Indicator is a type of Signal. Indicator is related to Note. Note is related to Comment. 
Hypothesis is a type of Concept. Hypothesis is a type of Proposal. Proposal is related to Date. Date is related to Blind. 
Signal <--IsA-- Indicator <--RelatedTo--> Note <--RelatedTo--> Comment 
Concept <--IsA-- Hypothesis --IsA--> Proposal <--RelatedTo--> Date <--RelatedTo--> Blind 