Use of "anti-quorum" systems in animal husbandry (review)
Antibiotics are considered the most effective drug for the treatment of bacterial infectious diseases. As the number of antibiotics has increased in recent decades in clinical and livestock production in humans, numerous multiple drug-resistant bacterial strains have been isolated. Now scientists try to find alternative approaches to the prevention and treatment of bacterial infections. The quorum sensitivity (QS) is a sample of bacterial communication used to determine the density and control of collective behavior. This process depends on the production, release and group detection of signaling molecules called au-toinducers (AIs), which are usually N-acyl homoserine lactones (AHLs) produced in gram-negative bacteria. QS plays an important role in the production of virulence factors and pathogenicity in PAO1. Many studies show that a violation of the QS system can reduce the secretion of virulence factors and the formation of biofilms, and this will be a reliable way to inhibit a bacterial infectious disease, that is, to create a stable «anti-quorum» system. Actions of phytobiotics on quorum increase interest to plant extracts as means of preventing and treating infectious inflammatory diseases that effectively inhibit Quorum Sensing (QS) system of bacterial pathogens. Evaluation of main ways and methods of QS inhibition indicates medicinal plants as a promising option for obtaining effective and safe compounds with similar activity, and the therapeutic effect of plants is due to the content in them of a large number of biologically active substances, various and diverse in their chemical composition and pharmaceutical action.