n 1. the death of a cell or group of cells in contact with living tissue. n 2. the local death of cells resulting from, e.g., loss of blood supply, bacterial toxins, or physical or chemical agents. necrosis, avascular. n the consequence of temporary or permanent cessation of blood flow to the bones. 1. the death of a cell or group of cells in contact with living tissue. n 2. the local death of cells resulting from, e.g., loss of blood supply, bacterial toxins, or physical or chemical agents. necrosis, avascular. n the consequence of temporary or permanent cessation of blood flow to the bones.