What to do for Zollinger-Ellison Syndrome ?
- Zollinger-Ellison syndrome is a rare disorder that occurs when one or more tumors form in the pancreas and duodenum.  - Experts do not know the exact cause of Zollinger-Ellison syndrome.  - About 25 to 30 percent of gastrinomas are caused by an inherited genetic disorder called multiple endocrine neoplasia type 1 (MEN1).  - Although anyone can get Zollinger-Ellison syndrome, the disease is more common among men 30 to 50 years old.  - Zollinger-Ellison syndrome signs and symptoms are similar to those of peptic ulcers.  - Some people with Zollinger-Ellison syndrome have only diarrhea, with no other symptoms. Others develop gastroesophageal reflux (GER).  - A health care provider diagnoses Zollinger-Ellison syndrome based on the following:      - medical history    - physical exam    - signs and symptoms    - blood tests    - upper gastrointestinal (GI) endoscopy    - imaging tests to look for gastrinomas    - measurement of stomach acid    - A health care provider treats Zollinger-Ellison syndrome with medications to reduce gastric acid secretion and with surgery to remove gastrinomas. A health care provider sometimes uses chemotherapymedications to shrink tumorswhen tumors are too widespread to remove with surgery.