DRUGS INHIBITING VIRUSES OF LYMPHOCYTIC CHOREOMENINGITIS AND LASSA FEVER IN VITRO
Objective. Evaluation of antiviral properties of allotropic vegetal and synthetic preparations demonstrating immunity modulating properties using cultures of cells infected with viruses of lymphocytic choreomeningitis (LCM) and Lassa fever was the purpose of the study. Materials and methods. Viruses of Lassa fever (Sierra-Leone strain) and of LCM (WE-54 strain) were used. The studies were performed on cultures of Vero E6 cells. Results. The drugs Corglyconum and Arpetol were determined to have unexpectedly high antiviral activity for experimental infection caused by LCM. Celanidum was found to be highly active and Allapinin — to be moderately active for that infection. In case of the cell cultures infecting by Lassa fever virus Corglyconum was determined to be highly active while Celanidum — moderately active. Conclusion. The drugs tested were shown to inhibit the LCM and Lassa fever viruses with different effects.