Indicators of Immune Status, Cytokine Profile in Sickly Children and Optimization of Approaches to Prevention of ARI
The authors have investigated the level of lymphocyte subpopulation, immunoglobulins IgA, IgM, IgG and the concentration of 10 cytokines in blood serum of 67 sickly children. All of them have chronic somatic pathology. The authors have ascertained absence of significant differences in immunological indicators. When the level of subpopulation composition of lymphocytes and IgG, IgA, IgM in the blood serum is normal, such children have a higher concentration of antiphlogistic cytokines 1L-1 β, IL-12p70, IL-8 whereas the balance of Th/Th2-cells is preserved. It is kept up by cytokines IL-2, IFN-γ, TNF-α, IL-4, IL-5, IL-10 in the conditions of chronic inflammatory process. The maintenance of this balance is the main goal and it should provide the basis for immunological correction of sickly children with chronic somatic pathology. The most appropriate drug for immunological correction in our research is ribosomal immunоmodulator Ribomunyl.