GIPOTIREOID MODELLING OF THE CONDITION AT THE RAT BY MEANS OF COAGULATION OF THE TOP AND BOTTOM THYROID ARTERY ON THE RIGHT
In literature are presented both medicamentous, and surgical models of a hypothyroidism. Majority of the medicamentous. But surgical allow to study pathophysiological consequences of this pathology more informatively. Therefore we made attempt of creation of model of a surgical hypothyroidism at a rat for further use on this model of TES-THERAPY. 10 nonlinear rats males to whom after an anesthesia carried out coagulation of the top and bottom thyroid artery on the right are included in experiment. During experiment by all animal carried out record electrocardiogram. From 10 animals without leaving an anesthesia, was lost 3. We conducted histologic research of a brain and heart of the dead of animals which confirms that the death of animals came from polyorgan insufficiency, against deep bradycardia. Us search of the reasons of a syndrome of the polyorgan insufficiency arising at creation of this model proceeds.