COMPARATIVE ANALYSIS OF IN VITRO GENOMIC INSTABILITY IN HUMAN BLOOD CELLS INDUCED BY CHRYSOTILE FIBERS MODIFIED WITH FERRIC CHLORIDE (III)
It has been revealed that in the рresenсе of asbestos genetic damages occur mainly in the cells that have passed through more than one cell cycle while cultivating. The nucleoplasmic bridges as well as asymmetric distribution of genetic material in the mitosis are dominating among detected genetic damages. Modified asbestos fibers induce mainly micronuclei and the largest number of the latter was detected in the cells after the first mitosis. It is very important that the fibers modified with the Ferric Chloride (III) induce significantly less amount of the genetic damages comparing with the fibers modified with asbestos. Basing on the study results, recommendations for analysis of genomic instability in individuals who contact with asbestos have been drawn up.