Development of evaluation method for vaccines upon dendritic cells action in vitro
We investigate in vitro action of vaccines upon dendritic cells of newborns and adults using live BCG vaccine and recombinant hepatitis B vaccine. It was shown, that dendritic cells, treated with BCG vaccine, demonstrated semimature phenotype, but stimulated interferon-g production by T-lymphocytes very efficiently. At the same time, hepatitis B vaccine stimulated interferon-g-stimulating capacity of dendritic cells only in adults, with no significant action upon this feature in newborns.