What does the strain of marijuana sativa do to you. They give a feeling of optimism and well-being, as well as providing a good measure of pain relief for certain symptoms.ut aside from that, a sativa high makes you feel much more active then a Indica high. It can normally be felt in the head and around the eyes and makes your mind wonder. Indica mostly just knocks you on your @ss, when the high hits you it spreads throughout your body and you get sensations all throughout your body.