ADIPOKINES AND INDICATORS OF CARBOHYDRATE METABOLISM IN PREGNANCY COMPLICATED BY GESTOSIS
Adipokines are secretory peptide hormones from adipose tissue but may also expressed in placenta and other organs. We assessed maternal and cord blood concentrations of adiponectin, resistin, leptin, insulin and glucose from healthy pregnant (n = 64) and suffering from gestosis (n = 14) women at third trimester of pregnancy (38 – 40 weeks of gestations). It was similar in age and height between study groups, whereas BMI tended to be higher in the group with gestosis. In fasting samples of maternal blood with gestosis we determined higher concentrations of leptin, when adiponectin, resistin, insulin and glucose had no significant differences compared with the physiological pregnancy. In contrast level of leptin in cord blood decreased significantly. Thus effects of adipo-nectin and resistin may not relate to pathogenesis of preeclampsia, whereas leptin may play a key role in preec-lampsia.