The FDA approved clindamycin for vaginal use in August 1972. PRESCRIBED FOR: Clindamycin vaginal cream is used for treatment of bacterial vaginosis, an infection of the vagina.It can be used to treat non-pregnant women and pregnant women during the second and third trimester of pregnancy.Medically Reviewed by a Doctor on 2/25/2015.he FDA approved clindamycin for vaginal use in August 1972. PRESCRIBED FOR: Clindamycin vaginal cream is used for treatment of bacterial vaginosis, an infection of the vagina.