Vascular endothelium reactivity and its relationship with hemorheological and biochemical factors in patients with essential hypertension and exertional angina
Background. Vascular response, particularly reactive hyperemia lower than 10 % or even vasospasm. may be due not only to imbalance of vasoconstrictory and vasodilatory factors but also to impaired smooth muscle sensitivity to these factors. In addition, these processes may be also influenced by other endogenous predictors. Aim. To study the production pattern of endothelial vasoactive substances in reactive hyperemia and to determine the connection of these substances with changes in hemorheological and biochemical factors in healthy individuals and patients with essential hypertension (EH) and exertional angina (EA). Materials and methods. The study included IHD patients with FC II-III stable EA (n=60), patients with stage 1-2, grade 1-2 EH (n=50) and individuals without apparent disease (n=20). Severity of changes in hemostatic and hemorheological parameters and in endothelial factors was evaluated by comparing them before and after local ischemia. Results. In patients with EH and HF, endothelial production of vasoactive substances can be modified by qualitatively and quantitatively different endogenous factors due to different origin of EH and HF and features of metabolic shifts typical of these patients. Conclusion. Most of obtained multiple regression models can be used for identification of early predictors for endothelial dysfunction in resistance blood vessels and for determining additional therapeutic means for multimodal treatment of the mentioned above cardiovascular abnormalities.