import * as t from 'io-ts' ; import { RTTI_id } from '../Scalar/RTTI_id' ; import { RTTI_Meta , IMeta } from './RTTI_Meta' ; import { RTTI_uri } from '../Scalar/RTTI_uri' ; import { RTTI_Element , IElement } from './RTTI_Element' ; import { RTTI_code } from '../Scalar/RTTI_code' ; import { RTTI_Narrative , INarrative } from './RTTI_Narrative' ; import { RTTI_ResourceList , IResourceList } from '../Union/RTTI_ResourceList' ; import { RTTI_Extension , IExtension } from './RTTI_Extension' ; import { RTTI_CodeableConcept , ICodeableConcept } from './RTTI_CodeableConcept' ; import { RTTI_Reference , IReference } from './RTTI_Reference' ; import { RTTI_Quantity , IQuantity } from './RTTI_Quantity' ; import { RTTI_MedicationKnowledge_RelatedMedicationKnowledge , IMedicationKnowledge_RelatedMedicationKnowledge } from './RTTI_MedicationKnowledge_RelatedMedicationKnowledge' ; import { RTTI_MedicationKnowledge_Monograph , IMedicationKnowledge_Monograph } from './RTTI_MedicationKnowledge_Monograph' ; import { RTTI_MedicationKnowledge_Ingredient , IMedicationKnowledge_Ingredient } from './RTTI_MedicationKnowledge_Ingredient' ; import { RTTI_markdown } from '../Scalar/RTTI_markdown' ; import { RTTI_MedicationKnowledge_Cost , IMedicationKnowledge_Cost } from './RTTI_MedicationKnowledge_Cost' ; import { RTTI_MedicationKnowledge_MonitoringProgram , IMedicationKnowledge_MonitoringProgram } from './RTTI_MedicationKnowledge_MonitoringProgram' ; import { RTTI_MedicationKnowledge_AdministrationGuidelines , IMedicationKnowledge_AdministrationGuidelines } from './RTTI_MedicationKnowledge_AdministrationGuidelines' ; import { RTTI_MedicationKnowledge_MedicineClassification , IMedicationKnowledge_MedicineClassification } from './RTTI_MedicationKnowledge_MedicineClassification' ; import { RTTI_MedicationKnowledge_Packaging , IMedicationKnowledge_Packaging } from './RTTI_MedicationKnowledge_Packaging' ; import { RTTI_MedicationKnowledge_DrugCharacteristic , IMedicationKnowledge_DrugCharacteristic } from './RTTI_MedicationKnowledge_DrugCharacteristic' ; import { RTTI_MedicationKnowledge_Regulatory , IMedicationKnowledge_Regulatory } from './RTTI_MedicationKnowledge_Regulatory' ; import { RTTI_MedicationKnowledge_Kinetics , IMedicationKnowledge_Kinetics } from './RTTI_MedicationKnowledge_Kinetics' ; import { IDomainResource } from './IDomainResource' ; export interface IMedicationKnowledge extends IDomainResource { /**
     * This is a MedicationKnowledge resource
     */ resourceType : 'MedicationKnowledge' ; /**
     * The logical id of the resource, as used in the URL for the resource. Once assigned, this value never changes.
     */ id ? : string ; /**
     * The metadata about the resource. This is content that is maintained by the infrastructure. Changes to the content might not always be associated with version changes to the resource.
     */ meta ? : IMeta ; /**
     * A reference to a set of rules that were followed when the resource was constructed, and which must be understood when processing the content. Often, this is a reference to an implementation guide that defines the special rules along with other profiles etc.
     */ implicitRules ? : string ; /**
     * Extensions for implicitRules
     */ _implicitRules ? : IElement ; /**
     * The base language in which the resource is written.
     */ language ? : string ; /**
     * Extensions for language
     */ _language ? : IElement ; /**
     * A human-readable narrative that contains a summary of the resource and can be used to represent the content of the resource to a human. The narrative need not encode all the structured data, but is required to contain sufficient detail to make it "clinically safe" for a human to just read the narrative. Resource definitions may define what content should be represented in the narrative to ensure clinical safety.
     */ text ? : INarrative ; /**
     * These resources do not have an independent existence apart from the resource that contains them - they cannot be identified independently, and nor can they have their own independent transaction scope.
     */ contained ? : IResourceList [ ] ; /**
     * May be used to represent additional information that is not part of the basic definition of the resource. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
     */ extension ? : IExtension [ ] ; /**
                     * May be used to represent additional information that is not part of the basic definition of the resource and that modifies the understanding of the element that contains it and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).
                     */ modifierExtension ? : IExtension [ ] ; /**
     * A code that specifies this medication, or a textual description if no code is available. Usage note: This could be a standard medication code such as a code from RxNorm, SNOMED CT, IDMP etc. It could also be a national or local formulary code, optionally with translations to other code systems.
     */ code ? : ICodeableConcept ; /**
     * A code to indicate if the medication is in active use.  The status refers to the validity about the information of the medication and not to its medicinal properties.
     */ status ? : string ; /**
     * Extensions for status
     */ _status ? : IElement ; /**
     * Describes the details of the manufacturer of the medication product.  This is not intended to represent the distributor of a medication product.
     */ manufacturer ? : IReference ; /**
     * Describes the form of the item.  Powder; tablets; capsule.
