiled coil motif.
A PHYRE2 protein structure prediction suggested that the first 200 residues of c10orf76 may