Complications of PVD can include: 1  blood clots that obstruct small arteries. 2  coronary artery disease. 3  limb amputation due to tissue death in the limb. 4  heart attack. 5  impotence. 6  pallor, or paleness. 7  pain when the legs are elevated. 8  severe pain that restricts mobility. 9  stroke. 10  wounds that donât heal.