I have found these Asics gel-lytes to be exceptional shoes for me.  I am a senior, but do exercies every day and use the treadmill a lot during the week in the winter, jog outside in warm weather, and these are the most comfortable shoes I've ever worn.  I purchased my first pair over a year ago and they have held up well under constant use.  I don't know how well they would work for serious runners, but for me they have worked well.