C6orf222 [SEP] chromosome
C6orf222
C6orf222 is a protein that in humans is encoded by the "C6orf222" gene (6p21.31). C6orf222 is conserved in mammals, birds and reptiles with the most distant ortholog being the green sea turtle,"Chelonia mydas". The C6orf222 protein contains one mammalian conserved domain: DUF3293. The protein is also predicted to contain a BH3 domain, which has predicted conservation in distant orthologs from the clade Aves.
Gene.
"C6orf222" is located on the negative DNA strand of the short arm of chromosome 6 at locus
localization sequence (NLS) found between residues 142-151.
Protein Protein Interactions.
Although the bioinformatics programs MINT, STRING and Gene Cards did not reveal any protein interactions with C6orf222. A predicted BH3 domain in the C6orf222 protein was found to interact with both Bcl-2 and Bcl-xL, implicating C6orf222 as being involved in apoptosis.
Table of Potential Transcription Factor Binding Sites in the Predicted "C6orf222" Promoter:
Homology and Evolution.
Homology and Evolution Orthologous Space.
82 organisms have predicted orthologs with "C6orf222