HUMAN ENDOGENOUS ANTIMICROBIALPEPTIDES (LITERATURE REVIEW)
In the article, the author delivers statistical data about main families of endogenous antimicrobial peptides (AMPs)that are produced by a human body.It is noted that these compounds are important nonspecific factors of humoral immunity characterized by microbicide, chemotactic, immune modulating, and cytotoxic activity, as well as being contributors to general protection of a human body and progression of inflammatory processes. Mechanism of action of AMPs is described that is universal even for microorganisms that during their evolution acquired resistance to various antibiotics. Meanwhile it is noted that many natural peptides can destroy human red blood cells besidesforeign microorganisms. Despite the insufficient knowledge about these and other aspects of AMPs implementation, the spread of the present-day scientific problems touched upon makes this issue topical and worth being further developed.