Alcohol consumption leads to activation of the neuroimmune system by the protein HMGB1
The review highlights recent research data that was aimed at studying the role of the protein of the highly mobile box-1 group (HMGB1) in neuroimmune signaling in brain structures during chronic alcohol abuse. The role of HMGB1 in activating the process of brain inflammation, which can lead to neurodegeneration, was shown. Studies reveal that glycyrrhizin, an inhibitor of HMGB1 protein translocation from damaged and activated cells, can be a potential target for the pharmacocorrection of neuroimmune signaling.