A car with an MPG of will need 9.64 gallons of gas to cover the route between Wilmington, NC and Winston-Salem, NC. The estimated cost of gas to go from Wilmington to Winston-Salem is $25.16. During the route, an average car will release 188.90 pounds of CO 2 to the atmosphere. Your carbon footprint is 0.91 pounds of CO 2 per mile.