Lumican [SEP] chromosome
Lumican
Lumican, also known as LUM, is an extracellular matrix protein that, in humans, is encoded by the "LUM" gene on chromosome 12.
Structure.
Lumican is a proteoglycan Class II member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. 
Like the other SLRPs, lumican has a molecular weight of about 40 kiloDaltons and has four major intramolecular domains: 
1. a signal peptide of 16 amino acid
these SLRPs in the development of correctly sized and aligned collagen fibers in tendon. Along with other extracellular matrix components, lumican expression was increased in equine flexor tendons six weeks after an injury.
Lumican is present in the extracellular matrix of uteral tissues in fertile women. There is an increase of lumican during the proliferative to secretory phase of the endometrium. In menopausal endometrial tissue, the level of lumican expression decreases and is also low in pathological compared to normal endometrium.
Lumican is highly expressed in pleural effusions (lung fluid