Leucyl/cystinyl aminopeptidase [SEP] found in taxon
Leucyl/cystinyl aminopeptidase
Leucyl/cystinyl aminopeptidase, also known as cystinyl aminopeptidase (CAP), insulin-regulated aminopeptidase (IRAP), human placental leucine aminopeptidase (PLAP), oxytocinase, and vasopressinase, is an enzyme of the aminopeptidase group that in humans is encoded by the "LNPEP" gene.
This gene encodes a zinc-dependent aminopeptidase (metalloexopeptidase) that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum
Amastatin
Amastatin, also known as 3-amino-2-hydroxy-5-methylhexanoyl--valyl--valyl--aspartic acid, is a naturally occurring, competitive and reversible aminopeptidase inhibitor that was isolated from "Streptomyces sp. ME 98-M3". It specifically inhibits leucyl aminopeptidase, alanyl aminopeptidase (aminopeptidase M/N), bacterial leucyl aminopeptidase ("Aeromonas proteolytica" aminopeptidase), leucyl/cystinyl aminopeptidase (oxytocinase/vasopressinase), and, to a lesser extent, glutamyl aminopeptidase (aminopeptidase A), as well as other aminopeptidases. It does not inhibit arginyl aminopeptidase