Syncing via USB cable. Open iTunes and connect your iPhone using the USB cable that came with the device. Click on the Device button located in the upper-right corner. Configure the types of content you want to sync, and then click Apply to sync your iPhone with your PC.Syncing via Wi-Fi.To set up Wi-Fi syncing, open iTunes and connect your iPhone via USB. Click on the Device button in the upper-right corner. From the Summary tab, select Sync with this iPhone over Wi-Fi.. Configure the types of content you want to sync, and then click Apply to enable syncing via Wi-Fi.lick on the Device button located in the upper-right corner. Configure the types of content you want to sync, and then click Apply to sync your iPhone with your PC. Syncing via Wi-Fi. To set up Wi-Fi syncing, open iTunes and connect your iPhone via USB. Click on the Device button in the upper-right corner.