SYNTHESIS AND MASS-SPECTRAL ANALYSIS OF SUBSTITUTED 3-OXY(SULFANYL)METHYL-6,8-DIMETHYLTHIAZOLE[3,2-F]XANTINES
The article presents the results of synthesis of substituted 3-oxy(sulfanyl)methyl-6,8-dimethylthiazole[3,2-f]xanthine by reaction of 3-chloromethyl-6,8-dimethylthiazole[3,2-f]xanthine with some nucleophiles. Synthesis of 3-alkoxylmethylsubstituted thiazoleaceticxantines was performed by boiling in the appropriate alcohol in the presence of equimolar amounts of sodium alcoholate. 3-Sulfanylmethyl derivatives were obtained by action on initial compound of potassium ethylxanthogenate and sodium N,N-diethyldithiocarbaminate under heating in DMF. We studied massspectra of the synthesized compounds, which are recorded by the apparatus "Finnigan mat. incos 50" using the technique of "direct input". It is established that under the action of electronic shock substituted 3-oxy(sulfanyl)methylthiazolidines undergo a variety of hydrogen and skeletal rearrangements. It was also found out that at the early stages of mass spectral decomposition ions, corresponding to at least two main areas of fragmentation, are being formed. The initial act of structure collapse is the separation of 3C-alkyl radical and the formation of regroup ion with the closure of the four-membered cycle through the oxygen atom with localization of charge. In addition, in the spectra of the compounds we observed a peak corresponding to the ion, the formation of which is accompanied by the separation of oxyalkylene groups and localization of charge on the sulfur atom.