A new marker for mantle cell lymphoma especially useful in Cyclin DI negative cases is:
(A) SOX 11 (B) Annexin V (C) MYD88 (D) ITRA I
(A) Answer- A. SOX 11SOXII expression h a highly specific for mantle cetl lymphoma and identifies the cyclin Dl-negative subtype.Mantle Cell Lymphoma (MCL)Immunophenotype:CD20 CD79a & PAX-5 positive establish B lineageCD5, CD43, FMC-7, cyclin Dl & SOX11 positiveSurface IgM & IgD positiveCDS+ve & CD23 -ve which help to distinguish it from CLL/SLL.