PRNP [SEP] found in taxon
PRNP
PRNP (prion protein) is the human gene encoding for the major prion protein PrP (for prion protein), also known as CD230 (cluster of differentiation 230). Expression of the protein is most predominant in the nervous system but occurs in many other tissues throughout the body. 
The protein can exist in multiple isoforms, the normal PrP and protease-resistant forms designated PrP such as the disease-causing PrP and an isoform located in mitochondria. The misfolded version PrP is associated with a variety of cognitive
deletion of "PRNP" in animals has yielded several conflicting findings. When Aβ oligomers were injected into the cerebral ventricles of a mouse model of Alzheimer's, "PRNP" deletion did not offer protection, only anti-PrP antibodies prevented long-term memory and spatial learning deficits. This would suggest either an unequal relation between PRNP and Aβ oligomer-mediated neurodegeneration or a site-specific relational significance. In the case of direct injection of Aβ oligomers into the hippocampus, "PRNP"-knockout mice were found to be indistinguishable from control