hat
Nou konnen ke se prezans nan microtubules dinamik nan vwazinaj la nan yon cortical selil vle pèse anvlòp oblije estabilize avancée, li pèmèt li kontinye. Sepandan, fòmil yo molekilè pa ki microtubules kontwole avancée selil rete yo dwe konprann. Nou konnen yon kantite faktè ki ko-kontwole tubulin ak aktin dinamik ak pwojè sa a pral eksplore fonksyon an nan aktin-tubulin ko-regilatè nan migrasyon selil direksyon.
eng
We know that the presence of dynamic microtubules in the vicinity of a protruding cell cortex is required to stabilise protrusion and allow it to continue. However, the molecular mechanisms by which microtubules regulate cell protrusion remain to be understood. We know a number of factors that co-regulate microtubule and actin dynamics and this project will explore the function of actin-microtubule co-regulators in directional cell migration.