ANGPTL3 [SEP] found in taxon
.
Angptl3 plays a major role in promoting uptake of circulating triglycerides into white adipose tissue in the fed state, likely through activation by Angptl8, a feeding-induced hepatokine, to inhibit postprandial LPL activity in cardiac and skeletal muscles, as suggested by the ANGPTL3-4-8 model.
Clinical significance.
In human, ANGPTL3 is a determinant factor of HDL level and positively correlates with plasma HDL cholesterol.
In humans with genetic loss-of-function variants in one copy of "ANGPTL3", the
. In fact, in December 2016 the original paper by Melton and Yi was retracted, putting the link between betatrophin and islets cells to rest. Given the status of betatrophin and taking into account that betatrophin is a member of the angiopoietin-like gene family and shares extensive homology with Angptl4 and Angptl3, the name betatrophin should be abandoned in favor of Angptl8. Other names for betatrophin include TD26, RIFL, and Lipasin.
Function.
Betatrophin is a putative peptide hormone found in mice that was proposed to increase the