FREQUENCY STUDY OF POLYMORPHIC ALLELIC VARIANTS OF LRRK2 GENE (PARK8) IN PATIENTS WITH PARKINSON`S DISEASE
The frequency of candidate markers (rs7966550, rs1427263, rs11176013 and rs11564148) was studied in patients with Parkinson's disease (PD) and healthy volunteers (Zheleznogorsk, Russia). Detection of SNPs made using primers synthesized by PCR in real time. The total frequency of wild and mutant alleles of polymorphic variants in patients with PD and control groups established, and values were higher in patients than in healthy individuals. A similar situation is observed in the analysis of the frequency of compound heterozygous in patients with Parkinson's disease and in healthy volunteers.