The Creative Assembly嘅製作公司將《異形：孤立》形容係一款生存恐怖遊戲而唔係動作射擊遊戲，因此俾遊戲嘅風格較為接近雷利·史考特執導嘅恐怖電影《異形》，而唔係詹姆士·卡麥隆嚟執導、較為偏向《異形2》嘅動作電影。有別於第啲《異形》主題嘅遊戲，《異形：孤立》入面大部分時間只會出現一隻異形而且無法被殺死，玩者需要生存落去使用匿埋技巧。雖然遊戲入面有武器，但呢啲武器只係對人類同「Working Joes」機器人有攻擊作用。
The Creative Assembly's production company describes Alien Isolation as a survival horror game rather than an action shooter, so the style of the game is closer to the horror movie Alien directed by Reilly · Scott than the action movie directed by James · Cameron, which is more oriented towards Alien 2. Unlike some of the first Alien-themed games, Alien Isolation only appears with one Xenomorph most of the time and cannot be killed, so players need to survive and use hiding skills. Although there are weapons in the game, these weapons are only offensive to humans and "Working Joes" robots.