The Cause of the Problem and How to Reduce Armpit Sweating. In extreme cases, the problem can be associated with the sympathetic nervous system. In such cases, medical procedures such as botox, iontophoresis, Anticholinergic drugs, and surgery are the primary options.ust apply a generous amount of the deodorant on your armpits two or three times a day. You can find home remedies in your kitchen. Apple cider vinegar and lime juice are both known to control sweating. Choose one of these and rub it onto your armpits twice a day.