Evaluation of local irritant effect supramolecular complexes of Niklomek received by mechanchemical technology
The local-irritant effect of the drug by skin and conjunctival samples was studied. It has been established that the drug does not cause any changes in the cutaneous applications and instillation of the drug in the conjunctiva of the eye. To study the local irritant effect, the investigational preparation niklomek was introduced in the native form at the rate of 1 ml/kg rabbit weight per cut skin on the right side of the rabbit. The same amount of distilled water was applied to the left side. The irritant effect of the drug on the mucous membranes was studied on 10 rabbits of chinchilla with weight of 3,28...4,16 kg, which were injected into the conjunctival bag of the right eye one drop of the drug solution. The results of researches allow us to conclude that the preparation niklomek with cutaneous applications does not cause any changes in the skin, which indicates that the preparation has no irritant effect on the skin. At the same time, a single instillation of the drug in the conjunctival bag also does not cause a response, indicating that the preparation does not irritate the mucous membranes.