hat
Akouchman nan dwòg makromolekul (egzanp, pwoteyin, peptides, ADN ki baze sou medikaman, elatriye) nan baryè a mukozal se trè enteresan. Nenpòt ki sistèm livrezon nanometrik optimisé yo anba kouch nan jèl larim ta dwe depreferans montre ranfòse pousantaj pénétration, Des lage dwòg soutni ankò ansanm, ase pwoteksyon nan direksyon pou anzimatik degradasyon nan dwòg yo makromolekul yo nan lòd reyalize yon ogmante byodisponibilite dwòg. Alexander pote ansanm yon consortium nan famasi sentetik, famasi fizik, famasyen ak byolojis yo devlope milti-modal patikil solid ak likid ki baze sistèm livrezon nanometrik se vre wi: inovatè.
eng
Delivery of macromolecular drugs (e.g., proteins, peptides, DNA-based drugs, etc.) through the mucosal barrier is extremely challenging. Any nanoscale delivery system optimized to penetrate the mucus gel layer should ideally show enhanced permeation rates, sustained drug release profiles yet simultaneously, sufficient protection towards enzymatic degradation of the macromolecular drugs in order to achieve an increased drug bioavailability. Alexander brings together a consortium of synthetic chemists, physical chemists, pharmacists and biologists to develop truly innovative multi-modal solid and liquid particle based nanoscale delivery systems.