ETHNIC ASPECTS OF CARRIAGE OF CYP2C9 GENE POLYMORPHISM IN CHILDREN AND ADOLESCENTS WITH EPILEPSY IN EASTERN AND NORTHEASTERN SIBERIA
The prevalence of polymorphism CYP2C9 gene of 2C9 isoenzyme of cytochrome P450 in children and adolescents, living in the Krasnoyarsk Territory, the Republic of Tuva and the Republic of Sakha (Yakutiya) was analyzed. The genotype of CYP2C9•1/•1 prevailed in yakuts (88,9%) and tuvan (81,5%) groups in comparison with the russian (65%) group. The heterozygous genotypes of CYP2C9•1/•2 and CYP2C9•1/•3 also prevailed in the russian group (18,0% and 15,0%, respectively) compared to yakuts (7,4% and 3,7%, respectively), and tuvan (6,0% and 12,5%, respectively). The main reason for the low prevalence of SNPs CYP2C9•2 and CYP2C9•3 in the Yakut ethnic group of children and adolescents with epilepsy is the relative isolation of the region transport, formation of regional genetic isolate.