Which of the following hormones will be affected most after the change in sex hormone binding globulin?
(A) Testosterone (B) Estrogen (C) Progesterone (D) DHEA
(A) Ans: A. Testosterone(Ref Ganong 25/e p 422, 24/e p424; Harper 30/e p 516. 517)Testosterone binds to SHBG with higher affinity than does estradiol.Hence SHBG level change a Greater change in free testosterone level than in free estradiol.Sex hormone binding globulin:Glycoprotein binding sex steroids with high affinity as.Order:DHT>Testosterone>>Esterone/ estradiol. Due to higher SHBG affinity for DHT & Testosterone, SHBG variation has profound effects on androgens levels.