I have been a fan of the Asics Gel-Kayano for years, these are the best shoes yet.

I am a heavy bloke (90 kilos) and run at least 60 Kilometers a week on Asphalt and concrete. As such I need a shoe with excellent cushioning and this shoe has heaps of it. I fell in love the moment I slipped into it. The asymmetrical lacing seems to work for me as the shoe fits perfectly.