Question: is this a 2) strong advice, 1) weak advice 0) no advice?

The reported disproportionate hyperinsulinaemia in carriers of these deletions is reminiscent of the phenotype of SH2B1 knockout mice [30], which previously led to the suggestion that haploinsufficiency of SH2B1 is the primary cause of obesity in these individuals [10]. 
user
This is no advice
assistant