ВПЛИВ C <sub>60</sub>-ФУЛЕРЕНУ НА ДИНАМІКУ ВТОМЛЮВАЛЬНИХ ПРОЦЕСІВ У КАМБАЛОПОДІБНОМУ М’ЯЗІ ЩУРА ПІСЛЯ ІШЕМІЇ-РЕПЕРФУЗІЇ
Effect of pristine C 60 fullerene aqueous colloid solution (C 60FAS; 1 mg/kg dose) on the dynamics of fatigue processes in rat soleus muscle after ischemia-reperfusion injury using the tensiometric method was studied. Experiments were conducted during the first 5 h and for 5 days after ischemia. The changes in maximal strength of muscle contraction and its level of generation between the beginning and end of stimulated irritation after intravenous and intramuscular administration of C 60FAS unmodified fullerene aqueous colloid solution were analyzed. The pronounced protective effect of this drug on the dynamics of skeletal muscle contraction was first determined. Protective effect of C 60FAS unmodified fullerene aqueous colloid solution relative to changes in the levels of muscle contraction strength generation between the beginning and end of stimulated irritation was 15% in the first 5 h after ischemia and increased to 92% on the 5 th day of the experiment. In such a case, the intravenous therapeutic administration of C 60 fullerene aqueous colloid solution was the most optimal: the protective effect was 67% versus 49% under intramuscular administration. Thus, the development of biomedical nanotechnology with the application of pristine C 60 unmodified fullerene as a strong antioxidant opens up new possibilities in prevention and treatment of ischemic injury in the skeletal muscles.