韓世灝出生於1971年12月22日，父親為韓德森先生，母親為汪玲女士。他是家中長子，其胞弟為韓世麟。韓家祖籍浙江餘姚，是明朝狀元韓應龍同族之後。1985年，韓世灝前往英國求學，就讀於阿賓漢姆學校。1993年，他從倫敦大學國王學院取得生物醫學榮譽學士學位，然後進入劍橋大學休斯大廳學堂深造，並獲得了精神病學博士學位。他還獲得了倫敦大學亞非學院的朝鮮研究碩士學位，亦完成了美國哈佛大學商學院 (高級經理培訓) 的「私人股權和風險資本課程」及「創業家總裁管理課程」。
Han Shihao was born on December 22, 1971, his father is Mr. Henderson and his mother is Ms. Wang Ling. He is the eldest son in the family, and his younger brother is Han Shilin. The ancestral home of the Han family is Yuyao, Zhejiang, and it is the same clan as Han Yinglong, the champion of the Ming Dynasty. In 1985, Han Shihao went to United Kingdom to study at Abingham School. He graduated with a BA (Hons) in Biomedical Sciences from King's College London in 1993 and went on to study at Hughes Hall School, University of Cambridge, where he obtained a Doctor of Psychiatry. He also holds a master's degree in North Korean Studies from the School of Oriental and African Studies, University of London, and has completed the "Private Equity and Venture Capital Program" and the "Entrepreneur President Management Program" at Harvard Business School (Senior Manager Training) at Harvard Business School in United States.