Let me preface this review in saying that I am a bicycle commuter who normally rides an endurance road bike with drop handlebars.  This review may very well not apply to you.

This is a terrible cycling backpack for anything other than upright riders.  It seems like a well made pack with plenty of pockets and holders, but it has two issues that, as a road bike commuter, I cannot live with.

1) The top part of the bag between the shoulder straps is very stiff and positioned forward to such a degree that it digs into the neck, even while riding on the top of the handlebars.  Over time the pack may break in and this very uncomfortable aspect may lessen, but I can't wait around for that to happen.

2) The pack is built in such a way that it sits on the lower back - this is difficult to explain, but the pack that this Osprey is replacing is built such that the load tends to sit higher up on the mid-back and shoulders.  The Osprey's load sits over the lower back, even when packed correctly with heavier items on the top.  This is an absolute deal killer for the cyclist who rides anything more aggressive than a flat bar hybrid.

Other than those issues the pack is well made with plenty of options for organization.  Were it not for the fact that Osprey markets this as an option for cyclists, then I would not be compelled to leave this review.