A new direction in the search for antiprotozoal drugs
The problem of eimeriosis and other protozoan diseases of fish, as well as birds and other mammals is currently no less urgent than in previous years, since there are no industrial-type farms where these diseases do not occur. This disease continues to seriously worry poultry, fish and rabbit breeders. This is due to the fact that Eimeria spp. have the ability to "get used to" the same drug when prescribed for a long time, and also due to the fact that in all countries with developed industrial livestock breeding, the development of means and methods of control of infestation is currently sharply reduced. Both in the case of antibacterial diseases and protozoan diseases the problem of drug resistance of protozoa is increasing, in this connection we have made attempts to screen new compounds with antiprotozoal activity of non-antibiotic origin. Syntheses in a series of fatty acid amide derivatives allow to obtain new cationic surface active compounds with high antimicrobial properties (antibacterial and antiprotozoal). As a result, fatty acid amides were found to be low-toxic to laboratory rats. The established facts provide a basis for further study of substances from the series of fatty acid amides as antiprostocidal agents in protozoosis of animals.