Limb is related to Bone. Bone is related to Flesh. 
Make is a type of Estimate. Give is a type of Estimate. Give is related to Donation. Donation is related to Donor. 
Limb <--RelatedTo--> Bone <--RelatedTo--> Flesh 
Make --IsA--> Estimate <--IsA-- Give <--RelatedTo--> Donation <--RelatedTo--> Donor 