hat
Epitou nan nòt se ke fòm oral la nan Clostebol se pa reyèlman fwa-toksik. Sa a se paske li fè pou sèvi ak èstr la acetate olye pou yo tradisyonèl alfabetik (ak efikas) c-17 alfa ke nou anjeneral jwenn sou estewoyid nan bouch. Malerezman, ester la acetate, pandan y ap bay yon degre nan pwoteksyon pou premye pas dwòg la nan fwa a, se pa trè efikas ... Se konsa, pandan ke sibstitisyon an 4-chloro pa fè anyen pou amelyore disponiblite oral, li ogmante rezistans nan aromatisasyon, osi byen kòm rezistans nan 5a ak 5b-rediksyon (konvèsyon nan yon metabolit dihydro aktif ak yon metabolit inaktif / nonanabolik, respektivman). Reyèl 5a-rediksyon (konvèsyon pou yon metabolid dihydro) jeneralman panse poukisa sèten estewoyid (ki se 5a-redwi oswa dyagnostik vèsyon chak se) yo panse yo lakòz akne ak pèt cheve.
eng
Also of note is that the oral form of Clostebol isn’t really liver-toxic. This is because it makes use of the acetate ester instead of the more traditional (and effective) c-17 alpha alkylation that we typically find on oral steroids. Unfortunately, the acetate ester, while providing a degree of protection for the drug’s first pass through the liver, isn’t very efficient…so while the 4-chloro substitution does nothing to enhance oral availability, it does increase resistance to aromatization, as well as resistance to 5a and 5b-reduction (conversion to an active dihydro metabolite and an inactive/nonanabolic metabolite, respectively). The aforementioned 5a-reduction (conversion to a dihydro metabolite) is generally thought to be why certain steroids (which are 5a-reduced or dihydro versions per se) are thought to cause acne and hair loss.