Question: is this a 2) strong advice, 1) weak advice 0) no advice?

A second statistical issue, common to all scans for variant associations, is that each of the many GSVs detected in even a small cohort is the subject of a separate independent hypothesis, so that substantial multiple testing correction of the significance threshold or rigorous control of the false discovery rate (FDR) is required if a large type I error rate is to be avoided. 
user
This is no advice
assistant