I went to a local running store to get a running shoe fitting.  I tried about 5 different pairs recommended by the sales person and did a running demo in each.  The Asics were hands down the most comfortable.  They were a little heavier than the other brands because the Gel cushioning system is a little heftier than the foam alternatives, but they are just so comfortable.  I'm not a hard core runner, I do about 5-10 miles a week mixed in w/ other cardio activities, but I can easily run an hour in these shoes without any knee or back pain.  There is plenty of room in the toe area for my toes to move and grip.  The positioning of the lace holes allows me to get a very adjustable, snug fit across the top of my foot, keeping my foot in place while running.  FYI, I threw out the floppy footbed thingies that came with the shoes and replaced them w/ a pair of "green" Superfeet insoles (that I bought from the local running store in exchange for the fitting service, since I didn't buy the shoes there... they only had one ugly color choice!).

I have purchased Asics exclusively for running shoes for the last ~10 years and I am convinced you cannot find a more supportive, better constructed shoe.