Clinical and neurological aspects of HIV-infection
One of the actual medical and social problems around the world is the HIV-infection and AIDS. There is steady increase of the HIV-infection incidence and according to the FBIS CRIE the total number of infected Russians with HIV amounted to 1 465 102 people on 30 June 2020. The spread of HIV-infection in our country remains among of the highest ones in the world. The first symptoms of the disease manifestation are damage of the central and peripheral nervous systems in 10-20% of cases. Patients do not know about their HIV-infection often. With the growing of immunodeficiency the neurological disorders are aggravated by opportunistic infections, tumors, and changes in the blood which masking the base disease that present significant difficulties in diagnosis occasionally. This leads to delayed diagnosis and treatment that influences the disease prognosis. In this review were reported data of the HIV-infection morphology, pathogenesis of the nervous system damage, classification and clinical manifestations of the nervous system damage as a result of the direct effect of the HIV- infection and by opportunistic infection.