This backpack is HUGE. Took a business trip, and I had room to spare after putting in 3 pair of jeans, 5 pair socks, 4 pair underwear, 4 long-sleeve t-shirts, 1 short-sleeve T, and a pair of shorts. I'm a 2x kind of guy, so take that into account of how much space that can take up

I also had
14" Laptop, Charger, label maker, zip-ties, velcro rolls, cell phone charger, 2nd cell phone, maps (in case of no cell reception), network cable, sunglasses

I still could have stuffed more into it...

I'd estimate that pack weighed in at around 35-40lbs, and I carried that all over TUL, MSN, and MSP airports. I'm not a hiker, I'm not used to carrying packs, but, overall it wasn't HORRIBLE, but, overall the pack itself wasn't uncomfortable.

It is too big for the overhead compartments.