First of all, Samsonite Silhouette luggage is probably the best on the market.  It is made of material that is more durable, abrasion resistant, and stain resistant.  The spinner wheels are superb--One of the best features in my opinion.  The telescoping handle has various lengths that you can pull it up to so it works with people of varying heights.  There is a "boston bag" that can be purchased separately that has slotted material on the back so that it fits perfectly over this or any of the telescoping handles in this series of luggage so that you don't have to carry it.

I own several pieces of the samsonite silhouette 11 (current model) as well as the samsonite silhouette 10 (last model).  I have had the "older" luggage for about 3 years and it looks as good as new.  the zipper quality is excellent, the material is excellent, wheels still function perfectly, etc.

The downside to this particular luggage is that the 22" does not conform to all carry on guidelines of all airlines.  Now that you have to pay for checked bags typically, this presents an even worse problem than before.  It is not only inconvenient to find out at the last minute you have to check your bag, but when it also costs $25-$35 to do so it can be extremely aggravating.  Also, human nature being what it is, it seems that many people try to stuff their luggage as much as possible (i am guilty for sure).  If you expand the 22", it won't meet any carry on guidelines.

So, if you are looking for awesome construction that will stand the test of time and move effortlessly through the airport and be guaranteed you can carry it on--go for the 20".  By the way, the 20", when expanded, holds as much as the 22" not expanded--and it still meets the carry on guidelines.  Major boon in my opinion.  (not to mention it costs less).

If you are not worried about the ability to carry on luggage and just need something this size--go for it!!

And, i can't say enough about how wonderful spinner wheels are.  I discovered them by mistake and now won't use luggage without them!!!

UPDATE:  another reviewer said this fits in overhead bins on domestic flights.  I want to make sure that my description is clear---it is accurate that it fits in the overhead bin on most flights.  However, when you look at the maximum size a carryon is allowed to be, this exceeds that size--you have to measure linear size which means from the floor to the top of the bag on both sides, added to the measurements of the top and bottom of the bad.  The four sides add up to the "linear" size of the luggage.  This exceeds the linear size on most, if not all airlines.  Now, if you flight isn't full and the crew is happy--you will be fine.  if the flight is full or the crew is cranky, they can make you check it because it doesn't meet their "linear size" guidelines.  I have personally witnessed on full flights, people not being allowed on the plane until they checked their bag---frustrating for them.  And, I wouldn't have the patience with it myself.  For me, flying is stressful enough, i don't want to have to worry about whether or not they will let me check my luggage.  And, by the way, on the last two extremely full flights I was on, one was a 757 and one was a 747 (this was 4/2010)---so the bins were certainly large enough--the bins were huge---and that didn't matter because the flight was full and they were enforcing the rules.  One flight was american airlines and one was United Airlines.