Perfluorinated membranes in pd-sensors for determination of components in dosage forms
The influence of perfluorinated sulfonated cation-exchange polymeric membranes type on the value of PD-sensors sensitivity (the response of PD-sensor is Donnan potential at the PSP membrane/test solution interface) in aqueous solutions of nicotinic acid, pyridoxine hydrochloride, novocaine hydrochloride, lidocaine hydrochloride was studied. The cross-sensitive PD-sensor with pH-selective electrode and reference electrode was used for quantitative determination of vitamins and pharmaceuticals in dosage forms. The multivariate calibration methods with nonorthogonal experimental design were used for calibration of PD-sensors in polyionic solutions. The calibration equations take into account the interference of organic electrolyte concentration and рН of solution on the value of cross-sensitive PD-sensor. The relative error of determination of substances in dosage forms was less than 8%.