Reversible diadenosine tetraphosphate intercalation into Mg/Al-layered double hydroxides nanoparticles
Preparation of Ap4A intercalateted into nanodimensional (100-200 nm) Mg/Al-layered double hydroxides (LDH) particles has been originally obtained. The intercalation has been shown not to alter Ap4A chemical structure. Parameters of Ap4A deintercalation from the nanoparticles first have been studied. It has been established that the release rate of Ap4A from the nanohybrid is obviously depend on pH (the release rate at pH 7.5 is remarkable lower than that at 4.4) and the buffer ionic composition. The results obtained show the possibility of LDH/Ap4A nanoparticles using as pH-controlled passive system of Ap4A drug delivery to the target cells.