Anticancer and antimetastatic activity of sulphated polysaccharide fucoidan derived from the Okhotsk Sea brown algae <i>Fucus evanescens</i>
In vitro model of transplantable Lewis's pulmonary adenocarcinoma in C57BL/6 mice allowed to study anticancer and antimetastatic effect of the sulphated polysaccharide fucoidan derived from the Okhotsk Sea brown algae Fucus evanescens. As shown, the intensity of antimetastatic effects depended on the dose of the drug. Single or repeated introduction of the drug in the dose of 10 mg/kg induced spontaneous moderate antimetastatic effect and potentiated antimetastatic but not anticancer activity of cyclophosphan. The smaller and larger doses (5 and 25 mg/kg) did not result in any noticeable effects on the growth and dissemination of adenocarcinoma. Combined with cyclophosphan, the fucoidan applied in the dose of 25 mg/kg intensified toxic action of the cytostatic drug.