Possibility of Chemotherapy with Cyclophosphamide, Vincristine, and Prednisolone (COP) in Cats with Malignant Lymphoma
The retrospective study was aimed to assess the efficacy of COP4chemotherapy protocol (cyclophosphamide, vincristine, and prednisolone) for feline lymphoma in 34 cats from 2008 to 2013. The complete remission (CR) was achieved in 27 of the 32 cats (61,8 %). The median4free period was 224 days and the median survival - 423 days. The progression of the disease was registred in 8 of the 32 cats (23,5 %). The results of treatment were: extranodal (CR 100 %) and multicentric form (CR 71,4 %), mediastinal form (CR 66,6 %). A slight effect was in alimentary (CR 58,3 %) and miscellaneous (CR 0 %) form of feline lymphoma. In cats with virus4associated lymphoma (FeLV4, FIV4positive) there were no result of the treatment in one case, four cats got complete remission and stabilization of the disease. Adverse effects, such as dyspepsia and hematologic toxicosis were noted in 23,5 % of cases, of which myelosuppression was noted in 14,7 %.