The sensitivity of pathogenic microorganisms to norfloxacin
A number of tasks are supposed to be performed to overcome antibiotic resistance, of which the first place is the problem of organizing monitoring of the sensitivity of pathogens to the drugs used. This study provides on the sensitivity of animal pathogens to norfloxacin. The sensitivity of 387 isolates of pathogenic microorganisms was analyzed by the disk-diffusion method according to the standard method. It was found that norfloxacin, like other fluoroquinolones, exhibits the greatest antimicrobial activity in relation to gram-negative microorganisms. The sensitivity to norfloxacin of the studied salmonella (Salmonella enteritidis, Salmonella choleraesuis, Salmonella typhimurium, Salmonella dublin) ranged from 83.3-100%, cultures with intermediate sensitivity values were 15.8% (S. choleraesuis) and 16.7% (S. enteritidis). Salmonella isolates resistant to norfloxacin were not isolated in our studies. Sensitive cultures of Escherichia coli were 78.2%, with 10.1% of the isolates having intermediate sensitivity, and 14% were resistant. We studied 11 isolates of Pseudomonas aeruginosa, of which 10 (90.9%) were sensitive and 1 (9.1%) was stable. All isolates of morganella and pasteurella (Morganella morganii, Pasteurella multo-cida) were sensitive to norfloxacin. Among pathogens of streptococcosis (Streptococcus spp.), Listeriosis (Listeria monocitogenes) and swine erysipelas (Erysipelotrix rhusiopa-tiae), norfloxacin-resistant isolates were not isolated. The proportion of sensitive cultures of Streptococcus uberis was 87.5%, coagu-lase-negative staphylococci - 91.8% and cultures of Staphylococcus pseudintermedius - 75%. Norfolloxacin-sensitive cultures of Staphylococcus hyicus and Staphylococcus aureus in the experiment were 57.1% and 84.8%, respectively, isolates with intermediate sensitivity values - 4.8% and 9.1%, and resistant - 38.1% and 6.1 %. The number of sensitive enterococci reached 63.3%, 20% of the isolates were of intermediate sensitivity, and 16.7% of the cultures were stable. In the experiment, a larger number of esherich-ia-resistant to norfloxacin (11.7%) was isolated than to ciprofloxacin (8.4%) and ofloxacin (9.2%). A greater percentage of norfloxacin-sensitive St. hyicus, St. aureus and enterococci.