In other cases the initial causes are more mysterious, and potentially more troubling. Symptoms of chronic fatigue tend to slowly worsen over time. Women, who are excellent multi-taskers, often ignore their fatigue until it leads to other symptoms, like depression, binge-eating and weight gain. Alternatively, some women tune out their bodiesâ signals until they become too loud to ignore â a case of the blahs turns into feeling bone-tired each and every day.