Question: is this a 2) strong advice, 1) weak advice 0) no advice?

However, when NPM/ALK expression was knocked out using an inducible siRNA silencing system, no significant evidence of BIM locus reacetylation could be found (Figure 6, C and D), suggesting that NPM/ALK expression is dispensable from maintaining BIM epigenetic silencing and that other, yet unknown pathways are required to maintain this process, probably involving DNMT1. 
user
This is no advice
assistant