I'm very glad i decided to try Vibrams.  I've had these for a few months and have run 2 miles at least a dozen times.  There is nothing I don't like about them.  They make you feel like running faster.  They make running more fun and interesting.  I notice a little difference in soreness in my calves and feet but there really was no dramatic or painful adjustment from running in regular shoes.  They are fantastic for running on the beach.
It may just be the novelty of them, but the way they make you run differently is really cool.  You don't feel like you are JOGGING (lumbering, pounding the ground, boom, boom, boom).  You are RUNNING (almost gliding, lighter on your feet, more agile).  I can't imagine ever running in 'normal' shoes again.