Steroids do not have a role in management of which of these tumors?
(A) Kaposi sarcoma (B) Chronic lymphoid leukemia (C) Hodgkin's lymphoma (D) Multiple myeloma Gram-stain, oropharynx
(A) Ans: A. Kaposi sarcoma(Ref Harrison 19/e p1270, 716; Goodman Gilman I2/e p1755; Katzung 13/e p954-955, 12/e p706: KDT 7/e p284-285, 6/e p285)Steroids - Therapeutic uses in cancer:Used as cytotoxic agents in treatment of acute leukemia in children & malignant lymphoma in children & adults.Component of curative regimens for Hodgkin's & non-Hodgkin's lymphoma, multiple myeloma & CLL.Glucocoicoids - Extremely helpful in controlling autoimmune hemolytic anemia & thrombocytopenia associated with CLL.Dexamethasone - Used in conjunction with radiotherapy - Reduces edema related to tumors in critical areas such as superior mediastinum, brain & spinal cords.