Treatment variants of the course periarthritis of the shoulder joint by microdoses of antybodies tumor necrosis factor-α.
To compare efficacy of shoulder joint periarthritis (SJP) treatment with artrofoon vs non-steroid anti-inflamatory drugs (NSAID) was the purpose of the research. SJP patients of the study group (12 males, 18 females, mean age 59,4 ± 8.9 years, the disease duration 6,5 ± 3,8 years) received artrofoon (I tablet 8 times a day for 3 months, in improvement of the condition the dose was reduced to 4 tablets a day). Parents of the control group (11 males, 19 females, mean age 58,3 ±9.6 years, the disease duration 5,1±4,1 years) were given NSAID (primarily diclofenac in a dose 100 mg/day with subsequent dose reduction in improvement). All the patients were examined, on the day of the treatment start, 2 weeks, 1 and 3 months later. The examination protocol included general examination, measurement of blood pressure, body mass, height, pain at rest and exercise, motility of the shoulder joint, subjective and objective efficacy and tolerance of the drugs. Total blood count, biochemical blood analysis, urine test, ECG, x-ray, ultrasound investigation of the joint were performed before and after therapy. The majority of the patients from both groups experienced nocturnal pain relief, artrofoon relived and also pain at the joint movement. Significant objective and subjective responses were registered in I5 and 14, partial response - in 10 and 12 patients of the study group, respectively, no response - in 5 and 4 patients, respectively. In the controls, the higher degree of the response was in 9 and I2, 18 and 16, 3 and 2 patients, respectively. Negative effects of the treatments were not seen. Conclusion. SJP treatment with artrofoon is effective. It relieves pain, improves motility of the joint, normalizes mental and somatic status of the patients.