Most impoant but nonspecific regulator of iron metabolism is:
(A) Hepcidin (B) DMT I (C) Ferropoin (D) Ferritin
(A) Ans: A. Hepcidin(Ref Robbins 91e p650 848 8/e p660)Hepcidin:Main regulator protein for iron absorption.Encoded by HAMP gene.Small circulating peptide synthesized & released from liver in response to increased intrahepatic iron levels.Proteins Involved in Iron MetabolismCeruloplasmindeg (ferrioxidase activity)DMT1degFerrireductasedeg (cytochrome b reductase I)FerritindegFerropinHeme transpoerHemojuvelinHepcidindegHephaestindegHFEdegIron-responsive element-bindingproteindegTransferrindegTransferrin receptors 1 & 2