Break is a type of Flee. Break is related to Take. 
Virus can cause/lead to Disease. Stroke is a type of Disease. Stroke is related to Brain. Brain is related to Reason. 
Flee <--IsA-- Break <--RelatedTo--> Take 
Virus --Causes--> Disease <--IsA-- Stroke <--RelatedTo--> Brain <--RelatedTo--> Reason 