LI-FRAUMENI SYNDROME: TP53-ASSOCIATED MULTIPLE PRIMARY MALIGNANT TUMORS
Li-Fraumeni syndrome belongs to a group of rear hereditary diseases and is characterized by high genetic and phenotypic heterogeneity. The paper reviews literature data concerning Li-Fraumeni syndrome, considers problems of clinical and genetic diagnosis of patients with Li-Fraumeni syndrome on the example of clinical cases with TP53-mutation associated multiple primary malignant tumors.