Your doctor may start you on a prescription treatment called pancreatic enzyme replacement therapy, or PERT. PERTs are the main treatment for EPIâthey replace the digestive enzymes that your pancreas isnât producing anymore. When taken with food, PERTs help break down the nutrients in food.our doctor may start you on a prescription treatment called pancreatic enzyme replacement therapy, or PERT. PERTs are the main treatment for EPIâthey replace the digestive enzymes that your pancreas isnât producing anymore. When taken with food, PERTs help break down the nutrients in food.