The level of blood pressure and DNA polymorphism of children and adolescents in St-Petersburg
This article represents the 90 th and 95 th percentiles of blood pressure (BP) of 2242 children aged 7-16 from St. Petersburg. Cardiovascular family history of202 children and the DNA polymorphism from 136 children were studied. Reliable correlations between children's systolic BP and parents/grandparents' essential AH were found. In the group of children whose grandparents had AH we found out the significant prevalence genotype AA ofA1983G polymorphism of the renin gene in comparison with those, who had negative AH family history. In the group of children whose mothers had AH during the pregnancy we found out the significant increase of G allele of C81G polymorphism of the p2- adrenergic receptor gene frequency in comparison with the children from normotensive mothers. The girls, who had relatives with stroke had the significant increase of the A allele of A3123C polymorphism of angiotensin II type 2 receptor gene in comparison with the children from negative stroke families. Key words: arterial hypertension, blood pressure, gene polymorphism, children.