Which of the following toxin is causing this:
(A) Botulism (B) Tetanus (C) Diphtheria (D) Cholera
(A) Botulinum toxin contains 2 chains- heavy and light. The heavy Chain binds presynaptically to nerve terminals and is responsible for mediating translocation of light chain into the cell. The light chain is active pa which cleaves host protein snap 25 The cleaved snap 25 prevent the release of neurotransmitter Acetylcholine and is responsible flaccid paralysis. The tetanus toxin causes cleavage of synaptobrevin and prevents the release of neurotransmitters GABA and Glycine which causes spastic paralysis. Diphtheria toxin causes ADP ribosylation of elongation factor 2 which inhibits protein synthesis. Cholera toxin causes ADP ribosylation of G stimulatory protein which causes increase in cyclin AMP and causes watery diarrhoea So according to the question the answer is botulinum toxin.