Calretinin [SEP] found in taxon
it the name) and cortical interneurons. Expression was found in different neurons than that of the similar vitamin D-dependent calcium-binding protein, calbindin-28kDa.
Calretinin has an important role as a modulator of neuronal excitability including the induction of long-term potentiation. Loss of expression of calretinin in hippocampal interneurons has been suggested to be relevant in temporal lobe epilepsy.
It is expressed in a number of other locations including hair follicles.
Clinical significance.
Calretinin is a diagnostic marker for some human diseases, including
, and a number of different calcium-binding proteins, such as calbindin, calretinin and parvalbumin. CR cells express several genes important in corticogenesis, such as reelin (RELN), LIS1, EMX2, and DS-CAM. CR cells selectively express p73, a member of the p53 family involved in cell death and survival.
CR cells receive an early serotonergic input, which in mice forms synaptic contacts.
In 2001, CR cells in the marginal zone were found to have electrophysiological fingerprints. Whole-cell patch