Carac is the trade name for fluorouracil cream. 5-FU cream and efudex and fluoroplex are other names for fluorouracil cream. In some cases, health care professionals may use the trade name carac or other names 5-FU cream or efudex or fluoroplex when referring to the generic drug name fluorouracil cream. As a topical cream or solution, a thin coating is applied to the affected skin lesions, treatment may continue over several weeks. 2  Use non-metal applicator or fingertips to apply cream. 3  Use care when applying cream or solution around the eyes, nose, and mouth.