What are the symptoms of Schnitzler syndrome ?
What are the signs and symptoms of Schnitzler syndrome? The signs and symptoms of Schnitzler syndrome vary but may include: Red raised patches of skin (urticaria) that may become itchy Recurrent fevers Join pain and inflammation Organomegaly (enlarged internal organs) often involving the lymph nodes, liver and/or spleen Bone pain Blood abnormalities Muscle aches Fatigue Weight loss People affected by Schnitzler syndrome also have an increased risk of developing certain lymphoproliferative disorders. The Human Phenotype Ontology provides the following list of signs and symptoms for Schnitzler syndrome. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Abnormal immunoglobulin level 90% Abnormality of temperature regulation 90% Arthralgia 90% Arthritis 90% Bone pain 90% Hepatomegaly 90% Increased bone mineral density 90% Lymphadenopathy 90% Myalgia 90% Splenomegaly 90% Urticaria 90% Anemia 50% Leukocytosis 50% Lymphoma 7.5% Peripheral neuropathy 7.5% Pruritus 7.5% Vasculitis 7.5% The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.