SIMULATING VASCULAR DYSFUNCTION IN CASE OF EXPERIMENTAL BRONCHIAL ASTHMA EXPOSED TO HOUSE DUST MITE EXTRACT
Summary - The authors present results of experimental study supplemented by simulation of bronchial asthma on male BALB/c mice using house dust mite extract as incitant of allergy. The study is aimed to research into the system manifestations of the disease and detect signs of endothelial dysfunction of magistral and cerebral arteries needed to record results by MRT scanning. As reported, the endothelium-dependent constrictive response of brain arteries against the bronchial asthma decreases, while the endothelium-independent one increases. The findings allow confirming the probability of applying the described bronchial asthma simulation to study system aspects of this disease in humans.