The research of akute toxity and diuretic activity among 7-zameschennykh-8-piperedinoteofilina
The research of akute toxity and diuretic activity of the 15 first-synthesized compounds among 7-zameschennykh-8-piperedinoteofillina was studied. In experiment, which was carried out on rats, was founded that during 4 hours the investigate samples increased a diuresis on 24,6-115,9 %. The highest diuretic activity was shown by combination №1 - 7-etil-8-piperedinoteofilina, it exceeded the diuretic effect of standard sample comparison gipotiazid 1,6 time. The mechanism of diuretic effect of combination № 1 caused by of reabsorption decreasing, increasing of sodium ions excretion in nephron's tubules and improvement of glomerular filtration in kidneys.