Clinical efficiency of vaccination and passive immunization against tick borne encephalitis in middle Urals
The Middle Ural is the intense natural focus tick-borne infections with constantly registered disease for many years. Due to active vaccination of the population of area against TBE, by 2006 achieve 72% scope by vaccination. Annually from 50 up to 90% of the persons receive passive immunization after a tick bite. The purpose of work: to study clinical efficiency of vaccination and passive immunization against TBE. Materials and methods: In study have been included 9674 patients TBE for last 15 years (1992-2006) and 134 patients with chronic forms of disease. Statistical processing was spent with the help of electronic programs: Biostat, Microsoft Excel 2000. Results: The analysis of clinical efficiency of vaccination prevention has revealed easier current of disease at vaccinated people with prevalence of fever forms TBE - 86,4±6,1% (in comparison with 68,3±6,2% (p<0,001) at unvaccinated patients), reduction of a share meningeal forms (at vaccinated - 12,5±6,2%, at unvaccinated people - 24,9±6,4%) and focal forms of TBE (up to 1,1±0,6%, in comparison with unvaccinated people - 6,6±1,2%). Among the patients having passive immunization, development of easy fever forms was higher 79,8±4,7% (p<0,05), than in the common group of patients TBE, but, conceded to group vaccinated patients 86,4±6,1% (p<0,001); authentically smaller% was meningeal forms TBE - 16,5±5,0% (p<0,05), as against the common group 22,6±5,2%; in 2 times less often at the patients who have passive immunization 3,7±2,1 of% (p<0,05), developed focal forms TBE, than at unvaccinated patients, but is more often, than at vaccinated patients - 1,1±0,6% (p<0,05). Among patients with chronic TBE the vaccinated patients (11,2%) was in 2 times less, than at acute forms TBE (22,9%), at 71,6% of patients were absent any measures of specific preventive maintenance. Conclusions: Despite of the proved clinical efficiency of preventive measures, passive immunization considerably concedes vaccination on development heavy focal forms of TBE, lethal outcomes and chronic current of disease.