This is not a 22".  It's more like 24" Domestic flights are not very strict unless you book use some cheap airlines.  So far I do not have problem with domestic flights.  Sometime I feel bad taking a lot of room because the luggage can not sit side ways in the cabinet.  I did have a problem coming back from from Europe flying Air France.  They told me I had to check in the bag because it was over 22".  I'm kind of disappointed in Osprey.