VIOLATION OF THE HOMOLOGOUS CHROMOSOMES APPROCHEMENT AS THE ANSWER TO THE SMALL DOSES OF ROENTGEN IRRADIATION
Any violation of the homologous chromosome DNA repair leads to the genome instability, characteristic for hereditary syndromes and for aging cells. Using low doses of ionizing radiation (3—10 cGy) we have found any transference of the homologous centromere loci of the chromosome 1 (1q12) from the periphery to the centre of the nucleus in the lymphocytes of young healthy donors. The same effect was found after any influence of RNA-polymerase inhibitor α-amanitine. Some changes in the chromatin structure during aging (70—80 years old patients) result in the difficulties in chromosome displacement, accompanied with any trouble in the approachement of the homologous chromosome loci as an answer to low doses of radiation.