LDHA [SEP] found in taxon
Lactate dehydrogenase A
Lactate dehydrogenase A (LDHA) is an enzyme which in humans is encoded by the "LDHA" gene. It is a monomer of lactate dehydrogenase, which exists as a tetramer. The other main subunit is lactate dehydrogenase B (LDHB).
Function.
Lactate dehydrogenase A catalyzes the inter-conversion of pyruvate and L-lactate with concomitant inter-conversion of NADH and NAD. LDHA is found in most somatic tissues, though predominantly in muscle tissue and tumours, and belongs to the lactate
complete lactate dehydrogenase enzyme consists of four protein subunits. Since the two most common subunits found in lactate dehydrogenase are encoded by the LDHA and LDHB genes, either variation of this disease causes abnormalities in many of the lactate dehydrogenase enzymes found in the body. In the case of lactate dehydrogenase-A deficiency, mutations to the LDHA gene result in the production of an abnormal lactate dehydrogenase-A subunit that cannot bind to the other subunits to form the complete enzyme. This lack of a functional subunit reduces the amount of enzyme