11 how many nucleotides make up a codon a 1 b 2 c 3 d 4 coursehero 11 how many nucleotides make up a codon a 1 b 2 c 3 d 4 explanation book pages url? Q webcache. Historically, it was not known how many nucleotides needed to make up a codon, but simple math suggested that 3 (4 (the number of a, 26 feb 2016 explanation codon is three and stands for one amino acid (or 'stop'.