Haven't really had any Kayano versions I didn't like.  For Asics and running, they are some of my favorites.  They are more lightweights than other Asics.  It takes a bit of time to break in running shoes (might get a blister or two if you run a lot those first few days.  Might be better to run a few miles for the first few days. But you might not get blisters even if you run a lot, depends on your foot shape and the type of shoe you buy).  Also, should always buy a half-size bigger in running shoes than your normal size because your feet swell when you run.

But yes!  I love Kayanos and almost all the kinds I've bought, including these, have been some of my favorite Asics.