1842年，《南京條約》簽訂，實施“五口通商”，廣州失去獨佔對外貿易嘅優勢。自1845年後，廣州港出入口貨物總值一路下跌，由鹹豐三年開始，英國大部分對華貿易就轉咗去上海，上海港成咗新嘅大中華外貿中心。香港畀英國攞低開埠成自由港，亦慢慢代替咗廣州成為貨物集散地。此外，由於《南京條約》解除咗十三行唯一代理對外貿易嘅權力，出入口貿易實際經營權逐漸畀廣州啲洋行主導返。
In 1842, the Treaty of Nanking was signed, and the five ports of uranium were used to trade uranium, and Guangzhou lost its monopoly on foreign trade. Since 1845, the total value of import and export goods in the port of Guangzhou has been declining, and since the third year of Xianfeng, most of United Kingdom's trade with China has been transferred to Shanghai, and the port of Shanghai has become a new foreign trade center of Greater China. Hong Kong opened the port to United Kingdom as a free port, and gradually replaced Guangzhou as a cargo distribution center. In addition, since the Treaty of Nanjing relieved the Thirteen Banks of the right to act as the sole agent of foreign trade, the actual management rights of import and export trade were gradually returned to Guangzhou Dianyang.