Non-heme dioxygenase that mediates dealkylation reactions such as regio- and substrate-specific O-demethylation and O,O-demethylenation in the metabolism of protopine, benzo[c]phenanthridine, and rhoeadine alkaloids; cleaves a methylenedioxy bridge leaving two hydroxyl groups. Catalyzes the O,O-demethylenation of methylenedioxy bridges on protoberberine alkaloids such as allocryptopine and protopine and the O-demethylation of cryptopine. No activity with (S)-reticuline, salutaridine, papaverine, (S)-corytuberine, oripavine, (S)-scoulerine, pavine, noscapine, codeine or thebaine