Deficit deepening of naive T-cells CD4+ in patients with HIV infection when co-infected with hepatitis C virus
Objective. In patients infected with the human immunodeficiency virus (HIV) and co-infected with the hepatitis C virus (HCV), CD4+ T-cell deficiency is more pronounced compared to HIV monoinfected subjects, due to a reduction in their naive subpopulation. This work is devoted to establishing the causes of the development of insufficiency of these cells. Methods. Two groups of HIV-infected persons were examined: HIV+HCV+ (n=21) and HIV+HCV- (n=21) receiving antiretroviral drugs for more than two years (HIV level ALT-RTE =-0.590, pAST-RTE=-0.468, p-) naive CD4+ T-lymphocytes (R =-0.535, p<0.02). Conclusions. Thus, hepatitis activity and increased microbial translocation from the intestine in HIV/HCV co-infection may have a negative effect on the number of naive CD4+ T cells. Naive elements of varying degrees of maturity are apparently affected. Specific mechanisms for the formation of a deficit of naive CD4+ T-lymphocytes in HIV/HCV-co-infected individuals have yet to be established.