EFFECT OF COMBINATION THERAPY WITH ACTIVITY phagocytosis in guinea pigs with experimental TUBERCULOSIS
Experiments conducted on outbred guinea pigs of either sex weighing 280-305 g investigated two combinations of TB drugs: isoniazid + rifampicin + isoniazid + kanamycin and ofloxacin + rifabutin. Immunotropic activity was studied by the method of determination of the phagocytosis as well as models of spontaneous and zymosan induced chemiluminescence lyuminolzalezhnoyi (LZHL) and NBT test. Established that animals infected with tuberculosis causes inhibition of cellular immunity. When treatment was the most appropriate combination of isoniazid and rifabutin ofloxacin. The results obtained for this combination of drugs approaching obtained for control groups of animals, indicating that the said composition has no direct immunotoxic action.