BRCA2 [SEP] chromosome
BRCA mutation, damaged DNA is not repaired properly, and this increases the risk for breast cancer. "BRCA1" and "BRCA2" have been described as "breast cancer susceptibility genes" and "breast cancer susceptibility proteins". The predominant allele has a normal tumor suppressive function whereas high penetrance mutations in these genes cause a loss of tumor suppressive function, which correlates with an increased risk of breast cancer.
The BRCA2 gene is located on the long (q) arm of chromosome 13 at position 12.3 (13q12.3)
knockout mice ["BRD7"(-/-)] are infertile and have higher levels of apoptosis and DNA damage in their germline cells.
Genetics Gene polymorphisms.
The human breast cancer susceptibility gene 2 ("BRCA2") is employed in DNA repair. A common single nucleotide polymorphism in "BRCA2" is associated with idiopathic male infertility with azoospermia.
Four genes involved in DNA double-strand break repair and chromosome synapsis ("TEX11", "TEX15", "MLH1" and "MLH3") have key roles in genomic