Which vitamin is required for glycogen Phosphorylase?
(A) PLP (B) TPP (C) Riboflavin (D) Lipoic acid
(A) Glycogen phosphorylase is the rate limiting enzyme of glycogenolysis. And it requires PLP. The active form of vitamin B6 is the coenzyme pyridoxal phosphate (PLP) PLP can be synthesized from the three compounds pyridoxine, pyridoxal and pyridoxamine. This PLP for this enzyme Glycogen phosphorylase is not required as co-enzyme, but it act as a phosphate donor. Enzyme glycogen phosphorylase will cut glycogen a (1-4) bond apa and the glucose released are transferred in Glucose-1-phosphate and that phosphate is taken from PLP.