PARL [SEP] chromosome
PARL
Presenilins-associated rhomboid-like protein, mitochondrial also known as mitochondrial intramembrane cleaving protease PARL is an inner mitochondrial membrane protein that in humans is encoded by the "PARL" gene on chromosome 3. It is a member of the rhomboid family of intramembrane serine proteases. This protein is involved in signal transduction and apoptosis, as well as neurodegenerative diseases and type 2 diabetes.
Structure.
Rhomboid family members share a conserved core of six transmembrane helices (TMHs), with the Ser and His residues required to
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