hat
Lè yo diseke ak egzamine sèvo bèt yo ' 45 minit pita, chèchè yo te jwenn espasyal eksplorasyon evoke plotonen aktivite nan formasyon nan newòn ipokanpal, jan yo detèmine pa nivo nan kfo, yon sa yo rele 'imedya byen bonè' jèn ki se chanje sou byen vit lè newòn kòmanse nan dife. Importantly, sourit pèmèt yo eksplore kaj yo te gen pi wo nimewo nan kfo-expressing granule cells than those left in their home cages for the duration of the experiment, and those that received optogenetic stimulation during the exploration had significantly higher numbers of kfo–positive neurons than those that did not.
eng
When they dissected and examined the animals’ brains 45 minutes later, the researchers found spatial exploration evoked activity in ensembles of hippocampal neurons, as determined by levels of cFos, a so-called ‘immediate early’ gene that is switched on quickly when neurons start to fire. Importantly, mice allowed to explore their cages had higher numbers of cFos-expressing granule cells than those left in their home cages for the duration of the experiment, and those that received optogenetic stimulation during the exploration had significantly higher numbers of cFos–positive neurons than those that did not.