0_Wizard
I have chronic fatigue syndrome. It really limits my daily activities.  
Chronic fatigue syndrome (CFS), also referred to as myalgic encephalomyelitis (ME), is a medical condition characterized by long-term fatigue and other symptoms that limit a person's ability to carry out ordinary daily activities.
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Chronic fatigue syndrome
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History of chronic fatigue syndrome
The history of chronic fatigue syndrome (CFS, also known by many other names) is thought to date back to the 19th century and before. Several descriptions of illness resembling those of chronic fatigue syndrome have been reported for at least two hundred years. In the 19th century, neurologist George Miller Beard popularised the concept of neurasthenia, with symptoms including fatigue, anxiety, headache, impotence, neuralgia and depression. This concept remained popular well into the 20th century, eventually coming to be seen as a behavioural rather than physical condition, with a diagnosis that excluded postviral syndromes.
Chronic fatigue syndrome
Chronic fatigue syndrome (CFS), also referred to as myalgic encephalomyelitis (ME), is a medical condition characterized by long-term fatigue and other symptoms that limit a person's ability to carry out ordinary daily activities. Biological, genetic, infectious, and psychological mechanisms have been proposed, but the cause is not understood. Diagnosis is based on a person's symptoms. The fatigue is not due to strenuous ongoing exertion, is not much relieved by rest, and is not due to a previous medical condition. Fatigue is a common symptom in many illnesses, but the unexplained fatigue and severity of functional impairment in CFS is comparatively rare.
Chronic fatigue syndrome treatment
Treatment of chronic fatigue syndrome (CFS) is variable and uncertain, and the condition is primarily managed rather than cured. Only two treatments, cognitive behavioral therapy and graded exercise therapy, have demonstrated reproducible evidence for their efficacy people with CFS who are walking. There are no Food and Drug Administration (FDA) approved medications for ME/CFS treatment, although medications are used without approval for the illness (off-label). Drugs have been used in experimental studies of the illness that haven't been approved for market for any condition in the United States (for example, isoprinosine and rintatolimod).
Clinical descriptions of chronic fatigue syndrome
The clinical descriptions of chronic fatigue syndrome (CFS) vary. Different agencies and scientific bodies have produced different guidelines to define the condition, with some overlap of symptoms between descriptions. Aspects of the condition are controversial, with disagreements over etiology, pathophysiology, treatment and naming between medical practitioners, researchers, patients and advocacy groups. Subgroup analysis suggests that, depending on the applied definition, the CFS population may represent a variety of conditions rather than a single disease entity. The most widely used diagnostic criteria for CFS are the 1994 research guidelines proposed by the "International Chronic Fatigue Syndrome Study Group", led by the Centers for Disease Control and Prevention.
Controversies related to chronic fatigue syndrome
Chronic fatigue syndrome (CFS) is an illness with a long history of controversy. For years, many professionals within the medical community did not recognize CFS as a true condition, nor was there agreement on its prevalence. There has been much disagreement over the pathophysiology of chronic fatigue syndrome, how it should be diagnosed, and how to treat it. The diagnosis is controversial, and its etiology is still not fully understood. Alternative names to describe the condition(s) have been used over time throughout the world. Patient groups have criticized the name "chronic fatigue syndrome," saying it trivializes the illness.
Daniel Peterson (physician)
Daniel Peterson is an American physician in private practice in the state of Nevada, and has been described as a "pioneer" in the treatment of chronic fatigue syndrome (CFS). He graduated from the University of Rochester School of Medicine, Rochester, New York, in 1976 and was an intern and resident at the University of Utah Medical Center from 1976 to 1979. In 1979, he became a Diplomat of the American Board of Internal Medicine. He is president of Sierra Internal Medicine of Incline Village, established in 1981. Along with Paul Cheney, Peterson was a treating physician at Incline Village during an outbreak of chronic fatigue syndrome that began in 1984 in the Lake Tahoe region.
Rintatolimod
Rintatolimod, sold under the tradename Ampligen, is a medication intended for treatment of chronic fatigue syndrome. However, there is only low-strength evidence that it can improve the ability to exercise. It is an immunomodulatory double stranded RNA drug synthesized in the 1970s and manufactured by Hemispherx Biopharma. Although Ampligen was cleared for use in Canada in 1997, and obtained orphan drug status for treatment of CFS in the European Union in 2000, it is so far without FDA approval, and therefore classed as experimental in the United States. In 2007, Hemispherx filed a New Drug Application (NDA) with the U.S. Food and Drug Administration (FDA) to market and sell rintatolimod for the treatment of CFS, but this was rejected in December 2009, because the FDA concluded that the two RCTs "did not provide credible evidence of efficacy" and "because of clinical, statistical, clinical pharmacology, nonclinical, product quality, and facilities inspection deficiencies."
