These shoes do require some time to adjust to the fit, so take that into consideration before heading out for a five mile run. But, they are very comfortable and natural once you have gotten used to wearing them. And my second toe is noticeably longer than my big toe (a condition called Morton's toe), but that doesn't cause any pain or discomfort in these KSOs.

If you have very hot feet when you run, you can really appreciate these as they feel cooler from the lack of all the padding you find in conventional running shoes. And of course they are super light so that you don't feel like you are hauling bricks on your feet. They are also nice for just walking around, though you will get looks.

A negative point is that you have to wash them quite often, or they will smell bad. This makes sense as these are more like socks than shoes, and you wouldn't wear your socks for a month without washing them, would you? Also with the amount they flex I had a pinch point in one of them that drew some blood after a while. The pinch eventually went away with wear and washing, but don't expect these to be heavenly when you first start running.