Definition. Premenstrual syndrome (PMS) has a wide variety of symptoms, including mood swings, tender breasts, food cravings, fatigue, irritability and depression.It's estimated that as many as 3 of every 4 menstruating women have experienced some form of premenstrual syndrome.Symptoms tend to recur in a predictable pattern.But the physical and emotional changes you experience with premenstrual syndrome may vary from just slightly noticeable all the way to intense.t's estimated that as many as 3 of every 4 menstruating women have experienced some form of premenstrual syndrome. Symptoms tend to recur in a predictable pattern. But the physical and emotional changes you experience with premenstrual syndrome may vary from just slightly noticeable all the way to intense.