Iron entry into enterocytes occurs which of the following?
(A) DMT-1 (B) Ferropoin (C) Transferrin (D) Hepcidin
(A) GI Luminal non-heme iron is mostly in the Fe3+ (ferric) state and must first be reduced to Fe2+ ferrous) iron by ferrireductases, such as b cytochromes and STEAP3. Fe2+ iron is then transpoed across the apical membrane of enterocytes by divalent metal transpoer-1 (DMT1).