Diagnosis And Prognosis Of The Course Of Breast Cancer Based On The Profile Of The Expression Of Microrna Of Tumour Exosomes
Objective of the research. To conduct a systematic analysis of the data available in current literature concerning the role of microRNA and exosomes in the formation and development of breast cancer. Materials and Methods. The review includes the data of foreign and national articles from Pubmed database, having been published primarily over the last 5 years. Results. Possible mechanisms of the participation of several dozens of major microRNAs in the formation of malignant processes are described. The article highlights role of exosomes in the exchange of microRNA and other regulatory molecules between cells including malignant degeneration and metastasis. Conclusion. It is necessary to conduct further research focusing on the influence of exosomal microRNA, circulating in the bloodstream, on the process of emergence and development of breast cancer with the objective of forming of diagnostic and prognostic panel needed for effective diagnosis and personalised selection of therapy for breast cancer.