Translocation seen in Ewing's sarcoma is:
(A) t(8,11) (B) t(11,22) (C) t(11,18) (D) t(14,18)
(B) Ans: B. t(11,22)Genetic exchange between chromosomes can cause cells to become cancerous. Most cases of Ewing's sarcoma (85%) are the result of a translocation between chromosomes 11 and 22, which fuses the EWS gene of chromosome 22 to the FLI1 gene of chromosome 11. Other translocations are at t(21;22) and t(7;22).