MODERN RANGE OF TRANSDERMAL DOSAGE FORMS IN THE PHARMACEUTICAL MARKET OF RUSSIA
Objective. Study of the nomenclature of transdermal dosage forms (transdermal gels, patches, transdermal therapeutic systems) registered on the pharmaceutical Russian market. Methods. A content analysis of the State Register of Drugs of Russia (as of 03.10.2021) was carried out with the subsequent quantification of the data obtained. The number of international non-proprietary names (INN) of drugs (MP) for which transdermal MF is registered, the number of transdermal MF and the total number of drugs in transdermal form, taking into account dosages, were calculated. Results. The analysis of the State Register of Drugs in 2021 revealed 24 trade names of drugs in various transdermal forms and dosages: gels (4.2%), transdermal patches (25%), transdermal therapeutic systems (70.8%). In comparison with the range of registered transdermal MF in 2013, there is no change in the number of names, but in comparison with 2012, the number of names of registered transdermal MF increased by 1.7 times. Analysis of the regulated lists showed that 9 trade names of drugs in the form of TDTS, as well as 1 name of drugs in the form of a transdermal patch, contain in the composition of the substance of list II of the list of narcotic drugs, psychotropic substances subject to control in the territory of the Russian Federation (fentanyl, buprenorphine). Fentanyl and rivastigmine in the form of TDTS are included in the list of vital and essential drugs. At the same time, in the List of the minimum range of drugs necessary for the provision of medical care, MP in transdermal MF are not represented. Conclusion. Transdermal delivery of drugs has great prospects as an alternative to oral, intramuscular and intravenous methods of administration of drugs, especially during the pandemic in conditions of limited availability of medical care to the population. The transdermal method of delivery allows to reduce the frequency of drug usage and increase the compliance of patients to the therapy.