Cancer can cause/lead to Death. Death is related to Fate. Fate is related to Twist. Twist is related to Tighten. 
Select is related to Appoint. Pack is a type of Appoint. Pack is related to Group. Family is a type of Group. 
Cancer --Causes--> Death <--RelatedTo--> Fate <--RelatedTo--> Twist <--RelatedTo--> Tighten 
Select <--RelatedTo--> Appoint <--IsA-- Pack <--RelatedTo--> Group <--IsA-- Family 