ICAM-1 [SEP] found in taxon
, which seems to bind and block ICAM-1.
Function Role in cell signaling.
ICAM-1 is an endothelial- and leukocyte-associated transmembrane protein long known for its importance in stabilizing cell-cell interactions and facilitating leukocyte endothelial transmigration. More recently, ICAM-1 has been characterized as a site for the cellular entry of human rhinovirus. Because of these associations with immune responses, it has been hypothesized that ICAM-1 could function in signal transduction. ICAM-1 ligation produces proinflammatory effects such as inflammatory leukocyte recruitment by signaling through cascades involving a number of kinases
Molecular biology Integrins.
Integrins involved in cellular adhesion are primarily expressed on leukocytes. β2 integrins on rolling leukocytes bind endothelial cellular adhesion molecules, arresting cell movement.
- LFA-1 is found on circulating leukocytes, and binds ICAM-1 and ICAM-2 on endothelial cells
- Mac-1 is found on circulating leukocytes, and binds ICAM-1 on endothelial cells
- VLA-4 is found on leukocytes and endothelial cells, and facilitates chemotaxis; it also binds VCAM-1
Cellular activation via extracellular chemokines causes pre-formed β2 integrins to be released from cellular stores