UPDATE: Even though I've gone on to purchase other running shoes (Saucony Kinvara 3's)  This pair is still my favorite to race in.  They are lighter and just feel faster.  Plus, they help so much with mid-foot strike.  I like the Kinvara's for my long run (8+ miles), but prefer Skechers for speed work.  I do rotate my shoes, but I am not noticing any further unusual wear and tear.  I consider myself a serious runner now, and I still love Skechers Go Run!

I purchased this shoe based on reviews and the fact that it was the only minimalist E-width shoe I could find.  I am new to running, 45 years old, averaging about 12 miles a week right now.
Pros:
1) A true wide width shoe!  My feet were so happy when I put these on.  They are wide in the toe box (of course) but also wide across the mid-foot - which is rare!
2) There is a pronounced "hump" mid-foot - which feels to me like major arch support.  It feels weird to walk in (at first) but is awesome to run in.  I have suffered from plantar fasciitis in the past and I can tell that that will not be a problem in these shoes with the fantastic arch support and heel cup!
3) These shoes are so light you will think the box is empty!  Seriously - I feel light as a gazelle in them!
4) No blisters!  Right out of the box I was wearing these shoes for 3-4 mile run/walks and have never experienced any blisters or rubbing at all!  I have tried them without socks,and they are quite comfy, but prefer to wear socks as it just feels strange to me to go sockless.
5) Price is on the low end compared to other minimalist shoes.

Sizing:
I wear size 9W street shoe and usually 9.5E in athletic shoes.  Even with socks on, 9E fit me perfectly.  I tried the 9.5E and it was way too long.

Cons:
1) Padding in the ball of the foot is minimal.  I'm not sure this can really count as a con since all minimalist shoes lack the padding that stability runners have.  I went to a running store to be fit for a shoe (hoping for a more padded minimalist type shoe)  I tried Brooks pure line, Saucony Kinvara 3, Altra Intuition (surprisingly, way too narrow mid-foot) as well as a few others - and even though they felt more padded, they also were too narrow (even in men's width) and felt too much like traditional running shoes compared to my Go Runs  (I did NOT try NB minimus.)
2) This is the big con - I've only put 60 or so miles on these and they are showing quite a bit of wear across the ball of my foot.  I have 3 year old Sauconys that show less wear in the soles!  I am not sure how this will play out over time - maybe it won't get any worse - but I do think Skechers needs to address this in the next model.

Conclusion:
Well, I bought another pair because I am so afraid of them being discontinued or changed.  No other athletic shoe has ever felt this good on my feet!  I am very active, and have suffered from various knee, ankle and foot problems over the years.  I am not having any of those old issues wearing these shoes.

Plea to Skechers:
PLEASE continue to make E-width shoes for women.  I know we are not a large market, but we are sorely underrepresented!