COMPARATIVE STUDY MORFOFUNKTCIONALNOE VIOLATIONS IN MODELING ADMA-SUCH PREECLAMPSIA AND PLACENTAL HYPOPERFUSION
The paper presents the results of a comparative issledovanieya morphological and functional disorders arise when modeling ADMA-like pre-eclampsia and uterine hypoperfusion. Simulation ADMA in rats - like preeclampsia is characterized by the rise of blood pressure, endothelial dysfunction, proteinuria, a reduction in the microcirculation of the placenta, the increase in fluid content greater omentum, disturbance of development of the fetus. Simulation of uterine hypoperfusion in rats led to disruption of the microcirculation in the placenta, decreased weight and fetal growth, as well as to postimlantatsionnoy fetal death. The mother's body was observed increase in blood pressure, endothelial dysfunction. The findings complement a basic understanding of the pathogenesis of preeclampsia and placental insufficiency. Both simulated version of the pathology can be used in pre-clinical stages of development of new drugs for the correction and treatment of preeclampsia and placental insufficiency.