Question: is this a 2) strong advice, 1) weak advice 0) no advice?

Another possibility is that since the cognitive tests were administered to middle-aged adults whereas only 4% of those with AD are estimated to be younger than 65 years of age [Hebert et al  2003], the relationship between rs670139 and cognitive function in particular may change over the life course so that MS4A4E is beneficial in early life and has different effects at older ages. 
user
This is no advice
assistant