Most commonly implicated drug for acute liver failure is -
(A) Paracetamol (B) Valproate (C) Warfarin (D) Tetracyclines
(A) Ans. A. Paracetamol Acute liver failure after administration of paracetamol at the maximum recommended daily dose in adults.Paracetamol is the most commonly used analgesic and antipyretic in the world; it can be bought without prescription in most countries despite being the commonest cause of acute liver failure in western Europe.Prescribing information suggests that it is safe to use in adults in divided doses that total 4 g daily.Malnutrition, starvation, chronic alcohol misuse, and concomitant use of drugs that induce cytochrome P450 enzymes increase the risk of hepatotoxicity induced by paracetamol.