CHIRALE BLOCKS FOR CARBAANALOGUES OF EPOTHILONES FROM THE D-CARVONE
The synthetic interesting approach to new gem-dimethylcyclopropane analog of epothilone A from d-carvone "in development" was described. The thiazole containing block with C-15 center correct stereochemistry was received. Proceeding by assistance of p-toluenesulphonic acid the new fragmentation reaction of (+)-б-3,4-epoxycaren-2-оl with the formation of (+)-3-caren-2-one was found.