hat
Monomethyl auristatin E mekanis nan aksyon se yon ajan antimitotik ki inibit divizyon selilè pa bloke polymerisation la nan tubin. Linker nan monoclonaux antikò a se ki estab nan likid ekstrazilè, men se klavye pa cathepsin yon fwa konjige a te antre nan yon selil timè, enben, aktive mekanis antimitotik la.
eng
Monomethyl auristatin E mechanism of action is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumour cell, thus activating the antimitotic mechanism.