Subcellular mechanisms for the development of inflammatory reactions
The results of the study of cellular reactions in inflammation by light and electron microscopy are presented in the article. Experimental inflammation was provoked by simulation of pneumoconiosis in albino rats, which were intratracheally injected with particles of quarts, coal and the lunar soil. There were analyzed the cells of an inflammation chamber in 1-7, 14 days and 1, 3 and 6 months after the introduction of the samples. As a specific inflammation there were studied cells with tuberculous granuloma in patients with fibro-cavernous tuberculosis of the lungs. It was established the presence of local immune reaction, which manifested itself in the blast transformation of lymphocytes actively synthesizing plasma cells. In the development of pneumoconiosis cytotoxic resistance of macrophages to fagocited particles was crucial. An autoimmune reaction was expressed only slightly