Agency is related to Central. Central is related to Middle. Middle is a different concept from Beginning. Birth is a type of Beginning. 
you are likely to find Basement in/at/on Building. you are likely to find Mouse in/at/on Building. Mouse is a type of Manipulate. 
Agency <--RelatedTo--> Central <--RelatedTo--> Middle <--DistinctFrom--> Beginning <--IsA-- Birth 
Basement --AtLocation--> Building <--AtLocation-- Mouse --IsA--> Manipulate 