PATHOGENETIC RELATIONSHIP CHANGES IN THE ULTRASTRUCTURE OF MEMBRANES AND ACCUMULATION OF LIPOPEROXIDATION PRODUCTS IN THE AMNIOTIC FLUID DURING PROLONGATION OF PRETERM PREGNANCY WITH PRETERM RUPTURE OF MEMBRANES
The analysis of lipid peroxidation in 64 pregnant women with premature rupture of membranes on gestation period 22 - 34 weeks, were treated in the Perinatal center of Saratov region in 2012-2014. The objectives of the study included a comparative assessment of the content in the blood of pregnant women surveyed lipid peroxidation products - diene conjugates and malondialdehyde, quantitative determination of peroxides as well as assessment of the overall antioxidant status, superoxide dismutase and ceruloplasmin content. Identified pathogenetic relationship between the activation of lipid peroxidation, which is manifested by an excessive accumulation of blood and amniotic fluid diene conjugates and malondialdehyde on a background of relative insufficiency of the antioxidant system, and the development of degenerative processes in the amniotic and chorionic membranes of the fetus in terms of prolongation of pregnancy in patients with premature rupture of membranes. The possibility of using indicators of lipid peroxidation in the blood as objective criteria for assessing the degree of damage to the amniotic and chorionic membranes of the fetus in patients with premature rupture of membranes is exist.