Substantial is a synonym of Solid. Ice is a type of Solid. Ice is related to Liquid. Vaccine is a type of Liquid. 
Guide is related to Helpful. Helpful is a synonym of Christian. Christian is related to Heaven. Heaven is the opposite of Horror. 
Substantial <--Synonym--> Solid <--IsA-- Ice <--RelatedTo--> Liquid <--IsA-- Vaccine 
Guide <--RelatedTo--> Helpful <--Synonym--> Christian <--RelatedTo--> Heaven <--Antonym--> Horror 