I am an over pronator and these shoes definitely work for me!  I've been very loyal to the Asics brand, as they are the only shoes that seem to support my foot really good.  I would highly recommend these shoes!  I've ran with them on the treadmill and outside and they've definitely proved to work.  I did get a blister on one foot the first time I wore them, but this is typical for me and any new shoe.  Size is definitely true to foot size also.