MUTAGENIC SAFETY OF MICROENCAPSULATED PROBIOTIC “ENZYMESPORINE” WITH AN ENZYME THAT IS USED IN THE FEEDING OF PIGS OF GENESUS GENETICS
In the article there are presented the results of researches of mutagenic activity of the microencapsulated probiotic preparation "Enzymesporine" with crystalline trypsin, that was made according to the original technology. The researches were based on on the induction of chromosomal aberrations in vivo and analysis of cells of bone marrow in rats taking into account gender and dosages (single injection of a daily therapeutic dose, daily subtoxic dose, administration during 5 days of a daily therapeutic dose). As negative control there was used 1% starch-based paste, as positive control there was used Cyclophosphane. Analysis of the results did not reveal neither a dose-dependent nor reproduced in different series of the research a statistically significant excess of the proportion of cells with chromosomal aberrations in the series of the research that received studied preparation in comparison with the negative and positive controls. On the basis of results of research there was made a conclusion about the mutagenic safety of the preparation, which gives grounds for its further use as an additive to the feeds used in feeding of pigs of Genesus genetics.