Еxperimental study of the diuretic activity among 7-substituted-3-methyl-8-morphlinoxanthines
The experimental study of influence on functional activity of kidney of 14 compounds among 7-substituted-3-methyl-8-morpholinoxanthines synthesized for the first time and also some mechanisms of this action were studied. The introduction of studied substances resulted in an increase of diuresis by 23,8-118,9% (р<0,05) for 8 hours of observation in albino rats. The most marked diuretic action was manifested by compound №8 - 3-methyl-7-( -chlorbenztenil-2) 8- morpholinoxanthines which excelled reference agents hydrochlorthiazide by 1,8 times. The mechanism of the diuretic effect of compound 1 is connected not only with a decrease of reabsorption and increase of excretion of sodium in realization of its pharmacodynemic effects.