Heterogeneity of Mu-Opioid Receptors as One of the Factors Sensitive to Narcotic Analgesics
A concept of heterogeneity of mu1-opioid is considered. The morphological differentiation of receptors determined by genetic variations should be considered as the most important proposition of this concept. Genetic variations are polymorphisms of the mu1-opioid receptor gene and the phenomenon of alternative splicing. Precisely they determine the multiplicity of mu-receptor isoforms that differ b