All are Gp lIbilIla inhibitors except:
(A) Prasugrel (B) Abciximab (C) Tirofiban (D) Eptifibatide
(A) Ans: A. Prasugrel(Ref Goodman Gilman 13/e p595, 12/e p870; Katzung 13/e p595, 12Ie p612; KDT 7/e p631)Prasugrel reduce platelet aggregation by inhibiting the ADP pathway of platelets. It irreversibly blocks the ADP receptor on platelets.Targets for platelet inhibitory drugs:Inhibition of prostaglandin synthesis (aspirin).Inhibition of ADP- induced platelet aggregation (clopidogrel, prasugrel, ticlopidine).Blockade of glycoprotein Ilb/IIIa receptors on platelets (abciximab, tirofiban, and eptifibatide). Dipyridamole & cilostazol - Additional antiplatelet drugs.