I am a 6', neutral-gait, 60+ years old male runner who weighs around 200 pounds.  I've been a runner for many years, but for the past year and a half have been coping with low back pain related to degenerative discs.  Back pain has come and gone over the years, but the recent difficulties are more "chronic" than has been the case in the past.  I've been working out at the gym regularly to strengthen my core and back, and incorporated more stretches into my workouts.  More recently, I've been running only a mile or two at a time several times a week as a compromise that allows me to maintain some level of aerobic fitness while minimizing back ache.  Still, I really miss being able to run greater distances, and wanted to find a shoe that offered superior cushioning in hopes that it would allow me to increase my running distance without also aggravating back pain.  After reading a number of shoe reviews on this site and others, I decided to take a chance on the Hoka One One Bondi 5.  I ordered the same size shoe that I typically wear for running shoes made by other manufacturers, and the Hokas fit just fine.  The toe box is a little larger than with other shoes and, for me anyway, that's a good thing.  I usually run on pavement, although I've run on a treadmill more often recently and, either way, the cushioning is superior to any other shoe I've used.  They're also extremely lightweight.  Results-wise, the difference is certainly noticeable in terms of reduced distress in the lower back after a run.  One thing I noticed about these shoes is that the "footprint" is somewhat larger than what I was used to, and I needed to be careful descending stairs at first because the heel seemed to protrude a bit and I'd strike the steps unexpectedly.
So, have these shoes "cured" my back pain?  No, and I suspect nothing will make it go away entirely.  Still, I can say that the Hokas are definitely a move in the right direction.  These shoes are too new for me to comment on durability but, one month in, I'm very pleased with the purchase.  I realize that one's choice of shoes is always a very personal decision, and what works for one person will not necessarily work for another, but I'd say that if your situation is similar to mine, these shoes deserve serious consideration.