  Suppose that X is a Fano manifold that corresponds under Mirror Symmetry to a Laurent polynomial f, and that P is the Newton polytope of f. In this setting it is expected that there is a family of algebraic varieties over the unit disc with general fiber X and special fiber the toric variety defined by the spanning fan of P. Building on recent work and conjectures by Corti--Hacking--Petracci, who construct such families of varieties, we determine the topology of the general fiber from combinatorial data on P. This provides evidence for the Corti--Hacking--Petracci conjectures, and verifies that their construction is compatible with expectations from Mirror Symmetry. 
On the Topology of Fano Smoothings