I run about 20 miles a week and use Nike air and Asics 2000 series shoes.  I decided to make a change for the Asics Stallion (Kinsei) and I must say I'm impressed.  They have the best cushion I've had while maintaining great support.

I know they are a little pricey, but I've bought two pairs because they feel like your running on Boobies.

ASICS Men's Kinsei 4 Running Shoe,Black/White/Gold,12.5 M US
ASICS Men's Gel-Kinsei 4 Running Shoe,Lime/White/Royal,12.5 M US