INVESTIGATION OF THE INFLUENCE OF THE BASE’S NATURE AND COMPOSITION ON RELEASING OF SUC-CIPHENATE AND DIACAMPH FROM SUPPOSITORIES
The kinetics of releasing in vitro of succiphenate and diacamph from suppositoriry bases, which are different by the nature and composition has been investigated by the methods of diffusion in agar and equilibrium dialysis via the permeable membrane. The method of spectrophotometric identification of succiphenate and diacamph in the phosphate buffer solution with pH 6.6) has been developed to registrate the concentration of the substances studied. Based on analysis of the data obtained the proxanol base providing a sufficient release of active ingredients has been chosen for further research. It has been shown that due to the presence of propylene glycol in the composition of the proxanol base and solubility of active substances in it the release of active substances from the given base increases.