Question: is this a 2) strong advice, 1) weak advice 0) no advice?

However, as illustrated by our analysis of the FOXP2 locus, it cannot be assumed that overlapping but distinct variants have similar effect sizes or even directions; furthermore, such ‘point-wise’ analysis entails multiple statistical tests at each GSV locus, leading to potential inflation in the reported P-value for the region as a whole. 
user
This is no advice
assistant