After the first 3 runs in these shoes which left my smallest 3 toes aching and numb, I have loved these shoes.  Because they hug and support my foot wonderfully,  I  prefer to wear a seamless athletic sock which has eliminated all issues with pressure point numbness.  The thick foam sole has been a welcomed relief on my knees and hips!
Originally Asics Kinsei or Cumulus were my 'go-to' shoe ... now these are my absolute favorite!