Which of the following is anaplastic lymphoma kinase (ALK) positive neoplasm?
(A) Synol sarcoma (B) Fibromatosis (C) Ewing sarcoma (D) Inflammatory myofibroblastic tumor
(D) Answer- D. Inflammatory myofibroblastic tumorInflammatory myofibroblastic tumor is anaplastic lymphoma kinase (ALK) positive neoplasm.Inflammatory myofibroblastic tumor, though rare, is more common in children, with an equal male-to-female ratio.Presenting symptoms include fever, cough, chest pain, and hemopytsis. It may also be asymptomatic.Anaplastic Lymphoma Kinase (ALK)- Anaplastic lymphoma kinase also known as ALK tyrosine kinase receptor or CD246 (cluster of diff-erentiation 246) is an enzyme that in humans is encoded by ALK gene.Anaplastic Lymphoma Kinase (ALK) Positive NeoplasmsAnaplastic large-cell lymphomasAdenocarcinoma of lungFamilial neuroblastomaInflammatory myofibroblastic tumor