Sometimes severe inflammation and ulceration can be helped by applying a prescription anti-inflammatory cream (only use this on the advice of your doctor). Do not use other creams, lotions or cosmetics on the area of skin you are treating with fluorouracil cream.If you forget to apply the cream one day then simply recommence use the following day. Do not double the dose or apply it more frequently to make up for it.fudix / Fluorouracil. EfudixÂ® is the brand name of a cream that contains fluorouracil. Fluorouracil (5-FU) is a chemotherapy agent that has been used in the treatment of cancer for many decades.