INDUCTION OF CHRONIC NEUROINFLAMMATION IN THE RATS SUBSTANTIA NIGRA CAUSED BY A SINGLE INTRAVENTRICULAR ADMINISTRATION OF BACTERIAL LIPOPOLYSACCHARIDE
We studied the delayed effects of LPS single injection into the ventricles of the rats brain. The results of immunohistochemical studies of rat brain slices showed that there are the increase in activity of microglia and astroglia, overexpression of alpha-synuclein in dopaminergic neurons and infiltration of lymphocytes into the substantia nigra 4 months after injection of LPS. Experimental animals in the test «open field» showed increased motor activity during the entire period of observation. These data indicate long-term preservation of inflammation in nerve tissue stimulation induced by a single bacterial endotoxin.