ASSESSMENT OF THE STATE OF HEMOSTASIS IN NEWBORNS WITH PERINATAL HYPOXIC LESIONS OF THE CENTRAL NERVOUS SYSTEM WITH TROMBOELASTOGRAPHY
To study the changes of hemostasis was performed tromboelastography study of 177 newborns with hypoxic-ischemic lesions of the central nervous system. Depending on the neurological status, data of neurosonogramms, all the children were divided into three groups: healthy children (group I); children with moderate lesions of CNS without hemorrhagic manifestations (group II); children with severe CNS lesions, with haemorrhagic manifestations (group III). It is shown that most of mothers II and III groups had extragenital pathology, complicated of pregnancy and borning with reliably significant increase in mothers of the III group. Analysis of indicators of tromboelastograms in newborns of II group in the dynamics of the first month of life testified disharmonious ratio of parameters and formation of coagulation syndrome. In newborns III group along with hypercoagulation orientation of hemostasis were observed phenomenon of increased fibrinolysis. These changes were seen as manifestations of endothelial dysfunction with subsequent disregulation of hemostasis system. These mechanisms of hemostasis should be regarded as a universal pathogenetic factors of ischemia-haemorrhagic disorders, determining the development of cerebral deficit of varying severity.