Synthesis, Structure and Biological Activity of Coordination Compounds of Copper, Nickel, Cobalt and Iron with Ethyl <i>N</i>'-(2-Hydroxybenzylidene)-<i>N</i>-prop-2-en1-ylcarbamohydrazonothioate
N -(Prop-2-en-1-yl)hydrazonocarbothioamide reacts with iodoethane in methanol with further addition of 2-hydroxybenzaldehyde to form hydroiodide of carbamohydrazonothioate (HL·HI). The coordination compounds were obtained by interaction of HL or HL·HI with copper, nickel, cobalt and iron salts CuLХ· n H2O [X = Cl-, Br-, NO3-; n = 0-1], Ni(L)2·HI·CH3OH, Сo(L)2X [X = I-, NO3-] and Fe(L)2NO3. The structures of three complexes were established by single crystal X-ray analysis. The synthesized complexes exhibit selective antimicrobial and antifungal activity against a series of standard microorganisms and fungi in the concentration range of 30-500 μg/mL. In addition, nickel and iron complexes selectively inhibit the growth and proliferation of cancer cells and do not adversely affect normal cells.