Patient with Type I diabetes mellitus, with complains of polyuria. Which of the following will occur normally in his body?
(A) Glycogenesis in muscle (B) Increased protein synthesis (C) Increased conversion of fatty acid to acetyl CoA (D) Decreased cholesterol synthesis
(C) The diabetic situation is same as fasting i.e. breakdown or catabolism will be increased & anabolism or synthesis is decreased. So in Diabetes, fats (TG) are broken down in adipose tissue to give fatty acids. These fatty acids go in blood & then to the liver. In liver, these fatty acids are broken down by beta-oxidation of fatty acids to give Acetyl CoA. This excess acetyl CoA obtained from fatty acids breakdown is used for the formation of fats e.g. fatty acids, endogenous TGs, VLDL & cholesterol. This is the only anabolic thing occurring in the liver of diabetic patients. Options A & B - wrong as the body is mainly in catabolism, not anabolism. Option C is correct i.e. increased conversion of fatty acid to Acetyl CoA. Option D - wrong- There is increased cholesterol synthesis.