Alveolar Hypoventilation. 1  CNS depression: asphyxia, maternal sedation, intraventricular hemorrhage, seizure, meningitis, encephalitis. 2  Airway obstruction: choanal atresia, laryngomalacia, Pierre Robin syndrome. 3  Neuromuscular disease: phrenic nerve inury, neonatal myasthenia gravis.