Molecular epidemiological features of M. tuberculosis family S in Sakha (Yakutia)
The genetic features of MBT strains of S genotype are described. Genotype S is the second among genetic families of M. tuberculosis in Sakha (Yakutia). The detection rate of S genotype was 16.7% (36/215) of cases. Family group S is represented by isolates with common Spoligotype (SIT 1253) in 83.3% (30/36), They have been collected in a separate cluster with similar MIRU-VNTR profiles on the phylogenetic tree. The cluster S256 was isolated (MIRU12 profile 233325153325), which, together with Beijing MIT17 subtype, demonstrated the highest rate of MDR in strains of Sakha (Yakutia). There is considered a hypothesis about long-standing introduction and formation of endemic variant of strains of S genotype.