MORPHOFUNCTIONAL EVALUATION OF RATS` LIVER IN VIVO IN CASE OF INTRAGASTRIC ACTION WITH SINGLE-WALLED CARBON NANOTUBES AND "AEVIT"
A two-week separate and combined intragastric action of in sunflower oil of single-walled carbon nanotubes at doses of 0.05 and 0.5 mg /kg and the antioxidant «Аevit» (аlpha-tocopherol acetate and retinol palmitate, AE) on the liver of male-rats of Vistar breed in 5 groups was studied. Two more groups of rats were control: the 1st group received intragastrically the sunflower oil, the second group received no exposure. Three morphofunctional indices were studied: the index of alteration of hepatocyte nuclei (in%), the index of alteration of the cytoplasm of hepatocytes (in%) and the degree of manifestation of fatty degeneration (in points). It was shown that the effect of single-walled carbon nanotubes at doses of 0.05 and 0.5 mg/kg caused a significant increase in the index of alteration of the cytoplasm of hepatocytes and the degree of manifestation of fatty dystrophy. AE in this experiment did not show antioxidant properties either in its separate action or in combination with single-walled carbon nanotubes, causing a hepatotoxic effect that is characterized by a reliable increase in the indices of the index of alteration of hepatocyte nuclei, the index of alteration of the cytoplasm of hepatocytes and the degree of manifestation of fatty dystrophy.