THE EVALUATION OF TOXIC-PHARMACOLOGICAL PROPERTIES OF NOVEL ANTIMYCOTIC DRUG, CONTAINING BACTERIAL STRAIN BACILLUS SUBTILIS ИБ-54
The safety of antimycotic strain of Bacillus subtilis IB-54 was studied in estimation tests of acute toxicity, reaction of delayed hyperresponsiveness and sensitizing action of liquid bacterial culture. The biologic activity of the preparation on base of the strain is evaluated in model of animal dermatomycosis. The carried out studies evidenced safety of B. subtilis IB-54 and occurrence of antimycotic activity in this strain in vivo and effectiveness of the preparation on its base at prevention and therapy of dermatomycoses.