The autoimmune/inflammatory syndrome induced byadjuvants and sarcoidosis
The autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is an entity that includes various autoimmune conditions observed after an exposure to an adjuvant. The possible reason for the development of sarcoidosis (SC) is the influence of various exogenous and endogenous trigger factors. The aim of this study was to evaluate the relationship between ASIA and SC. Materials and methods. A prospective comparative study was conducted. The first group consisted of patients with histologically verified lung SC (n=58), while the control group consisted of healthy donors (n=22). All the patients underwent a standard examination and were interviewed according to the standardized ”ASIA Research Questionnaire”. Statistical analysis was carried out with Statistica 10.0, p<0.05 was considered statistically significant. Results. Patients with ASIA-triggers, n=52 (89.6%) significantly more often demonstrated autoimmune symptoms in comparison with patients without ASIA triggers, n=6 (10.3%). 79.3% of the patients with SC met two major ASIA diagnostic criteria, which were significantly more frequent (p=0.000) than in the control group (22.7%) and had an average, statistically significant correlation between the number of ASIA-triggers and the number of symptoms typical for ASIA syndrome (rs=0.46). Conclusion. In patients with SC ASIA- triggers and clinical signs of autoimmune pathology were observed, that met ASIA diagnostic criteria.