Analysis of antibacterial drugs usage in nosocomial infections treatment
Analysis of antibacterial drugs usage in treatment of nosocomial infections, induced by multi-drug resistant gram-negative bacteria, showed that in 50% cases cephalosporins and carbapenems are prescribed. Aminoglycosides are the second group of antibacterial drugs by frequency of use (23,9%). Quinolones are prescribed in 16,4% cases. It should be noted that these particular drugs are traditional base drugs of antibacterial therapy of gram-negative nosocomial infections. It is reported that penicillins are frequently used despite the high level of resistance of causative microorganisms to them. Antibacterial drugs of other categories (tetracyclines, co-trimoxazole and 8-oxyquinolones derivates) usage does not exceed 1%. For the proper empiric antimicrobial therapy of nosocomial infections one should appreciate etiological structure and antibiotic resistance level of potential infection agents in each specific medical and preventive treatment institution.