Comparative evaluation of acute toxicity of drugs Stop-coccidia, Eymeterm suspension of 5% and Baycox 5% in intragastric administration to mice
The purpose of this study is to determine the parameters of acute toxicity in mice toltrazuril the introduction of drugs in to the stomach Stop coc- cidian production NPO "Api-san" (Russia), Eymeterm suspension of 5%, production of "Research and in novation center Agrovetzaschita" (Russian), Baycox5% of the company «Bayer Health Care AG» (Germany). Toltrazuril, a part of these drugs is derived triazintriona, has a broad spectrum anti coccidial effect on thein tracellu lars tages of the parasite. The results presented studies do not allow to set the parameters of acute toxic effect (LD16, LD50, LD84, LD100) studied drugs in their intra gastric administration to mice, since the use of drugs in doses of 250-1500 mg for DV/kg of animal mortality in mice lacking. With the introduction of the drug in doses 250-1250 mg for DV/kg of body weight, any notice ably pronounced signs of intoxication have been reported. According to GOST12.1.007-76 hygienic classification in accordance with the parameters of all study drugs belong to the 4th class of danger- low-hazard substances.