The mechanism of action of the drug Cardos on heart failure model in rats
Determined was the mechanism of action of the drug Cardos (antibodies to the C-terminal fragment of AT1 receptor of angiotensin II) in experimental heart failure in rats and determined was its effect on the ratio of AT1 and AT2-angiotensin II receptor subtypes and NO-synthase activity in cardiomyocytes. It is suggested that Cardos possesses modulating action on nitric oxide II metabolism in the myocardium.