Which is the most conspicuous sign in breast cancer?
(A) Nipple retraction (B) Peau d'orange (C) Puckering (D) Cancer en-cuirasse
(B) Peau-d-Orange Peau-d-orange is due to cutaneous lymphatic edema, where the infiltrated skin is tethered by sweat ducts, it cannot swell, leading to an appearance like orange skin. Due to obstruction of subdermal lymphatics (lymphatic permeation by tumor cells) Seen in advanced breast cancer (may be seen in chronic abscess)