TMEM69 [SEP] found in taxon
, 183, and 234; 1 for threonine at position 26; and 2 for tyrosine at position 57 and 159. NetGlyc on ExPASy predicted 5 glycation sites at positions 7, 60, 73, 156, and 239.
- Transmembrane Segments: TMEM69 contains 5 transmembrane regions occurring at positions 97-117, 122-142, 159-179, 185-205, and 216-236.
Expression.
TMEM69 is expressed ubiquitously at low levels throughout the human body, although EST Profile data reveal that TMEM69
.
Conservation.
TMEM69 is well conserved in a variety of organisms. Although most orthologs are found in placental mammals, some orthologs are found in bacteria and fungi. The most distant ortholog found to have sequence similarity with TMEM69 is "Pseudomonas putida W619", which is a type of soil bacterium. Particularly well conserved in even the most distant orthologs, including "Pseudomonas putida W619", is most of the second transmembrane segment of TMEM69. In strict orthologs, all five transmembrane domains are conserved. Conserved domains found