NEUROMODULATION EFFECTS OF HYDROGEN PEROXIDE ON CENTRAL NEURONS WITHIN FEEDING NETWORK IN THE MOLLUSC LYMNAEA STAGNALIS
Hydrogen peroxide at concentration of 100 pM was found to possess a pronounced correcting effect on motor (cells of R/L B1-B4 clusters) and modulatory (cells of R/L CGC) neurons of the feeding network in the mollusc Lymnaea stagnalis. The effect of hydrogen peroxide is expressed as a change of firing rate, membrane potential level and action potential amplitude of these cells. The observed effects were reversible, brief and reached their maxima within 1 min after application of the preparation. Injection of hydrogen peroxide into the cavity of the cephalopedal sinus did not result in statistically significant changes of the mollusc feeding behavior indicators. It is supposed that hydrogen peroxide may act as a fast neuromodulator in relation to neurons of the central generator of feeding rhythm in Lymnaea stagnalis.