Application is related to Apple. Apple is related to Doctor. Doctor is a type of Treat. Manipulate is a type of Treat. 
Arrow is a type of Film. Hire is a type of Film. Sign is a type of Hire. 
Application <--RelatedTo--> Apple <--RelatedTo--> Doctor --IsA--> Treat <--IsA-- Manipulate 
Arrow --IsA--> Film <--IsA-- Hire <--IsA-- Sign 