Study of the stability of the drug form of Mexicor® by gas chromatography mass spectrometry
A gas chromatography method with mass spectrometry detector was used for the examination of substances of 2-ethyl-6-methyl-3-hydroxypyridine succinate and colored and colorless dosage forms of the drug of Mexicor® preparation for injection. With the use of the GC-MS technique it was found, that a more intense coloration of the 2-ethyl-6-methyl-3-hydroxypyridine succinate solution acquires is due to the existence of a quinoid structure of one of tautomers of the starting compound. It is proposed to stabilize drug forms for injection bu adding of 5-8 % of ethanol.