Significant is a synonym of Meaningful. Meaningful is derived from Meaning. Meaning is related to Symbol. Symbol is related to Add. 
Surgeon is related to Operation. Operation is related to Opening. 
Significant <--Synonym--> Meaningful --DerivedFrom--> Meaning <--RelatedTo--> Symbol <--RelatedTo--> Add 
Surgeon <--RelatedTo--> Operation <--RelatedTo--> Opening 