  We present a new theoretical framework for the study of $B\to X_u \ell \nu$ decays, which includes all known perturbative and non-perturbative contributions and a description of leading and subleading Fermi motion effects. The perturbative and non-perturbative regimes are separated by a ``hard'' Wilsonian cutoff $\mu \sim 1$ GeV. We bring into focus some problems related to the high $q^2$ region and to Weak Annihilation effects. We provide estimates of the CKM parameter $|V_{ub}|$ using the described framework and discuss the related theoretical uncertainty. 
Semileptonic B decays and the inclusive determination of |V(ub)|