THE STUDY OF CORRELATIONS OF ACUTE TOXICITY OF SUBSTANCES FROM LIPOPHILIC CONSTANTS OF THE SUBSTITUENTS
Results of a research of dependence acute toxicity values of the synthesized substances on lipophilic constants of deputies for the purpose of establishment of a possibility of the directed synthesis of active and low-toxic connections are given. The research included definition of an average lethal dose (LD50) at 7 synthesized substances, search of correlation dependence between acute toxicity values and lipophilic constants of deputies. The acute toxicity of connections was determined by Prozorovsky at intravenous administration. As a result of a research of correlation dependence LD50 on lipophilic constants (p) of deputies at atom of nitrogen the correlation equation was offered. Experimental points well lay down to the line of regression.