hat
Pyridine sentèz nan Bohlmann-Rahtz pèmèt jenerasyon pyridines ranplase nan de etap pi gwo. Kondansasyon an nan enamines lè l sèvi avèk ethynylketones rezilta nan yon entèmedyè aminodiene ki, apre chalè-induit izomèrsizasyon, subi cyclodehydration yo pwodwi pirinin ksumoks-trisubstituted.
eng
Pyridine Synthesis through Bohlmann-Rahtz allows generation of substituted pyridines in two major steps. The condensation of enamines using ethynylketones results in an aminodiene intermediate which, after heat-induced isomerization, undergoes cyclodehydration to produce 2,3,6-trisubstituted pyridines.