Snake venom VEGFs may contribute to venom dispersion and prey subjugation by inducing vascular permeability and hypotension. This protein stimulates vascular endothelial cell proliferation (EC(50)=0.2 nM) in a similar manner than VR-1 and vammin. This angiogenesis probably occurs through VEGF receptor (KDR/VEGFR-2) signaling. Also induces drastic hypotension mediated by nitric oxide (NO), which is produced by VEGF-activated endothelium NO synthase. Also induces vascular permeability 