KIAA0922 [SEP] found in taxon
KIAA0922
Transmembrane protein 131-like(TMEM131L protein), alternatively named uncharacterized protein KIAA0922 (KIAA0922 protein), is an integral transmembrane protein encoded by the human gene KIAA0922 that is significantly conserved in eukaryotes, at least through protists. Although the function of this gene is not yet fully elucidated, initial microarray evidence suggests that it may be involved in immune responses. Furthermore, its paralog, prolyl endopeptidase (PREP) whose function is known, provides clues as to the function of TMEM131L.
Gene.
The KIAA0922 gene is found in the
131. The gene for transmembrane protein 131 is found on chromosomal location 2q11.2 and the protein is 1883 amino acids long and is also an integral membrane protein. However, research indicates that the TMEM131L protein is more highly methylated than the TMEM protein.
Conservation.
Following Biology Workbench multialign CLUSTAL W analyses, certain regions of TMEM131L protein are highly conserved through Eukaryotes as distantly as single-celled protists (24% identity with "Dictyostelium fasciculatum"). These exact same regions also appear to be conserved in the KIAA0922 paralog