Stereoselective Bioreduction of <i>p</i>-Methoxyacetophenone Into (<i>S</i>)-1-(4-Methoxyphenyl)Ethanol
The method for the synthesis of (S)-1-(4-methoxyphenyl)ethanol, an important precursor used in the production of various drugs, by bioreduction of prochiral p-methoxyacetophenone in the presence of D. carota culture cells is offered. The possibility of using of various exogenous reducing agents such as isopropanol, ethanol and glucose to increase the yield of the desired (S)-1-(4-methoxyphenyl)ethanol and the enantioselectivity of the p-methoxyacetophenone bioreduction process has been investigated