ENDOGENOUS INTOXICATION AFTER RECOVERY OF BLOOD FLOW IN EXPERIMENTAL TEMPORARY OCCLUSION OF THE INTERNAL AND COMMON ILIAC ARTERIES
In the experiment on 10 mongrel female dogs the authors studied the dynamics of the content of medium-weight molecules in the femoral, brachial veins, inferior vena cava and portal vein, depending on the variant of intraoperative time block of arterial circulation, which is used in laparoscopic surgery for uterine fibroid of large size. In the 1st series of experiments the temporary disruption of blood flow in the basin of the common iliac arteries was modelled in 5 animals, and in the 2nd series - in the basin of the internal iliac arteries. The formation and accumulation of medium-weight molecules (MWM) which are endotoxins were noted in common iliac arteries in the 1st series amid experimental intraoperative temporary occlusion of common illiac arteries due to disturbances of blood flow in the hind limbs of experimental animals. After the recovery of arterial blood flow they come into the femoral vein, inferior vena cava, portal vein and, indirectly, into the general circulation (shoulder vein). On the contrary, the increase of medium-weight molecules in the study samples of venous blood was reliably less in the 2nd series than in the 1st series after the recovery of arterial blood flow, because the clamping of internal iliac arteries in the 2nd series led to the failure of blood flow only in the pelvic organs. The results of the research testified the expediency of minimizing ischemic zone in the failure of the temporary arterial circulation in the uterus.