TO THE DEVELOPMENT OF THE COMPONENT CONSTITUTION OF THE PLANT COMPOSITION OF ANGIOPROTECTIVE ACTION
Objective. Establishing the optimal ratio of plant components in the composition of angioprotective action. Methods. Justification of the optimal component consists of the plant composition of the angioprotective effect according to the results of the quantitative content of biologically active substances and the effect on antioxidant activity. The quantitative content of flavonoids, phenolcarboxylic acids were determined spectrophotometrically, ascorbic acid and the amount of polyphenols were determined by the titrimetric methods. The antioxidant activity was studied in in vitro experiments on donor blood serum with the determination of the content of diene conjugates and malondialdehyde. The peroxidation induction was caused by Cu2+ ions. Results. 5 plant compositions containing raw materials of pharmacopeia plants with antioxidant, capillary-strengthening, venotinizing and anti-inflammatory effects were composed. Based on the phytochemical analysis of the extracts of plant compositions, the variant of composition C contained the largest amount of flavonoids, phenolcarboxylic acids, ascorbic acid, polyphenolic compounds, and extractive substances. A study of the antioxidant activity of the variants also showed the highest activity of composition C. Conclusion. The content of the plant composition of angioprotective action, including the raw materials of 6 pharmacopeia plants, is theoretically substantiated. The optimum ratio of the components in this plant composition containing the highest number of flavonoids, phenolcarboxylic acids, polyphenolic compounds, ascorbic acid, extractive substances and having high antioxidant activity was experimentally established.