Results of the use of Vetoril in treatment of the hypophysical form of hyperadrenocorticism in dogs
The article presents the results of using Vetoril in dogs with pituitary-dependent form of hyperadrenocorticism. Preliminary diagnosis was made in accordance with the symptoms of the disease - polyuria, polydipsia, polyphagia, change in trunk configuration, dermatological manifestations. Confirmed the diagnosis of biochemical blood tests, the study of urine on the ratio of cortisol / creatinine. The pituitary adrenal form of the disease was differentiated with a small dexamethasone test: dogs had a high basal level of cortisol, which was suppressed with a low dose of dexamethasone after 4 hours and again increased after 8 hours. In patients with dogs in serum, a significant increase in the activity of alkaline phosphatase, ALT, AST. The ratio of cortisol to creatinine in urine was increased by an average of 2.6 times with respect to the norm. The use of the drug Vetoril in a dose of 10.8 mg / kg led to the normalization of metabolic rates and a significant decrease in clinical symptoms on average for 32 days. As a result of treatment there was a significant decrease in ALT activity - 4.5 times, AST - 1.7 times and alkaline phosphatase - 7.4 times. A decrease in glucose concentration by 18.8% and cholesterol by 40.8% was revealed. The amount of fluid consumed decreased 2.28 times, the ratio of cortisol / creatinine in urine decreased by 5 times.