I'm a life long runner and have put 400 miles on my first pair of 2160's.  I bought these coming off an IT Band issue partially caused by some poorly designed Nikes I wore for too long. These shoes are great. Enough support and cushion, but not squishy or inefficient. I am a mid to forefoot striker and these are great. They look good and are easy to clean. I have the white ones with blue trim.
I highly recmomend. I will probably get another pair of these to train for Disney Marathon through the fall etc.