The study of parameters of acute toxicity of a new antioxidant drag for animals
One of the etiological factors in the development of many animal diseases is a disruption in the functioning of the body's antioxidant system and the associated increased concentration of reactive oxygen species. In the normalization of the oxidant-antioxidant balance, the most effective method is now pharmacological correction with the use of antioxidant drugs, and their development is an actual task of veterinary science. The article presents the results of studying the acute toxicity indicators of an antioxidant preparation for animals developed at the Stavropol State Agrarian University. As a result of the experiments, the maximum tolerated doses were established, which amounted to 1070 mg / kg for white mice and 1130 mg / kg for white laboratory rats. In the experiment to study the toxicological parameters of the developed drug, various doses were introduced and expressed the effects as a percentage of lethality and probit. As a result of the calculations, the average dose was calculated, which was 5564 mg / kg for mice, and 6780 mg / kg for rats. When constructing the probit charts, a 16 percent and 84 percent lethal doses of the new antioxidant drug were calculated. Using the data obtained in the analysis of the results of the acute experiment, the average error in the dose of the effect was calculated. Based on the results of scientific research, it has been established that the antioxidant preparation for animals belongs to the fourth class of hazard, that is, substances that are low-toxic in accordance with the current standard.