Alteration of Effector Activity of T-Lymphocytes in Mice Immunized against Tularemia, Using <I>in vitro</I> Stimulation by Tularin
It has been shown that tularin contains antigens that specifically interact with antibodies of sera of mice vaccinated with F. tularensis 15 NIIEG (15 th line of production, Research Institute of Epidemiology and Hygiene). Besides, it has been established that tularin specifically intensifies expression of CD69 receptor on the surface of CD4 + and CD8 + subpopulations of T-lymphocytes, and specifically enhances synthesis of IFN-γ and FNO-α cytokines by means of T-helpers (CD3 + CD4 + lymphocytes) isolated from mice, immunized against tularemia. Put forward is the proposition to use tularin in serological surveys and reactions in vitro for identification of postinfectious or postvaccinal immunity to tularemia.