劇情係用小說古仔做主幹，同時加咗啲原作同系列中嘅一啲原素嘅改編。故事講喺有一晚當楚留香（狄龍飾）請佢嘅好朋友無花和尚（嶽華飾）嗰陣，神水宮宮南燕（苗可秀飾）忽然間嚟到，話最近江湖上發生咗好多單命案，好似係用神水宮嘅天一神水行兇，同埋兇案都係楚留香做，並要楚交回天一神水。楚留香話唔係佢做，但宮南燕要佢喺一個月內搵出真兇，如果搵唔到神水宮宮主就會將佢殺死。楚留香為咗證明清白，同時喺好奇心之下，決定查呢單案...
The plot is based on the story of the novel, and at the same time some adaptations of the original work and some elements in the series. The story says that one night, when Chu Liuxiang (played by Dillon) invited his good friend Wuhua Monk (played by Yue Hua) to go to the battle, Shenshui Palace Gong Nanyan (played by Miao Kexiu) suddenly realized that there have been many single murders on the rivers and lakes recently, it seems that the Tianyi Shenshui of the Shenshui Palace was used to commit murders, and the murders were all done by Chu Liuxiang, and Chu was asked to return Tianyi Shenshui. Chu Liuxiang said that he didn't do it, but Gong Nanyan asked him to find out the real culprit within a month, and if he couldn't find the palace master of Shenshui Palace, he would kill him. In order to prove his innocence, Chu Liuxiang decided to investigate this case under curiosity...