RADIATION-INDUCED LUNG INJURY. A REVIEW
Radiation-induced lung injury (RILI) is one of the common complications of radiation therapy. Aim. The present review summarizes knowledge about the latest data on epidemiology, pathogenesis, diagnosis, and treatment of patients with radiation-induced lung damage. Materials and methods. Data were collected from PubMed, Elibrary databases and by general search queries. Results and its discussion. Radiation-induced lung injury is a common, severe and in some cases fatal complication of radiation therapy, leading to a decrease in the quality of life of cancer patients. The increasing cancer burden correlate with increased incidence of RILI. Epidemiological data shows that RILI is frequently misdiagnosed. There are no approved guidelines for the treatment and management of RILI. A well- known radioprotection and novel molecules have not been tested in prospective randomized controlled clinical trials. Conclusion. Despite, radiation-induced lung damage has been well studied in experimental models and in clinical observations, there are some diagnostic and management uncertainties require further research.