COMPLEX ANALYSIS OF ANTIBIOTIC CONSUMPTION IN A MULTI PROFILE HOSPITAL
Aim. To conduct a clinical economic and pharmacoepidemiological analysis of antibiotic consumption in the setting of a multi profile hospital. Methods. Financial expenditures for purchasing antimicrobial agents were assessed using clinical and economic analysis (ABC-analysis), the consumption of antibiotics - pharmacoepidemiological analysis using the ATC/DDD methodology, according to the WHO indexes of ATC/DDD in 2006 for J01 and J02 sections. Results. Shown was an increase in the share of expenditures on antimicrobial chemotherapy drugs for the «Medication» item of expense. The most expensive group of antimicrobial chemotherapy drugs were the cephalosporins, followed by carbapenems in the cost structure, third were the penicillins. Revealed were inconsistencies in the monetary cost and consumption level of carbapenems. The leaders of consumption were - cephalosporins, aminoglycosides and fluoroquinolones, during a low level of use of macrolides. In the group of cephalosporins the most used drugs were -ceftriaxone and cefazolin. A high level of antibiotic consumption was found in the department of general surgery, where the types of surgical wounds with elective interventions are either mostly clean or conditionally clean. Conclusions. Monitoring of the consumption of antimicrobial chemotherapy drugs makes it possible to make strategic decisions in optimizing antibiotic therapy; in the departments with high consumption of antibiotics required is the monitoring of DDD-indicators in order to match the number and range of the used antibiotics to profile of hospital units