Question: is this a 2) strong advice, 1) weak advice 0) no advice?

The negative association between LUMA methylation and later age at menarche is counter-intuitive because (a) a later age at menarche is known to protect from breast cancer, and (b) lower global methylation is expected to increase genome instability and thus increase cancer risk [8], [26]. 
user
This is no advice
assistant