Fetuin [SEP] found in taxon
"fetus"). Fetal bovine serum contains more fetuin than albumin, while adult serum contains more albumin than fetuin.
Family members.
Human fetuin is synonymous with α2-HS-glycoprotein (genetic symbol AHSG), α2-HS, A2HS, AHS, HSGA, and fetuin-A. Fetuin-A exists as a single-copy gene in the human and mouse genomes. A closely related gene, fetuin-B, also exists in the human, rat, and mouse genomes. Like fetuin-A, fetuin-B
inhibitor of vascular calcification in early 1990s. Since then the biologic roles attributed to fetuin-A have increased exponentially. Fetuin-A has been demonstrated to play an important role in free fatty acid induced insulin resistance in the liver. Increased fetuin-A in patients with pre-diabetes is associated with increased progression to diabetes and decreased reversal to normoglycemia. Hence fetuin-A is a predictor of adverse glycemic outcomes in pre-diabetes. Obese persons have elevated circulating Fetuin-A, which can be reduced by metformin, exercise