S1PR5 [SEP] found in taxon
S1PR5
Sphingosine-1-phosphate receptor 5 also known as S1PR5 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P.
Agonists.
- A-971432
- Sphingosine 1-phosphate receptor agonists: a patent review (2010-2012)
See also.
- Lysophospholipid receptor
a different cell specificity, although they are found at their highest density on leukocytes. S1PR1, 2 and 3 receptors are expressed ubiquitously. The expression of S1PR4 and S1PR5 are less widespread. S1PR4 is confined to lymphoid and hematopoietic tissues whereas S1PR5 primarily located in the white matter of the central nervous system (CNS) and spleen.
G protein interactions and selective ligands.
The sphingosine-1-phosphate (S1P) is the endogenous agonist for the five subtypes.