Effect of polymorphism of APOE and SLCO1B1 genes on the course of myocardial infarction associated with acute kidney injury in hospital and long-term periods
THE AIM: to assess the effect of APOE and SLC01B1 gene polymorphism on the course of myocardial infarction (MI) associated with acute kidney injury (AKI) in hospital and long-term periods. PATIENTS AND METHODS: 132 patients with МI were examined, which were divided into 2 groups: the first (I) - 68 patients with MI and AKI, the second (II) - 64 people with MI without AKI. RESULTS: In the distribution of genotypes, polymorphism of Leu28Pro of the APOE gene in the studied groups was revealed that LeuPro was more often inherited in patients of group I - 20,6 %, the average value of total cholesterol (TC) -6,01±0,3 mmol/l, and low density lipoproteins (LDL) - 3,37±0,21 mmol/l, compared with patients of group II, where the LeuPro genotype - 6, 2 %, TC - 5,03±0,3 mmol/l, LDL - 2,38±0,3 mmol/l, p<0,05. A similar situation was typical for the polymor- phism Val174Ala SLCO1B1 gene, where ValAla in patients of group I-26,5 %, in II-12,5 %, p<0.05. In heterozygotes I sample TC-5,59±0,3 mmol/l, and LDL - 3,30±0,14 mmol/l, in group II TC - 5,19±0,29 mmol/l, LDL - 2,75±0,23 mmol / l, p<0,05. The clinical picture of the hospital period in patients with MI and AKI, proceeded with the development of a greater number of complications, which reflected in the high mortality in group I - 16,2 %, in group II - 4,7 %, p<0,05. In the posthospital period, against the background of atorvastatin administration in both study groups, there was a positive trend of decrease in TC and LDL, but it was not possible to achieve the targets. Mortality in the long-term period in group I - 15,4 %, in group II-2,0 %, p<0.05. CONCLUSIONS: in patients with MI and AKI on the background of a more severe clinical course of the disease, both in hospital and in the long-term period, rare allelic variants of the genes APOE and SLCO1B1 were more often determined, which negatively affected the lipid profile.