OK, I'm not a runner. But I'm a walker and a hiker. And I like to go barefoot. These are the closest thing to barefoot that I've experienced in a full-footed shoe. The mesh top is soft and breathable, and the vibram sole is solid, but not inhibiting. If I could wear these to work, I would. I have yet to see how well they hold up and last, but other people who have had them a while give good reports on durability. Right now, these are my favorite shoes!
PS. I got these in 11.5 even though my regular shoe size is 10.5, so see if you can try them on in a store before you order them online (where they are significantly cheaper than in the shops)!