All of the following are true regarding oxygenases except :
(A) Incorporate 2 atoms of oxygen (B) Incorporate 1 atom of oxygen (C) Required for hydroxylation of steroids (D) Required for carboxylation of drugs
(D) Ans. d. Required for carboxylation reaction (Ref Harper 2R/e p9R-102: Lehninger 5/e p8l 6).Oxygenase (which belongs to oxido-reductase class) cause incorporation of 2 atoms of 0, (dioxygenase) or 1 atom of 02 (monoxygenase or hydroxylase). Carboxylase enzyme, which belongs to ligase class is required for carboxylation.Cytochromes P450 are (heme containing) monoxygenasesdeg which take pa in hydroxylase cycledeg (NADH, NADPH and Fe2 S2 required), detoxify drugs in liver microsomesdeg (with cytochrome b5, Fe2 S2 not required).