Overall is a synonym of Big. Big is related to House. 
Trouble is related to Circumstance. Circumstance is a synonym of Condition. Condition is related to Disease. Suicide is a type of Disease. 
Overall <--Synonym--> Big <--RelatedTo--> House 
Trouble <--RelatedTo--> Circumstance <--Synonym--> Condition <--RelatedTo--> Disease <--IsA-- Suicide 