this is my 4th healthy backpack  ..  i love these  and organizing pockets too!!
i have had leather , mico suede, the cloth one and now the poly suede.
I did not like microfiber.. it seems to show dirt/stains and does not clean well.
cloth i think is a good choice  can be washed etc.  The zipper stopped working on my cloth one so i am now trying the poly suede one I am very happy with this one