Key Points. 1  When reflux disease involves the larynx or pharynx, it is referred to as laryngopharyngeal reflux (LPR) or extraesophageal reflux, rather than gastroesophageal reflux disease (GERD). 2  Laryngopharyngeal reflux and GERD are two related, yet different, disease states with different risk factors, pathophysiology, treatment, and outcomes.