MELATONINUM AND METFORMINUM OPPRESS DEVELOPMENT OF TUMOURS OF A NECK OF A UTERUS AND A VAGINA, INDUCED DMBA AT MICE
To 120 mice-camkam SHR par ted on 4 bunches, for the purpose of an induction of a cancer of a neck of a uterus and a vagina introduced into a vagina 2 times a week within 2 months wads with DMBA. Since day of 1st introduction БП, to experimental mice of 5 times in a week within 26 weeks introduced with potable water Melatoninum (2 mg/l), Metforminum (200 mg/l) or their combination. Control mice received potable water without medicinal preparations. Frequency of development of all tumours of a neck of a uterus and a vagina has compounded 43, 50, 37 and 33 %, accordingly, in the bunches receiving DMBA + water, DMBA+melatoninum, БП+ Metforminum and DMBA+melatoninun+ Metforminum, and frequency of malignant tumours (planocellular keratosic and not keratosic cancers) has compounded 20, 3, 10 and 13 %, accordingly. Melatoninum, Metforminum and their combination reduced plurality of development of malignant tumours of a neck of a uterus and a vagina. Thus, as Melatoninum, and Metforminum oppressing impact on a carcinogenesis of a neck of a uterus and a vagina, induced БП at females of mice make.