In which of the inheritance, if father is affected no offspring is affected, but if mother affected, all offspring affected?
(A) Mitochondrial (B) X linked recessive (C) Autosomal dominant (D) Autosomal recessive
(A) Mitochondrial Inheritence Mitochondria is derived only from mother Mitochondrial disease has high incidence as : - Mitochondrial DNA repair cannot occur - Introns are not present - Continuous exposure to the oxygen free radicals Therefore have more chances of mutations in mitochondrial DNA Mitochondrial Inheritence Affected mother will transmit disease to all offsprings X linked disease No male to male transmission Y linked disease Affected father will transmit disease to all son Autosomal disease Equal frequency of these disease in male and female