Effects of bevacizumab on the regression of experimental functional cysts
The aim of the research. To study the influence of the inhibitor of vascular endothelial growth factor on the regression of functional cysts in the course of the experiment. Material and methods. The experiment was performed on sexually mature white female rats of the Wistar line. Group I (basic, n = 25) - functional ovarian cysts modelling (introduction of follicle stimulating hormone) and introduction of bevacizumab. Group II (comparable, n = 35) -functional ovarian cysts modelling without subsequent treatment. Control group (n = 20) - intact animals. The rats were removed from the experiment on the 7th, 15th, 30th and 60th days. Histological and morphometric studies were carried out on dewaxed sections of the ovaries stained with hematoxylin-eosin and by Van Gieson. Results. Functional ovarian cysts modelling in white rats was accompanied by an increase in the specific volume of vessels, increased atresia, decrease growing follicles and yellow bodies number and specific volume. The introduction of an inhibitor of vascular endothelial growth factor caused on the 15th day the decrease in number and specific volume of cysts, approximation of specific volume of vessels to the values of control group. By the 60th day, the number and specific volume of growing and atretic follicles and yellow bodies did not differ from the ones of the intact control group. Conclusion. Bevacizumab introduction accelerates the regression of functional ovarian cysts by reducing vascularization in the cyst wall. The detected decrease in the number of growing follicles and intensification of atresia in the follicles are short-term.