THE ANTI-INFLAMMATORY ACTIVITY OF THE PINUS SIBIRICA DU TOUR SEEDS SHELL EXTRACT
Pharmacological regulation of inflammation is one of the most important problems of medicine. The advantages of using anti-inflammatory herbal remedies are due to their better tolerability and reduced toxicity. One of the most promising kinds of biologically active materials are the Siberian pine seeds. In traditional medicine, cedar shell in the tinctures and decoctions form are being used for diseases treatment, such as gastrointestinal tract, joints, skin diseases, deafness, hemorrhoids, leukemia and others. The aim of the present work is to study the anti-inflammatory activity of the cedar shell extract, obtained by microwave extraction with water – alcohol solvent. To assess the anti-inflammatory activity of aqueous solution from dry pine nut shell extract at doses of 5, 25, 75 mg/kg it was determined its effect on different stages of inflammation: alteration, exudation and proliferation. It was found that the cedar shell extract stimulates regenerative processes effectively, resulting in a decrease of alteration area, and showed expressed dose-dependent proliferative and anti-exudative activity. At the same time, it was superior at the maximum dose than the comparator drug – butadion effect on all phases of inflammation.