A 6-month child presented with diarrhea and vomiting for three days. Which of the following enterotoxin is most likely responsible for the condition?
(A) NSP4 (B) NSP6 (C) VP3 (D) VP7
(A) Ans. A. NSP4Rotavirus nonstractural protein 4 (NSP4) is known to function as an intracellalar receptor at the endoplssmic reticalam (ER) critical to virul morphogenesis and is the first characterized virul enterotoxin.The associntion of NSP4 snd cuveolin-I contributes to NSP4 intrqcellular trfficking from the ER to the cell surfuce and speculate that exogenously added NSP4 stimulutes sigaaling molecules located in caveola microdomains.