RESEARCH OF ADHESION PROPERTIES POLYFUNCTIONAL GUM ADHESIVE FILM
The article presents the results of studies on the study of the adhesive properties of films for sticking to the gums of polyfunctional action. It is shown that the development of polyfunctional drugs based on active substances of synthetic and herbal origin for dental practice is an important direction. The prospects of creating films of polyfunctional action for sticking to the gums, containing a synthetic drug of anesthetic action and a complex of biologically active substances of plant origin with anti-inflammatory activity, are substantiated. The local anesthetic lidocaine hydrochloride with a pronounced local anesthetic activity and a fairly low level of side effects was introduced into the developed films. The complex of natural biologically active substances in the composition of the films is provided by the presence of a liquid extract of Japanese Sophora fruits, which have anti-inflammatory, antimicrobial and immunomodulatory activity. The main attention in the article is paid to the optimization of the composition of auxiliary components by studying their mucoadhesive characteristics, which ensure optimal contact of the drug with the oral mucosa. The qualitative and quantitative composition of the experimental compositions was established on the basis of scientific literature data on the recommended content of active and excipients in medicinal films. Methylcellulose, sodium carboxymethylcellulose, hydroxypropyl methylcellulose, and gelatin were used as film-forming substances. The preparation of compositions of the film mass was carried out in accordance with the physicochemical properties and recommended technological modes for obtaining solutions of film formers. The adhesive properties of the developed films were studied using a technique based on the use of a device that includes an equal-arm scale with a cup with a water container on one side and a glass plate on the other. As a result of the research, several compositions of films for sticking to the gums were identified, which had the best adhesive characteristics, which led to the conclusion that it is expedient to further study these compositions in the framework of pharmaceutical development.