RNAi causes the following in a gene:
(A) Knock in (B) Knock out (C) Knock down (D) Knock up
(C) Ans. C. Knock down (Ref Robbins 9/e p5) RNAi causes Knock down in a gene."Small interfering RNAs (siRNAs): Another species of gene-silencing RNA, called small interfering RNAs (siRNAs), works in a manner quite similar to that of miRNA. siRNAs are becoming powerful tools for studying gene function and may in the future be used therapeutically to silence specific genes, such as oncogenes, whose products are involved in neoplastic. transformation."-Robbins 9/c, p5.Knock outTargeted gene is completely removedfrom the DNA sequence by replacing itwith an aificial piece of DNAdegKnock downGene is not completely removed but itsexpression is suppressed by using RNAinterference technologydegKnock inSegment of a gene is inseed into aDNA sequencedeg