AGE-RELATED CHANGES IN CARBOHYDRATE METABOLISM IN HEALTHY YOUTH AND MATURE MEN UNDER THE NORTH CONDITIONS
Introduction. Currently, diseases caused by carbohydrate metabolism disorders are of great interest. For now, data on the status of carbohydrate metabolism and pancreas functional activity is still unavailable for both younger and working-age mature men, who are permanent residents of Magadan region (northeast of Russia).The aim of the study was to examine the correlation between age and severity of main indicators of carbohydrate metabolism in various age groups (youth, mature men) under the north conditions.Materials and methods. Fiftyve men of working age and one hundred forty-seven young men (mean ages were 36.8±0.8 and 18.7±0.8 yr, respectively), all Caucasians by origin residing in Russia’s north, participated in the study. Blood serum carbohydrate indicators were measured using the methods of ion-exchange chromatography, enzymatically enhanced chemiluminescence, as well as the hexokinase method.Results. The study results revealed that within the age range from youth to mature men was observed a signi cant increase in all examined indicators of carbohydrate metabolism and functional activity of the pancreas. Of all the participants, 10% of younger men and 46% of mature men have high level of glycosylated hemoglobin vs. the standard range. Hyperinsulinemia was observed in 20% of younger men and 36% of mature men with the HOMA-IR index exceeding the standard reference in both age groups (25 and 55%, respectively).Conclusion: The research ndings have shown rather unfavorable pictures through all age groups within the study, both for carbohydrate metabolism and pancreas functionality, which is manifested by an increase in the severity of disorders in the analyzed age groups. This tendency could be considered as evidence of a prediabetes, even in adolescence, with it worsening in the older age group. Thus, these findings could be considered as a risk factor for the development of type 2 diabetes.