1,2,4-Triazole-Based Hybrid Hydrazones of Some Heterocyclic Aldehydes and Their Influence on the Level of DNA Methylation
Hybridization is emerged as a promising strategy in the discovery of new drugs. In the present investigationa series of new hybrid hydrazones (azometines) of farmacologicaly active heterocyclic aldehydes were synthesized on the basic of 1,2,4-triazole bearing benzofuran and 5-methylbenzofuran moiety, and characterized by analytical and spectral (IR, NMR 1H, 13C) data. The newly synthesized compounds were evaluated for their in vitro influence on the level of DNA methylation. It has been found that some of tested compounds showed significant inhibitory activity.