Studying the Pharmacological Activity of a Gel with a Lipophile Extract of Hop Silves
Introduction. Today, the market of drugs for the treatment and prevention of vaginitis and vaginosis is mostly represented by preparations based on substances of synthetic or semi-synthetic origin. Therefore, recently preference is given to drugs based on plant extracts, since they are close in structure to the metabolites of the human body and have a milder effect and less pronounced side effects. The aim of the research was to study the specific pharmacological activity of the gel based on the lipophilic extract of hop cones (LEHC). Materials and methods. The object of research was a gel based on lipophilic extract of hop cones (LEHC). The chemical composition of the raw material suggests the presence of anti-inflammatory, reparative, and other properties of the studied extract. That will help to reduce irritation of the vaginal mucosa (IVM), eliminate erosion and ulcers, accelerate regeneration processes on the vaginitis model caused by the action of mechanical factors. Results and discussion. The results showed that the five-day treatment of animals with the investigated agents after the last mechanical scarification weakened the symptoms of inflammation against the background of vaginitis. The therapeutic effect of the LEHC gel on vaginitis also manifested itself in the stabilization of trophic processes.The results of the research of hematological parameters on the 11th day of the experiment also indicate the suppression of IVM inflammation and their therapeutic effect by gel with LEHC. Normalized ESR and a decrease in the leukocyte count to the almost intact level, a recovery in leukocyte counts and an increase in hemoglobin and erythrocyte counts were observed.The effect of the gel with LEHC on the course of experimental “mechanical” vaginitis in rats was significantly positive, preventing the formation of pathological changes in inflammatory genesis in IVM, and reducing the signs of acute inflammation in the case of formed pathology.Conclusions. The findings suggest that the gel with LAHC showed pronounced anti-inflammatory activity in an experimental model of mechanical vaginitis. The gel with a lipophilic extract of hop cones has a pronounced therapeutic effect and, in terms of its pharmacological effect, is superior to the comparator drug - suppositories with sea buckthorn oil at a dose of 17.64 mg / kg.