Substituted 2-(2-Aryl-1-ethenyl)quinazolines: Synthesis and Structure
By the interaction of 2-methyl-4 H -3,1-benzoxazin-4-one and its 6-iodo-derivative with a number of amines in the polyphosphoric acid (PPA) medium 3- and 6-substituted-(unsubstituted)-2-methyl-4(3 H )-quinazolin-4-ones were synthesized. The latter are brought into interaction with a number of aromatic and heterocyclic aldehydes under conditions of co-heating in the absence of solvents with the preparation of 2-[( E )-2-aryl-1-ethenyl]quinazoline-4(3 H )-ones. The structure of the synthesized compounds was confirmed by the method of twodimensional 1H NOESY NMR spectroscopy and X-ray crystallograpy (XRC).