What are the genetic changes related to Crouzonodermoskeletal syndrome ?
Mutations in the FGFR3 gene cause Crouzonodermoskeletal syndrome.  The FGFR3 gene provides instructions for making a protein that is involved in the development and maintenance of bone and brain tissue. It remains unclear how a mutation in the FGFR3 gene leads to the characteristic features of Crouzonodermoskeletal syndrome. This genetic change appears to disrupt the normal growth of skull bones and affect skin pigmentation.