Synthesis of substituted 6-benzyl- and 6-pyridinylmethyl-1, 2, 3, 4, 5, 6-hexahydroazepine [4,3-b] indoles
Optimal methods of obtaining and synthesis of previously unknown substituted 1, 2, 3, 4, 5, 6- hexahydroazepine [4, 3-b] indoles have been proposed and have been carried out. Some of obtained compounds have been discovered to manifest antihistamine properties and ability to effectively block the calcium channels. However, 1, 2, 3, 4, 5, 6-hexahydroazepine [4, 3-b] indoles are not active with respect to serotonine 5-HT6 receptors. Named biologic properties depend considerably on nature and amount of substituents in positions "2", "6" and "9" of the heterocyclic system. Structure of obtained compounds has been proved by 1H NMR spectroscopy and LCMS.