First of all, I only run 10-14 miles a week. I have ran a couple times in these shoes now, and I run with a mid-foot strike, and have pain in the ball of my foot that I didn't have in my old Acics Gel-1150s. I don't know about what kind of cushioning these have, but I don't think they are designed with the mid-foot strike in mind. I put some insoles in, so hopefully that will improve the impact on the balls of my feet.