I run about 30-50 miles a week, I run in "regular" shoes (currently New Balance 101's, 110's, 310's & 730's) run everything from 5Ks to Ultra marathons, when someone told me these socks "feel great" I was skeptical. I was thinking that my shoes would be too tight (I have a wide foot, and I was thinking the sock would make my foot wider - 2 layers of sock between each toe?), so I bought 2 pair and ran only a short distance the first time (3 miles - road) and they were great.  Next day stepped it up a bit, 6 miles on a trail, and now I'm an Injinji convert.