到咗宋代，理學家二程同埋朱熹等人，進一步將呢個意理發揚開去，將“格物致知”視為求學做人嘅重要功夫。程頤講：“今日格一物，明日格一件。積習既多，然後脫然自有貫通處。”朱熹亦都有話“所謂致知在格物者，言欲致吾之知，在即物而窮其理也。蓋人心之靈莫不有知，而天下之物莫不有理，惟於理有未窮，故其知有不盡也。是以《大學》始教，必使學者即凡天下之物，莫不因其已知之理而益窮之，以求至乎其極。”
In the Song Dynasty, physicists Er Cheng and Zhu Xi and others further carried forward this principle, and regarded "learning from things" as an important effort to learn and be a man. Cheng Yi said: "One thing today, one thing tomorrow." There are many habits, and then there is a connection of its own. Zhu Xi also said, "The so-called knowledge is in the object, and the words want to know the thing, and the thing is exhausted." The soul that covers people's hearts knows everything, and the things in the world are all reasonable, but the reason is not endless, so its knowledge is endless. It is the beginning of teaching with the "University", so that the scholars, that is, all the things in the world, will benefit the poor because of their known principles, so as to seek it to the extreme. ”