As with any barefoot shoes, it is an adjustment to go from heavily supported athletic shoes to unsupported "barefoot." Start off by wearing these around the house for a short time, walk around in them. Personally, I still just wear them for walking and daily use - I am not a runner. But if you do like to run, make sure you take time to adjust to walking in them before running. I love the large toe box. My feet are happy in these.