Storage of drug in the tissues is suggested by:
(A) Large volume of distribution (B) Small volume of distribution (C) Excretion in urine (D) Excretion in saliva
(A) Answer- A. Large volume of distributionVolume of distribution (VD) is the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration, which is observed in the blood plasma.The VD of a drug represents the degree to which a drug is distributed in body tissue rather than the plasma.VD is directly correlated with the amount of drug distributed into tissue; a higher VD indicates a greater amount of tissue distribution.A VD greater than the total volume of body water (approximately 42 liters in humans) is possible, and would indicate that the drug is highly distributed into tissue