Methodology of 1<sup>st</sup> trimester screening for preeclampsia and intrauterine growth restriction according to Fetal Medicine Foundation algorithm (FMF)
The article presents a description of the combined 11+1-13+6 weeks preeclampsia and intrauterine growth restriction screening test based on FMF algorithm. The individual risks for preeclampsia and intrauterine growth restriction were calculated at the same time with Down syndrome screening. The screening for preeclampsia and intrauterine growth restriction was done by a combination of maternal factors, mean arterial pressure, uterine artery pulsatility index, pregnancy-associated plasma protein-A (PAPP-A) level and placental growth factor (PlGF) in the maternal blood. The predictive value of the each parameter of combined test is presented in the paper. The diagnostic significance and practical advantages of the early screening test for preeclampsia and intrauterine growth restriction according to FMF algorithm compared to the performance of screening for preeclampsia based on the risk factors from the medical history only were outlined.