1966年，文化大革命發生後，市內陷入混亂狀態，經濟近乎癱瘓，所有學校停課搞「階級鬥爭」，後來學生喺校園「復課鬧革命」，但好多學校早就畀「讀書無用論」嘅風氣籠罩，文化堂學習非常唔規範，老師上堂缺乏教材講義，而且文化課堂成日會變成「革命大批判」嘅政治堂。文革期間，歷史建築受到非常嚴重嘅破壞，石室聖心大教堂啲彩色玻璃畀人打爛曬，仲變成埋垃圾崗；光孝堂啲書籍畀人焚燒；光孝寺、六榕寺啲百年佛像同神像畀人打爛曬，後者大部分廟宇畀拆咗；琶洲塔嘅寺廟畀拆咗；華林寺嘅五百羅漢像畀毀曬；四牌樓畀打爛曬；黃花崗七十二烈士墓啲碑文幾乎全畀破壞；喺廣州昔日園林寺觀中，保存落來嘅古代匾額數之不盡，僅光孝、六榕兩寺廟，往日匾額對聯多不勝數，但喺經歷文革後均蕩然無存。大量地名同商號都畀改埋名，如蓮香樓畀改成「東升樓」，六榕路、朝天路、米市路三條路，變成南北「朝陽路」等，似東風路、北京路、福今路、前進路、進步裏等至今沒有恢復原名。
In 1966, after the Cultural Revolution, the city fell into a state of chaos, the economy was almost paralyzed, all schools were closed to engage in "class struggle", and later students "resumed classes to make a revolution" on campus, but many schools have long been shrouded in the atmosphere of "the uselessness of reading", the study in the cultural hall is very non-standardized, the teachers lack teaching materials and handouts, and the cultural classroom often becomes a political hall of "revolutionary criticism". During the Cultural Revolution, the historical buildings were seriously damaged, the stained glass of the Stone Chamber Sacred Heart Cathedral was broken and turned into a garbage hill; the books of Guangxiao Hall were burned; the century-old Buddha statues and statues of gods in Guangxiao Temple and the Six Banyan Tree Temple were broken, and most of the temples of the latter were demolished; the temple of Pazhou Pagoda was demolished; the 500 Arhat statues of Hualin Temple were destroyed and sunburned; the four archways were broken; the inscriptions on the tombs of the 72 martyrs of Huanghuagang were almost all destroyed; in the garden temples of Guangzhou in the past, the ancient plaques that have been preserved are innumerable, only the two temples of Guangxiao and the Six Banyan Trees, and there are countless plaque couplets in the past, but they are all gone after the Cultural Revolution. A large number of place names and business names have also been renamed, such as Lianxiang Building was changed to "Dongsheng Building", Liurong Road, Chaotian Road, Mishi Road three roads, into the north and south "Chaoyang Road", etc., such as Dongfeng Road, Beijing Road, Fujin Road, Qianjin Road, Progress Lane, etc. have not been restored to their original names.