Toxicological effects on metilfosfonata rates of metabolism of female mice
Were studied biochemical parameters of blood and liver of females of laboratory mice in 72 hours after hypodermic introduction methylphosphonic acid (MPA) in the range of doses from 2 to 10-18 mg/kg with step to three order. It is shown that MPA authentic impact on antioxidation and detoxication systems of an organism of females mice makes, resulting primarily in changes in energy metabolism and oxidative modification of proteins; while adaptive possibilities of females of small rodents allow to resist to single introduction MPA in low doses.