Ex-orphan receptors as targets for potential medicines
The orphan receptors are brought the review of modern literature on endogenous ligands of large group. It is shown that intermediates of carbohydrate, fatty and protein metabolism, a cycle the three-carbonic acids actively participate in regulation of exchange processes, and their synthetic analogs - ligands to orphan receptors (both agonist, and antagonists) are perspective objects of development new drugs at a wide range of diseases (diabetes, obesity, a metabolic syndrome, autoimmune diseases, a hypertensive illness, myocardium ischemia, a myocardium hypertrophy, neurodegenerative diseases, immunodeficiency, liver diseases, etc.). Concerning several ex-orphan receptors potentially perspective chemical compounds which can act as ligands to receptors of metabolic type of activation are presented.