I am a long term runner, over 40 years.  I'm over 70 now and run about 4 miles 3 or 4 times a week.  I'm 6'1" and weigh 210.  I love Asics shoes and have been running in them for years.  For the past 5 years I've run in the Asics Gel Cumulus, various numbers.  With the most recent shoe, the #14, the price went to $140.  I decided to try a less expensive shoe so based on customer ratings and price I tried the GEL-Landreth.  The shoe fit OK and was comfortable but the toe box is smaller than in the Cumulus.  I do like the way the heel section works.  But this shoe bothered my toes (small toe box) and left my feet "tingling" after running.  I can only assume that the cushioning is less than the Gel Cumulus.  I ordered another pair of Gel Cumulus and my problems went away.