Which of the following is false about Transfusion-Related Acute Lung Injury?
(A) Develops within 24 hours (B) Mostly seen after sepsis and cardiac surgeries (C) It's a cause of non-cardiogenic pulmonary edema (D) Plasma is more likely to cause it than whole blood
(A) Ans: A. Develops within 24 hours(Ref Harrison 19/e 138e-5, 18/e p1217)Transfusion-Related Acute Lung Injury (TRALI):MC cause of transfusion related fatalities.Cause:Usually results from transfusion of donor plasma.Risk factors:Smoking.Chronic alcohol useShockLiver surgery (transplantation).Symptoms development:During or within 6 hrs of transfusion.Develops symptoms of hypoxia (PaO2/FIO2 <300 mmHg).Non-cardiogenic pulmonary edema signs including bilateral interstitial infiltrates on chest X-ray.