The actual approaches to treatment of inflammatory periodontal diseases in women with gynecological pathology
In the recent years, extensive attention is attended to studying of the role of deficiency of estrogen in development and course of inflammatory diseases of periodont. The data exists confirming genome impact of estrogen on receptors of cells of epithelium of gum. The objective. To study possibilities of application of indole-3-carbinol and epigallocatechin-3-gallate in complex treatment of inflammatory diseases of periodont in women against the background of hormonal unbalance. Materials and methods. The study sampling included 114 women with inflammatory diseases of periodont against the background of gynecological pathology with hormonal unbalance. The main group was applied complex treatment of periodontal diseases with inclusion of indole-3-carbinol and epigallocatechin-3-gallate into pharmaceutical correction. The control group included 33 women with inflammatory diseases of periodont against the background of gynecological pathology with hormonal unbalance and having no treatment with pharmaceutical. The periodontal status was established using indices HI, GI, PBI, measurement of depth of periodontal recesses and Fuchs index. To control effectiveness of prescribed therapy immune histochemical methods (detection of в-estrogen receptors and proliferation activity (Ki67) of sells of epithelium of gums) were applied. The data was processed with statistical techniques. Results and discussion. In the main group significant amelioration of condition of tissues ofperiodont was noted. The positive dynamics was observed also in restoration of alveolar bone ( in main group Fuchs index consisted before treatment 0,61±0,08 and in a year - 0,71±0,06; p<0,05). In two months after applied treatment decrease of signs of chronic inflammation validated hystologically was established. In female patients of main group in gum epithelium significantly decreased percentage of cells expressing в-estrogen receptors (before treatment - 50,5±16,7 and after treatment - 17,5±5,8) and Ki67 (20,0±9,7 and 5,2±2,6 correspondingly). Conclusion. The application of indole-3-carbinol and epigallocatechin-3-gallate in complex treatment of inflammatory diseases of periodont in women against the background of gynecological pathology increases effectiveness of common therapy.