The CONFIRM study, a comparison trial of fulvestrant. 250 mg/month (one 5-mL injection of fulvestrant plus one. 5-mL injection of placebo) with 500 mg/month (two 5-mL. injections: 500 mg on days 0, 14, and 28 of month 1, then. every 28 days thereafter) for advanced breast cancer pretreated.