Which of the following drugs is a P-glycoprotein inducer?
(A) Azithromycin (B) Ketoconazole (C) Itraconazole (D) Rifampicin
(D) Answer- D. RifampicinRifampicin induces the isoenqymes CYP3A4, 2C8, 2C9, 2CI9, 286, and the transpoer P-glycoprotein. When coadministeredwith drugs that are substrates of the same enzymes, their metabolism may be accelerated resulting in lowerconcentration and less efficacy.Inducer-AmprenavirClotrimazoleDexamethasoneIndinavirMorphineNelfinavirPhenothiazineRetinoic acidRifampinRitonavirSaquinavirSt John's wo