Acknowledge is a synonym of Confirm. Confirm is a type of Strengthen. 
Do is a different concept from Refuse. you are likely to find Refuse in/at/on Dump. Dump is related to Trash. 
Acknowledge <--Synonym--> Confirm --IsA--> Strengthen 
Do <--DistinctFrom--> Refuse --AtLocation--> Dump <--RelatedTo--> Trash 