SVCAM-1 VASCULAR CELL ADHESION MOLECULES AND HEART STRUCTURAL AND FUNCTIONAL CHANGES IN PATIENTS WITH ACUTE LEFT VENTRICULAR ANEURISM FOLLOWING MYOCARDIAL INFARCTION
AIM. To study the expression of sVCAM-1 soluble vascular cell adhesion molecules in patients with acute left ventricular aneurysm following myocardial infarction and assess the relationship with the processes of heart remodeling. METHODS. 170 patients diagnosed with acute myocardial infarction in the presence of Q-wave were examined. The expression of sVCAM-1 soluble vascular cell adhesion molecule, electrocardiogram and Doppler echocardiography changes were studied depending on comorbidities and the development of acute left ventricular aneurysm following myocardial infarction. RESULTS. ST-segment elevation was still detectable in patients with left ventricular aneurysm compared to patients with no aneurism on the 3rd and 5th day after the disease onset, its amplitude was significantly higher, no dynamic changes of the T-wave in the anterior chest leads were registered. The prevalence of left ventricular dilatation, mitral regurgitation, reduced systolic function of left ventricle and type II diastolic dysfunction was higher in patients with left ventricular aneurysm. The relationship between sVCAM-1 vascular adhesion molecules expression with early remodeling after the myocardial infarction and left ventricular aneurysm development in acute stage of myocardial infarction in the presence of Q-wave was revealed. CONCLUSION. In the presence of such comorbidities as hypertension and diabetes, a higher level of sVCAM-1 vascular adhesion molecules expression was revealed in patients with left ventricular aneurysm following myocardial infarction. ST-segment elevation and no dynamic changes of the T-wave were still registered by electrocardiography till the 5th day after the disease onset. Amplitudes of ST-segment and T-wave were significantly higher in patients with left ventricular aneurysm following myocardial infarction compared to patients with no complications of myocardial infarction.