Most important prognostic factor in congenital diaphragmatic hernia –
(A) Pulmonary hypertension (B) Size of hernia (C) Timing of surgery (D) Gestational age
(A) "Compression of the lung results in pulmonary hypoplasia involving both lungs, with the ipsilateral lung being the most affected. In addition to the abnormal airway development, the pulmonary vasculature is distinctly abnormal in that the medial muscular thickness of the arterioles is excessive and extremely sensitive to the multiple local and systemic factors lcnown to trigger vasospasm. Thus, the two main factors that affect morbidity and mortality are pulmonary hypoplasia and pulmonary hypertension."-Sabiston 18th/e p2073