Galectin-3 [SEP] chromosome
cell adhesion, cell-matrix interactions, macrophage activation, angiogenesis, metastasis, apoptosis.
Galectin-3 is encoded by a single gene, LGALS3, located on chromosome 14, locus q21–q22. Galectin-3 is expressed in the nucleus, cytoplasm, mitochondrion, cell surface, and extracellular space.
Function.
Galectin-3 has an affinity for beta-galactosides and exhibits antimicrobial activity against bacteria and fungi.
This protein has been shown to be involved in the following biological processes: cell adhesion, cell activation and chemoattraction, cell growth
LGALS3BP
Galectin-3-binding protein is a protein that in humans is encoded by the "LGALS3BP" gene.
Function.
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell–cell and cell–matrix interactions. Using fluorescence in–situ hybridization, the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds to galectin 1.
Clinical significance.
LGALS3BP has been found elevated in