GCSH [SEP] chromosome
the one-carbon fragment from the intermediate lipoyl residue to tetrahydrofolate, while the L-protein, a lipoamide dehydrogenase, catalyzes the oxidation of the dihydrolipoyl residue of H-protein and reduction of NAD.
Structure.
Structure Gene.
Human GCSH gene has 5 exons spanning 13.5kb and resides on chromosome 16 at q23.2.
Structure Protein.
The GCSH is a heat-stable small protein with a covalently attached lipoic acid prosthetic group which interacts with the three enzymes during the catalysis. The chemically determined amino acid sequence
GCSH
Glycine cleavage system H protein, mitochondrial (abbreviated as GCSH) is a protein that in humans is encoded by the "GCSH" gene. Degradation of glycine is brought about by the glycine cleavage system (GCS), which is composed of 4 protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein; this protein), T protein (a tetrahydrofolate-requiring aminomethyltransferase enzyme), and L protein (a lipoamide dehydrogenase). The H