Experience of Usage Fixed-Combination of Antiglaucoma Drugs for Treatment of Primary Angle-Closure Glaucoma in Dogs
Purpose. To evaluate the effectiveness of the proposed scheme of fixed combinations of local antihypertensive drugs in the treatment of patients with PACG, based on IOP in dynamics Materials and methods. The animals - 16 dogs (26 eyes) aged 3 to 13 years with a diagnosis of PACG - were divided into three groups according to the stage of glaucoma and depending on the stage of the glaucomatous process: early stage - 1...5 days (7 dogs - 10 eyes), advanced stage - 6...30 days (5 dogs - 8 eyes), terminal stage - 30 or more days (4 dogs - 8 eyes). Drug therapy of PACG in dogs included the use of local antihypertensive eye drops in fixed combinations: 0.004 % solution of travoprost + 0.5 % solution of timolol maleate, 0.2 % solution of brimonidine, 1 % solution of brinzolamide + 0,5 % solution of timolol maleate. Drug therapy PACG in dogs included two stages. The observation period lasted 6 months. Results. In early and advanced stage of PACG, a decrease in IOP was observed in the dogs on average by 51 % and 45 %, respectively, at the terminal stage, the decrease in IOP averaged 28 % of the baseline for the entire follow-up period. Achieving the target level of IOP in animals with tearly stage of glaucomatous process was 80 %, in animals with advanced stage - 75 %, in animals with terminal stage - 37.5 %). The main side effects of combined antiglaucoma therapy were conjunctival hyperemia (69 %) and corneal erosion (31 %). Conclusion. The proposed two-stage scheme with the use of local antihypertensive drugs for the conservative treatment of PACG in dogs allows for a long time to monitor a stable tolerable level of IOP (6 months). Fixed combinations of drugs have many advantages, the most important of which is the ability for the owner of an animal to comply with the instillation regime, which effectively reduces IOP and maintains it at an acceptable level.