Use of high-throughput sequencing (NGS) to prevent chromosomal abnormalities in ART (Assisted Reproductive Technologies) program
The article presents data on preimplantation genetic screening of 750 embryos, taken from 254 patients of ART program by high-throughput sequencing (NGS). The result of the analysis of the sequencing showed that 62.3 percent of violations are located in the trophectoderm cells. The frequency of embryos with abnormalities in the group 35-40 years was statistically significantly higher compared to group up to 35 years (p=0,0107) and in the group older than 40 years, the frequency of pathology was statistically significantly higher compared to group 35-40 years (p=0,0005). The study showed that NGS can be recommended for use in the ART as a measure to prevent miscarriage and a birth of the sick child delivery.