Question: is this a 2) strong advice, 1) weak advice 0) no advice?

Therefore, despite the evidence that NPM/ALK is not critical for the maintenance of BIM epigenetic silencing, these findings, albeit preliminary, suggest that NPM/ALK itself may be the initiator of the BIM epigenetic silencing pathway and that other NPM/ALK-independent mechanisms may be then recruited to maintain its repressed status. 
user
This is no advice
assistant