I really like this briefcase but more for work than weekend travel. I can squeeze an outfit and pajamas in the briefcase along with my 15" MacBook Pro, but adding a few papers, wallet, etc, it gets a bit tight.
As long as I take the minimum clothes (which is ok by me) I can still take this bag. I hope to beat it up a bit to soften it.

I would like to add: IF you use this bag with the wheels attached, it doesn't fit under the airplane seats - unless you are business class or better - but then, you have more room above your head, too.