These shoes are the perfect solution for me.  I am not a runner so can't comment of that aspect, but I do walk alot.  I've always had problems with blisters on the bottom on a couple of my toes.  These shoes straighten those toes right out and I haven't had a problem since I've started wearing them.  It's a little difficult to wiggle those said toes into the proper place, but once in....bring it on!!!