Mechanism of action of Oseltamivir (Tamiflu) as an antiviral agent is:
(A) Inhibition of M2 receptor (B) Neuraminidase inhibition (C) Inhibition of RNA dependent DNA polymerase (D) Apoptosis of infected cells
(B) Answer- B. Neuraminidase inhibitionThe neuraminidase inhibitors oseltamivir and zanamivir, analogs of sialic ocid, interfere with release of progenyinfluenza vitus from infected host cells, thas halting the spread of infection within the respiratory tract. These agentscompetitively and reversibly interact with the active enzyme site to inhibit viral neuraminidase activity at low nanomolar concentrations.