Morphometric method in the differential diagnostics of pyogenic granuloma and "irritated" capillary hemangioma
The absence of a single theory of the etiopathogenesis of pyogenic granulоma causes significant difficulties in morphological verification and differential diagnosis with "irritated" capillary hemangioma. The aim of the study was to conduct a comparative analysis of morphological and morphometric characteristics of pyogenic granuloma and capillary hemangioma. We analyzed 73 specimens of the skin lesions. The histological features and morphometric parameters of angiomatous and stromal components estimated. Pyogenic granuloma has specific morphological features. The symmetric shape of a node, the presence of a defect of the epithelium in the central zone and the epidermal "collar" near the base of the node, high mitotic activity of the endothelium, the expressiveness and cell constituent of the inflammatory infiltrate are the differential histological features. The morphometric method revealed statistically significant differences between pyogenic granuloma and "irritated" capillary hemangioma. It confirms the validity of the mentioned histological features.