Etiological, pathogenic and clinical peculiarities of chronic obstructive lung diseases formation in Amur river region children
Differentiation-diagnostics algorithm used to study chronic and recurrent obstructive lung diseases (asthma was not included) in children showed, that 89,9% of the disorders develop when there is congenital lung malformation. Past history analysis revealed that the main contributing factor is intrauterine infections. Morphological and morphometric investigation of ratslungs, subjected to lead nitrate in antenatal period of development, showed ontogeny defects in bronchi-pulmonary system development. Broncho-pulmonary development defects aggravated by secondary inflammatory process result in chronic obstructive pulmonary disease (COPD). Clinically COPD manifests in acute attacks of either bronchi type, or pneumonic type. Both episodes vary in the same child. Pneumotropic agents (mostly S.pneumoniae and H.influenzae) predominate in the structure of etiologic reasons. These data obtained allow us define treatment strategy and regular medical check-in of patients with COPD and to provide prophylactic methods aimed at preventing this pathological condition.