I've owned several pair of Vibram five-fingers (which I love), but can't really wear them to work (until the Kangaroo leather ones come out this fall).  When I saw Merrell's new Barefoot line, I was immediately impressed.  Almost all of my other shoes and boots are Merrell's.  I found these shoes to be very comfortable both with, and without socks.  I wear them all day at work and around town.  Since I got these as casual footwear, I have not tried them for running or hiking.