THE ROLLE OF GENETIC PREDISPOSITION FOR OCCUPATIONAL LIVER DISEASES IN WORKERS OF PETROCHEMICAL PLANTS
The aim of this study was to investigate the association of polymorphism of the glutathione-S-transferase genes with the risk of occupational liver diseases in workers of petrochemical plants. Materials and Methods. 544 DNA samples of petrochemical workers and 322 healthy persons DNA sample were used for genotyping by polymerase chain reaction and restriction fragment length polymorphism. Results. It was found that the genotype Val/Val of polymorphic locus rs1695 of GSTP1 gene is less common in patients with toxic hepatitis (χ2=4,405, р=0,036) than in healthy workers. Analysis of the association of polymorphic loci GSTM1 and GSTT1 with the development of occupational liver lesions revealed no statistically significant results. Conclusion. The data obtained suggest that the homozygous genotype Val/Val of polymorphic locus rs1695 of the GSTP1 gene is protective of the development of occupational toxic hepatitis.