hat
Reyaksyon nan 4-manm konpoze heterocyclic tou demontre enfliyans souch son. Dyagram ki anba la a montre kèk egzanp. Asid-kataliz se yon karakteristik tipik nan divès reyaksyon bag-ouvèti demontre nan egzanp 1,2, ak 3a. Nan reyaksyon 2 nan thietane, souf subi elektwofil klorinasyon ki mennen nan fòmasyon an nan entèmedyè chlorosulfonium ak sibstitisyon nan ion klori-ouvèti louvri. Nan reyaksyon 3b, nukleofil fò yo tou wè yo louvri etè a egzajere. Reaksyon klakaj beta-lactòn yo ka rive swa pa asid-catalyzed acyl echanj jan yo wè nan 4a. Li kapab tou pran plas pa alkyl-O rupture pa nucleophiles tankou nan 4b.
eng
Reactions of 4-membered heterocyclic compounds also demonstrate ring strain influence. The following diagram shows some examples. Acid-catalysis is a typical feature of various ring-opening reactions demonstrated in examples 1,2, and 3a. In reaction 2 of thietane, sulfur undergoes electrophilic chlorination leading to the formation of chlorosulfonium intermediate and substitution of ring-opening chloride ion. In reaction 3b, strong nucleophiles are also seen to open the strained ether. Beta-lactones’ cleavage reactions may happen either by acid-catalyzed acyl exchange as seen in 4a. It can also take place by alkyl-O rupture by nucleophiles like in 4b.