OSMOTIC RESISTANCE OF ERYTHROCYTES MEMBRANES AT RATS WITH HYPER-AND HIPOCALCAEMIA
The aim of the current work was studying of osmotic resistance of erythrocyte membranes during experimental hyper-and hypocalcaemia, and clarification of correlation degree with lipids peroxidation profiles and antioxidant protection system. Research was conducted on 30 Wistar rats, in which hypercalcaemia (3,12±0,34 mmol/l) was created daily, within two weeks, by intragastric administration of vitamin D (akvadetrym) at a dose of 10 000 ME/100g, and hypocalcaemia model (1,84±0,15 mmol/l) was performed by removal of parathyroid glands. The changes of calcic homeostasis in both cases weakened osmotic firmness of membranes of erythrocytes, increasing percent of the hemolyzed ones. At the same time the content of hydroperoxides and malone dialdehyde raised, and activity of enzymes of antioxidant protection decreased. Thus, we noted correlation dependence of osmotic firmness of erythrocyte membranes both with lipids peroxidation (strong, positive at hypercalcaemia and negative at hypocalcaemia), and antioxidant system (similar, but weak).