I've tried different brands of Men's underwear over the years, but I've really found the Hugo Boss to be the most practical, comfortable and durable underwear.  More importantly, they just seem to be the most comfortable underwear I've used, much more so than Calvin Klein's, Costco underwear, etc.

They cost more, but I've been immensely more happy and comfortable in them!  Buy them in the multi-pack and they're reasonably priced.