Risk factors of adverse cardiovascular events in patients with isolated non-compaction cardiomyopathy
Objective. To identify the risk factors of adverse cardiovascular events in patients with isolated non-compaction cardiomyopathy (NCCM). Material and methods. There were 90 patients with isolated NCCM aged 25 - 47 years (median 34 years; 47 men and 43 women) and symptoms of chronic heart failure (CHF) NYHA class I-II. In addition to conventional examination, all patients underwent contrast-enhanced cardiac magnetic resonance. The endpoints of the study included progression of CHF up to NYHA class III requiring in-hospital treatment, ventricular tachyarrhythmias and embolic events. Results. CHF symptoms progressed up to NYHA class III in 22 out of 90 (24.4%) patients with isolated NCCM throughout the follow-up period from 6 to 90 months (median 25 months). Univariate analysis showed that the following variables were independent risk factors of CHF progression: baseline symptoms of CHF NYHA class II (HR 2.2; 95% CI 10.3-4.8, p 0.04), reduced LV EF ≤50% according to CMR (HR 9.1; 95% CI 3.2-26.0, p500 beats/min on 24-hour ECG monitor (HR 5.8; 95% CI 1.9-17.6, p=0.002) and GLS ≤11% (HR 0.79; 95% CI 0.66-0.96, p500 beats /min according to 24-hour ECG monitoring. These parameters can be used to identify high-risk patients.