CD244 [SEP] found in taxon
CD244
CD244 (Cluster of Differentiation 244) is a human protein encoded by the gene. It is also known as Natural Killer Cell Receptor 2B4
This gene encodes a cell surface receptor expressed on natural killer cells (NK cells) (and some T cells) mediating non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
asparagine-linked glycosylation sites at positions 40, 44, 104, 162 and 189, respectively. Approximately 35-40% of the total molecular weight is attributed to the carbohydrate side chains.
Interactions.
CD48 was found to have a very low affinity for CD2 with dissociation constant (formula_1) < 0.5 mM. It was found that the preferred ligand of CD48 is 2B4 (CD244), which is also a member of the CD2 subfamily SLAM of IgSF expressed on natural killer cells (NK cells) and other leukocytes