On the problems with quantitative GC analysis
Gas chromatography is widely used to analyze volatile compounds. However, quantitative analysis needs special consideration. Depending on the containing functional groups and heteroatoms the signal intensity of a flame ionization detector differs. Response factors that consider this can be determined experimentally or calculated via an increment system. A comparison between experimental determined and calculated response factors was done for different compounds. Furthermore, a method for quantitative analysis using a mass selective detector is proposed. A calibration for every substance in the certain concentration range needs to be done since a prediction of the response behavior is impossible.