Interaction of Superoxide Radicals with Reactive Dicarbonyl Compounds
In this paper, we studied the interaction of superoxide anion radical (O2-) with reactive dicarbonyl compounds (methylglyoxal, glyoxal and malondialdehyde). It was shown that glyoxal and methyl-glyoxal inhibited superoxide-dependent accumulation of formazan while malondialdehyde stimulated this process. The generation of O2- in these experiments occurred during decomposition of an azo-initiator, SOTS-1. However, in this O2- generation system all studied dicarbonyls were competing for the superoxide with TIRON spin trap. These compounds also inhibited luminоl-dependеnt chemiluminescence in the system of egg phosphatidylcholine liposome peroxidation induced by the azo-initiator AIBN. The mechanism of antiradical and antioxidant action of the studied dicarbonyl compounds, that implies the formation of free radical intermediates in their reactions with O2- or its protonated form, is suggested.