Features of cytokine secretion in patients with pulmonary multidrug-resistant tuberculosis receiving anti-mycobacterial therapy
The aim of this study was to examine the features of cytokine secretion in patients with pulmonary multidrug-resistant tuberculosis (MDR TB) under the influence of standard tuberculosis (TB) treatment. Studied the features of the dynamics of interleukin (IL)-2, IL-4, IL-10 and interferon-γ (IFN-γ) in serum enzyme immunoassay. The study involved 140 patients with various forms of pulmonary TB and 30 healthy donors. Patients were divided into two groups, depending on the form of TB: 1 st group - 74 patients with MDR TB and 2 nd group - 66 patients with pulmonary TB without MDR TB. In addition, the mentioned groups were divided into two subgroups depending on the presence of recurrant or newly diagnosed pulmonary TB. The study revealed an accurate increase of IL-2 and IFN-γ and decrease of IL-4 and IL-10 in patients with pulmonary TB before treatment in comparison with the healthy grop. After two months of treatment a significant decrease of IL-2 and IFN-γ and increase of IL-4 and IL-10 in patients with TB was estimated. More pronounced signifi cant pathological changes as a violation of the immune response before treatment so after two months of chemotherapy were observed in patients with pulmonary MDR TB, especially in patients with relapse than in patients without MDR TB and newly diagnosed pulmonary TB.