I purchased these shoes for everyday use, not for running, and they are great.  These shoes are extremely flexible, allowing your foot to work the way it has evolved to.  The sole's cushioning is excellent and the upper is soft.  The man-made suede of the upper appears to be easy to clean; just an old toothbrush should be needed.  If that's not good enough, a bit of water should help too.  I can't really speak to how long they last, as I've worn them only three days.

UPDATE: I've had these shoes for awhile now and have lowered my review from 5 to 3 stars.  This is because the large difference in thickness between the shoe's heel and forefoot is so large too much weight is shifted onto the ball of the wearer's foot.  I found that the ball of my foot, especially where my toes attach, would become sore after only a few hours in this shoe.  A flatter profile would more evenly distribute the wearer's weight and avoid this issue.  These shoes have largely been retired and are used only when I don't anticipate being on my feet much.