Which of the following is true about intracellular iron homeostasis in iron deficiency anemia?
(A) Transferrin receptor-1 iron responsive elements increase transferrin receptor mRNA concentration and synthesis (B) Transferrin receptor-1 iron responsive elements decrease transferrin receptor mRNA concentration and synthesis (C) Apoferritin mRNA iron response element decreases and ferritin synthesis decreases (D) Apoferritin mRNA iron response element decreases and ferritin synthesis increases
(A) Answer- A. Transferrin receptor-1 iron responsive elements increase transferrin receptor mRNA concentration and synthesisIn iron deficiency anemia, transferrin receptor-I iron responsive elements increase transfetin receptor mRNA concentration and synthesis."The regulation of iron metabolism at the cytoplasmic mRNA level by interaction of iron regulalory protein (IRP-I) and the iron-responsive elements (IREs) to apoferritin mRNA and transferrin receptor mRNA. When the cytoplasmic iron concentration is low, IRP-I binds to the IREs of both mRNAs.