AMINOSELETON-BASED CORRECTION OF IMMUNE STATUS IN WHITE RATS VACCINATED FROM SALMONELLOSIS AND CHRONICALLY EXPOSED TO T-2 TOXIN
The carried out research revealed negative impact of chronic T-2 toxin intoxication on immune status of white rats vaccinated against Salmonellosis. This is illustrated by erythropoiesis inhibition and amenia development. The immunized animals and animals chronically exposed to T-2 toxin typically demonstrate a decrease in the number of erythrocytes by 13% and in the level of hemoglobin by 9.6% due to reduced hemolotic action of xenobiotics and hematopoiesis depression. The use of aminoseleton in the vaccination scheme enhances adaptive immunity and natural resistance of the organism under these conditions. On day 30 post vaccination the vaccinated rats demonstrated an increase (in comparison to the control animals) in the number of erythrocytes - by 14.1%; hemoglobin - by 11.7%, number of leukocytes - by 6.5%, absolute number of segmentonuclear neutrophils - by 23%, immature neutrophils - by 11.1%. It is related to active formation of neutrophils in the marrow and their further migration to the blood circulation system for phagocytosis. The detected morphological changes in blood of the vaccinated and exposed animals suggest hematological disorder associated with T-2 toxicosis demonstrated as erythropoiesis inhibition and leucopenia. Decrease in specific humoral immunity and natural resistance caused by chronic T-2 toxicosis following experimental infection with Salmonella cholerae suis had a negative effect on the animal lifetime and safety.