Question: is this a 2) strong advice, 1) weak advice 0) no advice?

Estrogen administration in ovariectomized rats mutes glucocorticoid negative feedback, resulting in higher ACTH levels, whether corticosterone or a synthetic glucocorticoid is administered by single bolus injection to test fast feedback via nongenomic mechanisms (25) or infused continuously to test slow feedback via nuclear glucocorticoid receptors (4). 
user
This is no advice
assistant