Children with germline retinoblastoma are more likely to develop other primary malignancies in their later lifetime course. Which of the following malignancy can occur in such patients?
(A) Osteosarcoma of lower limbs (B) Thyroid carcinoma (C) Seminoma (D) Renal cell carcinoma
(A) Answer- A. Osteosarcoma of lower limbsChildren with germline retinoblastoma are more likely to develop other primary malignancies in their later lifetime course.Osteosarcoma of lower limbs can occur in such patients.Retinoblastoma Syndrome (Primary site malignancy)- Familial Retinoblastoma