G308A tumor necrosis factor-а gene polymorphism and depression in an open male population aged 25-64 years from Novosibirsk (an epidemiological study according to the WHO MONICA-psychosocial program)
Objective: to investigate the association of G308A tumor necrosis factor-а (TNF-а) (rs1800629) gene polymorphism with depression in an open male population aged 25-64 years in Novosibirsk. Patients and methods. The investigation was conducted within the framework of the WHO MONICA-psychosocial (Multinational Monitoring of Trends and Determinants of Cardiovascular Disease) program using the material of Screening III of a representative sample of 25-64-year-old men (n=657; mean age, 44.3+0.4 years; response rate, 82.1%) from an open Novosibirsk population in 1994. The depression scale (Mopsy Test) form was used to assess depression. Depression was assessed as none, moderate (MD), or severe (SD). Results. The prevalence of depression in the 25-64-year-old male population was 29% (MD, 25.9%; SD, 3.1%). There were TNF-а G/G, G/A, and A/A genotypes in 79.1, 19, and 1.9% of cases, respectively. The G allele was present in 88.6% of the men and the A allele was only in 11.4%. Comparative analysis showed that the G/A genotype was more common in men with MD (28.8%) than in those without depression (14.8%): х!=6.486; df=1; p=0.011; odds ratio (OR), 2.316; 95% confidence interval (CI), 1.202-4.463. The G/A genotype was also more frequently observed in individuals with depression (MD and SD, 26,5%) than in men without depression (14.8%): х2=5.256; df=1;p=0.022; OR, 2.072; 95% CI, 1.103-3.892 compared with G/G genotype carriers. Carriage of the A allele was more often noted in individuals with MD (17.4%) than in those without depression (8%) (х2=9.67; df=1; p=0.002; OR=2.43; 95% CI, 1.371-4.307; similarly, A allele carriers were more common among the individuals with MD and SD (163.6%) than among the examinees without depression (8%) (х2=9.122; df=1; p=0.003; OR=2.296; 95% CI, 1.325-3.98). Discussion. Analysis of the association of G308A TNF-a gene polymorphism with depression showed that although the G/G genotype proved to be most frequently found in the G308A TNF-a gene polymorphism, the heterozygous G/A genotype and the homozygous A/A genotype, the A allele were more often detected in depression. Subsequent comparative analysis confirmed that the OR for the development of MD and depression (MD and SD) in individuals with the G/A genotype was increased by 2.3 and 2 times, respectively. Conclusion. A significant association was found between depression and G308A TNF-a gene polymorphism.