Myc [SEP] chromosome
In the human genome, "C-myc" is located on chromosome 8 and is believed to regulate expression of 15% of all genes through binding on enhancer box sequences (E-boxes).
In addition to its role as a classical transcription factor, "N-myc" may recruit histone acetyltransferases (HATs). This allows it to regulate global chromatin structure via histone acetylation.
Discovery.
The "Myc" family was first established after discovery of homology between an oncogene carried by the Avian virus
, Myelocytomatosis ("v-myc"; ) and a human gene over-expressed in various cancers, cellular Myc ("c-Myc"). Later, discovery of further homologous genes in humans led to the addition of "n-Myc" and "l-Myc" to the family of genes.
The most frequently discussed example of "c-Myc" as a proto-oncogene is its implication in Burkitt lymphoma. In Burkitt lymphoma, cancer cells show chromosomal translocations, most commonly between chromosome