Glanders in the XXI centure: dissemination, scientific achievements
On the basis of genetic investigations of the last 10 years the taxonomic position of Burkholderia mallei as an deletion mutant of B. pseudomallei has been determined. In natural conditions outbreaks of glanders occurs among solid-hoofed animals in some regions of Asia, Africa and South America. Now effective genetic and engineering methods of iden tification and typing of B. mallei (PCR, VNTR) have been developed. The most effective for glanders chemotherapeutic drugs are combined sulfonilamides, tetracyclines, carbapenems, fluorchinolones. Their therapeutic effect increases in combinations and using in liposomal forms or clathrates.