THE METHOD OF TREATING ANTERIOR UVEITIS IN ANIMALS BASED ON INTRACAMERAL ADMINISTRATION OF A PREPARATION COMBINING FIBRINOLYTIC AND MYDRIATIC PROPERTIES
One of the most common eye diseases observed in horses is the anterior uveitis. This pathology causes serious economic damage due to its high incidence and widespread prevalence both in the Russian Federation and abroad. The objective of this study was to develop an efficient preparation and a method for treating anterior uveitis in horses. Experimental, clinical and laboratory studies were conducted at the Department of Therapy and Pharmacology of Voronezh State Agrarian University, and testing was performed on animals belonging to Voronezh Hippodrome in Babyakovo village. For the treatment of anterior uveitis the authors have developed a preparation combining fibrinolytic and mydriatic properties (Actilyse + Mesaton), which was injected into the anterior chamber of the eye with an insulin needle in a dose of 50 μg after epibulbar anesthesia with local ophthalmic anesthetics. In the first series of experiments the authors used laboratory mice to study the effect of combined use of Actilyse and Mesaton on the heart, liver, kidneys and spleen (histological studies). The second series studied the local irritant effect of solutions of the preparation at different concentrations (on rabbits and rats). In the third series the authors evaluated the therapeutic effect of the preparation on rabbits with acute and chronic anterior uveitis. In the fourth series of experiments the efficiency of the proposed method of treating uveitis in horses was evaluated in clinical cases. The following findings were observed: intragastric administration causes no destructive changes in the structure of organs; the native preparation and its aqueous solutions exert no irritant effect on the cornea and conjunctiva; the intracameral method of administration ensures the delivery of the preparation directly to the lesion focus, which gave a quick therapeutic result. In addition to a good fibrinolytic effect the combined use of Actilyse (alteplase) and Mesaton (phenylephrine) has additional mydriatic properties, which allows preventing the development of adhesions in the anterior chamber of the eye.