Influence of immunopathological reactions on myocardial remodeling and development of systolic dysfunctionof the heart in patients with ischemic cardiomyopathy
The study included 246 patients (the Ist group) with ischemic heart disease and normal systolic function of the left ventricle (LV), and 25 patients with ischemic cardiomyopathy (the IInd group). The immune pathological reactions were identified in patients of both groups (manifestations of autoimmune reactions, the levels of inflammation and immune depression were more pronounced in the IInd group). The development of remodeling of the left ventricle and heart failure in patients with ischemic artery disease is associated with very high level of vascular endothelial growth factor (VEGF). The increased secretion of VEGF is unfavorable prognostic factor of progression of heartfailure and adverse remodeling of the left ventricle.