OXIDATIVE STRESS, APOPTOSIS AND THE SAME COMPONENTS OF IMMUNE SYSTEM DURING HYPOXIA
Emissions of road transport are the leading source of air pollution in Voronezh city during 2012-2013. Nitrogen dioxide, carbon monoxide, sulfur dioxide are the main course of atmospheric pollution. This leads to development of oxidative stress, and as a consequence, to appearence of a pathologу such systems as cardiovascular, nervous, immune and respiratory system. The level of superoxide dismutase reduced by 60%. The level of malondialdehyde, oxidative modification of proteins and IL-6 increased by 1.25, 1.44 and 1.54 times, respectively, during hypoxia in patients with chronic obstructive pulmonary disease and hypertonic disease. This indicates an intensification of free radical oxidation and probably apoptosis. To evaluate the apoptotic processes we need conduct further investigation with using fluorescence microscopy, and determination of other markers of apoptosis, such as IL-lß, IL-2, IL-4, IL-8, IL-10, TNF-a, interferon-γ, activity of caspase.