Familial case of hereditary hemochromatosis, associated with hepatitis C virus
Presented family case of hereditary hemochromatosis. A man 33 years old, suffering from cirrhosis of the liver associated with hepatitis C virus, identified hereditary hemochromatosis, confirmed by molecular genetic detection result in the HFE gene H63D mutations in the homozygous state. During genetic testing of his sister, her son and the son of the patient, in the HFE gene H63D mutations are also found: sister - in the homozygous (genotype G / G), children - heterozygous (genotype C / G). Against the background of the NG and HCV association, was noted the absence of virologic response to combined antiviral therapy and progression of cirrhosis. Supplement to the bloodletting treatment reversed the patient’s condition.