Clinical efficacy of desmopressin in children with complicated forms of enuresis
The objective of the work was to study the clinical efficacy of a synthetic analogue of the antidiuretic hormone (Minirin®) for treatment of children with polysymptomatic nocturnal enuresis. A clinico-laboratory examination of 55 schoolchildren aged 6-11 years with enuresis was performed. Among the examined children patients with complicated (polysymptomatic) forms of enuresis (50 children) prevailed. The dynamic observation group comprised 44 children with nocturnal enuresis, randomized into the basic group (n = 26) receiving therapy with a synthetic analogue of the antidiuretic hormone (Minirin), and the reference group (n = 18) receiving a nootropic drug (piracetam). A genealogical analysis of medical histories in families of children from the both groups revealed significant burden with regard to enuresis (84.6 and 38.8%, respectively) and diseases of the urinary system (50 and 16.7%, respectively). A comparison of the clinical efficacy of therapies in children with enuresis showed a positive effect of Minirin in 88% of observations with predominantly high (46%) or average (42%) degrees of the efficacy of the drug in patients with complicated forms of enuresis. Development of a long-term effect in younger children (6-7 years) was noted in 77.8%, in senior children (8-11 years) - in 46.7% of cases (p = 0.446). In patients of the reference group receiving piracetam therapy absence of effect from treatment was observed significantly more often (50.1%, p = 0.000).