I will start off emphasizing the point that you REALLY should try a pair of FiveFingers on before ordering. I tracked a store down and tried on a pair thinking I would be a size 43 which is what the online sizing chart told me I should be upon measuring my foot. Though my measuring skills could have been the issue, it turns out I am a size 45.
Now that I have them, I am very satisfied with the feel and protection they provide. It takes me a bit longer to put these on than a regular shoe, but taking them off is a breeze with the Velcro strap.  I have been playing basketball and running around town putting about 15 miles on them, so I felt it was a good time to review. I see no wear besides traces of dirt.  I am looking forward to hitting some trails soon as well and have no worries about the protection of my feet.  These seem to be the most "rugged" which is what led me to this model.  That was my only concern switching to this type of footwear, and now that concern has been obliterated.  I will be buying more in the future.