Regulate is a synonym of Determine. Format is a type of Determine. Format is a type of Information. 
Reader is a type of Textbook. Reader is the opposite of Writer. Writer is a type of Artist. Artist is related to Studio. 
Regulate <--Synonym--> Determine <--IsA-- Format --IsA--> Information 
Textbook <--IsA-- Reader <--Antonym--> Writer --IsA--> Artist <--RelatedTo--> Studio 