明朝初期，一改宋、元時期嘅對外開放政策，實施海禁，廣州成為當時大中華唯一向大部分國家開放嘅通商港口，就係咁重新成為全國第一大港。1368年（明洪武元年）設廣州府，廣東布政使司、廣州府及番禺與南海縣治。
At the beginning of the Ming Dynasty, the Song and Yuan dynasties changed the policy of opening to the outside world and implemented the sea ban, and Guangzhou became the only treaty port in Greater China that was open to most countries at that time, and in this way it became the largest port in the country again. In 1368 (the first year of Hongwu in the Ming Dynasty), Guangzhou Mansion was established, and the Guangdong Provincial Political Envoy, Guangzhou Mansion and Panyu and Nanhai County were governed.