DETERMINATION OF THE KEY SITES FOR COVALENT BONDING OF GOSSYPOL TO DIALDEHYDE POLYSACCHARIDES
This study is devoted to determination of the key sites for covalent bonding of gossypol to dialdehyde polysaccharides, which are used as conventional drug carriers. It has been found that gossypol irreversibly interacts with hemiacetal cycles of oxidized units and reducing terminal groups via aldehyde moiety only. The products of gossypol glycosilation have been synthesized and used as low molecular mass models to determine the bonding sites and chemical structure of resulting polymers.