How to reset Outlook to first run status. 1  All the accounts settings will be deleted from your computer. 2  Upon launching Outlook (after the procedure), the following message will be displayed:  Welcome to Microsoft Outlook .ow to reset Outlook to first run status. 1  All the accounts settings will be deleted from your computer. 2  Upon launching Outlook (after the procedure), the following message will be displayed:  Welcome to Microsoft Outlook 3  . Close Outlook. 4  Press Windows Key + R to display the Run tab. 5  Type regedit and click on OK.