Functional Interactions of Na,K-ATPase with Molecular Environment
The present review ravers the analysis of research in the field of intermodular ieraions of Na,K-ATPase whid underlie novel cellular regulatory medanisms. The capability of Na,K-ATPase to form mmou regulatory rampes and take part as a scaffolding protein in formation of cell funrtional and signaling microcompartments is ransidered. Particular attention is directed to membrane lipid miCTodomains (rafts, caveolae). Medanisms of signaling and neuroprotective functions of Na,K-ATPase as well as the involvement of endogenous cardiotonic steroids in their realization are disoassed. This review demonstrates novel data on funrtional ieraions of Na,K-ATPase with neurotransmitter receptors and other proteins involved in regulation of synapti; transmission.