ON THE MECHANISMS OF DEVELOPMENT OF RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS TO INH AND PZA CAUSED BY THE EXPRESSION OF A NUMBER OF GENES
Based on the literature data, the mechanisms of development of M. Tuberculosis drug resistance to isoniazid (INH) and pyrazinamide (PZA) were analyzed. It was revealed that one mechanism of resistance to INH is a single amino acid mutation in the inhA gene (S94A). And the diverse nature of pncA mutations is unique for the resistance of M. Tuberculosis to PZA.