EXPERIMENTAL INVESTIGATION OF METABOLISM FEATURES OF VALPRAZOLAMIDE
In rabbit experiments, the metabolism of valprazolamide, a new antiepileptic agent from the valproate group, has been studied. The content of valprazolamide and its metabolites in blood plasma and urine of rabbits was determined by chromatography-mass spectrometry. Mass-spectrometric identification of valprazolamide, its glucuronide and phos-phate was carried out with positive polarization according to the value of MRM transitions: m/z 256.1 → m/z 130.1 and m/z 81.0; m/z 432.2 → m/z 129.1; m/z 336.1 → m/z 129.2, respectively. It is shown that in the body valprazolamide is almost completely metabolized, in an unchanged form with urine output average 0.05%. The main direction of metabolism is its conjugation with glucuronic and phosphoric acids.