PHOSHOLIPIDS OF ERYTHROCYTE MEMBRANE BILAYER DURING CHEMICAL INHALATION COMBINED WITH IONIZING RADIATION
The purpose was toxicological evaluation of isolated and combined effects of chemicals and radiation on the animal organism by changes in the phospholipid composition of erythrocyte membranes. The experiments performed with senior male mice F1(CBA∙C57BL/6) included inhalation of a low-dose mixture of chemicals, fractional γ-irradiation, and combined exposure. As it was shown, isolated prolonged inhalation of low-dose chemicals gives invokes compensatory adaptation aimed to eliminate energy deficit by release of non-esterified fatty acids from the adipose depot and recovery of the lipid bilayer in erythrocyte membranes (EM). Isolated fractional γ-irradiation at the total dose of 350 cGy enhances EM lipolysis. The combination of 2 factors results in summation of the effects and is characterized by prevalence of the EM lipodestruction till day 90 of recovery.