I run 10+ miles a day, every day.  I've been running in the gel noosas for over 6 months with no injuries.  I'm a mid to forefoot runner who concentrates a lot on her running form to avoid getting hurt.  I invested in a pair of Newtons, just to try them out, and I can't make it through an entire run in them without my foot aching where that weird lug on the bottom is.
Asics never disappoint me.  The toe box is roomy, it's lightweight and has just enough cushioning without feeling klunky.  Plus, the colors are great!  And they have lots of reflective material for those early morning, or after dark runs.  The mesh tops keep my feet nice and cool, and now that winter has come, I just wear a heavier pair of socks and my feet never feel cold.
I highly recommend them.