Pegloticase is used in
(A) Chronic gout (B) Paralytic ileus (C) Psoriatic ahritis (D) Rheumatoid ahritis
(A) Pegloticase - It is recombinant uricase, an enzyme which oxidises uric acid to highly soluble allantoin, that is easily excreted by kidney. Humans lack this enzyme. In this preparation, the enzyme has been coupled with methoxy polyethylene glycol (mPEG) which serves to prolong its sojourn in the body, permitting i.v. infusion of the drug to be given every 2 weeks. It is indicated only in rare cases of refractory symptomatic gout because it is immunogenic and carries high risk of infusion reactions, including anaphylaxis.