and supplements. If you have exocrine pancreatic insufficiency (EPI), your body may not absorb the nutrients from the food you eat. Your doctor may prescribe vitamin and mineral supplements to help you maintain proper levels of the fat-soluble vitamins A, D, E, and K.our doctor may start you on a prescription treatment called pancreatic enzyme replacement therapy, or PERT. PERTs are the main treatment for EPIâthey replace the digestive enzymes that your pancreas isnât producing anymore. When taken with food, PERTs help break down the nutrients in food.