FEATURES OF HISTOLOGICAL STRUCTURE IN THE WHITE PULP OF RAT SPLEEN DURING DIFFERENT PERIODS OF POSTNATAL ONTOGENESIS UNDER EXPERIMENTAL IMMUNOSUPPRESSION
During the experiment, conducted on 180 white outbred male rats of three age periods (pubertal, reproductive and of expressed age-related changes) with the use of histological and morphometric methods, followed by statistical analysis, it was established that experimentally simulated immunosuppressive condition caused morphological remodeling in the animal spleen, which was manifested as white pulp hypoplasia. The highest level of spleen reactivity in response to a cytostatic agent was observed in pubertal animals. Changes in the spleen white pulp of rats with expressed age-related changes took place against the background of involutive processes.