  Many chemical and biological experiments involve multiple treatment factors and often it is convenient to fit a nonlinear model in these factors. This nonlinear model can be mechanistic, empirical or a hybrid of the two. Motivated by experiments in chemical engineering, we focus on D-optimal design for multifactor nonlinear response surfaces in general. In order to find and study optimal designs, we first implement conventional point and coordinate exchange algorithms. Next, we develop a novel multiphase optimisation method to construct D-optimal designs with improved properties. The benefits of this method are demonstrated by application to two experiments involving nonlinear regression models. The designs obtained are shown to be considerably more informative than designs obtained using traditional design optimality algorithms. 
Optimal Design of Experiments for Nonlinear Response Surface Models