A 40 year male complaining of hot flushes each time he baths. Hb: 20%gm, Platelet: 89,000/mL, WBC: 30,000/mL, Investigation revealed JAK2 mutation. What is the most likely diagnosis?
(A) PMF (B) CML (C) PCV (D) Essential thrombocytosis
(C) diagnosis Polycythemia Vera Polycythemia | platelet | WBL | | RBC | JAK2 mutation Polycythemia Vera | WBC | Basohils | histamine release - contribute to hot flushes or itching Every time patient takes bath (aquagenic pruritis) impoant diagnostic feature: Serum erythropoietin level below normal. Impoant diagnostic feature: Serum erythropoietin level below normal. Rx=Hydroxyurea Cells count control Option A- PMF Should show SplenoHepatomegaly Pancytopenia No TLC RBC drop mentioned Option B- CML ||| WBL upto 1 lakh Jak2 must along with bcr-abl fusion transcription present. Option D- Essential thrombocytosis Leads to |only platelet count initially other counts will increase Later significant increase in platelet count upto 5-6 lakh approx.: less in our of answer.