I am a big guy...about 280lbs...and I overpronate a little. I need a good stability shoe to run comfortably. I was previously running in the Asics Kayano 18 and I was very happy with them at first. That was an extremely comfortable shoe. That comfort didn't hold up very long though and they seem to have lost their support rather quickly. I attributed that to the fact that I am well over 200lbs and they just were not built for someone my size. Recently, however, I have read some good things about how well the Mizuno Wave line can benefit heavier runners like myself because they have a reputation of being able to hold up longer. I would have to revisit this review later on down the road to see how they do , in fact, hold up long term, but out of the box these shoes feel amazing. They fit like a glove. This is possibly the best fitting running shoe I have ever tried on. The combination of support and cushioning is just right. And when you walk or run in these you can literally feel how smoothly your foot transitions forward so naturally. I have heard many great things about the Inspire series in particular and they certainly live up to the hype. Mizuno really hit it out of the park with this shoe and I hope they don't do anything to change it. If they can keep this shoe consistently like this...I don't think I'll ever switch to another shoe. So Mizuno...if you're listening...don't mess with this one too much!!!