In chronic allergy which lg are more persistent in the body?
(A) lg G (B) lg E (C) lg A (D) lg M
(B) IgE is highly potent and mediates type I hypersensitivity reactions by binding to the mast cells causing its degranulation. lgE response is seen in various allergic (both acute and chronic) conditions, such as asthma, anaphylaxis, hay fever, etc. lgE has : lowest serum concentration, Shoest half-life, minimum daily production, only heat labile antibody (inactivated at 56degC in one hour), has affinity for the surface of tissue cells (mainly mast cells) of the same species (homocytotropism).