Acetazolamide is given to a patient of angle closure glaucoma. It is a non- competitive inhibitor of carbonic anhydrase enzyme. Which of the following should be the effect of this drug?
(A) Decrease in Vmax (B) Decrease in Km (C) Decrease in both Km and Vmax (D) No change in Vmax
(A) Enzyme inhibition is of 3 types: Type of inhibition Km Vmax Competitive inhibition Increases No change Non competitive inhibition No change Decreases Uncompetitive inhibition Decreases Decreases In question non competitive inhibitor is given, so answer is decrease in Vmax.