HMOX1 [SEP] found in taxon
HMOX1
HMOX1 (heme oxygenase (decycling) 1) is a human gene that encodes for the enzyme heme oxygenase 1 (). Heme oxygenase mediates the first step of heme catabolism, it cleaves heme to form biliverdin.
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, carbon monoxide, and ferrous iron. The biliverdin is subsequently converted to bilirubin by biliverdin reductase. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes,
acid residues which is encoded by the HMOX1 gene. A study has found levels of HO-1 in lung tissue were directly related to infection with Tuberculosis or infection-free areas, and knockout mice were found susceptible, showing the essential role of this enzyme.
Heme oxygenase Heme oxygenase 2.
Heme oxygenase 2 (HO-2) is a constitutive isoform that is expressed under homeostatic conditions in the testes, endothelial cells and the brain. HO-2 is encoded by the HMOX2 gene. HO-2 is 36 kDa and shares 47% similarity with the