MOLECULAR BASIS OF DEVELOPMENT AND PROGRESSION OF HEART FAILURE IN MIDDLE AND OLD AGE
This article discusses the current level of research on the molecular mechanisms of development and progression of chronic heart failure in elderly and senile age. Described contribute to the pathogenesis of diseases of various signaling molecules and subsystems from the point of view neuro-immuno-endocrinology. The significance of cytokines and endothelial dysfunction in the pathogenesis of the disease is proved. Put forward a new hypothesis about the role of TNF-α in the development of chronic heart failure.