THE PERSPECTIVES OF ENZYMATIC TEST APPLICATION IN PATIENTS WITH GASTROINTESTINALAND LUNG CANCERS
Purpose: to evaluate the diagnostic relevance of thymidine phosphorylase (TP) in case of gastrointestinal and lung cancers. Materials and methods: The comparative study of TP activity by means of spectrophotometric method in solid gastric and lung tumors, non-neoplastic tissues of resection margin and blood plasma of 88 patients. Results: TP activity in patient plasma in case of advanced cancer of various localization was determined to be 2,2 - 3,5 times lower (p < 0,001). In most cases it is accompanied by the decrease of tumorous activity (by 1,9 - 2,7 times, p < 0,01). The levels of CD 34 expression were determinated in 20 samples of tumors of lung cancer with increasing individual TP activity. The positive correlation between the intensity of the of CD 34 expression and TP activity was shown (the index of Spearman’s rank correlation, i.e. ρ = 0,67; p <0,05). Conclusion: 1. Investigation of TP activity in blood plasma may be used as the individual prognostic test. 2. Tissue enzyme activity correlates with the intensity of angiogenesis.