Sapérangan gedhé lelara rematik ditambani nganggo analgesik, NSAID (Non-Steroid Anti-Inflammatory Drugs), steroid (sajeroning kasus serius), DMARD (Disease-Modifying Anti-Rheumatic Drugs), antibodi monoklon, kaya infliksimab lan adalimumab, lan reseptor TNF larut etanersept.