1 Mastectomy: Mastectomy, or removal of the breast, is recommended in some cases. 2  Lumpectomy alone. 3  Hormonal therapy after surgery: These treatments, which block or lower the amount of estrogen in the body, are typically used if the DCIS tests positive for hormone receptors. Radiation treatment is usually given as daily treatments 5 days per week over 5 to 7 weeks. 2  Treating the whole breast with radiation after lumpectomy remains the standard of care. 3  In cases of DCIS, radiation therapy can reduce the risk of the cancer coming back by about 60%.