Conorfamide As2a: this amidated form is active on both ASIC channels and nicotinic acetylcholine receptors (nAChRs). Potentiates ASIC1a (EC(50)=10.9 uM). Inhibits desensitization of ASIC1a and to a lesser degree ASIC3 currents, resulting in a sustained opening of channels in the presence of low pH. Inhibits with a slow reversibility human alpha-7/CHRNA7 nAChRs (IC(50)=689-3867 nM) and with a rapid reversibility human alpha-1-beta-1-delta-epsilon (CHRNA1-CHRNB1-CHRND-CHRNE) nAChRs (IC(50)=208 nM)