My go to shoes have almost always come from the Mizuno Wave Rider line.  Their most recent 16 has a narrower heel that dug into my ankle and did not work for me.  I returned that pair and gave the Brook's Ghost 5 a shot.  I went with them due to what I've heard from Runner's World and a high recommendation from my local running specialty shop.  I'm so glad I did!  They are incredibly comfortable and stylish, I have the yellow pair.  Best of all, my ankle pain has disappeared.  There is a good amount of cushion to these shoes, but they still feel light and fast.  I love running, but I love it even more when I can be comfortable and pain free.