Like most others I thought that these looked ridiculous.  After a friend convinced me to give them a try, I ordered the Fila Skele-Toes.  Have been using them now off and on for about four weeks.  Running in these is  completely different than running in normal shoes.  The design actually forces you into a more natural gait for which our bodies were designed; shorter strides with impact primarily on the forefoot rather than the heel.  The effect is a more natural stride that minimizes injuries to knees.  However, you should be warned that depending on how far you run, you will experience soreness in the calf area (at first).  I normally run between 4-5 miles five to six times per week and have already become accustomed to the difference and therefore am experiencing minimal soreness now.  I mentioned above that these are being used off and on right now.  The only reason I am not using them full time is that I do not have enough pairs of the toe socks to allow for full time use.  Toe socks are between $10-$12 a pair so if you run a lot, you will need a lot of toe socks.  Sizes for these run true to normal shoe size.  Downside is that there are no half sizes (at least in my range) so mine are a little loose and must be tightened significantly to get the snug feel required for running.  Another minor downside is that they are rather difficult to get on unless you have perfectly aligned toes (I do not). Highly recommended!