All of the following are potentially serious side effects of thioamide group of antithyroid drugs except:
(A) Hepatic dysfunction (B) Severe rash (C) Agranulocytosis (D) Anaphylaxis
(D) Ans: D. Anaphylaxis(Ref. Goodman Gilman 12/e p1149; Katzung 13/e p671, 12/e p688)Adverse effects of anti-thyroid drugs:Most serious reaction: AgranulocytosisMC reaction: Mild, purpuric, uicarial papular rash.Less frequent complications: Pain & stiffness in joints, paresthesias, headache, skin pigmentation & loss of hair.ANCAs in -50% of patients receiving propylthiouracil.Cholestatic jaundice - More common with methimazole than propylthiouracil.Propylthiouracil-associated hepatic failure.