XB130 [SEP] found in taxon
XB130
XB130 (also known as AFAP1L2) is a cytosolic adaptor protein and signal transduction mediator. XB130 regulates cell proliferation, cell survival, cell motility and gene expression. XB130 is highly similar to AFAP and is thus known as actin filament associated protein 1-like 2 (AFAP1L2). XB130 is a substrate and regulator of multiple tyrosine kinase-mediated signaling. XB130 is highly expressed in the thyroid and spleen.
Molecular structure.
The XB130 gene is located on human chromosome 10q25.3 and encodes an 818 amino acid protein.
-coil domain, which shares partial similarity with AFAP's leucine zipper domain. Both the C-terminal and N-terminal regions of XB130 are required for XB130's role in its translocation to the lamellipodia. Despite XB130's structural similarity to AFAP, XB130 does not behave like an actin filament-associated protein. The actin-binding site present in AFAP is only partially present in XB130.
Function.
Function Role in cell cycle and survival.
XB130 has been demonstrated to play a role in cell proliferation and survival