COMPREHENSIVE PHARMACORRECTION IMMUNE DEPRESSIVE STATE IN CALVES POST PERNATAL PERIOD
The article addresses the level of changes in metabolic processes and the immunological status of calves in the postnatal period with signs of an immuno-depressive state and after pharmacocorrection. The most effective scheme of pharmacocorrection of the immunosuppressive state in calves using enterobifidin, roncoleukin, eleovit, nucleopeptide, biomix is proposed. The normalization of protein-carbohydrate (total protein - 66.3 ± 4.2 g / l; glucose - 3.8 ± 1.23 mmol / l) and mineral (iron - 20.1 ± 0.9 μmol / l) is proven ; copper - 18.3 ± 1.1 μmol / l; zinc - 17.9 ± 1.3 μmol / l) metabolism in calves, as well as immunological indicators (IgG - 19.7 ± 1.2 mg / ml ;; IgA - 1.8 ± 0.2 mg / ml) and clinical status. Moreover, the dynamics of clinical changes in the calves of the experimental group was characterized by a gradual weakening of the signs of an immunosuppressive state, starting from the 15th day of therapy, and optimization occurred on the 30th day from the start of the pharmacocorrection course.