THE SYNTHESIS AND PHYSICOCHEMICAL PROPERTIES OF NEW DERIVATIVES OF 5-R-PHENYLAMINO-2-МЕRCAPTO- 1,3,4-ТHIADIAZOLE
With the aim of obtaining new biologically active substances the synthesis of amides of 5-R-phenyl- amino-1,3,4-thiadiazole-2-yl-thioacetate acid and 5-phenylamino-1,3,4-thiadiazole-2-yl-thio-1-phenon has been conducted. As initial substances 5-R-phenylamino-2-mercapto-1,3,4-thiadiazoles, the cor- responding analides of chloracetate acid and chloracetate phenon were used. The reaction of alkyl- ation was conducted in the ethanol medium in the presence of potassium hydroxide. The structure of the compounds synthesized has been confirmed by the method of 1Н NMR-spectroscopy. The physicochemical properties and the pharmacological potential of the substances synthesized are discussed. According to the results of calculation methods of prediction of the biological activity (PASSOnline) the probable types of the biological activity of the substances synthesized have been estimated. In compliance with the data of the РАSSOnline computer-based prognosis the antineoplastic action (STAT inhibitor of transcription factors) is principally inherent for most compounds of this class.