Resign is a type of Accept. Accept is a synonym of Estimate. Estimate is related to Guess. Suspect is a type of Guess. 
Biological is the opposite of Adopt. Adopt is a type of Choose. Choose is related to Menu. 
Resign --IsA--> Accept <--Synonym--> Estimate <--RelatedTo--> Guess <--IsA-- Suspect 
Biological <--Antonym--> Adopt --IsA--> Choose <--RelatedTo--> Menu 