TMEM143 [SEP] found in taxon
TMEM143
TMEM143 (Transmembrane protein 143) is a protein that in humans is encoded by TMEM143 gene. TMEM143, a dual-pass protein (two transmembrane domains), is predicted to reside in the mitochondria and high expression has been found in both human skeletal muscle and the heart. Interaction with other proteins indicate that TMEM143 could potentially play a role in tumor suppression/expression and cancer regulation.
Gene.
Located on the negative strand of human DNA, TMEM143 spans 31,882 base pairs on human chromosome 19 (19q13.33
data. Illustrating predicted gene regulation with different microRNA (miRNA) under ionizing radiation conditions, TMEM143 and DD12, JLHL31, C14orf28, TRIN71, and CPEB all share predicted regulatory miRNAs. TMEM143 has also been found to be associated with adipocyte differentiation. Along with other genes, TMEM143 has been documented as a PPARγ (peroxisome proliferator-activated receptor gamma) target. This indicates the possibility of TMEM143 participation in lipid metabolic pathways and lipid cell differentiation