I grew up wearing traditional briefs, and switched to boxers a few years back. Boxer-briefs are somewhere in between the two, and are now my favorite. The ExOfficios are the most comfortable I've found, and I have a full complement of them now--I wear them every day.

Many others have posted about how you can hand wash these and hang them dry, so you can travel light. This is true, though I rarely do it. Others have also commented about how they're comfortable for guys with large, muscular thighs--I'll have to take their word on that. I'm just a normal, somewhat overweight guy who likes comfortable underwear, and these are great.