Alcohol abuse is one of the usual causes of this condition. If you are a heavy alcohol drinker and ages 40 and above, you should consult a doctor if you experience these gallbladder disease symptoms: 1  Irritable bowel syndrome. 2  Difficulty in digesting fatty foods. 3  Lower abdomen pain. 4  Appendicitis. 5  Stomach ulcers. 6  Pneumonia.