Atrial natriuretic peptide 1-28 concentration and renin activity in blood plasma of patients with hemorrhagic fever with renal syndrome
We revealed the decrease in ANP1-28 concentration in severe and moderate HFRS patients in oliguric phase (Me = 83.6 ng/ml and Me = 55.1 ng/ml correspondingly), in polyuric phase (Me = 57.8 ng/ml and Me = 33.0 ng/ml) and in early reconvalescence phase (Me = 68.2 ng/ml and Me = 52.8 ng/ml). The significant increase in plasma renin activity is observed in patients with moderate (Me = 11.2 ng AT-1/ml/h) and severe (Me = 18.5 ng AT-1/ml/h) HFRS in oliguria whereas in polyuria its level remain relatively low: Me = 0.2 ng AT- 1/ml/h in patients with moderate HFRS and Me = 0.8 ng AT-1/ml/h in patients with severe HFRS.