THE EFFECT OF RECOMBINANT INTERFERON ON THE MAIN INDICATORS OF METABOLISM IN COWS WHEN STUDYING HARMLESSNESS
The article presents study materials on the effect of the drug of recombinant interferon on the common clinical and morpho biochemical blood indicators of clinically healthy lactating cows. The experiments were conducted on Black Motley animals of the 2nd-3rd lactation with dairy productivity of 6500-7000 kg of milk for the last lactation. The drug tolerance was studied in 15 cows, divided into three groups. The animals of the first group (n = 5) were not prescribed the drug; they served as a control. Cows of the second group (n = 5) were once intramuscularly injected at a therapeutic dose (10.0 ml/animal), and the third (n = 5) at a 3 fold therapeutic dose (30.0 ml/animal). The toxic effect of the drug was evaluated by the clinical condition of the animals (a clinicalexamination was performed, temperature, pulse and respiration were measured). In 7 and 14 days after the administration of interferon, blood was obtained from the tail vein and hematological (red blood cells, ESR, white blood cells) and biochemical indicators (total protein, protein fractions, urea, glucose, total lipids, total bilirubin, total calcium and inorganic phosphorus, ALP, GGT, ALT, AST activity) were studied. It was found that the preparation of interferon with a single intramuscular injection at a therapeutic dose and at a dose three times higher than the therapeutic one did not adversely affect the main metabolic parameters, the morphological composition of the blood and the general clinical status of animals.