SOLKOSERYL ANTIOXIDANT EFFECTS IN EXPERIMENTAL BRAIN TRAUMA
Authors describe the results of the experimental investigations aimed to solkoseryl antioxidant efficacy investigation in condition of experimental brain trauma. Brain trauma was shown to correspond with blood plasma peroxidation products– MDA and DK – levels increasing as well as antioxidant enzymes – catalase, SOD and GP – activity decreasing. Solkoseryl administration results in the investigated compound activity normalization with its maximal effectiveness revealed on the 14 th day after brain trauma. It should be mentioned that solkoseryl resulted in DK level and catalase and SOD activity normalization on the 7 th day after brain trauma. These experimental results are in favour that antioxidant profile is one of the mechanism of solkoseryl neuroprotective effect in conditions of brain trauma.