I am writing this review after putting 600 miles on these shoes. Here's what type of runner I am:

I run 30-45 miles/wk. I'm 32, 6'0", 180 lbs, with normal to narrow feet and my biomechanics are:
 - very mild overpronator
 - low, but strong arch, no problems ever
 - slight bowed legs (slight "varus")
 - forefoot striker... midfoot at worst when very tired
 - normal foot rotation
 - dynamic leg axis is normal
 - good flexibility
 - I had a enflamed anterior tibial tendon sheath once. My laces were laced too high and they had aggravated it. Rested and dropped my laces down one hole and the problem was gone.

Pros of the Inspires are an open toe box, snug extremely comfortable fit, drain well, light, supportive, and had a nice feel during my active gait. The sole is an excellent design for a heel or midfoot striker. They are incredibly comfortable shoes. I never experienced blisters or discomfort in any weather, or on any surface (aside from the self induced tendon inflammation). I have done trail runs, road runs, and runs pushing a double stroller with two kids in temps varying from -19 F to 75 F. I've run through snow, torrential rain, dust, dirt, mud, everything. No problems.

These shoes are good for anywhere between 500-600 miles. I got 600. There are two holes in each shoe (I posted the user pic), but what can you expect after the abuse I dished out to them?! I feel that two minor holes after that many miles means these shoes performed awesome!

That is the good... and there is no bad. They have a bit too high of a drop for me, but I am particular and am searching for the 'perfect' shoe for me. Mind you, I'm saying that after I made huge gains in my running ability while wearing them! I spent the last five months perfecting my running form and I am now a dedicated forefoot runner. That said, these shoes are not great for that. They have a 12 mm rise, so I hope there is something better out there! The last few months, I've had to run in a forced forefoot strike so as to not land on the heel. It doesn't cause discomfort, I just know that it is not as efficient of a gait as it could be. At the mileage I'm looking at doing, efficiency is huge. So, I'd like something with a lower drop than the Inspires, but NOT a minimalist shoe.

I'm looking at:

Road:
Saucony Mirage
Newton Gravity
Altra Torin

Trail:
New Balance Leadville 1210
Brooks Cascadia
Altra Lone Peak 1.5

My local shoe store has set all six aside, and when I get home in a few days, I'm going for some test jogs. If there is interest, I'll post my results!

To sum up. Great amazing shoes for a midfoot striker. If this is you, you will be VERY happy with these supportive shoes!

UPDATE:
I tested all of the above shoes. I ended up with the New Balance Leadville 1210 for trail shoes. They are awesome. Check out my review on their page.

For the road shoes, I tried 6 pairs out and brought two home for overnight tests. After all of that... I ended up coming back to the Inspires! These shoes are really tough to beat. The combination of support, comfort, performance and price make them a force to be reckoned with. I still feel that they could use a slightly lower drop... here's to hoping that either Mizuno feels the same, or that someone comes out with a shoe with these characteristics.

Happy running!