Which TCA intermediate is used in haem synthesis:
(A) Fumarate (B) Alpha keto gluterate (C) Malate (D) Succinyl CoA
(D) Solutions: - The first step of haem synthesis uses succinyl CoA which is intermediate to TCA. Fumarate, Alpha keto gluterate and malate (4C) is also intermediate to TCA. Malonate (3C) or malonyl CoA is inhibitor of 3 pathways in body - Succinate DH of TCA - Complex 2 of ETC - Beta oxidation of Fatty acid Acetyl CoA is not an intermediate of TCA. Haem synthesis It occurs in Mitochondria + cytoplasm (So, doesn't occurs in RBC)