Acquired long QT syndrome and capability to use modern geno-phenotype studies as its predictors
Recently the long QT syndrome takes an important place among contemporary clinical cardiological problems, as it is associated with great risk of torsades de pointes and sudden cardiac death. The basis of this syndrome is slow repolarization resulted from impaired К+, Na+ и Са 2+ movement into and out of the cell. So, we consider it worthwhile to study the long QT syndrome in association with functional state of the cell membranes, which is evaluated by means of the rates of Na+-Li+-countertransport in erythrocyte membrane. Recent studies showed that patients with arrhythmia have different response to antiarrhythmic therapy in association with the rates of Na+-Li+-countertransport, and at its high rates significant QT prolongation is observed.