hat
Monomethyl auristatin E (MMAE, vedotin) se yon trè ki pisan antimitotik ajan ki inibit divizyon selilè pa bloke polymerisation nan tubin.The fanmi nan auristatin yo se analogue sentetik nan pwodwi a antineoplast natirèl Dolastatin 10, inhibiteur mikrotibul ultrapotan mikrotubilik ki klinikman itilize kòm charj nan konjige antikò-dwòg.
eng
Monomethyl auristatin E (MMAE, vedotin) is a very potent antimitotic agent that inhibits cell division by blocking the polymerisation of tubulin.The family of auristatins are synthetic analogues of the antineoplastic natural product Dolastatin 10, ultrapotent cytotoxic microtubule inhibitors that are clinically used as payloads in antibody-drug conjugates.