hat
Nan kominikasyon sa a nou rapòte yon sentèz total stereoselektif nan N-Boc-dolaproine (CAS 120205-50-7) (Dap), yon résidans asid amine nan pentapeptide a pentapeptide dolastatin 10. Estrateji nou an baze sou yon reyaksyon Baylis-Hillman ant Acrylate N-Boc-prolinal ak methyl, ki te swiv pa yon dyastereoselektif doub idojèn kosyon ak idrolyse nan fonksyon ester la.
eng
In this communication we report a stereoselective total synthesis of N-Boc-dolaproine (CAS 120205-50-7) (Dap), an amino acid residue of the antineoplastic pentapeptide Dolastatin 10. Our strategy is based on a Baylis–Hillman reaction between N-Boc-prolinal and methyl acrylate, followed by a diastereoselective double bond hydrogenation and hydrolysis of the ester function.