Method of integrative preclinical diagnosis of exacerbation of erosive gastroduodenitis and duodenal ulcer disease in children
Chronic gastroduodenal disease localization is a very common, accompanied by frequent relapses and insufficient effectiveness of the therapy. Relevance of the problems largely depends on the complexity of a combination of factors, contributing to the formation of the disease. The causes leading to the development of chronic erosive gastroduodenitis (HEG) and duodenal ulcer (DU) in children, remain insufficiently studied, and the data published in the literature about the role of individual predictors contradictory. The conducted research made it possible to justify its own concept of pathogenesis of peptic ulcer of stomach and duodenum in children, based on the comprehensive action defining, predisposing and aggravating factors. The developed model of the formation of erosive and ulcerative lesions of upper gastrointestinal divisions served as a justification in the development and implementation of non-invasive clinical and instrumental method of pre-clinical diagnostics ROFES-diagnostics).