Subject is a synonym of Item. Item is related to Coat. Button is part of Coat. 
Work requires Concentrate. Work is related to Burden. Pill is a type of Burden. Pill is related to Control. 
Subject <--Synonym--> Item <--RelatedTo--> Coat <--PartOf-- Button 
Concentrate <--HasPrerequisite-- Work <--RelatedTo--> Burden <--IsA-- Pill <--RelatedTo--> Control 