Development and study of hydrophilic gels with phytic acid and xymedone for the treatment of burn wounds in exeriments on rats
The formation of complexes of myo-inositol hexakisphosphate (phytic acid) with 1-(β-hydroxyethyl)-4,6-dimethyl-1,2-dihydro-2-hydroxypyrimidine (xymedone ®) in aqueous medium has been studied by IR- and 13C-NMR spectroscopy and potentiometric titration. Hydrophilic gel containing complexes of xymedone phytates and sodium hyaluronate as the base has been developed. The gel has high osmotic activity and may be recommended for burn treatment. Wound healing activity of new gel has been proved in the experiments by rats in modeling thermal burn and it is probably due to the high antioxidant properties of phytic acid.