I travel quite a bit and I had never heard anything about packing cubes.  While looking at suitcases, I came across these and started doing research.  I thought for the price, what the heck.  If I can keep things neat and tidy it's worth a shot.  Where have these been all of my life?  I can keep everything neat and tidy and items are not any more wrinkled than straight packing (less wrinkles I think!).  You can get more in your suitcase as everything fits so much better.  It will compress some items like cotton shirts.  I used to pack on a trip up north for the week and they were great.  I would just open each cube the night before and would hang up the next days clothes.  No digging through clothes to get what I wanted.  They are awesome!!  Highly recommended!