I have not tried running in these yet but they are very comfortable for every day wear. I purchased my normal size 9 and they were a little tight at first but quickly broke in and are perfect now. There isn't a whole lot of arch support but I'm a believer in not having your arch artificially propped up unless necessary.
I prefer not to have any leather on my sneakers and these have a little bit around the edges and that is the only reason for the 4 stars. They are mostly nylon and that I like because its way more comfortable not to have all that stiff leather on your feet while your running.