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Pandan Dezyèm Gè Mondyal, swiv dekouvèt Lè sa a, sekrè Glenn Seaborg la nan plitonyòm, Ernest Orlando Lawrence la Radyasyon Laboratwa te kòmanse kontra avèk U.S nan. Lame yo devlope bonm atomik la. UC Berkeley fizik pwofesè J. Robert Oppenheimer te rele tèt syantifik nan Pwojè a Manhattan nan 1942. Ansanm ak laboratwa a Lawrence Berkeley Nasyonal (ansyen Laboratwa a Radyasyon), Berkeley se kounye a yon patnè nan jere de lòt laboratwa, Los Alamos National Laboratory (1943) ak Lawrence Livermore National Laboratory (1952).
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During World War II, following Glenn Seaborg’s then-secret discovery of plutonium, Ernest Orlando Lawrence’s Radiation Laboratory began to contract with the U.S. Army to develop the atomic bomb. UC Berkeley physics professor J. Robert Oppenheimer was named scientific head of the Manhattan Project in 1942. Along with the Lawrence Berkeley National Laboratory (formerly the Radiation Lab), Berkeley is now a partner in managing two other labs, Los Alamos National Laboratory (1943) and Lawrence Livermore National Laboratory (1952).