Huge is a synonym of Massive. Massive is a synonym of Significant. Significant is related to Partner. Partner is a synonym of Spouse. 
Multiple is related to Reaction. Reaction is related to Panic. Panic is related to Running. 
Huge <--Synonym--> Massive <--Synonym--> Significant <--RelatedTo--> Partner <--Synonym--> Spouse 
Multiple <--RelatedTo--> Reaction <--RelatedTo--> Panic <--RelatedTo--> Running 