PRACTICAL ASPECTS OF DIAGNOSIS CONSUMPTION OF PSYCHOACTIVE COMPOUNDS NBOME GROUP. DETECTION OF NBOME AND ITS METABOLITES IN BIOLOGICAL OBJECTS BY GAS AND LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY
Synthetic compounds, which names include the combination of letters «NBOMe» and are derivatives of 2-(2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine, are referred to a large family of «designer drugs» or new psychoactive compounds (NPS). NBOMe undergo intensive metabolism, and the detection of their metabolites, as well as unchanged compounds, is difficult due to the lack of awareness of analytics about metabolism and chromatography-mass spectrometry features. In this paper, the practical aspects of detection of both unchanged NBOMe and major metabolites by gas and liquid chromatography-mass spectrometry in biological objects are considered