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Deskripsyon J147, Yon potansyèl neuroprotective ak nerotwofik konpoze, anba non an IUPAC N- (2,4-dimethylphenyl) -2,2,2-trifluoro-N - [(E) - (3-methoxyphenyl) methylideneamino] asetamid, yon konpoze hydrazid phenyl ki te montre anpeche defisi memwa nan yon modèl sourit alzayme a. nan vitro: Yon potansyèl neuroprotective ak nerotwofik konpoze (EC50 = 25 - 200 nM) nan vivo: Redwi soluble Aβ40 ak Aβ42 nivo ak ogmante nivo BDNF nan ipokanp la
eng
Description J147, A potent neuroprotective and neurotrophic compound,under the IUPAC name N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N-[(E)-(3-methoxyphenyl)methylideneamino]acetamide, a phenyl hydrazide compound that has been shown to prevent memory deficits in an Alzheimer’s disease mouse model. in vitro: A potent neuroprotective and neurotrophic compound (EC50 = 25 – 200 nM) in vivo: Reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus