AGE FEATURES OF CYTOGENETIC EFFECTS OF SPRING-SUMMER ENCEPHALITIS AMONG RESIDENTS OF NORTHERN WESTERN SIBERIA IN CONNECTION WITH POLYMORPHISM FOR GENES OF GLUTATHIONE-<i>S</i>-TRANSFERASE
The aim of this work was a comparative study of the effects of spring diseases cytogenetic years of tick-borne encephalitis in elderly and young age due to differences in genes of glutathione- S -transferase. Surveyed by routine cytogenetics 120 patients with tick-borne encephalitis residents North of Tomsk region. We have taken in the study persons aged 20-35 years (Group 1) and 65-85 years old (Group 2). Material for study (buccal epithelium) was taken from each subject 3-5 times: 1st-2nd day after hospitalization, in 1 week, 1, 3 and 6 months. Tick-borne encephalitis infection causes a signiﬁcantly large changes in cytogenetic regimens using buccal epithelium in the elderly than in younger patients. Restoring cytogenetic norms observed in a group of young in 3 months after hospitalization, in the elderly - in 6 months. When comparing cytogenetic effects of encephalitis shows: the young patients tick-borne encephalitis level by routine cytogenetics abnormal cells was signiﬁcantly higher in carriers of inactive forms of gene GSTM 1 (0)/ GSTT 1 (0) than containing active homozygous variants of these genes. Such patterns have not been noted in a group of elderly patients.