2 people in my family who have purchased these shoes have complain of numbness and bruising around the front ball of the foot (the area in the foot which one would use to pivot).  In these cases it was the left foot.  One person also experienced some discomfort in the rear part of the arch in the left foot as well.  These effects lasted for about 1 week of regular daily usage.  Eventually the effects disappeared and both are enjoying the shoes.  I myself only had a slight amount of numbness in the left front part of my foot for the first 3 hours of use.

I would blame this on the "break-in" period but none of us had these problems with the 2160's.  We are were all disappointed, but are now enjoying them.  My comment to ASICS is... "Don't fix it if it ain't broke!"