Symptoms of renal cell cancer may include the following: 1  Hematuria (blood in the urine). 2  Pain in the flank (side or back above the waist) that will not go away. 3  Noticeable mass (lump) in the flank. 4  Weight loss. 5  Fatigue (feeling tired). 6  Loss of appetite. 7  Fevers. 8  Night sweats. 9  Malaise (feeling blah).