Manufacturer is related to Make. Make is related to Profit. Profit is related to Earnings. 
Dose is a type of Medicine. Medicine is related to Disease. Disease is related to Effect. 
Manufacturer <--RelatedTo--> Make <--RelatedTo--> Profit <--RelatedTo--> Earnings 
Dose --IsA--> Medicine <--RelatedTo--> Disease <--RelatedTo--> Effect 