     */ doseForm ? : ICodeableConcept ; /**
     * Specific amount of the drug in the packaged product.  For example, when specifying a product that has the same strength (For example, Insulin glargine 100 unit per mL solution for injection), this attribute provides additional clarification of the package amount (For example, 3 mL, 10mL, etc.).
     */ amount ? : IQuantity ; /**
     * Additional names for a medication, for example, the name(s) given to a medication in different countries.  For example, acetaminophen and paracetamol or salbutamol and albuterol.
     */ synonym ? : string [ ] ; /**
     * Extensions for synonym
     */ _synonym ? : IElement [ ] ; /**
     * Associated or related knowledge about a medication.
     */ relatedMedicationKnowledge ? : IMedicationKnowledge_RelatedMedicationKnowledge [ ] ; /**
     * Associated or related medications.  For example, if the medication is a branded product (e.g. Crestor), this is the Therapeutic Moeity (e.g. Rosuvastatin) or if this is a generic medication (e.g. Rosuvastatin), this would link to a branded product (e.g. Crestor).
     */ associatedMedication ? : IReference [ ] ; /**
     * Category of the medication or product (e.g. branded product, therapeutic moeity, generic product, innovator product, etc.).
     */ productType ? : ICodeableConcept [ ] ; /**
     * Associated documentation about the medication.
     */ monograph ? : IMedicationKnowledge_Monograph [ ] ; /**
     * Identifies a particular constituent of interest in the product.
     */ ingredient ? : IMedicationKnowledge_Ingredient [ ] ; /**
     * The instructions for preparing the medication.
     */ preparationInstruction ? : string ; /**
     * Extensions for preparationInstruction
     */ _preparationInstruction ? : IElement ; /**
     * The intended or approved route of administration.
     */ intendedRoute ? : ICodeableConcept [ ] ; /**
     * The price of the medication.
     */ cost ? : IMedicationKnowledge_Cost [ ] ; /**
     * The program under which the medication is reviewed.
     */ monitoringProgram ? : IMedicationKnowledge_MonitoringProgram [ ] ; /**
     * Guidelines for the administration of the medication.
     */ administrationGuidelines ? : IMedicationKnowledge_AdministrationGuidelines [ ] ; /**
     * Categorization of the medication within a formulary or classification system.
     */ medicineClassification ? : IMedicationKnowledge_MedicineClassification [ ] ; /**
     * Information that only applies to packages (not products).
     */ packaging ? : IMedicationKnowledge_Packaging ; /**
     * Specifies descriptive properties of the medicine, such as color, shape, imprints, etc.
     */ drugCharacteristic ? : IMedicationKnowledge_DrugCharacteristic [ ] ; /**
     * Potential clinical issue with or between medication(s) (for example, drug-drug interaction, drug-disease contraindication, drug-allergy interaction, etc.).
     */ contraindication ? : IReference [ ] ; /**
     * Regulatory information about a medication.
     */ regulatory ? : IMedicationKnowledge_Regulatory [ ] ; /**
     * The time course of drug absorption, distribution, metabolism and excretion of a medication from the body.
     */ kinetics ? : IMedicationKnowledge_Kinetics [ ] ; } export const RTTI_MedicationKnowledge = t . recursion ( 'IMedicationKnowledge' , ( ) => t . intersection ( [ t . type ( { resourceType : t . literal ( 'MedicationKnowledge' ) } ) , t . partial ( { id : RTTI_id , meta : RTTI_Meta , implicitRules : RTTI_uri , _implicitRules : RTTI_Element , language : RTTI_code , _language : RTTI_Element , text : RTTI_Narrative , contained : t . array ( RTTI_ResourceList ) , extension : t . array ( RTTI_Extension ) , modifierExtension : t . array ( RTTI_Extension ) , code : RTTI_CodeableConcept , status : RTTI_code , _status : RTTI_Element , manufacturer : RTTI_Reference , doseForm : RTTI_CodeableConcept , amount : RTTI_Quantity , synonym : t . array ( t . string ) , _synonym : t . array ( RTTI_Element ) , relatedMedicationKnowledge : t . array ( RTTI_MedicationKnowledge_RelatedMedicationKnowledge ) , associatedMedication : t . array ( RTTI_Reference ) , productType : t . array ( RTTI_CodeableConcept ) , monograph : t . array ( RTTI_MedicationKnowledge_Monograph ) , ingredient : t . array ( RTTI_MedicationKnowledge_Ingredient ) , preparationInstruction : RTTI_markdown , _preparationInstruction : RTTI_Element , intendedRoute : t . array ( RTTI_CodeableConcept ) , cost : t . array ( RTTI_MedicationKnowledge_Cost ) , monitoringProgram : t . array ( RTTI_MedicationKnowledge_MonitoringProgram ) , administrationGuidelines : t . array ( RTTI_MedicationKnowledge_AdministrationGuidelines ) , medicineClassification : t . array ( RTTI_MedicationKnowledge_MedicineClassification ) , packaging : RTTI_MedicationKnowledge_Packaging , drugCharacteristic : t . array ( RTTI_MedicationKnowledge_DrugCharacteristic ) , contraindication : t . array ( RTTI_Reference ) , regulatory : t . array ( RTTI_MedicationKnowledge_Regulatory ) , kinetics : t . array ( RTTI_MedicationKnowledge_Kinetics ) } ) ] ) ) ;