Study of the Efferts of Low Intensity Light Radiation in Red (A = 635 nm) and Green (A = 520 nm) Ranges on Proliferative <sup>v</sup> max <sup>7</sup><sup>v</sup> max <sup>7</sup> ~ Adivity and Gene Expression Profiles of MNNG/hos and Fetal Human Fibroblasts Cell Lines
It has been shown that a single exposure at low intensity (0.146 mW/cm2) with the red light (Amax = 635 nm) in a dose equal to 175.2 mJ/cm2 resulted in a slight stimulation of the fetal human fibroblasts cell culture growth and there has been no change in the proliferative activity of cultured fibroblasts upon irradiation by green light (Amax = 520 nm) with the same dose. The growth pattern of the transformed cells from MNNG/hos cell line remained unchanged under selected exposure modes. Both exposure modes altered gene expression profile in proliferation and osteogenic differentiation of fibroplast culture. In the transformed cells from MNNG/hos cells red light irradiation contributed to sternness gene expression, gene expression during osteogenic differentiation and the expression of cell death markers. The green light increased the transcriptional activity around cell death markers and checkpoints.