Dynamics of neuropathic pain in patients with carpal tunnel syndrome in the complex treatment
The influence of intravenous laser irradiation of blood (ILIB) with phenibut on the pain severity, the lactate and piruvate plasma level and ratio of them, pro-, antioxidant system, substance P and noradrenalin concentrations in patients with neuropathic pain due to carpal tunnel syndrome (CTS) have been investigated. Visual analog scale (VAS) and Neuropathy Symptom Score (NSS) have been used to evaluate the pain. The patients of main group received basic therapy and ILIB by semiconductor laser at λ=0,67 μm and radiation power at 3,0 mW with application time of 20 min, 6–8 procedures per course with phenibut. It has been established the reduction of neuropathic pain in patients with CTS in main group was move evident than patients in control group. Combined treatment with ILIB led to the restriction of the lipid peroxidation reactions, the normalization ratio of the lactate and piruvate plasma level, decreasing of substance P concentration and increasing of noradrenalin concentration in patients with CTS.