Question: is this a 2) strong advice, 1) weak advice 0) no advice?

This phenomenon was accompanied by a significant down-modulation of BIM expression (Figure 6G) that cannot be explained by the NPM/ALK-mediated phosphorylation of FOXO3a, because in BCR/ABL-positive cells, such as LAMA-84, FOXO3a is similarly inactivated by serine/threonine phosphorylation and cytoplasmic translocation [52] through a PI3K-dependent mechanism. 
user
This is no advice
assistant