ROLE OF APOPTOSIS IN THE DEVELOPMEMT OF SYSTEMIC AUTOIMMUNE DISEASES
One of trigger the development of systemic autoimmune diseases is inefficient fiacitibine dying cells. The reason for this may be the increased number of apoptosis, which is the result of many different influences, violation opsonization dying cells and defect functions of professional cells were observed in patients with systemic autoimmune diseases. Excessive availability of modified antigens displayed on the external surface of dying cells and released from them in the later stages of apoptosis, leads to their accumulation in the extracellular space and feature activation of the complement system that promotes survival self-reactive b-cells, formed as a result of the process of somatic Hyper-mutations. Produced antibodies, communicating with their antigens and forming immune complexes, cause damage to tissues and organs, the destruction of cells and the development of chronic inflammation. In this review, we have tried to summarize the currently known data on the role of apoptosis in the initiation of autoimmune process and to trace the entire sequence of events leading to the development of autoantibodies and clinical signs of systemic autoimmune diseases.