A New Method for Synthesis of 2,4,6,8-Tetramethyl2,4,6,8-tetraazabicyclo[3.3.0]octan-3,7-dione Using Hydroxyethylene Diphosphic Acid as Catalyst for “Green Chemistry”
A new method for the synthesis of 2,4,6,8-tetramethyl-2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7-dione using hydroxyethylene diphosphonic acid (HEDP) as a catalyst for “Green chemistry” with a satisfactory yield of 62% is developed. A stepwise chemism of this process is proposed, which is partially confirmed by the NMR method using model processes for the formation of substances. In addition, the influence of the environment and the individual action of HEDP on the reaction components: 1,3-dimethylurea, 1,3-dimethyldihydroxyimidazolidin-2-one and 2,4,6,8-tetramethyl-2,4,6,8-tetraazabicyclo[303.0]octane-3,7-dione by 1H and 13C NMR in D2O in neutral, acidified solutions (AcOH- d 4) and in solutions containing one equivalent of HEDP was studied.