GAS-TRANSPORT METABOLISM IN THE PERIPHERAL BLOOD AT GENERAL COOLING OF THE ORGANISM
The aim of the research is to study in experimental conditions the character of changes of acid-base balance and bioenergetic processes in erythrocytes of the peripheral blood of rabbits at general cooling of the organism. It is established that as a result of daily cooling (from 15 till 30 days) of animals under experiment during three hours at temperature -30ºС pH of rabbits blood falls to 7.34±0.013 by the 30th day of the experiment, and the quantity of pCO2 in blood increases to 49.5 mm of mercury. The quantity of adenosinetriphosphoric acid in erythrocytes of the peripheral blood decreases to 0.34±0.06 mkmole/ml (control - 0.65±0.07 mkmole/ml), and the concentration of 2.3-biphosglycerate increases to 6.9 mkmole/ml. There is a drop of hemoglobin erythrocytes oxygenation to 96.0±3.2% (control - 99.5±3.0%), which leads to hypoxia in the organism of animals under experiment. Thus, the cooling of the organism suppresses energetic processes in erythrocytes of the peripheral blood and causes metabolic acidosis.