Which of the following is not glucogenic?
(A) Pyruvate (B) Oxaloacetate (C) Acetyl-CoA (D) Lactate
(C) Ans: C. Acetyl-CoA(Ref. Harper 30/e p185, 29/e p187)Acetyl CoA is not a substrate for gluconeogenesis (not glucogenic) and cannot be conveed back to glucose."Acetyl CoA is not a substrate for gluconeogenesis and cannot be conveed back to glucosee. This is because acetyl CoA cannot be conveed back to pyruvateQ since its carbon backbone is lost in citric acid cycle as CO2."