RAS p21 protein activator 1 [SEP] found in taxon
RAS p21 protein activator 1
RAS p21 protein activator 1 or RasGAP (Ras GTPase activating protein), also known as RASA1, is a 120-kDa cytosolic human protein that provides two principal activities:
- Inactivation of Ras from its active GTP-bound form to its inactive GDP-bound form by enhancing the endogenous GTPase activity of Ras, via its C-terminal GAP domain
- Mitogenic signal transmission towards downstream interacting partners through its N-terminal SH2-SH3-SH2 domains
The protein encoded by this gene is located in the cytoplasm
. Four transcript variants encoding two different isoforms have been found for this gene.
Interactions.
PTK2B has been shown to interact with:
- BCAR1,
- Cbl gene,
- DDEF2,
- DLG3,
- DLG4,
- Ewing sarcoma breakpoint region 1,
- FYN,
- GRIN2A,
- Gelsolin,
- NPHP1,
- PITPNM1,
- PTPN11,
- PTPN6,
- Paxillin,
- RAS p21 protein activator 1,
- RB1CC1,