Question: is this a 2) strong advice, 1) weak advice 0) no advice?

While TNF causes NF-κB activation in Caco-2 cells and macrophages, the discrepant effect of TNF on ABCA1 expression (upregulated in macrophages and downregulated in Caco-2) suggests that mechanisms other than NF-κB may modulate ABCA1 expression (53). 
user
This is no advice
assistant