Effect of intrauterine Argumistin® on reproductive performance of lactating dairy cows diagnosed with purulent vaginal discharge
The objectives of the study were to assess effectiveness of a new antibacterial nanosilver!based veterinary drug Argu! mistin® (10 or 50 ppm of silver nanoparticles, 100 ppm of benzyldimethyl[3!(myristoylamino)propyl]ammonium chlo! ride monohydrate) in treatment of cows with purulent vaginal discharge (PVD) when administered intrauterine. One experimental and two control groups in total included 114 holstein cows (average milk yield per cow per year 7000 - 7200 liters) with PVD from Komsomolskaya Dairy Farm (Altai region, Russia). The reference drugs used in two control groups contained benzethonium chloride and 8!hydroxyquinoline as active components. Therapeutic efficacy of Argumistin® at PVD was 89,5 %; the duration of treatment was reduced to 4,1 days (P<0,001), with an increase in fer! tilization effectiveness up to 9,25 % and reduced service interval to 7,7 days (P<0,01), when compared with the the! rapeutic efficacy of reference drugs.