Aplastic anemia symptoms may include: 1  Fatigue. 2  Shortness of breath with exertion. 3  Rapid or irregular heart rate.  Pale 1  skin. Frequent or prolonged infections.  Unexplained or easy 1  bruising. Nosebleeds and bleeding 2  gums. Prolonged bleeding from  cuts. 1  Skin rash. Dizziness.  Headache.