Question: is this a 2) strong advice, 1) weak advice 0) no advice?

In addition, trabectedin dose reductions became mandatory in case of liver toxicity [increase in bilirubin >ULN; and/or alkaline phosphatase (AP) >2.5 × ULN; and/or aminotransferases >2.5 × ULN] between cycles that has not recovered by day 21 of the cycle4,16. 
user
This is no advice
assistant