SOME ASPECTS OF INFLUENCE OF SEROTONIN ON THE MORPHOLOGICAL AND FUNCTIONAL CONDITION OF THE LIVER AND THE PROCESS OF ITS REGENERATION
The article provides an overview of the literature data showing pronounced regulatory properties of serotonin to ensure its participation in a number of physiological functions: transmission of nerve impulses, regulate motility of the gastrointestinal tract, hemostasis, vascular tone, intensity of metabolic processes, and others. In recent years, serotonin is considered as a modulator of hepatic regeneration, since it affects not only vascular tonus, but also on the proliferation of fibroblasts and smooth muscle cells. Ability of serotonin participate in the process of liver regeneration taking place against the background of partial hepatectomy, and provide a protective effect in terms of its toxic and ischemic injury. Demonstrated in the article active mitogenic and protective effect of serotonin proves the feasibility of further study of the properties of its pharmacological analogue to empower its application in the arsenal of modern medicine.