Conduction of clinical investigations: historic aspects and current state
The active formation of the rules for conducting clinical investigations (CI) by the international community began only in the middle of the 20th century. By that time, many facts of the grossest violation of ethical norms and the rights of CI subjects have been recorded. With the development of state and international structures for monitoring the conduct of clinical investigations, the situation improved and today there is a single set of rules for Good Clinical Practice (GCP). The literature review presents data on the historical development and modern approaches to conducting of clinical investigations.