Direct Coombs test is positive in all the following except:
(A) Hemolytic anemia due to transfusion (B) Hemolytic anemia due to transfusion (C) Aplastic anemia (D) Drug-induced AIHA
(C) Ans: C. Aplastic anemia(Ref: Robbins 9/e p643).Direct Coomb's test is negative in aplastic anemia.Direct Coomb's testAlso known as direct antiglobulin testdegDetect antibodies of complement bound to RBC surfaceantigens in vivodeg.It is used for:Immune-mediated hemolytic anemia degHemolytic disease of the newborndegRh D-hemolytic disease of the newborn degABO hemolytic disease of the newborndegDrug-induced immune-mediated hemolysisdegMismatch transfusion reactiondeg.