I haven't taken this duffle on any long vacations or flights yet, which will be the true test.  However, I tested it out over a long-weekend trip to Boston and it was fantastic.  The backpack straps are a very welcome addition and make the bag easy to carry if you have other bags.  The bag is constructed very well and appears as though it will be sturdy enough to hold up over time.  I'm convinced that the 32" size will be large enough to hold clothes for a week's vacation.

PROS:
-Well constructed, nice looking bag
-Wheels, handle and backpack straps all make for easy transport
-Large enough to hold a week's worth of clothing

CONS:
The zippers around the bottom compartment seem a little tricky and get stuck easily

Overall, I'd definitely recommend this product.