Question: is this a 2) strong advice, 1) weak advice 0) no advice?

Epigenetic silencing can be triggered by CpG methylation through two main mechanisms: DNA methylation can repress transcription by directly impairing the binding of transcriptional activators to cognate DNA sequences [47,48] or MBP can bind to methylated DNA sequences, thus recruiting multi-protein corepressor complexes carrying HDAC activity. 
user
This is no advice
assistant