EFFECTIVENESS OF INTEGRATED OZONE THERAPY FOR INFLAMMATORY DISEASES OF UTERINE APPENDAGES
The analysis of the results of treatment of 67 patients with acute nonspecific inflammatory diseases of the uterine appendages was carried out. Depending on the complex treatment of this pathology with the use of local and general ozone therapy, 2 groups of patients were formed. All patients considered in this study signed an informed consent and mutual agreement on the confidentiality of personal data and research program. 36 patients of Group I were given standard treatment of acute nonspecific inflammatory diseases of the uterine appendages. Group II (n=31) was given ozone therapy on top of the standard treatment. Ozone therapy included both local and general effects. When conducting local ozone therapy daily, 2 times a day, the genital tract was sanitized by irrigation with ozonated 0.9% sodium chloride solution. To correct local hypoxia and neutralize endotoxicosis, intravenous infusions of 200.0 ml of 0.9% NaCl solution were carried out daily 2 times a day. The analysis criteria were the dynamics of oximetry indicators, nitrogen balance (residual nitrogen (OA), creatinine, urea, uric acid, nitrogen-containing compounds (ACC) and the CASS / OA ratio, reflecting the state of endogenous intoxication upon admission and its change after 3 days against the background of treatment. Comparative analysis of oximetry indices showed that 3 days after the start of treatment, oxygen saturation in patients of Group II increased significantly faster (P <0.05) than in Group I, where ozone therapy was not carried out in the treatment of nonspecific inflammatory diseases of the uterine appendages. In Group II, the indicators of nitrogen balance and the coefficient of endogenous intoxication of CASS / OA normalized, which indicated the high efficiency of ozone therapy in the treatment. At the same time, the positive dynamics in Group II significantly exceeded the indicators in Group I (P <0.05), which testified to the pathogenetic feasibility of including ozone therapy in the complex of measures in the treatment of acute nonspecific inflammatory diseases of the uterine appendages.