With all the other reviews, what more can I say?  I've run on Gel-Kayanos for years, various models and tried other shoes (Nike, New Balance) that were worse.  But my feet began to hurt no matter what shoes I bought, and I gradually quit running in favor of other exercise.  Until now.  These are like putting on the first good pair of running shoes you ever bought, after switching from Keds.  I'm running again and enjoying it.  The extra $50 from what I used to spend is completely worth it.  I just hope they keep making them about the same as they do now.