THE ACTUAL ASPECTS OF DEVELOPMENT AND STANDARDIZATION OF STOMATOLOGICAL PHYTOPREPARATION "DENTOS"
As a result of conducted pharmacognosy and microbiological investigations there were substantiated the composition of the new combined medicine «Dentos» in the form of complex tincture on the basis of five types of the medicinal plants: leaves of Eucalyptus viminalis Labill., bark of Quercus robur L., flowers of Calendula officinalis L., herbs of Echinacea purpurea (L.) Moench., essential oil of Caryophyllus aromaticus L. There were developed the methodics of the qualitative analysis of «Dentos» consisting in chemical reactions and parameters of the electronic spectrum of absorption. There were developed the methodics of the quantitative analysis of the main groups of the biologically active compounds with using the standard samples of eucalimin, rutin and caffeic acid and established the quantitative characteristics: the total oxidized substances – not less than 0,7 %; the phenolaldehydes – not less than 0,1 %; the total flavonoids – not less than 0,2 %; total phenylpropanoids – not less than 0,2 %. There was developed the technology of receiving remedy «Dentos» in the form of complex tincture and there was substantiated the choice of the optimum prolonged medicinal form for developed medicine – stomatologic gel «Dentos». As a result of conducted pharmacognosy and microbiological investigations there was substantiated the composition of the new combined medicine «Dentos» in the form of complex tincture. As a result of the conducted pharmacological researches medicine «Dentos (in the form of tincture and gel) was carried out to a class of low-toxic substances. There was found the high regenerating, antimicrobial and anti-inflammatory activity, which are comparable to a synthetic preparation of comparison («Сhlorhexidinum») and having advantages over a herbal remedy of the comparison («Stomatophyt»).