The more lymph nodes that contained cancer at the time of the mastectomy, the higher the chances of breast cancer recurrence. Local recurrence after a mastectomy is usually treated with surgery followed by radiation therapy (if radiation therapy was not part of initial treatment).ecurrence and support. Treatment for breast cancer can be a trying and draining process. If the cancer returns, you may have a strong emotional and physical reaction. A breast cancer support group, especially one focused on breast cancer recurrence, may help you address these concerns.