GENETIC FEATURES OF XENOBIOTICS METABOLISM AND SUSCEPTIBILITY TO PATHOLOGY OF PREGNANCY. PART I
The vast majority of xenobiotics is able to influence the vital processes and causes the development of pathology. Pregnant women are especially susceptible to the toxic effects of environment xenobiotics. The genes of xenobiotic-metabolizing enzymes in women can provide good candidates for the role of predictors to pathology during pregnancy (recurrent miscarriage, premature births, intrauterine growth retardation and congenital malformation in fetus). In this part of review considers the known data on the effect of polymorphisms CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP2E1 genes and external factors (industrial pollution of air and water, smoking, diet) on the susceptibility to pathology in pregnant women.