Number is related to Addition. Addition is related to Cream. Cream is related to Food. 
Issue is a type of Store. Issue is related to Problem. Problem is related to Answer. Answer is the opposite of Guess. 
Number <--RelatedTo--> Addition <--RelatedTo--> Cream <--RelatedTo--> Food 
Store <--IsA-- Issue <--RelatedTo--> Problem <--RelatedTo--> Answer <--Antonym--> Guess 