ACUTE TOXICITY TEST OF ANTIVIRAL DRUG - TRIAZAVIRIN
The purpose of the study was investigation of acute toxicity of Triazavirin in test mice. The test was carried out on laboratory white outbred mice. During the first test with a single subcutaneous administration of the drug at a dose of 0.002 g dissolved into 0.2 ml of physiological solution in the back of 10 test mice there was no toxic effect found. According to the biochemical data from the second test it may be concluded that the drug at a dose of 0.002 g after administration to 20 g weighted mice during 14 days has a toxic effect on kidneys and liver; the drug administration causes active suppression of the thyroid function and typical reduction in T4 hormone synthesis. The drug administration in the third test at a dose of 0.01 g to test mice of 20 g in weight during 14 weeks caused leukocytosis in animals. Analyzing biochemical results, it may be concluded that the drug results in a significant increase in the creatinin level, causes the rise of the AST level up to ULN, and has a slight toxic effect on kidneys and liver. No lethality was recorded in all test groups. No acute toxicity parameters LD50were identified. So, following the results of the study it may be concluded that by the toxicity level this new antiviral drug belongs to the class of low-toxic compounds.