A neonate on routine examination at bih was found to have hepatomegaly. Rest of the examination was essentially unremarkable. On investigations, Anti-HCMV antibodies were found to be positive. What sequelae in later life is the child at risk of?
(A) Renal failure (B) Mental retardation (C) Hepatic fibrosis (D) Sensorineural hearing loss
(D) Ans: D. Sensorineural hearing loss (Ref: (Ghai 8/e p272 ; Nelson 20/e p 592-1594)Positive human cytomegalovirus (HCMV) antibodies at bih - Suggestive of congenital asymptomatic CMV infection.Symptomatic child at increased risk a Develops mental retardation.Asymptomatic child is at as high as 7% risk a Develop sensorineural hearing loss.Congenital CMV infection:Characteristic signs & symptoms:Clinically manifested infections - Intrauterine growth restriction, prematurity, hepatosplenomegaly, jaundice, blueberry muffin--like rash, thrombocytopenia and purpura, microcephaly & intracranial calcifications.Neurologic problems:Chorioretinitis, sensorineural hearing loss & mild increases in cerebrospinal fluid protein.