INFLUENCE OF THE BENZOFUROCAIN ON THE ACTIVITY OF KAL-LIKREIN-KININE, IMMUNE AND ENDOTHELIAL SYSTEMS IN GEN-ERALIZED PERIODONTITIS IN THE EXPERIMENT
In the work it has been shown that in the improvement of the stomatologic status and decreasing of the periodontal indexes under treatment of generalized periodontitis with non-narcotic analgesic benzofurakain leads the normalization of the activity prekallikrein- kallikrein system and decreasing of bradykinin synthesis. It has been established that anti-inflammatory action of benzofurakain occurs as a results of the decreasing of the content of proinflammatory cytokines and mediator of pain and inflammation, prostaglandin E2 (PGE2). The closed interrelationship between level of PGE2 and bradykinin (r = 0,8, p2, tumor necrosis factor a, endothelin-1 and prostaglandins.