Impact of genetic polymorphisms in the renin-angiotensin-aldosterone system on the expression of clinical signs of hypertrophic cardiomyopathy
Genetic polymorphisms in the renin-angiotensin-aldosterone system and clinical signs of hypertrophic cardiomyopathy in patients with this pathology were investigated. The influence of ACE gene I/D-polymorphism, CMA1 gene -1903A>G polymorphism and AGTR1 gene 1166A>C polymorphism on the severity of left ventricular hypertrophy was found, association II genotype of ACE gene and CT genotype of CYP11B2 gene with a greater severity of ischemic changes, and association DD genotype of ACE gene with increased QT dispersion was identified.