Anti-centromere antibodies are seen in which of the following conditions?
(A) Drug-induced lupus (B) SLE (C) Sjogren syndrome (D) Scleroderma
(D) It is seen in Systemic Sclerosis (Scleroderma). Limited form of scleroderma known as CREST syndrome is characterised by presence of anti-centromere antibodies positive and generalized form shows anti-topoisomerase antibodies Anti-histone antibodies are positive in drug-induced lupus. Anti-SS-A (RO) antibodies and anti-SS-B(LA) antibodies are positive in Sjogren's Syndrome. Most specific in SLE: anti ds-DNA and Anti-Smith antibodies