Thiamine deficiency decreases cellular metabolism because:
(A) Thiamine is a coenzyme for pyruvate dehydrogenase and alfa-ketoglutarate dehydrogenases (B) Activity of transketolase is inhibited (C) It is required for the process of transamination (D) It is a cofactor in oxidative reduction
(A) Thiamine deficiency results in decreased energy production because TPP interferes with its coenzyme for pyruvate and alphaketoglutarate dehydrogenase.Chronic peripheral Neuritis, Beriberi & Wemicke Encephalopathy with Korsakoff's Psychosis.Thiamin requirements increase in excess intake of carbohydrates and its deficiency leads to decreased energy production