ELECTRICAL ACTIVITY OF THE NEOCORTEX IN ADULT RATS AFTER PRENATAL HYPOXIA AND IN EPILEPSY MODEL
Changes in electrical activity of neocortex after prenatal hypoxia (day 14 of embryogenesis - E14, 7% O2 for 3 hours) and these combined with intracortical microinjection of epileptogenic 4-aminopyridine (4-AP) have been studied in adult rats. We analyzed the frequency-time parameters of electrocorticogram (ECoG) during sleep and wakefulness as well as spike-wave discharge (SWD) in 4-AP-induced epileptiform model. The results showed that in rats subjected to prenatal hypoxia the theta rhythm had a lower frequency and sleep spindles were characterized by lower spectral power in low-frequency domain in comparison with the control group. In rats with prenatal pathology delayed onset of epileptiform activity and altered frequency distribution of the spectral power of 4-AP-induced SWD were revealed.