I was running in the Nimbus 12 for a while before thinking about buying a new pair of shoes so I can alternate between runs. While the Nimbus provides a lot of support and more bounce (I feel), the Kayano makes you work harder to achieve the same performance. My knees and ankles seem to hurt more when I run with these too.

I don't hate the shoes. They're still way better than what I've tried from Adidas or Nike, but I just have something else better (and cheaper?) that's from the same brand, to compare to. I'll stick to the Nimbus from now on.