VACCINE FROM ATTENBOROUGH SALMONELLA STRAINS AND ITS EFFECT ON THE ORGANS OF IMMUNITY IN FOXES AFTER ORAL VACCINATION AGAINST SALMONELLA
Work was performed in veterinarian laboratory of all-Russian scientific - research Institute of hunting economy and fur farming named after professor B. M. Zhitkov, and in animal breeding farm, JCS "Vyatka", Kirov region. We used young foxes (Aloplex lagopus) at the age of 5 months; there were formed control and experimental groups of 20 animals each: the experimental group of foxes was immunized with oral vaccine from Attenborough Salmonella strains at a dose of 50 billion microbial cells per head. Immunizing dose of the vaccine was fed to animals together with feed twice with an interval of 14 days; foxes of the control group were not vaccinated. The article presents the data obtained under the morphological study of immune system organs in foxes after oral vaccination against salmonellosis of attenuating strains. We conducted hematological, biochemical, immunological studies of blood serum in the mandibular lymph nodes and spleen, that allows us to evaluate objectively the structural changes, the immunogenic quality and harmlessness of the vaccine, to determine the degree of immunoreactivity of the organism. We can state that after oral vaccination method the number of immunoblasts increases which are responsible for the formation of cellular immunity, and later severe plasmocytoma reaction comes, which is responsible for the production of antibodies. On the basis of the researches it is established that oral immunization of foxes with Salmonella attenborough strains vaccine is harmless and gives very weak reaction. The level of immune processes provides the necessary immunogenicity. Taking into account its efficiency, low labor intensity, the lack of stress effects on the body of animals it is feasible and promising as a preventative measure, recommended for introduction into veterinary practice of fur farming.