APOPTOSIS OF PERIPHERAL BLOOD LYMPHOCYTES IN PATIENTS WITH LRRK2-ASSOCTATED PARKINSON'S DISEASE
Mutations in the Leucine Reach Repeat Kinase 2 (LRRK2) gene are the most frequent cause of familial Parkinson's disease (PD). Although the precise physiological and pathological role of LRRK2 is unclear, a direct lin between mutant LRRK2 and apoptosis has been suggested. Using How cytometric analysis (PI+Annexin V(FITC)) we showed increased spontaneous apoptosis of peripheral blood lymphocytes in patients with LRRK.2-associated PD compared to controls after 24 (P P FAS mRNA level in peripheral blood lymphocytes of patients with LRRK2-associated PD compared to controls (P P FAS expression between patients with LRRK2-associated PD and controls remained after three years and was detected after 1 and 24 h during lymphocyte incubation (P FAS expression in patients with LRRK2-associated PD suggest that LRRK2 mutations may lead to the activation of extrinsic apoptotic way.