THE INHIBITORY ACTIVITY OF MONO AND COMPLEx ANTIMICROBIAL DRUGSIN R ELATION TO MICROORGANISMS ISOLATEDFROM COWS WITH ENDOMETR ITIS
The article presents the results of the study of the inhibitory activity of 8 antibacterial drugs in relation to microorganisms of the genera Escherichia, Salmonella, Staphylococcus and yeast-like Candida, isolated from the utero-vaginal contents of 20 cows with clinically expressed purulent-catarrhal endometritis. The studies found that tylozin used for a long time in the farm did not show inhibitory activity in any case. Combined preparation«Endometrioma-T», containing tylozin in its composition, had a bacteriostatic effect only in relation to monocultures of E. coli and staphylococci isolated from two samples of utero-vaginal content. A relatively low inhibitory activity was noted in trimethoprim, which had a bacteriostatic effect on Salmonella and Escherichia monocul- tures isolated from three and two sick animals, respectively. Gentamicin and amoxicillin showed inhibitory activity in relation to microorganisms isolated from nine of twenty cows with endometritis. Drugs «Florfenicol»,«Endometramag-K» and «Enrofloxacin» showed antibacterial activity in relation to microorganisms isolated from the 14, 15 and 19 animals. Based on the results of the research «Florfenicol», «Endometramag-K « and «Enro-floxacin» are recommended. The complex drug «Endometramag-K» is considered to be preferable, possessing antimicrobial and myotropic action due to the presence of gentamicin, colistin and propranolol.