The nucleotide sequences variability of genomes of tick-borne encephalitis virus associated with their structure
For detection of correlations in nucleotide substitution occurrence in TBE-virus genome nucleotide sequences, the method of revealing of the connected changes in the symbolical sequences, based on calculation of the relative information was used. By the results of the analysis, statistically significant correlations have been found out in nucleotide substitution occurrence (both synonymous, and not synonymous) on the sites of genome, removed from each other. Comparison of known descriptions of nucleotide sequence of structural elements with the received circuit of correlations has shown, that the found out correlations are revealed for unpaired nucleotides in stalks of RNA hairpins. Such hairpins cooperate with each other in formation of tertiary RNA-structure. The presented method allows to define RNA sites, which are important in formation of tertiary structure of a molecule.