Reprimo [SEP] found in taxon
Reprimo
Reprimo (RPRM), is a gene located at human chromosome 2q23 whose expression in conjunction with p53, along with other genes which are p53-induced, is associated with the arrest of the cell cycle at the G2 phase."Reprimo's" protein product is a highly glycosylated polypeptide which, upon its expression, is localized to the cytoplasm where it is primarily active. As the expression of "reprimo" is controlled by p53, which is in turn controlled by a wide array of convergent signal pathways pertaining to DNA damage
be useful information for the diagnosis or prognosis of certain types of cancer.
Utility in cancer detection and prognosis.
Given "reprimo"'s inherent role in cancer prevention, investigations have focused on whether it is a point of failure worth monitoring for the purposes of diagnosis. In contrast to non-malignant tissues, in which it has been found in less than eleven percent of samples, methylations to "reprimo"'s promoter region have been detected in a majority of gastric, gallbladder, lymphoma, and colorectal cancers,