I bought these shows after having a very bad experience with another highly rated shoe, so I was a little wary, but these have proven to be all they were cracked up to be.  They are incredibly comfortable and awesome to run in, even with the damage that my previous shoes did to my heels.  I have bad knees and issues with my back, so cushioning is very important for me, and these are not only the most comfortable running shoe I have ever tried, but also I have found that the aches and pinched nerves I often get in my shoulders and neck when I run have been dramatically diminished

One word of warning - if your feet are wide you may want to get the half size up - the fit is very snug.  I personally find it very comfortable, but my feet are a standard width

All in all, if you are looking for a running shoe and cushioning is important in your selection criteria, I highly recommend!