Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin also inhibits high voltage-activated (HVA) calcium channel currents in rat DRG neurons (27% inhibition at 1 uM toxin) probably by activating GABA(B) receptors (GABBR1 and/or GABBR2)