PERSPECTIVES OF MICRORNA AND SMALL INTERFERING RNA USAGE FOR HIV INFECTION THERAPY
Due to use of antiretroviral therapy (ART) the life span and quality of HIV-infected patients increased dramatically. However ART is accompanied by development of resistant HIV variants, life-time drug therapy and inability to eradicate virus from latent reservoirs. Thus the development of molecular biological approaches to affect the proviral DNA integrated to host genome is extremely actual. Gene therapy represents one of these approaches. Main directions of this approach are regulation of synthesis of viral proteins and cellular factors necessary for HIV entry to target cell and further replication, prevention of proviral DNA integration to host genome, removal of integrated HIV DNA from target cell genome or mutagenic deactivation of viral genes. This review is devoted to analysis of perspective strategies of HIV infection gene therapy.