For which of the following is PPV-23 is most beneficial:
(A) Cystic fibrosis patient (B) Sickle cell anemia patient (C) Patient with recurrent rhinitis and sinusitis (D) Child less than 2 years
(B) Repeated microinfarction can destroy tissues having micro vascular beds prone to sickling. Thus splenic function is frequently lost within 18-36 months of life causing susceptibility to infection paicularly by pneumococci. So ( PPV-23) polysaccharide pneumococcal vaccine is beneficial in sickle cell anemia.