MODERN APPROACHES FOR DIAGNOSIS OF WILSON’S DISEASE
Wilson's disease - is a hereditary disease, that damages liver and CNS. This disease is mainly manifests through autosomal recessive type of inheritance, in which isolation of populations and close relative marriages have the most influence on manifestation of the disease. Special features of the disorder are phenotypic manifestations of having the same gene and a large number of gene mutations, which complicate the genetic verification of the disease. The diagnostic problem is in the absence of dominating clinical or laboratory feature. In this study, clinical features of the debut of the disease and stages of pathological process are surveyed, the analysis of clinical conditions and changes in common clinical data is conducted, of which conditions indicate the need to exclude the possibility of Wilson's disease. In this article several methods of laboratory diagnosis are presented, and rated according to their importance in different clinical forms of the disease in patients and their siblings.