HYPOPERFUSION OF ISOLATED HEART BY EMPTY LIPOSOMES AND LIPOSOMES WITH ANTIOXIDANTS AFFECTS ULTRASTRUCTURE OF MYOCARDIUM
Isolated rat hearts were perfused by Langendorff method and underwent 30 min ischemic hypoperfusion by empty liposomes and liposomes with antioxidants (epoxipine and dihydroquercetin) following 15 min reperfusion. Hearts were exposed standard probe preparing for electro-microscoping research after the reperfusion. Results of research showed that all used composition of liposomes had reduced ultrastructural damages of tissues after circle of ischemia-reperfusia, but had demonstrated different activity. The extent of damaged myocardium was lower after exposition to empty liposomes compared to liposomes with antioxidants. This can be explained by higher functional stress during the reperfusion after exposition to liposomes with antioxidants. The results showed that ultrastructural rebuildings of miocardian cells during the ischemic hypoperfusion with followed reperfusion had depended on exposition of liposomes.