Which are all the factors determining the GFR?
(A) Afferent aeriolar resistance (B) Efferent aeriolar resistance (C) Aerial pressure (D) All of the above
(D) Ans. D. All of the aboveDeterminants of GFR:Increase glomerular capillary hydrostatic pressure increases GFR. Glomerular hydrostatic pressure is determined by the following variables : i) Aerial pressure, ii)Afferent aeriolar resistance; iii) Efferent aeriolar resistance.Contraction of mesangial cells (therefore decrease in GFR) is produced by : - Endothelin, angiotensin II, vasopressin, norepinephrine, PAF, PDGF, thromboxane A2,PGF2, Leukotrienes C4 & D4, Histamine.