RENAL LESIONS IN METABOLIC SYNDROME AND POSSIBILITIES OF MEDICINAL CORRECTION OF MARKERS OF RENAL FUNCTION DISORDERS
Markers of renal damage and the effects of antihypertensive drugs were assessed in 81 patients with meta- bolic syndrome (MS). Impaired renal function was found in 57 (70.4%) patients with MS, particularly in 18 (22.2%) patients occurred hyperfiltration, and in 39 (48.2%) - hypofiltration. Mean values of endothelin-1 was 0,3 (0.2; 0.9) fmol/l (normal values of endothelin-1 - less than 0.26 fmol/l) and increased with increasing baseline BP. Antihypertensive drugs in patients with CKD in the presence of initial hyperfiltration leads to a decrease of GFR and the presence of hypofiltration - an increase of GFR. Endothelin-1 decreased from 0.3 (0.2; 0.9) 0.2 (0.1, 0.5) fmol / l in group zofenopril (p=0.142) and 0.4 (0. 2, 0.9) 0.2 (0.1, 1.4) fmol / l in the nebivolol group (p=0.008). In addition, these patients nebivolol does not adversely influence lipid and carbo- hydrate exchanges.