A patient has normal blood glucose level as estimated by glucose-oxidase peroxidase method, shows positive Benedicts test in urine. Which of the following is the most likely cause?
(A) Fructosemia (B) Denaturation of glucose (C) Galactosemia (D) False positive
(C) Ans: C. Galactosemia(Ref Harper 30, e p205,- Actsan 20,c p726,- Harrison I9/e p433e-5)Galactosemia:Apa from glucose, both fructose & galactose gives positive Benedict's test.Classic galactosemia:Caused by galactose 1-phosphate uridyl transferase (GALT) deficiency.Diagnosis:Urine of patient shows reducing sugar (galactose) - Detected by Benedict's reagent.Negative glucose oxidase test - Specific for glucose.Presence of reducing sugar (galactose) in urine.