Mutual Disposition of Nucleosomes and Exons Differs from Common Genome Pattern at DNA Segments Containing Periodic Nucleotide Sequences
The correlation was observed between D N A segments characterized by periodic patterns of nucleotides and nucleosome D N A binding sites predicted by the profiles of local D N A flexibility. Exons of human type I and VII collagen genes loci have been chosen as a sample set of periodic D N A segments. It was pointed that short periodic exons coding fibrillar part of these proteins are localized near borders of the D N A sequence that binds the histone core. One of the borders of exon and of this sequence coincide as a rule. In non-fibrillar parts of collagen genes exons (longer on average) dispose, in contrast, in any place of the D N A sequence bound to the nucleosome core.