THE ASSOCIATION OF ITGB3 AND ITGA2 GENE POLYMORPHISMS WITH CLINICAL EVENTS AND OUTCOMES IN ACUTE CORONARY SINDROM WITH ST-SEGMENT ELEVATION
The objective is to determine the frequency of polymorphisms of the genes ITGBIII, ITGA2 in male and female with acute coronary syndrome with ST segment elevation, to determine the association of genotypes with risk factors, anamnestic data, clinical events and outcomes in these patients. Materials and methods. The study included patients with STEMI: 75 males and 75 females. All patients underwent a molecular genetic study to determine the SNP in the genes ITGB3, ITGA2. After 1.5 years, combined endpoints (CE) were evaluated. Primary CE included cases of mortality cardiovascular events. The secondary combined endpoint covered patients with revascularization, resumption symptoms of angina pectoris. The Mann-Whitney test, the chi-square test and the Fisher test were used. Results. The frequencies of the genotypes of the ITGBIII and ITGA2 genes in males and females with STEMI in the Transbaikalian Region were determined. There were no differences in the genotype frequencies between the groups of men and women. In men, an association of the CC genotype and the C allele of the ITG-BIII gene was detected with previous PCI. In the group of women, an association of allele C in the ITGBIII gene with a heart attack-dependent artery PNA was detected. An association of CT genotype in the ITGA2 gene in men with a heart attack-dependent anterior descending artery was found. Women with TT genotypes of the ITGA2 gene differed from women with SS genotypes (p = 0.001) in fibrinogen concentration. In the group of men, an association of the TT genotype and the T allele of the ITGA2 gene and the secondary endpoint was revealed. In the group of women, an association of the T allele and the secondary endpoint was revealed Conclusion. Thus, despite the fact that there were no statistical differences between the groups of men and women, there is a different influence of the genotypes of the studied genes in these groups.