Oct-4 [SEP] found in taxon
cells.
Oct-4 is a member of the octamer transcription factor family, so named because they bind the octameric (8-unit) DNA nucleotide sequence "ATTTGCAT".
Expression and function.
Oct-4 transcription factor is initially active as a maternal factor in the oocyte and remains active in embryos throughout the preimplantation period. Oct-4 expression is associated with an undifferentiated phenotype and tumors. Gene knockdown of Oct-4 promotes differentiation, demonstrating a role for these factors in human embryonic stem cell self-renewal. Oct-4 can form a heterodimer with Sox2
2018
- Indianapolis, IN - From 22 Aug to 26 Aug 2018
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