Frame is a type of Application. Application is related to Apply. Apply is a synonym of Practice. 
Exit is the opposite of Door. Door is related to Post. Post is a different concept from Mail. Mail is related to Office. 
Frame --IsA--> Application <--RelatedTo--> Apply <--Synonym--> Practice 
Exit <--Antonym--> Door <--RelatedTo--> Post <--DistinctFrom--> Mail <--RelatedTo--> Office 