CONVENTIONAL RISK FACTORS AND ARTERIAL BED PARAMETERS IN PATIENTS WITH CORONARY ARTERY DISEASE YOUNGER AND OLDER THAN 50 YEARS
Aim. To study conventional risk factors and arterial stiffness parameters to identify non-invasive markers of coronary atherosclerosis in patients with and without history of cardiovascular disease, with premature and physiological vascular aging. Material and methods. The study included 198 patients with coronary artery disease (CAD) and 57 healthy people. The subjects were divided into two cohorts: younger and older than 50 years. Each group included patients with newly diagnosed acute coronary syndrome with/without history of cardiovascular disease (CAD and/or hypertension). Conventional risk factors were analyzed in all subjects. Ultrasound radiofrequency of common carotid arteries (CCA), applanation tonometry, volume sphygmography were performed. Results. Analysis of arterial parameters in individuals 1 - 0,742, threshold - 7,3 (p=0,000). In patients >50 years of age, AUC for the IMT was 0,948, threshold - 607,5 (p=0,000); for the beta stiffness index - 0,740, threshold - 8,84 (p=0,000); for L-/CAVI1 - 0,861, threshold - 8,4 (p=0,000). Conclusion. Timely identification of atherosclerotic markers using noninvasive techniques can improve the prediction of cardiovascular events. A comprehensive non-invasive examination of the arteries with determination of IMT, beta stiffness index, and L-/CAVI1 will probably identify young people with an unfavorable absolute cardiovascular risk.