These are the most comfortable shoes I've ever owned.  I wear them all the time.  I even have a second pair at the office to wear during the winter (don't think about wearing them in the snow if you want to have toes later in life).  I've found them very comfortable for running as well.  Be prepared for constant questions about the shoes.

There seems to be a lot of debate about needing socks with these shoes.  You definitely need toe socks, or the shoes are going to smell awful.  This might not be a big deal if you only run and then lock your shoes in a vault, but if you wear them all the time and take them off in your house, you will care.