SNX27 [SEP] found in taxon
SNX27
Sorting nexin family member 27, also known as SNX27, is a human gene.
This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mice is responsible for the specific recruitment of an isoform of the serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for
GLUT1 is also a receptor used by the HTLV virus to gain entry into target cells.
Clinical significance Role as a Histochemical Marker for Hemangioma.
Glut1 has also been demonstrated as a powerful histochemical marker for hemangioma of infancy
Interactions.
GLUT1 has been shown to interact with GIPC1. It is found in a complex with ADD2 and DMTN and interacts (via C-terminus cytoplasmic region) with DMTN isoform 2. It also interacts with SNX27; the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling