Question: is this a 2) strong advice, 1) weak advice 0) no advice?

Furthermore, although subjects carrying a highly-penetrant causative variant might naïvely be expected to display the phenotype regardless of ethnicity, geographical origin or environmental exposure, we have very little information on the potential for cohort-specific modifiers that can confound that expectation, or on differences in the frequencies or characteristics of rare variants between different populations. 
user
This is no advice
assistant