Autophagy-related protein 101 [SEP] chromosome
Autophagy-related protein 101
Autophagy-related protein 101 also known as ATG101 is a protein that in humans is encoded by the "C12orf44" gene (chromosome 12 open reading frame 44).
Autophagy is the process of forming a vacuole around proteins and nucleic acids that are to be broken down in lysosomes. The transcribed mRNA sequence of C12orf44 is 1287 base pairs, and following translation the sequence is 218 amino acids in length. The ATG101 protein is localized in the cytoplasm, but can possibly also be found bound
ATG5
Autophagy related 5 (ATG5) is a protein that, in humans, is encoded by the "ATG5" gene located on Chromosome 6. It is an E3 ubi autophagic cell death. ATG5 is a key protein involved in the extension of the phagophoric membrane in autophagic vesicles. It is activated by ATG7 and forms a complex with ATG12 and ATG16L1. This complex is necessary for LC3-I (microtubule-associated proteins 1A/1B light chain 3B) conjugation to PE (phosphatidylethanolamine) to form LC3-II (LC3-phosphatidylethanolamine conjugate). ATG5