Mitochondrial Dysfunctions'' Role in Pathogenesis of Different Liver Disorders
Objective of the Review: To analyze mitochondriaL dysfunctions' roLe in the development of Liver disorders of various etiology. Key Points: Obesity and reLated insuLin resistance (IR) contribute to the deveLopment of nonaLcohoLic fatty-Liver disease. InsuLin resistance enhances the production of free biLe acids, most of which are transported to the Liver. MitochondriaL oxidation of fatty acids is activated in order to reduce fat accumuLation in the Liver. If reguLation of the respiratory chain does not accompany these processes, an excessive formation of reactive oxygen species wiLL occur, resuLting in mitochondriaL dysfunction. The Latter is a key trigger of oxidative stress and the subsequent progression of hepatic steatosis. Conclusion: Understanding the mechanisms Leading to mitochondriaL dysfunction in Liver disorders can be a basic component in the deveLopment of optimaL diagnostic and therapeutic strategies.