RNA Polymerases, RNA-Dependent (Molecular Biology) In all organisms the major flow of genetic information is from DNA to RNA using DNA-dependent RNA polymerases, with the DNA itself being replicated by DNA-dependent DNA polymerases. Some of the DNA synthesis, primarily of specific viruses (retroviruses) and retroelements, is from RNA by reverse transcriptase. However, there are many viruses of both prokaryotes and eukaryotes that have RNA genomes and that replicate by the synthesis of RNA from the genome.