FEATURES OF APOPTOSIS IN CHILDREN UNDER CHRONIC AIRBORNE PHENOL EXPOSURE
Phenol impact on apoptosis markers in children living in conditions of exogenous aerogenic chronic phenol exposure has been evaluated. To identify the ranges of the immune system responses exposed children were divided into groups according to the analyte content in blood samples (from 0,010 to 1,864 mg/dm3). It was found that the range of phenol concentration in blood of exposed children determines the dynamics of changes in apoptosis indicators. Maximum statistically significant (p < 0,05) decrease in the number of TNFR – receptor on T-lymphocytes and statistically significant (p < 0,05) decrease in p53 protein expression was found in the range of phenol concentration in biological media from 0,081 to 1,864 mg/dm3. Thus, inhibition of cell death by apoptosis type has been marked in children living in conditions of chronic exogenous phenol impact.