Question: is this a 2) strong advice, 1) weak advice 0) no advice?

Other limitations include: 1) possible extra-adrenal effects of KTCZ; however, exogenous cortisol normalized ACTH concentrations otherwise stimulated by KTCZ administration; 2) possible diurnal or seasonal effects (26, 40); 3) unknown effects of CBG per se on feedback by cortisol; and 4) uncertainty regarding long-term gonadal-steroid effects on HPA axis regulation. 
user
This is no advice
assistant