1_Apprentice
sorry to hear that. What are the symptoms?
0_Wizard
Mostly it's long-term fatigue that rest does not help. No one knows the cause.
Chronic fatigue syndrome (CFS), also referred to as myalgic encephalomyelitis (ME), is a medical condition characterized by long-term fatigue and other symptoms that limit a person's ability to carry out ordinary daily activities.
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Chronic fatigue syndrome
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Cancer-related fatigue
Cancer-related fatigue is a subjective symptom of fatigue that is experienced by nearly all cancer patients. Among patients receiving cancer treatment other than surgery, it is essentially universal. Fatigue is a normal and expected side effect of most forms of chemotherapy, radiation therapy, and biotherapy. On average, cancer-related fatigue is "more severe, more distressing, and less likely to be relieved by rest" than fatigue experienced by healthy people. It can range from mild to severe, and may be either temporary or a long-term effect. Fatigue may be a symptom of the cancer, or it may be the result of treatments for the cancer.
Listener fatigue
Listener fatigue (also known as listening fatigue or ear fatigue) is a phenomenon that occurs after prolonged exposure to an auditory stimulus. Symptoms include tiredness, discomfort, pain, and loss of sensitivity. Listener fatigue is not a clinically recognized state, but is a term used by many professionals. The cause for listener fatigue is still not yet fully understood. It is thought to be an extension of the quantifiable psychological perception of sound. Common groups at risk of becoming victim to this phenomenon include avid listeners of music and others who listen or work with loud noise on a constant basis, such as musicians, construction workers and military personnel.
Auditory fatigue
Auditory fatigue is defined as a temporary loss of hearing after exposure to sound. This results in a temporary shift of the auditory threshold known as a "temporary threshold shift" (TTS). The damage can become permanent (permanent threshold shift, PTS) if sufficient recovery time is not allowed for before continued sound exposure. When the hearing loss is rooted from a traumatic occurrence, it may be classified as noise-induced hearing loss, or NIHL. There are two main types of auditory fatigue, short-term and long-term. These are distinguished from each other by several characteristics listed individually below.
Chronic fatigue syndrome
Chronic fatigue syndrome (CFS), also referred to as myalgic encephalomyelitis (ME), is a medical condition characterized by long-term fatigue and other symptoms that limit a person's ability to carry out ordinary daily activities. Biological, genetic, infectious, and psychological mechanisms have been proposed, but the cause is not understood. Diagnosis is based on a person's symptoms. The fatigue is not due to strenuous ongoing exertion, is not much relieved by rest, and is not due to a previous medical condition. Fatigue is a common symptom in many illnesses, but the unexplained fatigue and severity of functional impairment in CFS is comparatively rare.
No One Knows
"No One Knows" is a song by American rock band Queens of the Stone Age written by band members Josh Homme and Mark Lanegan. It was the first single and second track from their third album, "Songs for the Deaf", and was released on November 26, 2002. "No One Knows" was a chart success, becoming the band's only single to top the US Modern Rock charts. The song was also critically acclaimed, receiving a nomination for Best Hard Rock Performance at the 2003 Grammy Awards. According to Homme, "No One Knows" existed before the recording sessions for "Songs for the Deaf":  We have patience with music, a year or five years down the road it may kind of rewrite itself and become what it's supposed to be.
The Spirit of the Age
The Spirit of the Age (full title "The Spirit of the Age: Or, Contemporary Portraits") is a collection of character sketches by the early 19th century English essayist, literary critic, and social commentator William Hazlitt, portraying 25 men, mostly British, whom he believed to represent significant trends in the thought, literature, and politics of his time. The subjects include thinkers, social reformers, politicians, poets, essayists, and novelists, many of whom Hazlitt was personally acquainted with or had encountered. Originally appearing in English periodicals, mostly "The New Monthly Magazine" in 1824, the essays were collected with several others written for the purpose and published in book form in 1825.
Fatigue (medical)
Fatigue is a subjective feeling of tiredness which is distinct from weakness, and has a gradual onset. Unlike weakness, fatigue can be alleviated by periods of rest. Fatigue can have physical or mental causes. Physical fatigue is the transient inability of a muscle to maintain optimal physical performance, and is made more severe by intense physical exercise. Mental fatigue is a transient decrease in maximal cognitive performance resulting from prolonged periods of cognitive activity. It can manifest as somnolence, lethargy, or directed attention fatigue. Medically, fatigue is a non-specific symptom, which means that it has many possible causes and accompanies many different conditions.