Hyperglycemia and Hyperuricemia in Acute Myocardial Infarction
Coronary disease is known to be associated with hyperuricemia and carbohydrate disorders. Meanwhile, it remains not clear how in these cases carbohydrate and purine exchanges are related to each other. The aim of the study was to study the frequency of carbohydrate and purine metabolism disorders and assess the relationship between them in patients with acute myocardial infarction. The article presents the results of the analysis of the prevalence of carbohydrate disorders and hyperuricemia in 135 patients with acute myocardial infarction. The patients' age ranged from 29 to 82 years, the average age was 62.6 years (median 64 years), women were 45, men 90. Deviations in carbohydrate metabolism were recorded in 59.3±4.2%, hyperuricemia in 47.0±5.5% surveyed. Among carbohydrate disorders, stress hyperglycemia prevailed (66.2±5.3%). The relationship between carbohydrate and purine metabolism disorders has been established. Uricemia correlated with ranked carbohydrate metabolism (Rs = +0.24, p = 0.0236), the frequency of hyperuricemia in patients with impaired carbohydrate metabolism (31/51, 60.1±6.8%) was significantly higher than in persons with normal carbohydrate metabolism (8/32, 25.0±7.7%, χ2 = 10.1, p = 0.0015). The combination of stress hyperglycemia and hyperuricemia in acute myocardial infarction suggests a pathogenetic link between these conditions. The conclusion is made about the importance of continuing research in this direction. including with the aim of determining the possibility of optimizing the treatment of acute myocardial infarction by active drug exposure to disorders of purine and carbohydrate metabolism.