Question: is this a 2) strong advice, 1) weak advice 0) no advice?

It is interesting to note that this second replicated locus lies only 600 kb from that previously identified, also on chromosome 16p11.2, and that both deletions arise de novo with high frequency, probably reflecting general chromosomal instability on chromosome 16p due to the presence of multiple segmental duplications [10], [12], [21]. 
user
This is no advice
assistant