Investigation of Physicochemical Properties of Both Glutathione Peroxidase I and its Complexes with Polyelectrolytes as Promising Agents for the Treatment of Central Nervous System Diseases
A study of kinetics of thermal inactivation of glutathione peroxidase I was carried out. Glutathione peroxidase is an enzyme that plays a key role in the antioxidant protection system of the body. It was shown that oligomeric glutathione peroxidase I is inactivated by monomolecular mechanism (37ºC, pH 7.0, the enzyme concentrations of 0.3 and 1 mg/ml). An effective way to stabilize the enzyme by polyelectrolytes of different nature was proposed.