Question: is this a 2) strong advice, 1) weak advice 0) no advice?

Although attempts were made to take account of multiple testing (e.g. exclude GSVs present in the Database of Genomic Variants, including only rare GSVs, empirical estimate of FDR), it is unclear to what extent these methods are effective – methods developed for association analysis of rare sequence variants are not consistently well-powered even for large sample sizes [42]. 
user
This is no advice
assistant