Preeclampsia: The Modern State of the Problem
Objective of the Review: To conduct a systematic analysis of the available data from the Russian and foreign literature on the pathogenesis of preeclampsia, possible prognosis and pathology prevention. Key Points. The generally accepted theory is that preeclampsia is caused by defective spiral artery remodelling during early gestation associated with reduced placenta perfusion; however, such changes in spiral arteries are not unique for preeclampsia. It is not impossible that increased resistivity of uterine vessels with defective uterine perfusion can lead to abnormal invasion and trophoblast dysfunction; therefore, preeclampsia is discussed secondary to maternal cardiovascular symptoms. Conclusion. Analysis of maternal system and local uterine hemodynamics, molecular gestational sac pathology, its interaction with the environment and modifiable risk factors will facilitate biological understanding of the basis of preeclampsia; therefore, we will be more able to predict, prevent and manage this pathology.