hat
Endocannabinoids tankou gncerol 2-arachidonoyl (2-AG) ak etanolamid arachidonoyl yo se lipid biyolojik aktif ki patisipe nan yon kantite pwosesis synaptik ki gen ladan aktivasyon nan reseptè Cannabinoid. JW 642 se yon inibitè ki pisan nan lipase monoacylglycerol (MAGL) ki montre valè IC50 nan 7.6, 14, ak 3.7 nM inhibition nan MAGL nan sourit, rat, ak imen sèvo imen, respektivman. JW642is selektif pou MAGL, ki egzije konsantrasyon pi wo nan efektivman anpeche asid gra aktivite amid idrolase (IC50s = 31, 14, ak 20.6 μM pou mouvman sourit, rat, andemoni sèvo, respektivman).
eng
Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. JW 642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM forinhibition of MAGL in mouse, rat, and human brain membranes, respectively. JW642is selective for MAGL, requiring much higher concentrations to effectively inhibit fatty acid amide hydrolase activity (IC50s = 31, 14, and 20.6 µM for mouse, rat, andhuman brain membranes, respectively).