Question: is this a 2) strong advice, 1) weak advice 0) no advice?

The putative mechanisms whereby increased permeability and reduced TJ expression might mediate IBS-D symptoms are increased water flux, resulting in looser-consistency bowel movements, and visceral hypersensitivity, as demonstrated by Bertiaux-Vandaële et al. (3), who observed association of lower occluding expression with more severe abdominal pain. 
user
This is no advice
assistant