I have this in black.

Really nice leather.  Looks stylish and feminine, and also boardroom-ready.  My 17" laptops fit inside fine.  Laptop protection is fine.  Telescoping handle/wheels work well.  A great change from lugging shoulder bags.  I love it!

I haven't detached it more than a couple of times.  Nice to have that option, especially in stormy weather.

The wheel assembly doesn't add a particularly insane amount of weight. It goes up/down stairs fine in a pinch.

I do not plan take this through airports on a regular basis. The stiff leather seems pretty durable, but more pretty than bulletproof.

Be aware:
 - The black one comes w/VERY red piping.  The black leather has a matte finish.
 - The orange one is CONSTRUCTION ORANGE.  This color comes with a lovely pearlescent finish, but it does glow in the dark like a traffic cone.  I wish they had gone with more of a blonde/natural leather color.
 - I need more expansion space for papers + folders + adapter/cable.
Where to stash cables (if you carry lots of things with cables and chargers) is a challenge.
 - After several months, the interior cloth dividing the laptop from the "everything else" side is getting a bit frayed on the sides where laptops have been pulled in/out daily.  The lining is pretty but not durable.
 - The rain-resistant cover (not shown in the photo but comes with it) has come in handy a few times but is inefficient/flimsy protection from a real downpour.
 - Cel phone pocket won't nearly hold a Blackberry & is useless for nearly all other functions (minor annoyance); other pockets for stashing other small objects seem OK.