FEATURES OF LOCAL AND SYSTEMIC IMMUNITY, AND MORPHO-FUNCTIONAL STATE OF ENDOMETRIUM IN WOMEN WITH ANOVULATORY SYNDROME
Persisting acyclic hypoestrogenemia and progesterone insufficiency in the women with anovulatory syndrome and altered reproductive functions are associated with disturbed endometrial morphology, increased expression of receptors for estrogenes, progesterone, redistribution of NK cells with predominance of CD16+ NK cells in endometrium. Meanwhile, decreased number of CD16+ NK cells and cytotoxic CD8+ T cells in blood was accompanied by increased serum IFNy levels, and enhanced spontaneous production of TNFб. (Med. Immunol, vol. 10, N4-5,pp 353-360)