The multi-colored Gel Nimbus 14 was so pretty that I bought them thinking there couldn't be that much difference between them and the similarly-priced Kayano. I was wrong. Anyone with knee problems that have been eased by Kayano will NOT find the same relief in the Nimbus. I'm not a runner but have been a distance walker, and am at an age where I'm paying for the privilege. If you use Kayano successfully, Nimbus will not substitute, no matter how pretty.