I didn't realize just how big the largest size is, because I meant these to go in the last two of my three in a row ear lobe piercings. The largest is definitely for the first piercing. I started out with the three largest in order in my piercings, but I didn't really like how that looked. So, I usually put the smallest two in my second and third piercing and a different style earring in my first piercing. I think it is a nice look, nothing too crazy, just classy looking. They usually get mistaken for gold earrings. So far I have had no reactions with my skin and the metal, which I needed, because I think I was having a reaction with the pairs I used to wear most often. Although, I think my ears are just kinda pissy in general.