Which of the following binds mRNA with ribosome in prokaryotes?
(A) tRNA (B) Shine Dalgarno sequence (C) 7 methyl guanosine capping (D) Poly A tail
(B) Shine Dalgarno sequence Only in prokaryotes present at -10 position on mRNA, Rich in purines. SD sequence is complementary to 16 s rRNA, Their binding helps in binding of mRNA with ribosome during initiation of translation * In eukaryotic cells, ribosomes recognize most eukaryotic mRNAs by binding to the 7-methylguanosine cap at their 5' terminus.