In iron poisoning drug Desferoxamine is given.what is its mechanism of action -
(A) By binding with trivalent Fe3+ (B) -by inhibiting Hepcidin (C) -by inhibiting DMT1 (D) -by inhibiting ferropoin
(A) Ans. A. By binding with trivalent Fe3+Deferoxamine works in treating iron toxicity by binding trivalent (ferric) iron (for which it has a strong affinity), forming ferrioxamine, a stable complex which is eliminated the kidneys.100 mg of deferoxamine is capable of binding approximately 8.5 mg of trivalent (ferric) iron.Deferoxamine works in treating aluminum toxicity by binding to tissue-bound aluminum to form aluminoxamine, a stable, water-soluble complex.The formation of aluminoxamine increases blood concentrations of aluminum, resulting in an increased concentration gradient between the blood and dialysate, boosting the removal of aluminum during dialysis.100 mg of deferoxamine is capable of binding approximately 4.1 mg of aluminum.