MORPHOBIOCHEMICAL STATUS OF COWS AT COMBINED THERAPY OF ACUTE POSTPARTUM ENDOMETRITIS
Combined therapy for cows with acute postpartum endometritis, which comprises the use of myotropic(uteroton), etiotropic (tylosinocar) and immunocorrective (aminoseleferon) agents, is accompanied by a clinicalrecovery of 93.3 % of animals on average in 11.7 ± 0.5 days at the least amount of intrauterine drugs - 5.01 ± 0.34. During the recovery of animals subjected to combined therapy, a decrease in blood leukocyte content by 17.6 % was found, including eosinophils - by 34.5 % (P < 0.001), stab neutrophils - by 11.8 %, monocytes - by25.9 % (P < 0.01), medium molecular peptides (MMP) - by 28.1 % (P < 0.01), medium weight molecules (MWM) - by 21.2 % (P < 0.001), stable metabolites of nitric oxide - by 26.0 % (P < 0.05), index of endogenous intoxication (IEI) - by 16.1 %, with an increase in the concentration of vitamin A by 1.5 times (P < 0.01), vitamin E - by 37.5 % (P < 0.001), activity of catalase - by 18.0 % and glutathione peroxidase - by 22.5 %, which indicated a decrease in the inflammatory process in the uterus, the intensity of lipid peroxidation, activation of the humoral and cellular immunity, enzymatic and non enzymatic link of antioxidant protection.