Cytotoxic and Immunomodulating Properties of Gold Nanoparticles
Results of the investigation of cytotoxic and immunomodulating properties of gold nanoparticles of different sizes (12, 16, 22 and 35 nm) on primary and transformed cells in vitro are presented. Their localization and distribution in cells are studied. It is established that gold nanoparticles are not toxic within concentration range 0.06–6 mg/ml for all the cell cultures used, actively penetrate into the cell and get accumulated inside the vacuoles of different sizes, selectively activate the anti-inflammatory immune response depending on nanoaprticle size and cell type.