CLINICAL AND MORPHOLOGICAL CHARACTERISTIC OF MILD CEREBRAL ISHEMIA IN FULL-TERM INFANTS WITH INTRAUTERINE PARAINFLUENZA AND MIXED-RESPIRATORY VIRUS INFECTION
The aim of the work is to give clinical and morphological characteristic of mild cerebral ischemia of full-term infants with intrauterine parainfluenza and mixed respiratory virus infection. There were studied clinical features of cerebral ischemia, ultrasound picture of the brain and blood flow in the middle cerebral artery in 27 full-term infants; and pathomorphologic changes of soft brain tunic, cortex, ependyma and vascular plexus of lateral ventricles of cerebrum in 18 dead infants with intrauterine parainfluenza of 1 and 3 types (1 st group), as well as in 25 children of perinatal age and in 20 dead infants with antenatal mixed-respiratory virus infection caused by the combination of parainfluenza of 1 and 3 types with influenza B, adenovirus with parainfluenza of 1 and 3 types and parainfluenza of 1 and 3 types with respiratory-syncytial virus (2 nd group). The control group consisted of 32 healthy full-term infants from mothers with physiologic course of pregnancy and 25 dead children of 38-40 weeks with the birth trauma. It was found out that the infants of the 2 nd group in comparison with the 1 st group had the signs of hyperexcitability and physical disorders much longer and echographic markers of brain immaturity (in 32.0 and 3.7%, р<0.05) were registered oftener at the absence of any changes of the vessel resistance in the middle cerebral artery. At the same time the dead infants of this group morphologically were found to have the parts of the increase of collagenisation of soft brain tunic blood vessels, alternative neuron changes, glial cellular elements and ependymocytes of lateral ventricles of cerebrum, more intensive perivascular edema, full-blown vascular congestion and vascular plexus as well as tiny hemorrhages, which is explained by significant neurotoxic and angiotoxic influence of some viruses and products of their metabolism.