I have run in Asics for a very long time, and usually the fit is perfect. I wanted to love these but I found them too narrow. Hotspots where my foot would get sore from pressure around the midfoot. Usually the thing to do would be to get a wider size, but they don't make this in any other widths - and the default D width appears to be narrower than other Asics shoes in exactly the same size. I did an experiment putting Kayano on one foot and Cirrus33 on the other, just walking around the house for a while, and found a clear difference in pressure spots.  So I went back to Kayanos and I'm happy again. Can't figure out why the "low profile" running movement has adopted such differences to shape.