THE ROLE OF RHEUMATOID FACTOR IN THE REGULATION OF AUTOIMMUNE REACTION IN EXPERIMENTAL MODEL OF AUTOIMMUNE HEMOLYTIC ANEMIA IN MICE
The work is devoted to study of the role of rheumatoid factor subset in the regulation of autoimmune response in experimental autoimmune hemolytic anemia in mice. Autoimmune hemolytic anemia in mice was caused by immunization with rat erythrocytes. In these experiments RF was measured with help of agglutination techniques employing rat IgG-coated tanned erythrocytes as antigen. The dependence of anti-erythrocyte antibody production on intensity of rheumatoid factor response indicates the participation of rheumatoid factor in the regulation of autoimmune response in hemolytic anemia in mice.