Cause is related to Affect. Affect is a synonym of Overcome. 
Reason is a type of Fact. Fact is the opposite of Voice. Voice is related to Beautiful. Beautiful is the opposite of Poor. 
Cause <--RelatedTo--> Affect <--Synonym--> Overcome 
Reason --IsA--> Fact <--Antonym--> Voice <--RelatedTo--> Beautiful <--Antonym--> Poor 