EXPERIMENTAL MODEL OF PULMONARY MUCORMYCOSIS CAUSED BY LICHTHEIMIA ORNATA
The increasing number of pulmonary mucormycosis cases in patients with immunodeficiencies requires enhanced research of the disease pathogenesis in experimental models on laboratory animals. Resistance of mucormycosis etiologic agents to many antifungal drugs necessitates the development and preclinical testing of new antifungal agents. The paper describes the murine pulmonary mucormycosis model: fungal strain, procedure of animals preparing to infection, route of infection. Data on mice lethality and results of cultural and histological investigations of murine lungs with invasive mucormycosis is presented.