Some immune system indices in experimental hyperhomocysteinemia
Homocysteine influence on the immune system indices has been studied experimentally. Liminal hyperhomocysteinemia has been detected to be accompanied by absolute and relative decrease of lymphocyte number due to T-lymphocyte population. Moderate hyperhomocysteinemia was on the contrary characterized by sharp increase lymphocyte number which testified to the development of compensatory and inflammatory reactions of the body. The dynamics of the T-lymphocyte subpopulation number in groups under study at the same time proved to be of different character. Increased TNFα, INFγ, IL 17α concentrations were registered in all experimental groups, maximal levels being marked in case of homocysteine quadruplicate administration per day.