Manipulate is a type of Treat. Administer is a type of Treat. Administer is a synonym of Deal. 
Activity is related to Smell. one thing you do when you Smell is Shower. Shower is related to Clean. Brush is a type of Clean. 
Manipulate --IsA--> Treat <--IsA-- Administer <--Synonym--> Deal 
Activity <--RelatedTo--> Smell --HasSubevent--> Shower <--RelatedTo--> Clean <--IsA-- Brush 