Clindamycin Phosphate Topical Solution is a topical (for the skin) antibiotic used to treat acne vulgaris. Clindamycin Phosphate Topical Solution is available in generic form.Common side effects of Clindamycin Phosphate Topical Solution include burning, itching, dry skin, redness, oily skin, or peeling.ell your doctor all prescription and over-the-counter medications you are taking. Clindamycin Phosphate Topical Solution should be used during pregnancy only if prescribed. It is not known if the topical form of this medication passes in breast milk. Oral forms of clindamycin pass into breast milk.