SELECTIVE INHIBITORS OF SEROTONIN REVERSE CAPTURE IN THE CORRECTION OF PSYCHO-VEGETATIVE DISORDERS IN WOMEN WITH CLIMACTERIC SYNDROME
Aim - to evaluate the efficacy of selective inhibitors of serotonin reverse capture in the correction of psycho- vegetative disorders in women with climacteric syndrome.Materials and methods. 69 women aged 45-55 years with climacteric syndrome of various severity degree were examined; among them 36 patients took paroxetine (rexetin) in the dose of 20 mg per day because substitutive hormone therapy was contraindicative; and 33 women were administered substitutive hormone therapy by transdermal estradiol (divigel) in the dose of 1 mg daily. The treatment was conducted within 12 weeks. Complex examination was performed. Psycho-somatic, somatic, vasomotor and sexual manifestations of climacteric symptoms in women were evaluated by Green Climacteric Scale (GCS). These parameters were estimated before the treatment and one and three months after it.Results. High efficacy in the treatment for hot flush in climacteric syndrome was obtained in the administration both paroxetine and that of substitutive hormone therapy but complete hot flush disappearance took place sta- tistically frequently for certain in hormone therapy. Partial effect namely the decrease of hot flush frequency and intensity also general perceived well-being improvement took place in patients who were administered paroxetine. There was no effect of paroxetine therapy in 4 patients. It was demonstrated that psycho-emotional tension, anxiety and depression manifestation, somatic, vegetative and sexual disorders were decreased in 1 and 3 months of paroxetine intake. But analogous estradiol effects were proved to be statistically higher than those ones of paroxetine.Conclusions. Selective inhibitors of serotonin reverse capture reduced the manifestation of psycho-vegetative disorders and may be administered in the presence of contradictions to substitutive hormone therapy in women with climacteric syndrome.