SOME RESULTS OF MOLECULAR GENETIC RESEARCHES OF AGING AND LONGEVITY
This review is devoted to the description of research achievements in genetics of aging and longevity. It represents a certain interest for understanding of a problems of aging as a whole. There is a huge amount of results of diverse genetic studies of aging and longevity. Studies were performed with using different experimental strategies on model organisms or samples from different human populations of the world. The search for aging and longevity genes was carried out within international consortiums. The ﬁrst results of whole genome sequences of super-centenarians were received. The genes inﬂ uencing life expectancy were revealed in organisms of different systematic groups. Many of these genes are evolutionarily conservative. Associations between APOE, FOXO 1 A, FOXO 3 A, AKT 1 gene polymorphisms and human longevity were conﬁrmed in independent studies.