Rational use of antibiotics in posttraumatic osteomyelitis treatment considering dynamics of resistance change
Objectives. To evaluate antibiotics sensitivity of pathogens obtained from the patients with the posttraumatic osteomyelitis and to work out recommendations on concerning rational antibiotics therapy. Methods. 191 patients with the posttraumatic osteomyelitis were examined using the biological method. Microorganisms' identification was carried out by means of the test-systems on the biochemical analyzer ATB Expression. Evaluation of the microorganisms sensitivity to the antibacterial preparation was carried out on the biochemical analyzer ATB Expression as well as using original test-systems «AB-STAPH», «AB-PSEU», «AB-GRAM(-)» and «AB-ENTER». Results. Equal ratio of gram-positive and gram-negative floras during the whole period of patients' hospitalization was determined. Pseudomonas aeruginosa was reliably more frequently observed in the quaternary inoculations compared with the primary ones. Reliable growth of microorganisms' resistance to antibacterial preparations is registered. Conclusions. Use of the developed scheme of the rational empirical antibiotics therapy in the complex treatment of posttraumatic osteomyelitis permitted to shorten hospitalization terms from 38±2,7 to 21,1±2,3 days (p<0,05).