Question: is this a 2) strong advice, 1) weak advice 0) no advice?

There have been several more recent reports in which the AD GWAS loci have been evaluated more comprehensively and either eight [Vivot et al  2015] or nine [Carrasquillo et al  2015] AD-associated loci were tested for association with cognitive decline, including ABCA7, CD33, CLU, CR1, and MS4A4E that were nominally associated with cognitive phenotypes in the ARIC study. 
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This is no advice
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