Khan, sing miwiti karir ing filem "Biwi Ho To Aisi" (1988), ngrengkuh suksès sing sepisanan sajeroning filem "blockbuster Maine Pyar Kiya" (1989), lan menangaké Filmfare Best Male Debut Award. Khan uga main ing sawatara filem Bollywood paling suksès, kaya déné "Saajan" (1991), "Hum Aapke Hain Kaun" (1994), "Biwi No.1" (1999).