ADAPTATION OF FOOT AND MOUTH DISEASE VIRUS TYPE O TO THE ORGANISM OF TWO-THREE-DAYS RABBITS
The results of studying the adaptation of the virus type O, isolated in the Republic of Tajikistan from cattle and its accumulation in the body of two-three-day old rabbits, are described. As the number of passages increased, a regular increase in infectious activity was observed - from 2.5 to 6.75 and 7.0 lg LD50 / ml, as well as a reduction in the time of death of animals - from 72 hours after infection in the first passage to 24 hours - at 7 8 passages. The titer of complement-binding antibodies to the virus began to be detected from the third passage (1:2) and by the 8th passage was 1: 8. This virus adapts well and accumulates in the body of newborn rabbits for 7-8 passages.