After wearing Asics Gel-Kayano for 15 years, I made the switch to Brooks Ghosts 10 since Ascis redesigned the Kayano 23 models to be dramatically, and terribly, different with a more narrow, smaller and less supportive fit. Yesterday I ran 5 miles in the Ghosts which felt very different but good.  They are much more flexiblable, less stiff and lower to the ground if that makes sense. I felt more connected to the earth. I ran with no problems and felt good during and after. Compared to the Asics Kayano, the Brooks Ghost have much more room in the toe box. I normally wear a size 10 (B) average but in there I ordered 10 D (wide) which provided room for swelling and extra comfortable. Also there was plenty of depth and orthotic inserts fit perfectly. No foot popping out. Great ankle stability. Update: Sadly I realized after a few runs these are not a stability shoe which was my own fault. I returned but a great shoe for neutral runners.