The recommended dose is as follows: Start treatment with Qsymia 3.75 mg/23 mg (phentermine/topiramate extended-release) daily for 14 days; after 14 days increase to the recommended dose of Qsymia 7.5 mg/46 mg once daily. Evaluate weight loss after 12 weeks of treatment with Qsymia 7.5 mg/46 mg.