Antibodies to <i>Yersinia </i>and serum cytokines in patients with diffuse toxic goiter with damage of the cardiovascular system
In 78 patients with diffuse toxic goiter and absence of clinical or anamnestic data about a history of yersiniosis, the levels of some cytokines (TNF-α, IL-8, IL-10) and antibodies to Y. enterocolitica and Y. pseudotuberculоsis were studied. As is shown, in patients with diffuse toxic goiter that had a prolonged course, large total volume of the thyroid gland, damage of the cardiovascular system diagnostic titres of antibodies to Yersinias were detected. The immunoblotting method was used to determine the class G antibodies to Yersinia antigens YopM (Yop2a), YopH (Yop2b), V antigen, YopD. In all patients with high diagnostic titres of antibodies in agglutination reaction IgG were detected. Considerable strain and imbalance of the cytokine system, prevalence of proinflammatory activation were revealed in patients with diffuse toxic goiter and with high titres of antibodies to Yersinias.