NOVEL DERIVATIVES OF ENT-BEYERAN DITERPENOID ISOSTEVIOL WITH OXIME AND THIOSEMICARBAZONE MOIETIES
Interaction of diterpenoid isosteviol (16-oxo- ent -beyeran-19-oic acid), methyl ester of isosteviol and 15-oxoisosteviol with the thiosemicarbazide has been studied. It is shown that 15-oxoisosteviol reacts with thiosemicarbazide and hydroxylamine only by means of the C 16=O group. 15-oxoisosteviol is established to inhibit the in vitro growth of Mycobacterium tuberculosis (H37R V) at MIC value 20µg/ml and to form complexes with Cu 2+.