STUDY OF A NEW CLASS OF COMPOSITE FIBROUS MATERIALS BASED ON BIOPOLYMERS FOR REGENERATIVE MEDICINE
The creation of modern nanocomposite fiber materials with valuable functional properties based on biodegradable polymers and modifying additives allows not only solving environmental problems and reducing environmental pollution, but also offering new approaches to the creation of innovative materials for regenerative medicine. The purpose of this research work is to study the nature of the biodegradation of a new class of composite fibrous materials based on biopolymers and modifying additives for regenerative medicine. The paper proposes an approach to modifying the structure and properties of PHB-based composite materials obtained by electrospinning through the use of hemin molecular complexes. The structure of new materials has been studied by such methods as optical and scanning electron microscopy, electron paramagnetic resonance, and differential scanning calorimetry. During the work it was found that the introduction of 1-5% wt. hemina has a significant effect on the supramolecular structure, morphology, and properties of PHB-based fibers. An increase in hemin concentration leads to a decrease in the proportion of the crystalline phase by 8-10%, which corresponds to a decrease in the density of the amorphous phase by 15-70%, respectively. The addition of hemin leads to an improvement in the strength characteristics of the material: the elongation at break increases by 1.5 times, and the tensile strength increases by 3 times. The antimicrobial activity of hemin-containing composite materials against E. coli and S. Aureus was confirmed.