Which of the following disease modifying anti-rheumatoid drugs acts by increasing extracellular adenosine?
(A) Leflunomide (B) Hydroxychloroquine (C) Azathioprine (D) Methotrexate
(D) Answer-D. Methotrexate"Methotrexate is the DMARD of choicefor the treatment of RA and is the anchor drug for most combination therapies.At the dosages ased for lhe treatment of RA, methotrexale has been shown to stimulate adenosine release from cells, producing an anti-inflammatory effect.Methotrexate (MTX) is a folic acid analog that binds with high affinity to the active catalytic site of dihydrofolate reductase (DHFR).