Which among the following is not true about ankylosing spondylitis?
(A) Enthesis is the primary site of pathology (B) More common in Females (C) TNF plays an impoant role in the pathogenesis of ankylosing spondylitis (D) Sacroiliitis is the earliest manifestation of ankylosing spondylitis
(B) Ans.B. More common in FemalesAnkylosing spondylitis is more common in males.(M:F is between 2:1 to 3:1).There is preferential involvement of entheses ( Site of attachment of ligament or tendon to the bone).TNF a plays a major role in immunopathogenesis.Sacroiliitis is often the first manifestation of ankylosing spondylitis. Synovitis, pannus, subchondral granulation tissue and marrow edema, enthesitis and chondroid differentiation are also found.