Sequence is a type of Determine. Determine is a synonym of Arrange. 
Intense is related to Profound. Profound is a synonym of Fundamental. Fundamental is similar to Significant. Significant is a synonym of Historic. 
Sequence --IsA--> Determine <--Synonym--> Arrange 
Intense <--RelatedTo--> Profound <--Synonym--> Fundamental <--SimilarTo--> Significant <--Synonym--> Historic 