Size runs slightly large. I am usually a large in landau but I'm medium in these. The only thing is the length of Med Couture scrub pants run a bit SHORT. I am 5' 6" and usually buy the the "Tall" and then have a tailor shop make the inseam 30" (I think the inseam is 29" for reg length and like 34" for tall). Fabric is awesome and resists wrinkles!