Specificities of the immune status in children with post-infection bacterial excretion of salmonellas
The objective. To detect defects in the immune response in children with long-term bacterial excretion of salmonellas. Patients and methods. The immune status was studied in 63 children with a history of salmonellosis. In the course of the study the values of phagocytosis (the phagocytic index of neutrophils and macrophages, intracellular bactericidal action of leukocytes, spontaneous and induced hemiluminescence); humoral immunity indices (IgG affinity, concentrations of IgG, IgM, IgA); values of lymphocyte subpopulations (CD3+, CD4+, CD8+, CD16+, CD19+, CD4+/CD8+); leukocyte migration values were examined. Results. Disorders of all links of the immune response were found in patients with long-term post-infection bacterial excretion. Abnormalities of phagocytosis were detected (decrease of intracellular bactericidal action of leukocytes, of spontaneous and induced hemiluminescence); decreased IgG-antibodies and their affinity levels; decreased CD4+-lymphocytes and immunoregulation index, and also suppression of leukocyte migration in leukocyte migration inhibition reaction in both nonspecific and specific stimulation. Conclusion. A simultaneous decrease of several links of the immune response in children with long-term bacterial excretion of salmonellas might be a reason for including immunity-correcting preparations in a complex therapy in such children.