KLF2 [SEP] chromosome
KLF2
Krüppel-like Factor 2 (KLF2), also known as lung Krüppel-like Factor (LKLF), is a protein that in humans is encoded by the "KLF2" gene on chromosome 19. It is a member of the Krüppel-like factor family of zinc finger transcription factors, and it has been implicated in a variety of biochemical processes in the human body, including lung development, embryonic erythropoiesis, epithelial integrity, T-cell viability, and adipogenesis.
Discovery.
Erythroid Krüppel-like
-cells in this indolent lymphoma are CD5+/−, CD10−, CD19+, CD23−, CD43−, CD103−, and do not express cyclin D1. These cells may bear deletion in the "q" arm of chromosome 7 (30% of cases), and mutations in "NOTCH2" (10-25% of cases), "KLF2" (10-40% of cases), and, rarely, "MYD88" genes. The monoclonal cells are also CD200− and are complete Ig+. Patients with this lymphoma commonly