Switched to this after about ten years' sticking to the 2000 series.  For some reason my usual Asics started giving me this uncomfortable red spot on my arches, and a bit of online searching revealed I was not the only one who experienced this.
What I appreciate most is the ball-of-foot gel insert that makes for a comfortable energy transition, not to mention encourage a fuller, more balanced footstrike, as opposed to striking hard with the heel alone, where most shoes tend to beef up the cushioning.
For all the support it gives, it is surprisingly flexible, owing to the open mesh upper that also keeps your skin breathing and retards bacterial growth.  Very happy to have this shoe.