KATP-CHANNEL MODULATORS IN REGULATION OF MYOCARDIUM MITOCHONDRIA FUNCTIONING UNDER ADRENALINE MYOCARDIUM DYSTROPHY IN RATS
Influence of KATP-channel opener pinacidil and inhibitor glibenclamide under adrenaline myocardium dystrophy on the main parameters of functional State of myocardium mitochondria were studied. Pinacidil has a protective effect on mitochondrial energy support in myocardium under adrenaline myocardium dystrophy. These changes are caused by increasing of α-ketoglutarate oxidation efficiency with decrease of lipid peroxidation. This prevents the negative effects of oxidative phosphorylation disruption caused by significant doses of catecholamines.