For the diagnosis, see depersonalization disorder. Depersonalization (or depersonalisation) is an anomaly of self-awareness. It can consist of a reality or detachment within the self, regarding one's mind or body, or being a detached observer of oneself.epersonalization is a symptom of anxiety disorders, such as panic disorder. It can also accompany sleep deprivation (often occurring when suffering from jet lag), migraine, epilepsy (especially temporal lobe epilepsy), obsessive-compulsive disorder, stress, anxiety. and in some cases of Low Latent Inhibition.