STIM2 [SEP] found in taxon
STIM2 participates in processes of the development and functioning of many cell types, including smooth muscle myoblasts, cells of the immune system and neurons, and is involved in tumorigenesis, the development of autoimmune diseases and mechanisms of neuronal damage after transient ischemic conditions.
Gene.
In 2001, "STIM2" was identified as a new human homologue of the "STIM1" gene, representing the second member of a two-gene family in vertebrates. The "STIM2" gene contains 12 exons and 11 introns located on the human
The STIM2 function has been controversial. Initial studies found that siRNA knockdown of STIM1, but not STIM2, strongly reduced SOCE in mammalian cells. Liou "et al". reported a slight reduction in SOCE also by knockdown of STIM2 in HeLa cells. Soboloff "et al". suggested that STIM2 inhibits SOCE when expressed alone, but coexpressed with Orai1 causes substantial constitutive SOCE. In contrast, Brandman "et al". suggested that STIM2 could act as a regulator that stabilizes basal cytosolic and ER Ca levels. Parvez