隋唐陣，廣州仍維持著海上貿易中心地位。隋文帝廢南海郡，置廣州總管府。601年（仁壽元年）因避太子楊廣之諱而改廣州名叫“番州”。607年（大業三年）恢復南海郡，屬番州。621年（唐武德四年）恢復廣州，開初係總管府，後尾改成都督府。627年（唐貞觀元年），分全國為10道，其中嶺南道治所設喺廣州。
In the Sui and Tang dynasties, Guangzhou still maintained its status as a maritime trade center. Emperor Wen of Sui abolished Nanhai County and placed it in the Guangzhou Governor's Office. In 601 (the first year of Renshou), Guangzhou was renamed "Fanzhou" because of the avoidance of the prince Yang Guangzhi. In 607 (the third year of the Great Cause), Nanhai County was restored and belonged to Fanzhou. In 621 (the fourth year of Tang Wude), Guangzhou was restored, first as the governor's office, and later changed to the Chengdu governor's office. In 627 (the first year of Tang Zhenguan), the country was divided into 10 provinces, of which the Lingnan Provincial Governance Office was located in Guangzhou.