I am quite picky about the quality of running shoes.  I've gone from Mizuno Wave Riders (started with v9, jumped ship at v14) and Inspire, to Nike Pegasus 29 (too spongey), to the Brooks Ghost 4, and now to the Ghost 5.  The Ghost 4 is the first shoe to work perfectly for me.  No knee pain, no ITB issues, perfect!  The Ghost 5 is just as nice so far.  I will update my review if anything changes, but the new 5 is real nice.  It has just a hair more cushion than the 4 in my opinion.

One thing... I initially bought the blue color... they are HORRIBLE looking.  Like someone else said, they look like old man shoes.  I'm 33 and couldn't look down at that on my feet.  My wife said they looked like Sketchers Shape-ups or something (hilarious!).  I returned them for the orange color and they are MUCH better.