These running shoes from Asics are by far the best cushioned running shoe I've ever tried on.  Unfortunately, even in a size 4E width they are too snug.  By that I mean they are still too narrow and most important they are far to small on the top of the foot where the shoe is laced.  For me to get into these shoes I would have to have them so loosely laced that I could barely tie the shoe.  And I do not have what I would consider wide/large feet. Bottom line I think is that if you like a very snugly fitting running shoe that is very well cushioned these may be a good choice for you.  But if you are like me, where I prefer something not so tight fitting when running I would steer clear of this shoe.  I've tried other Asics shoes and have found the same issue.  I think this is just how they build all their shoes.  Too bad since I really like their cushioning the best.  Hopefully they will respond to customers on this.  I do not have big feet - in fact I can pull any 11.5 wide shoe off the shelf at a Walmart or Target and virtually any of their shoes will fit (which I've done in the past but now want better shoes for cushioning).  But in these premium brands - not only Asics - I've found it is another story.  Sizes are not standardized and it is virtually impossible to find a good fit unless you go through multiple brands and products within a brand.  Sizes can vary by more than full sizes in both length and width even though they are listed the same size.  Whatever you choose, I strongly advise NOT buying shoes online unless there is a no shipping cost return policy.  I had to go through 3 brands of shoes until I finally found one that fit properly - then I ordered 3 of those to make sure I will have shoes that fit in the near future given how difficult it is to find properly sized shoes.  I really wish these companies would get their act together and standardize sizes!!!