Functional and structural digestive disorders in children: in searches for boundaries and criteria
Functional digestive disorders should be considered as a change in the function of an organ due to its neurohumoral dysregulation. Nervous regulatory disorders that are closely related to the mental sphere have sufficiently long been known, but there has recently been new evidence for the importance of humoral factors. For example, a premium is placed upon the impaired secretion of the regulatory peptide ghrelin in functional dyspepsia. This concept is not contradicted by the discovery of low active mucosal inflammation in irritable bowel syndrome as in this case, there is peculiar humoral regulation of the sensitivity of visceral receptors in the intestinal microflora. Of importance is also the evolution of functional disorders that can be considered to be arbitrarily favorable only for a certain time, rather than in the long term.