THE STUDY OF AFFECTED TISSUES IN THE DYNAMICS OF CT ONCOHEMATOLOGICAL DISEASES
According to modern concepts, GENDER is the leading pathogenetic mechanism of the development of anthracycline lesions of myocardial tissues. Activation of free radical oxidation processes under the action of AA occurs due to the enzymatic conversion of quinones of anthracyclines into semiquinones, followed by their participation in a cascade of redox reactions, as well as due to the formation of a complex of anthracyclines with iron ions, which also enters into "redox cycling". Activation of the oxidation-reduction reaction cycle leads to the formation of superoxide anions, hydroxyl radicals and hydrogen peroxides. Increased sensitivity of heart tissues to active forms of oxygen is associated with a low level of activity of the myocardial AOS system. In order to identify the imbalance of the processes of POL and AOS and to identify the role of this disorder in the potentiation of anthracycline-induced myocardial lesions in the dynamics of CT oncohematological diseases, the concentration of TBK reactants and SOD activity in the blood serum was determined. The aim of the work was to study the role of the imbalance of the processes of POL and AOS in the potentiation of the cardiotoxic effect of anthracyclines in patients with acute hemoblastosis with concomitant coronary artery disease against a background of low AA CD 100-200 mg/m2.