THE BRAIN PLASTICITY: PEPTIDE BIOREGULATORS IN THE THERAPEUTIC CORRECTION AMNESTIC PSYCHO-EMOTIONAL AND BRAIN ASYMMETRY DISORDERS OF THE MAMMALS
The present work is devoted the comparative study of the peptide bioregulators (PB) drugs such as Semax, Selank and ACTH6-9 in the therapeutic correction on the amnestic, psycho-emotional disturbances (anxiety, depression) and brain asimmery of the mammals ascending row. The model of the chronic fatique syndrome (CFS) was used. CFS has been creation earlier on the monkies and rats. The main symptoms of the CFS were identified by the objective parameters of the Higher Nervous Activity (EEG, EKG, respiratory and video monitoring). It have been shown that in rodents level the influence of the different PB drugs more expressed on the inherent forms of the nervous activity. The antiamnestic effects of the neuropeptides drugs lasted a short time and manifested as a strongly marced tendency. The new data obtained that of the rats small doses of the Semax and ACTH6-9 exerted antidepressive effects. The antidepressive effects of the ACTH6-9 was more significant. It have been shown that in the rats PB exerted the different influence on the brain asymmetry which depended from basic profile of the bechaviour. The new experimental data have been represented that in primate level the antiamnestic effects of the PB studied has a different character. It was found that the Selank effects more wide and lasted a long time. On the Selank background the cognitive disturbances disappeared, the capacity for work was increased. EEG was normalized on the amplitude-frequency spectrum. The new experimental data has been shown that at the third stage of CFS in monkeys the anxiety developmented. The small doses of the Selank experted a compensatory effect of the all indicators of the Higher Nervous Activity, espetially amplitude-frequency spectrum of EEG. The new experimental data obtained, that in primate level ACTH6-9 possessed the antidepressive influence. The dynamic and duration these effects more spacious as comparative rats. The wide computer analysis of the EEG disturbances of the monkeys with CFS development have been shown that more significant disturbances of the handling reactions recorded. After Sel administration took place the restaration of the handling reactions to normal level.