If you are using the fluorouracil cream on your face you may find that the redness and inflammation makes you self conscious and that you do not wish to be seen in public while your face looks like this. The reaction is a sign that the treatment is working.fudix / Fluorouracil. EfudixÂ® is the brand name of a cream that contains fluorouracil. Fluorouracil (5-FU) is a chemotherapy agent that has been used in the treatment of cancer for many decades.