Screen-printed thiol-sesnsitive sensor elements for determining the activity of butyrylcholinesterase and analysis of its inhibitors
A method for analyzing thiocholine, enzyme activity of butyrylcholinesterase (BChE) and their inhibitors using thiol-sensitive planar sensors has been proposed. Sensor sensitivity to thiocholine is provided by mediator layer of manganese dioxide formed on the working carbon electrode. The detection limit for BChE and its inhibitor diazinon was 1·10 -10 М и 1·10 -9 М, respectively. The developed approach simplifies the analysis of inhibitors and can be used to water quality control and environmental monitoring.