DETERMINATION OF THE AFFINITY OF EUKARYOTIC DDX3 RNA HELICASE TO THE CHARACTERISTIC ELEMENTS OF mRNA SECONDARY STRUCTURE
DDX3 RNA helicase is involved in many processes of RNA metabolism in eukaryotic cells. Many studies of DDX3 have shown that it is also involved in the translation initiation process, both cap-dependent and IRES-dependent. However, the specificity of the 5'–UTR secondary structure of mRNA, which require DDX3 RNA helicase for the effective translation, has not yet been determined. We performed a bioinformatic analysis of the 5'-UTR secondary structures in the pool of DDX3-dependent mRNAs in silico and found that the length of 5'-UTR is less than the average for the genome, and there are also characteristic hairpin structures in the region of the first 50 nucleotides from the 5'-end of the mRNA.