Effect of metoprolol and bisoprolol on the course of experimental bronchial asthma
In this article were shown the results of monoand combination therapy with antiinflammatory.-blockers in rats with experimental bronchial asthma. It is observed, morphological changes in the lungs, revealed changes in the density of.-adrenergic receptors by the action of basis antiinflammatory therapy. It was found that the selective.-blockers in animals with experimental asthma, inhalation or oral administration does not increase the severity of inflammatory change equations in the broncho-pulmonary tree. On top of basis therapy of bronchial asthma, with the additional use of.-adrenoblockers density of.-adrenergic receptors does not decrease, but also has a tendency to increase. Thus, it seems perspective to further researching the possibility of application, efficacy and safety of combined use of.-adrenoblockers with basic treatment of asthma, in patients with asthma and in patients with combined cardio-pulmonary pathology.