1 Review. 1 Review. Betamethasone dipropionate is the generic name of Diprolene and Diprolene AF, used to relieve skin discomfort caused by rashes, itching, and irritation. Betamethasone comes in a topical cream, lotion, and ointment, as well as a solution for injection.It has many uses, depending on the form your doctor prescribes.lthough betamethasone topical cream and lotion are used to treat irritation and inflammation of the skin, doctors prescribe the injectable form of betamethasone, Celestone Soluspan, for multiple sclerosis flares and to help mature the lungs of babies born prematurely.