What are RADIESSEÂ® and RADIESSEÂ® (+)? RADIESSEÂ® and RADIESSEÂ® (+) are dermal fillers that are used for smoothing moderate to severe facial wrinkles and folds, such as nasolabial folds (the creases that extend from the corner of your nose to the corner of your mouth). RADIESSEÂ® is also used for correcting volume loss in the back of the hands.