Palladium-Catalyzed Synthesis of 4-Aminoquinazolines from Amidoxime Ethers and 2-Iodobenzonitrile
4-Substituted O -benzylbenzamidoximes react with 2-iodobenzonitrile in the presence of 0.1 mol% [Pd2(dba)3], 0.2 mol% XantPhos and a 1.5-fold excess of Cs2CO3 in dioxane under argon atmosphere to form 4-amino-2arylquinazolines. This reaction is a new type of cascade process leading to 4-aminoquinazoline derivatives without the use of highly reactive chlorinating agents.