DETERMINATION OF CONDITIONS FOR THE DERIVATIZATION OF SULFUR MUSTARDS HYDROLYSIS PRODUCTS FOR ANALYSIS BY GAS CHROMATOGRAPHY/MASS-SPECTROMETRY
The silylation procedure of the sulfur mustards hydrolysis products by tert-butyldimethylsilyl-N-trifluoroacetamide in the presence of N-methylimidazole was developed. The derivatization procedure provides tert-butyldimethylsilyl ethers formation at the room temperature in 10 minutes. The detection limits of silyl derivatives varies from 0,025 to 0,1 mkg/mL. The derivatization procedure makes it possible to analyze the sulfur mustards hydrolysis products using gas chromatography/mass spectrometry.