Pharmacological interaction of the enantiomers of ethylmethylhydroxypyridine malate and rosuvastatin in an experimental model of acute hyperlipidemia
The study was conducted on sexually mature male Wistar rats. Acute hyperlipidemia was modelled by administration of an oil suspension of cholesterol in the dose 50 mg/kg daily by gastric intubation for 40 days till the total cholesterol dose 2000 mg/kg was achieved, and also by single intraperitoneal injection of Tween-80 in the dose 250 mg / 100 g on the 40th day. Then animals were divided into groups and received a 14-day course of treatment with the laevorotatory enantiomer of ethylmethylhydroxypyridine malate (LEEM), rosuvastatin, and also with a combination of these drugs, against the background of continuing administration of cholesterol. On the 14th day from the beginning of treatment, and also on the 24th day, blood was taken from the retro-orbital sinus and serum lipid profile was assessed. The most marked hypolipidemic effect was established for intake of a LEEM combination with rosuvastatin, realised first of all due to a decrease of total cholesterol levels. The most marked cumulative hypolipidemic effect in the experiment was demonstrated by a combination of the examined drugs. The maximal hypolipidemic effect was obtained by the 24th day of the experiment.