The effect of cabergoline on folliculogenesis in females during the nonoestral period
The results of an experiment carried out on a group of females with the aim of estrus induction in the anoestral period are presented in the article. For the study, a drug belonging to the dopaminomimetic group - cabergoline was used. The experiment was carried out on healthy females in anestrus. Cabergoline was administered to experimental animals daily, once, at a dose of 0.015 mg / kg body weight of the animal, the course duration was 10 days. The effect of the drug was assessed by the combination of clinical signs, the cytological picture of vaginal smears-prints and the level of progesterone in the blood of animals treated and not treated with cabergoline. In the course of the experiment, it was established that cabergoline induces the appearance of signs of proestrus in females on day 10 from the start of the drug, and the signs of estrus are manifested approximately by day 16. During this period, typical bleeding from the genitals becomes evident for estrus, some softening of the vestibule occurs, the females show a positive reaction to the touch of the croup and external genital area, the supernumerary keratinized cells predominate in the strokes-prints, the level of progesterone increases. The concentration of progesterone in the peripheral blood reaches the optimum values for insemination on day 18. Based on the obtained results, it can be concluded that dopaminomimetic-cabergoline is capable of inducing full-fledged proestrus and estrus in females during the anesthetic period after a course of use at a dose of 0.015 mg / kg of body weight of the animal. Induced by cabergoline, estus did not differ from the spontaneous manifestation of clinical signs and their duration.