A low GPA is probably the hardest area to improve. But it can be done. In our last Medical School Reapplicant Advice: 6 Tips for Success segment, we talked about how to best present yourself in your secondaries and interviews.irst, you need to get your GPA up â a year of good grades in upper-level science courses might be enough to get you up to a 3.0. At that point, you can apply to an SMP with strong links to a medical school. This will take you a minimum two years, which might not seem appealing at this point.