Rational approach to the use of fixed and non-fixed drug combinations in patients with arterial hypertension
Objective: to compare the pharmacological and clinical efficacy, the feasibility of using various therapies, including fixed and non-fixed combinations of diuretics, ACE inhibitors and ARA II, in relation to hypertension combined with MS. Methods: 136 women with first or second degree arterial hypertension were selected for implementation. A set of examinations was carried out at all stages of the study, including a biochemical blood test and an ECG. Results: During the analysis of the effect of therapy, it turned out that the use of a combination of eprosartan and indapamide was comparatively better than the combination of eprosartan and hydrochlorothiazide, perindopril and indapamide in reducing the blood pressure level in women with arterial hypertension of I and II degrees and metabolic syndrome in both age groups. When using a non-fixed combination of drugs, the percentage of patients who reached cut-off BP values was quite high. Conclusions: the clinical effects of some drugs are more pronounced in reducing SBP, while the effects of others - in reducing DBP. However, at the same time, it cannot be denied that the non-fixed therapy is superior to the fixed one in a specific group of subjects - women 40-49 years old.