Question: is this a 2) strong advice, 1) weak advice 0) no advice?

Clusterin can bind reversibly to Aβ [Ghiso et al  1993; Zlokovic et al  1996], and has been implicated in Aβ clearance across the blood-brain barrier [Bell et al  2007; DeMattos et al  2004]. 
user
This is no advice
assistant