THE EFFECT OF CENTRAL ASIAN COBRA VENOM ON THE ACTIVITY OF ROTENONE SENSITIVE AND INSENSITIVE NADH OXIDASES OF RAT LIVER MITOCHONDRIA AND THEIR CORRECTION BY FLAVOSAN.
After the administration of venom of Central Asian spectacled cobra into rats’ organism, the oxidation of NADH from the internal pathway of the respiratory chain of the liver mitochondria slows down, but in the external path, on the contrary, is enhanced. These changes are observed against the background of the release of cytochrome c from the inner mitochondrial membrane. As a result, electron transport from the respiratory chain to the oxygen molecule slows down. If flavosan is introduced into the animal organism with the subsequent administration of poison, the oxidation of NADH in the respiratory chain of the inner mitochondrial membrane is accelerated, but on the external, on the contrary, it slows down.