Instruction is a synonym of Direction. Direction is related to Sail. 
Load is the opposite of Write. Write is related to Make. Make is related to Trouble. Trouble is related to Apple. 
Instruction <--Synonym--> Direction <--RelatedTo--> Sail 
Load <--Antonym--> Write <--RelatedTo--> Make <--RelatedTo--> Trouble <--RelatedTo--> Apple 