SEARCH OF CORRECTORS METABOLIC ABNORMALITIES IN DIABETES MELLITUS TYPE 2 AMONG 5-SUBSTITUTED BENZIMIDAZOLES, CONTAINING CYCLIC ALKYLAMINO GROUP IN SECOND POSITION
We studied the effect of 5-substituted benzimidazoles containing a cyclic alkylamino group in the second position on the activity of dipeptidyl peptidase type 4, glycogen phosphorylase and antiglycation, antioxidant effects in test systems in vitro. As a result, three compounds were found to effectively inhibit dipeptidyl peptidase type 4, but did not measure up to the drug of reference, sitagliptin. In addition, the two compounds showed an antioxidant effect comparable with dibunol.