Which of the following is clinical use of tafenoquine?
(A) Radical cure of Plasmodium vivax (B) Prophylaxis of malaria in pregnancy (C) Treatment of severe falciparum malaria (D) Treatment of endemic malaria in children < 2 years
(A) Radical cure - About 8-30% P.v. cases relapse due to persistance of exoerythrocytic stage. Drugs which attack this stage (hypnozoites) given together with a clinical curative achieve total eradication of the parasite from the patient's body. Drug of choice for radical cure of vivax and ovale malaria is: * Primaquine 15 mg daily for 14 days * Tafenoquine is a new long-acting exoerythrocytic schizontocide, has been developed as a single dose anti-relapse drug for vivax malaria.