Which of the following cannot be diagnosed without positive ANA?
(A) Drug induced lupus (B) SLE (C) Sjogren syndrome (D) Scleroderma
(B) Repeated negative testing for ANA indicates least chances of having SLE. ANA is positive in 98% of patients with SLE Limited form of scleroderma known as CREST has anti centromere antibody positive and generalized form has anti topoisomerase positive antibody Anti histone antibodies are positive in drug induced lupus Anti SS-A (RO) antibodies and anti SS-B(LA) antibodies are positive in Sjogren's Syndrome