A I 6-y ear-old girl presented with abdominal pain after administration of a sulfa drug. She was incoherent and suffered a seizure. Which of the following is the most likely possibility?
(A) Acute intermittent porphyria (B) Congenital erythropoetic porphyria (C) Adenosine deaminase deficiency (D) HGPase deficiency
(A) Ans.a Acuteintermittentporphyria (Re/: Harrison 19/ep2521, 18/ep3168-3169)Acute intermittent porphyria is precipitated by barbiturates, alcohol, exposure to heavy metals, sulfa drugs.Acute Intermittent Porphyria:Precipitated by barbiturates, alcohol, exposure to heary metals, sulfa drugsPresent with nonspecific neurovisceral pain: Abdominal pain, psychiatric disorders, seizures, coma and bulbar Paralysis