DETECTION OF HELICOBACTER PYLORI DNA FTAGMENTS IN PERIPHERAL BLOOD MONONUCLEAR CELLS
The paper includes results of the examination of 77 patients suffering from chronic gastritis and peptic ulcer. Biopsy samples of mucous membrane of gastro-duodenal area were used as material for the study, which were obtained during endoscopic examination of patients, as well as peripheral blood mononuclear cells. Occurrence of Helicobacter pylori in biological material has been determined through polymerase chain reaction. Unknown evidence of persistence of Helicobacter pylori genom in peripheral blood mononuclear cells has been identified. Study of mononuclear cells CD4+, CD8+, CD14+ subpopulations has demonstrated various occurrence of fragments of ureC, cagA, vacA of Helicobacter pylori genome there. Close relationship between the intensity of pathological process in mucous membrane of gastrointestinal system and circulation of pathogenic agents in peripheral blood has been identified.