Which of the following is not a characteristic feature of multiple myeloma?
(A) Increased Ig levels in serum (B) Positive ANA (C) Plasmacytosis (D) M spike on electrophoresis
(B) Ans. B. Positive ANASerum electrophoresis: Abnormal spike in the region of gamma globulin (myeloma spike) is present in 90% of cases.* Bone marrow plasmacytosis in multiple myeloma is characteristically more than 30%.* The immunoglobulin least commonly involved in Multiple Myeloma is IgD.* The immunoglobulin most commonly involved in Multiple Myeloma is IgG. - Low haemoglobin, - high ESR (usually very high), - increased total protein, - A/G ratio reversed, - increased serum calcium, - normal alkaline phosphatase. - Urine: Bence Jones proteins are found in 30% of cases.