Ozone therapy in a complex of means and methods of treatment of alcohol withdrawal syndrome
The main idea of therapeutic approach is in the synergetic combination of two effective multifunctional methods of intensive therapy: single-needle membrane plasmapheresis and oral administration of ozonated olive oil. The study involved 22 male patients with alcohol abstinence syndrome, the drink abuse time was 5 to 15 years. The main group was of 12 patients (aged 39.5±10.7 years), the control group consisted of 10 patients (aged 37.5±1.4 years). The combined detoxication therapy was carried out in the traditional complex of pharmacologic preparations together with oral administration of ozonated olive oil for internal use with the initial ozone barbotage concentration of 4000-5000 mcg/l in ozone-oxygen mixture, 1 teaspoon 3-4 times a day, 30 minutes before eating, within 7-10 days and during the course treatment by using the method of membrane plasmapheresis (2-3 procedures per course, at 3-day intervals between procedures), with exfused plasma volume of 600 to 1000 ml). The assessment of therapeutic detoxication effect was carried out with regard for dynamics of laboratory findings (bilirubin, ALT, ACT etc.). The obtained results prove the reasonable selection of the combination therapy of alcohol abstinence state with using the method of ozone therapy and plasmapheresis for reduction of somato-neurologic and psychopathologic disorders preconditioned by alcohol dependence syndrome.