Synthesis and Antibacterial Activity of New Poly Heteroconjugated and Binuclear Systems Based on <i>N</i>-Substituted 2-Imino-2,5-dihydrofuran-3-carboxamides
New N -substituted iminodihydrofurans containing thiourea residue have been synthesized by the interaction of N -substituted 2-imino-2,5-dihydrofuran-3-carboxamides with thiosemicarbazide. Next the synthesized N -substituted iminodihydrofurans have been condensed with ethyl chloroacetate, farther heterocyclization to oxothiazolidinylidene ring afforded binuclear and polyheteroconjugated systems. Synthesized compounds exhibited moderate to defined antibacterial activities against Gram-positive ( Staphylococcus aureus - 209p, Bacilus subtilis ) and Gram-negative ( Shigella Flexneri 6858, Esherichia coli 0-55) bacteria compared to furazolidone.