Depersonalization is the third most common psychological symptom, after feelings of anxiety and feelings of depression. Depersonalization is a symptom of anxiety disorders, such as panic disorder.It can also accompany sleep deprivation (often occurring when suffering from jet lag), migraine, epilepsy (especially temporal lobe epilepsy), obsessive-compulsive disorder, stress, anxiety. and in some cases of Low Latent Inhibition.epersonalization is a symptom of anxiety disorders, such as panic disorder. It can also accompany sleep deprivation (often occurring when suffering from jet lag), migraine, epilepsy (especially temporal lobe epilepsy), obsessive-compulsive disorder, stress, anxiety. and in some cases of Low Latent Inhibition.