hat
Plizyè metòd ki pèmèt sentèz de tetra ak trisubstituted piridin nan yon pwosesis yon sèl etap yo te devlope dènyèman. Olye pou yo fè sèvi ak butynone kòm yon substra, Bagley teste Solvang divès kalite pou konvèsyon nan mwens temèt ak chè 4- (trimethylsilyl) men-3-nan-2-yon sèl. Li te demontre ke sèlman DMSO ak EtOH yo se solvang ideyal. EtOH se byen klè te favorize kòm yo te polè ak pwotik sòlvan kont DMSO kòm sòlvan a polè aprotic. Nan de Solvang yo, protodesilylation te pran plas natirèlman. Bagley te demontre tou ke catalysis asid pèmèt cyclodehydration a kontinye nan yon pi ba tanperati.
eng
Several methods which allow synthesis of tetra and trisubstituted pyridines in a single-step process have been developed recently. Instead of making use of butynone as a substrate, Bagley tested various solvents for conversion of less volatile and inexpensive 4-(trimethylsilyl)but-3-yn-2-one. It was demonstrated that only DMSO and EtOH are ideal solvents. EtOH is clearly favored as being polar and protic solvent vs. DMSO as the polar aprotic solvent. In the two solvents, protodesilylation took place spontaneously. Bagley has also demonstrated that acid catalysis allows the cyclodehydration to continue at a lower temperature.