Which of the following is true?
(A) Latanoprost is used with caution in patients of bronchial asthma (B) Topiramate can cause bilateral angle closure glaucoma (C) Methazolamide causes decrease in ocular blood flow (D) Central scotoma is seen in open angle glaucoma
(B) 1. Bronchial asthma pt. we have to avoid b - blockers, therefore , latanoprost cannot be used in bronchial asthma. Latanoprost can be used in: Herpes Uveitis Cystoid macular edema 2. Topiramate is a sulfa derivative They increase the vascularity of the cilio choroidal circulation due to which the ciliary body and choroid plexus swells up and it pushes the lense forward and it blocks the angle by pushing the iris forward leading to drug induced angle closure glaucoma. 3. Methazolamide is a carbonic anhydrase inhibitor Increases the ocular blood flow Used in low tension glaucoma 4. Central scotoma - seen in optic neuritis / toxic neuritis / toxic amblyopia. 5. Paracentral scotoma - seen in open angle glaucoma.