天主教澳門教區係天主教會喺澳門設立嘅教區。呢度係東亞歷史最悠久嘅教區，喺1576年1月23號成立。今時今日嘅管轄範圍係澳門特別行政區全境。奉錫耶納聖加大肋納及聖方濟各沙勿略為主保聖人，格言係「科學與道德」（拉丁文：Scientia et Virtus）。
The Catholic Diocese of Macao is a diocese established by the Catholic Church in Macau. It is the oldest diocese in East Asia, founded on January 23, 1576. Today, the jurisdiction is the entire territory of the Macau S.A.R.. Dedicated to St. Catharene and St. Francis Xavier of Siena, the motto is "Science and Morality" (Latin: Scientia et Virtus).