ASSOCIATION OF SINGLE-NUCLEOTIDE POLIMORPHISMS IN FOLATE PATHWAY GENES WITH THE RISK OF DIFFUSE LARGE B-CELL LYMPHOMA: META-ANALYSIS
The results of original studies often show the different effects of single nucleotide polymorphisms (SNPs) in folate pathway genes on the risk of diffuse large B-cell lymphoma (DLBCL). Meta-analysis allows integrating the accumulated data. To assess the impact MTHFR C677T and A1298C, MTR A2756G, SHMT1 C1420T, CBS 844ins68 on the risk of DLBCL, we performed a meta-analysis of the case-control studies among the Caucasian population. The 12 publications were selected for the study according to the selection criteria. Taking into account the heterogeneity of the data, the calculation was performed using a random effects model. There was no association of MTHFR A1298C, MTRA2756G, SHMT1 C1420T, CBS844ins68 with the risk of DLBCL. The meta-analysis revealed an association of the rare genotype MTHFR 677T/T with an increased risk of DLBCL (OR 1.2 CI [1.008-1.572], p = 0.041).