Clarksburg is located at , along the West Fork River and Elk Creek. According to the United States Census Bureau, the city has a total area of 9.74 square miles (25.23 km 2), all of it land. Clarksburg is located in West Virginia's North-Central region. It lies within the ecoregion of the Western Allegheny Plateau. Clarksburg is located at the junction of U.S. 50 and U.S. 19, two miles west of the junction of U.S. 50 with Interstate 79.