Which of the following finding are there in iron deficiency anemia?
(A) | TIBC, | Ferritin, | Transferrin saturation (B) | TIBC, | Ferritin, | Transferrin saturation (C) | TIBC, | Ferritin, | Transferrin saturation (D) | TIBC, | Ferritin, | Transferrin saturation
(A) The diagnosis of iron deficiency anemia ultimately rests on laboratory studies. The serum iron and ferritin are low, and the total plasma iron-binding capacity (reflecting elevated transferrin levels) is high. Low serum iron with increased ironbinding capacity results in a reduction of transferrin saturation to below 15%. Reduced iron stores inhibit hepcidin synthesis, and its serum levels fall.