A 22-year-old female gives the history of recurrent joint pains. She has now developed petechial hemorrhages. She is most likely to have:
(A) Megakaryocytic thrombocytopenia (B) Amegakaryocytic thrombocytopenia (C) Platelet function defects (D) Acquired factor VIII inhibitors
(D) Answer:. d. Acquired factor VIII inhibitors (Wintrobes p1442-144-.'74;Harrison19/ep734-735, 740, 18/e p982).The clinical presentation in a young female of recurrent joint pains with petechial hemorrhage is suggestive of an autoimmune disease.A female patient is unlike to have hemophilia, as it is an X-linked disorder. However, she can have autoantibodies against factor VIII.