COMPARATIVE ANALYSIS OF LUNGS FUNCTION BY REGULATION OF ELECTROLYTES AT PATIENTS WITH DIFFERENT PATHOLOGY IN THE CRITICAL STATE
Aim. Carry out a comparative analysis of lung function by regulation of electrolytes in patients with different pathologies in critical states in dependence from hypocoagulating function. Materials and methods. In order to determine the participation of lungs in regulation of blood electrolytes were compared the patients in critical states with different pathologies : I group - 119 puerperas with hemorrhagic syndrome, complicated by acute renal failure (ARF), II - 85 patients with severe craniocerebral trauma (SCCT), III - 110 patients with bronchial asthma at bronhoastmatic state. The findings were compared with the control group (IV) - 20 healthy people. Lung function by regulation of blood electrolytes was determined by veno-arterial difference between mixed venous blood (MVB) and flowing arterial blood (FAB), taken simultaneously, by indicators of electrolytes - potassium, sodium - in plasma and erythrocytes and calcium. Results. At patients in critical states with different pathology observed disorders of water-electrolyte balance in the form of retention by light Na+ from plasma of the FAB. It points to the beginning of interstitial hypostasis of lungs, not yet manifested in the radiological examination of lungs. Process of retention of sodium by lungs has a direct correlation dependence with the degree of disorders of hypocoagulating lung function and severity of patients status, compounded from 1 to 3 group, which influences to severity of patients. Detected the process of transmineralization or «sick cell syndrome» during the transition of sodium into the cell and potassium from the cell, growing in more severe patients of 2-3 groups. Consumption by lungs of calcium from blood, as clotting factor, occurs particularly active from 1 group to 3 under all studied pathologies during disorders of hypocoagulating lung function. Conclusion. Determination of concentration of Na+ and K+ in plasma and erythrocytes, Ca2+ in plasma of MVB and FAB has diagnostic and prognostic value for determining and early diagnosis of interstitial hypostasis of lungs and cells transmineralization syndrome, and also status of hypocoagulating lung function in critical states, which makes possible to determine the severity of state and disease outcome.