INVESTIGATION OF PHYSICAL AND CHEMICAL PROPERTIELS OF THE DRUG SEKSTAFAG® FILMS
The article features the results of the studies of physical and chemical properties of the Sekstafag drug films based on gelatin. The paper presents the results of the studies of the physico-chemical properties of the medicinal films Sextafag® based on gelatin. Adhesive properties of polymers determine the strength of the film fixation at the site of application. It has been that established at a density of 38.25 - 54.25 mg / cm2 and a thickness of 0.3 - 0.4 mm, the bioavailability of bacteriophages from matrix systems is maximal. The increase or decrease in density leads to a decrease in the detachment from the substrate and the strength of fixation in place of application. Absorption properties (swelling) characterize the diffusion capabilities of polymer systems, determine the rate and completeness of the release of bacteriophages from the matrix, predicts a prolonged action, and the ability to absorb exudate. It has been demonstrated that as the density of the experimental films of the drug Sextafag® increases, the degree of absorption decreases. The compositions were absorbed from 122% to 252% of the biological fluid within 15 minutes and from 300% to 500% within 60 minutes, having indicated the gelatin good absorbent properties. The swelling kinetics has shown that the gelatin-based films with a density of up to 52 mg / cm2 are of best absorption properties. The vapor permeability characterizes the fibrillarity of the structure of the films, its porosity and the degree of aeration of the underlying tissues. Medicinal films Sextafag® with a density of up to 52 mg / cm2 and a thickness of 0.4 mm are characterized by a vapor permeability sufficient for aeration of tissues at the site of application and ensure the greatest bioavailability of bacteriophages from the matrix systems. The study of the influence of the technological drying factor at 37 °C on the stability of bacteriophages in the gelatin-based drug films showed the decrease in the lytic activity of the sextapage in the matrix polymeric systems with a density of more than 60 mg / cm2. In all experimental samples based on gelatin with a density of 25 to 83 mg / cm2, the components of the complex preparation Sextafag® retained the lytic activity in dilutions no lower than 104. The study of the physico-chemical properties and lytic activity of Sextafag® gel-based drug films showed that the optimal physiological properties have matrix systems with a density of 50-55 mg / cm2, characterized by a high ability to absorb exudate, aerate the tissues, firmly fix on the site of application and save specific special bactericidal activity.