PATHOGENETIC SIGNIFICANCE OF LOCAL HYPOXIA IN THE EFFECTIVENESS OF TREATMENT OF VAGINAL INFECTION
The analysis of the results of treatment of 112 women with chronic infectious vulvovaginitis was carried out. All study participants signed informed consent and an additional bilateral agreement on non-disclosure of personal data and the specifics of the study program. Depending on the oxygen content in the vaginal wall, according to oximetry data, the patients were divided into 2 groups. Group I included 68 women, whose coefficient of oxygen content in the wall of the vaginal mucosa (Kliz%) exceeded 97.0%. Group II consisted of 44 women, whose coefficient of oxygen content in the wall of the vaginal mucosa (Kliz%) was below 97.0%. Accordingly, in group I K-muc% was 97.9 ± 0.2%, and in group II - 96.5 ± 0.3%, while the differences in the indices of the K-muc% coefficient, reflecting the oxygen content in the vaginal wall before the start of treatment, were significant. (P  0.05). The frequency of detection of "key cells" in the material from the vagina, the number of which exceeded the permissible threshold of 3.0% in group II, where local hypoxia took place, was significantly higher than in group I (P <0.05). The results obtained indicated that against the background of hypoxia of the vaginal walls, the development of local immunodeficiency of its mucous membrane is noted, which negatively affects the results of treatment and increases the risk of recurrence of the pathological process. Evaluation of the effectiveness of general and local ozone therapy for the correction of local hypoxia of the mucous membrane in the treatment of chronic vulvovaginitis seems to be a promising direction for further research.