All are true for the following about methanol poisoning EXCEPT:
(A) Fomepizole is a competitive inhibitor of aldehyde dehydrogenase (B) Minimum lethal dose of methanol is 1.25 ml/kg body weight (C) Formic acid is mainly responsible for toxicity (D) Methanol causes snow field vision
(A) Answer- a-Fomepizole is a competitive inhibitor of aldehyde dehydrogenaseFomepizole:Fomepizole (4-methylpyrazole) is a specifc inhibitor of alcohol dehydrogenase- retards methanol metabolismLoading dose is 15 mglkg IV followed by l0 mg/kg every 12 hours till serum methanol falls below 20 g/dl, has been found effective and safe.Minimum lethal dose of methanol is 1.25mVkg body weight: Minimum lethal dose of methanol is 0.3-1.0 gm/kgFormic acid is malnly rcsponsible for toxicity:The methyl alcohol poisoning there is CNS depression, cardiac depression and optic nerve atrophy. These effects are produced due to Formaldehyde and formic acid.The specifc toxicity of formic acid is retinal damage.