I am a 20+ miles per week runner with two marathons under my belt in the last year. Being 6'1" and 220 lbs plus a "heavy stepper" doesn't make it easy to find a shoe. I have tried most brands of "true" running shoes (Asics, Pearl Izumi, Brooks) plus many Nike running shoes always opting for the "cushioning" model and have liked other shoes as long as I keep my distance down. Once over 5 miles, I start to feel the difference. Once over 10 miles, no other shoe even compares.

I have ran with Mega-Bounce for over the last 2 years.

Pros -
Best cushioning heal to toe of any shoe I have ever tried.
The cushioning doesn't effect performance. It's not like running with a down pillow attached to your foot, more like a spring.
Durability is awesome.

Cons -
Inherent in the design that makes it the "best cushioning" is the height of the shoe off the ground. This height makes increases probability ankle twists/sprains.
Narrow toe box. But I do have a fat foot. The '09s are better than the '08s because the mesh is more flexible than the stiff nylon, but still could use some improvement or at least a width size choice.