hat
Inconvénient la se konpatibilite a limite ak substrats yo asid-sansib. Pou egzanp, asid-catalyzed dekonpozisyon nan enamin yo pran plas ak Cyano ak tert-butylester kòm gwoup retire elèktwon. Yon lòt altènatif modere se aplikasyon an nan Amberlyst-15 ion echanje reaktan ki tolere tert-butyles.
eng
The downside is the limited compatibility with the acid-sensitive substrates. For instance, acid-catalyzed decomposition of the enamines takes place with cyano and tert-butylester as electron withdrawing groups. Another mild alternative is the application of Amberlyst-15 ion exchanging reagent which tolerates tert-butylesters.