As others have noted, these are a bit narrow in the toe box. But since the "3" version is sold out in my size I had no choice. I can wear 12D and 11.5E (sometimes even 11E) in most ahtletic shoes. In fact, I buy 12D running shoes most of the time.

Since I got an 11.5D in these Gel-Resolution 4s, I should have expected it to be a bit narrow. However, my toes have more room ahead of them than in my 12D Salomon running shoes, so the last seems to be off for Asics. Fortunately, they offer excellent side stability. My feet don't move length-wise so overall this is a good shoe for me. Grip is excellent as well.