What dose of misoprostol is used orally to control bleeding in post paum hemorrhage?
(A) 400 micrograms (B) 600 micrograms (C) 800 micrograms (D) 1000 micrograms
(B) Ans: B. 600 micrograms(Ref Williams 24/e 1785)Approved dose of misoprostol in emergent management of postpaum hemorrhage = 600 pg.Misoprostol (Cytotec):Synthetic prostaglandin E1 analogue.Effective in prevention & treatment of atony & postpaum hemorrhage.Derman (2006) compared a 600 ug oral dose given at delivery against placebo and found that the drug decreased hemorrhage incidence from 12 to 6 percent and that of severe hemorrhage from 1.2 to 0.2 percent.