I've been running for about a year now, two or three times a week.  While I'm up to 4-8 miles I've been having issues with lower back pain and runner's knee.  I have a flat, wide foot with a natural mid-foot strike and faster cadence.  While researching my next shoe purchase I discovered "pose" style approach and realized that it exactly what I already do.  This shoe seemed to fit the bill for me, the reviews were good.  I tried them on at a local store along with 4 to 5 competitors.  They fit me well so I decided to buy them through Amazon to try them out.  So far the difference has been impressive.

Over three runs (Sat, Sun, Monday), I've already noticed that my form feels much more natural, my stride and pace come together; it all seems to just make sense.  No pain!  My 4 mile time is down about 2 minutes without feeling that I'm actually trying harder.  I can feel that I will go farther too.

Do not buy this shoe if you are looking to heel strike; it is intended for mid to fore-foot strike.

Your calves will get a work out, so I suggest that if you haven't had previous experience with biking (doing a lot of climbing) take your time and ease into it.  Great shoe and great price.