Which of the following is done for screening of Down's syndrome in first trimester?
(A) Beta HCG and PAPP-A (B) Unconjugated estradiol and PAPPA (C) AFP and Inhibin A (D) AFP and Beta HCG
(A) Ans: A. Beta HCG and PAPP-A1st trimester aneuploidy screening:Human chorionic gonadotropin (either intact or free (b-hCG).Pregnancy-associated plasma protein A (PAPP-A).Fetal Down syndrome in 1st trimester:Higher serum free beta-hCG level.Lower PAPP-A levels.Trisomy 18 & 13:Lowered levels of both HCG PAPPP-A.2nd trimester analytes:Serum integrated screening.Accuracy of aneuploidy detection:Greater on combination with,Sonographic NT measurement.