ANALYSIS OF CHANGES IN REDOX REACTIONS IN INTOXICATION WITH NICKEL CHLORIDE AND THE NO-SYNTHASE INHIBITOR
Intoxication syndrome was induced by exposure of the nickel chloride and its combination with L-NAME for 30 days in Wistar rats. LPO activity, antioxidant system (AOS), the content of total nitric oxide (NOx) metabolites as well as the activity of membrane enzyme Na+,K+-ATPase in renal, hepatic and myocardial tissue homogenates and the level of organ-specific and excretory plasma enzymes were determined. The data showed intensification of the LPO process and decreased NOx content in blood. Free-radical oxidation in cell membranes of internal organs contributed to their permeability and the level of organ-specific, membrane and excretory enzymes in blood plasma. The activity of Na+,K+-ATPase in organ homogenates decreased. L-arginine administration resulted in increased level of NOx, inhibition of LPO, increased AOS activity and decreased activity of organ-specific enzymes in blood plasma, increase in the activity Na+,K+-ATPase.