IMMUNOHISTOCHEMICAL ANALYSIS IN THE ASSESSMENT OF LOCAL IMMUNE PATHOGENETIC MECHANISMS IN THE DEVELOPMENT OF ALOPECIA AREATA
The immune mechanisms of alopecia areata comprises a local CD4+-and CD8+ T cell-cytotoxic inflammatory response that triggers the fas-Fas-ligand pathways of hair follicle cell apoptosis, rapidly resulting in telogen. The cytotoxic response is maintained by a dysregulated immune response. The absence of immunoregulatory CD25/IL2Rα+-cells in the foci of baldness may be considered to be a condition for the development of autoimmunization while their presence is a prognostically good sign