Question: is this a 2) strong advice, 1) weak advice 0) no advice?

Commensurate with this more pronounced defect in excitability, the leftward (hyperpolarized) shift for inactivation was much greater for V1442E (-30 mV, Fig. 5A) than the -10 mV shift observed for R672 mutants in HypoPP. 
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This is no advice
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