I'm a very large guy.  6'1" and 450-470lbs depending on the season.  I wear 60x30s in these jeans.  I am sure most don't have to get the size I do, but these are the only cut of jeans I've found that are comfortable and look good on me.  I've been buying these for several years now, but only recently bought these from Amazon because they were way cheaper than my local "Fat People Store".  The ones from Amazon are darker than the dark stonewash I get in the store which I like because it doesn't take long for the dark stonewash to become medium after a few months of washing.  I've tried other jeans from other brands and even other cuts from Levi's (550s etc). and none fit comfortably like these 560s.  Plenty of room to get all the way up over my bum and also plenty of room up front in the crotch area.  These last a long time before they wear out too.  I don't know about the smaller sizes, but if you're a big guy in the 50s+ for waist size, definitely give these a try.