I realize I am going against many 5-star reviews, but these are my respectfully submitted findings. ( I just finished an 8 hour, 17 mile hike - the circumambulation of Mt. Tamalpais in Marin County, CA- that my wife and I do a couple of times a year - Temp at start was in the 50's, and nearly 90 by the time we finished - I carried no more than 10 pounds - Terrain is very rough in some parts - a lot of talus and scree).
First; The lacing system is awful - it is a prime example of nothing more than marketing, technology that has arrived well in advance of a real need, and a slightly different way to do something that has been around for a long time.
Here is why: The lacing system does NOT allow you to lace for specific terrain-if you are descending a rough, steep trail, regular lacing would allow the upper laces to be tighter, while allowing the lower (closer to the toe) laces to be looser, thus keeping the foot from sliding forward into the shoe and compressing the toes.  This is not possible with these shoes. If you tighten the laces, the compression is distributed over all the lace points, thus compressing the foot from instep to toe. I suspect that for many purchasers, they probably do not have a lot of experience with older, less flashy, less 'engineered' shoes, and so this current pool of hiking footwear is all that they know (no discourtesy intended)
Second: There is no way to easily replace the stock laces with 'store bought' laces, though I am working on this today and will find a solution....
Third: the end of the laces - the part with the padded rubber pull - keeps coming out from under the mesh panel that supposedly is there in part to keep the rubber pull from flapping around....If the laces are pulled hard enough, you have a hell of a time getting the rubber pull tucked in anywhere to keep it out of the way....
Fourth: IMHO, these are NOT trail RUNNING shoes - they would be great on flat to moderately grades trails, but for steep downhills, as I previously stated, I think the lacing system is not well suited. These shoes are too clunky and boxy -especially the rearfoot- for serious trail running.  We DID run part of our hike, but these shoes simply felt like we were running in hiking shoes.
The best shoes I have ever worn - this will tell you how old I am - are the original Nike LAVA DOMES - Simple, bullet-proof, long lasting (Thousands of miles across India, Nepal, the Muir Trail several times)......they were superb.
But back to this review....Buy them if you want pretty good protection for your feet - though I felt a little disconnected from the trail surface due to the 'clunkiness' of the shoes; buy them if this lacing system appeals to you; buy them if you will not be encountering steep down hills-especially if not carrying much weight on your back.

(August 28, '11) Addendum to my earlier review.....I have used these shoes a bit more under similar conditions as described in my first review...Respectfully submitted are the last words I'll say about these shoes.  FIRST- After searching for replacement laces that would allow me to tie the shoes the way they would work best for me (the ability to adjust the tightness at instep independent of the toe area), I found some great, strong, colorful VENETIAN BLIND CORD-1.8 mm braided nylon (not polypropylene) and happily cut off the original laces.  This works PERFECTLY! Don't worry-you do not need that little rubber gadget that cushions the tightening procedure...it is just a gadget.  You can tie the ends of the laces together in order to be able to pull both at once as with the original setup. Just pull the laces and that's it.....May I also suggest something that I have used that also works perfectly-a small diameter ZipTie- for the toe area....

SECOND:  I say again, these simply are not trail running shoes....Of course you can run in them, but compared to other models (New Balance, for example), there is a world of difference.  Ok...That's it from me!

UPDATE  MAY 2013....This is the last time I will most emphatically state that these are not the trail running shoes they are touted to be....They have been perfectly fine for hiking long stretches (10-20 miles) at a time, and they seem to be wearing pretty well, but compared to Brooks and New Balance models, these are markedly clunkier, stiffer, and convey much less of a 'sure-footed' feeling.....The zip-tie still works fine when I want to vary the lacing 'tightness' in the fore-foot c/w the rest of the shoe.....Thank you.