SYNTHESIS OF β-AGONIST HIGENAMINE
The article discusses a four-stage method for obtaining a β-agonist of higenamine using available reagents. As a result of condensation of 2-(3,4-dimethoxyphenyl)ethylamine and 4-methoxyphenylacetic acid, N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(4-methoxyphenyl)acetamide was obtained, which was further cyclized with subsequent recovery of the resulting dihydroisoquinoline derivative. In the final step, the methoxy groups were removed by the action of bromine tribromide