Role of apoptosis factors in pathogenesis of oligomenorrhoea and uteral bleedings in puberty
The research of systemic parameters of apoptosis in peripheral blood such as a tumour necrosis factor - α (TNF - α), soluble forms of TNF-α receptors (sTNFRI), soluble forms of a Fas-receptor (sFAS), Fas-liganda (sFASL) and caspase-8 was carried out at patients with uterine bleedings in puberty (I group), at teenagers with oligomenorrhoea (II group) and at healthy girls (a control group). FNO-α deficiency and sTNFRI (р55) hyperproduction was revealed at patients with uterine bleeding in puberty and with oligomenorrhoea that indirectly specifies apoptosis blocking at a stage of induction by a soluble receptor and liganda complex. The revealed deficiency of apoptosis factors both at an initiation stage (sFASL) and in an effector phase (caspase-8) can have pathogenetic value in formation of reproductive system pathology in a pubertal period shown in the form of uterine bleeding and oligomenorrhoea. In spite of apoptosis soluble marker decrease sFAS/sFASL index exceeded values of the control group that specifies in parity infringement in sFAS-sFASL system with displacement of a final eff ct towards apoptosis blocking at patients with uterine bleeding and oligomenorrhoea.