I have a narrow heel, so every running shoe I've ever had has given me blisters.  These shoes were comfortable out of the box, and hugged my feet like bedroom slippers.  The fit was perfect for me, but might not be ideal for someone with with a very wide foot or heel.  I'm not a novice to the minimalist running concept, so getting used to the shoe was easy for me.  Amazon says order a half size up if you plan to wear socks - I normally wear a 7 and this is what I bought.  I tried mine on in the store and the fit is perfect.  I wear my shoes with a lightweight wicking sock and have no issues.

Note:  a minimalist shoe WILL require changing your stride, even if you're only wearing it for walking.  If you don't change your stride and continue to walk with a heel-first strike point, you can develop foot problems like plantar fascitis.

I'm not a long-distance runner (right now) although I have taken this shoe around the circuits at the gym, on the treadmills, on the pavement, and through enough casual "urban jungle" conditions to know that this is a fantastic all-around shoe which works for a variety of situations.  I'm so in-love with my NB shoes that I've tossed my much-loved (heavy) running shoes and the seriously stiff trainers that I could never really bond with.

A sign of a fantastic shoe is ordering another pair (or two) before it sells out...  I've just ordered two more pairs.  Love it, love it love it.