I have tried several brands of scrubs, and the Grey's Anatomy seem to be the most comfortable for me. They wash easily (wrinkle easily though if you just leave them in the dryer). They are sturdy and have held up to multiple washings without the color fading. They are just the right weight, so not too hot in the summer and not too cold in the winter. Pockets are perfect for my use. I believe these tend to run a little large. I typically wear medium scrubs, but need a small with this brand. I accidentally ordered a medium a while back, and even though I can still wear them, they are a little too big. Have not experienced any fraying at the seams or material defects with this brand.