ASSESSMENT OF EFFICIENCY OF COMBINED APPLICATION OF HETEROCYCLIC COMPOUNDS WITH CHEMICAL DRUGS IN VIVO
The aim of the study was to assess the effectiveness of combined use of heterocyclic compounds with chemotherapy drugs for the lifespan of Af-line tumor carrier mice. The study showed that effectiveness of antineoplastic action of chemotherapy drugs is preserved even with a decrease in their dosage by several times provided that they are combined with heterocyclic compounds in the dosages that are indifferent to tumor cells. In particular, with the use of methotrexate in a ten-fold reduced dosage, together with the tested heterocyclic compounds (PS2150), an anti-tumor effect, comparable to that observed with the use of chemotherapy drugs in the dosages recommended by the international community, is achieved.