I've always heard great things about Timbuk2 bags, and I'm now a fan as well.  I've owned at least a dozen bags over the years and this ranks up at the top. Its sleek and light, but very strong and has all the compartments I need to carry all the stuff a road-warrier needs along.

Could be used as a overnight bag, as the center compartment could easily handle a change of clothes and some toiletries in a pinch.

Timbuk2 includes small touches I appreciate very much.  For example,  the extra velcro sections with removable covers under the flap.  Most of the time I don't use them, but occasionally I'm traveling to a place where I do alot of walking in the elements, and knowing I can really seal down the flap to keep things dry is a real plus.

Another nice touch is the "Napoleon" pocket you can get to without opening the whole flap.  Didn't think much about it when I saw it in the description, but the first time I needed to grab my wallet in a hurry, I was hooked.

Not having to take out my laptop and iPad while going through airport security has been very handy as well.  Nice to keep everything together and not mixed up with all the others going through at the same time.

The flap buckles are interesting.  Really like the idea, as I can quickly slide the buckles out quickly with one hand.  However, I've noticed when I have the flap open, those buckles hang down and tend to slide into cracks and get caught.  Not a huge issue, just something to watch out for.