Nature is related to Outside. Outside is similar to Outer. Outer is the opposite of Middle. 
Reply is related to Put. Put is related to Matter. you are likely to find Matter in/at/on Universe. 
Nature <--RelatedTo--> Outside <--SimilarTo--> Outer <--Antonym--> Middle 
Reply <--RelatedTo--> Put <--RelatedTo--> Matter --AtLocation--> Universe 