A 35-year-old male is put on thiazides for the treatment of primary hypeension. What would be the status of his urinary sodium, potassium and calcium in the first 24-hours of drug administration?
(A) Sodium and potassium increases, calcium increases (B) Sodium and potassium decreases, calcium decreases (C) Sodium and calcium increases, potassium decreases (D) Potassium and calcium increases sodium decreases
(A) Answer: a. Sodium and potassium increases, calcium increases (1(e j..Ciuodnian unman iLe pod,* Urinary sodium, potassium and calcium increase in the first 24 hours of thiazide administration.* The acute effects of thiazide on Ca" excretion is variable:* It has been seen in various trials that urinary excretion increases in the initial stages of thiazide diuretic therapy. When administered chronically, thiazide diuretics decrease Ca" excretion.