Chromosomal aberrations and genetic polymorphism in the xenobiotics detoxification and DNA repair enzymes genes in fuel and energy complex employers
The results of the investigation of the interrelationship between frequency of chromosomal aberrations and detoxification enzymes (GSTM1, GSTT1) and DNA repair (hOGGl, XPD) genes in the employees of fuel energy complex in Kemerovo are presented. In the group of the workers frequency of metaphases with aberrations (3,9 ± 0,2%; n = 288) was shown to be significantly higher than in the comparison group (2,1 0,2%; n =± 141). In the group of workers and control donors statistically significant differences were revealed in the frequency of distribution of the GSTT1 and hOGG1 genes. The level of chromosomal aberrations was established to be higher in patients with GSTM1 genotype "0/0" in the group of control donors.