Ganglionic transmission is mediated by:
(A) Presynaptic alpha-receptors (B) Postsynaptic beta-receptors (C) Postsynaptic dopaminergic receptors (D) Postsynaptic nicotinic receptors
(D) Ans: D .Postsynaptic nicotinic receptors(Ref: Goodman Gilman 13/e p108, 12Ie p255; Katzung 13Ie p108, 12/e p98).Ganglionic transmission is mediated by nicotinic receptors present post-synaptically.Nicotinic acetylcholine (ACh) receptor mediates neurotransmission post-synaptically at the neuromuscular junction and peripheral autonomic ganglia.In CNS, controls release of neurotransmitters from presynaptic sites.The receptor is called the nicotinic acetylcholine receptor - Due to both alkaloid nicotine & neurotransmitter ACh can stimulate the receptor.