I have not been able to wear a synthetic fibers bra for a few days due to an allergic reaction on my skin. It has been very hard to find a good almost 100% cotton bra on the market - I've looked in all the major stores like Target, JC Penney, Belk, V's Secret - just about every bra is synthetic. I found this one from Fruit of the Loom which is 95% cotton, 5% spandex. It's very comfortable, no allergy so far (only wore it for a few hours), and it has enough lift. Not the best lift as a synthetic bra, but good enough and most of all, very comfortable and looks good under dress shirts and t-shirts. It also does not feel tight around my chest and back like traditional nylon bras feel. Cautiously optimistic! HerRoom delivered quickly.