A medical assistantâs salary is no different. Skill level and experience affects salary, location affects salary, and so does the economy. For example, the top 10 percent of the medical assisting field will get paid more than the bottom 10 percent of the field.If youâre located in an area with a high cost of living, youâre likely to get a higher medical assisting salary also.ere are some criteria that may affect the salary rate and how you might compensate to increase your salary in your favor. Education Level. Every medical assistant must graduate from an accredited medical assisting program to receive a competitive salary.