喺15～16世紀期間，以渡島半島南部為勢力範圍嘅蠣崎氏，先後畀當時實際統治日本嘅豐臣秀吉（關白、太閤）、德川家康（徵夷大將軍）認可咗擁有對蝦夷地嘅支配權，同埋貿易權。到咗江戶時代後，蠣崎氏改咗名叫松前氏，仲俾列入咗大名、當主松前慶廣分封做松前藩，領有而家北海道南部嘅「和人地」同蝦夷地。後尾，北海道太平洋側同千島俾改埋名做東蝦夷地、北海道日本海側同庫頁島就俾改叫西蝦夷地。而東蝦夷地喺1799年、西蝦夷地喺1807年，先後俾幕府歸做佢自己嘅直轄地。1809年，庫頁島改名「北蝦夷」。1821年，蝦夷地全境試過再度成為咗松前藩領地，但到咗1855年又再俾嗮幕府劃成佢自己嘅直轄地。
During the 15th ~ 16th centuries, the Sakizaki clan, whose sphere of influence was in the southern part of the Toshima Peninsula, successively allowed Toyotomi Hideyoshi (Sekihaku, Taiti) and Tokugawa Ieyasu (Shogun), who actually ruled Japan at the time, to have the right to dominate the Ezo land and the right to trade. After the Edo period, the Sakizaki clan changed its name to the Matsumae clan, and it was also included in the Daimyo and the lord Matsumae Keihiro was divided into the Matsumae Domain, and owned the "Wajin" and Ezo land in the southern part of Hokkaido. Later, the Pacific side of Hokkaido and the Kuril Islands were renamed Higashi Ezo, and the Japan side of Hokkaido and Sakhalin were renamed West Ezo. In 1799 and 1807, the East Ezo Land and the West Ezo Land were successively classified by the shogunate as their own direct jurisdictions. In 1809, Sakhalin Island was named "North Ezo". In 1821, the entire territory of Ezo was once again a domain of the Yamamatsumae domain, but in 1855 it was again wasted by the shogunate and made it his own direct domain.