INTERRELATION OF THE DISTRIBUTION OF THE ACTIVITY OF GLUTATHIONPEROXIDASE IN THE SERUM OF BLOOD AND TISSUES OF WHITE IMPEDIQUE RATS
Uncompensated formation of reactive oxygen species or oxidative stress leads to a number of pathological conditions. The antioxidant defense of the body, which is central to the glutathione reductase / glutathione peroxidase system, counteracts the free radical oxidation of biosubstrates, ensuring the detoxification of peroxides, thereby preserving the integrity of cell membranes. The antioxidant effect of glutathione peroxidase (HG) in the chain of free radical oxidation of lipids and proteins, initiated by reactive oxygen species, is as follows: the selenium-containing HM prevents the continuation of the free radical oxidation process, first of all, neutralizing the fatty acid hydroperoxides that have already formed, and second, prevents them formation, splitting hydrogen peroxide, which reacts with a superoxide anion radical, generates a hydroxyl radical that is extremely actively oxidizing organic molecules seh types. The dynamics of the formation of HP allows to draw conclusions about the mechanism of compensation of maladaptation shifts, about the features of metabolism in the regulation of free radical oxidation processes and to predict the development and dynamics of pathological states in warm-blooded organisms. When the goal of the study was achieved, the relationship between the distribution of glutathione peroxidase activity in rat blood serum and tissues was solved, the following tasks were solved: the activity of glutathioperoxidase in blood serum and tissues of the liver, brain, heart, and rat skeletal muscle tissue was determined; The interrelation of the distribution of the activity of glutathio peroxidase in the serum and tissues of rats was revealed.The article presents the results of a non-parametric correlation analysis for assessing the relationship between the distribution of the activity of glutathioperoxidase in blood serum and tissues of white outbred rats.