A patient of HIV is on treatment with indinavir, zidovudine, lamivudine and ketoconazole. He developed nephrolithiasis, hyperlipidemia, central obesity, hyperglycemia and insulin resistance. Which of the following drug is likely to produce above adverse effects?
(A) Lamivudine (B) Indinavir (C) Zidovudine (D) Ketoconazole
(B) Protease inhibitors (-navirs) can cause lipodystrophy syndrome characterized by weight gain, increased glucose, increased lipids and insulin resistance. Lipodystrophy syndrome can also be caused by anti-psychotic drugs. Special side effects of various protease inhibitors: Indinavir: Renal stones Tipranavir: Intracranial hemorrhage Saquinavir: QT prolongation. Atazanavir: Hyperbilirubinemia.