hat
Albumin pèt nan pipi a (mikroalbuminuri) reflete domaj nan mikrovaskulèr nan ren (glomerul a) epi yo ka asosye ak tou de glomerul andotelyo (GEnC) glycocalyx pèt ak jeneral malfonksyònman andotelyo. Sèvo andotelyo faktè kwasans (VEGF) Yon kontwole veso pèmeyabilite ki ak overactivity lakòz veso ki gen fuit ak albuminuri. Nan kilti selil VEGFA ogmante GEnC pèmeyabilite ki pwoteyin Lè nou konsidere ke VEGFC diminye li epi yo gen efè diferans sou glycocalyx la.
eng
Albumin loss into the urine (microalbuminuria) reflects damage to the kidney microvascular (the glomerulus) and can be associated with both glomerular endothelial (GEnC) glycocalyx loss and general endothelial dysfunction. Vascular endothelial growth factor (VEGF)A regulates vessel permeability and overactivity causes leaky vessels and albuminuria. In cell culture VEGFA increases GEnC protein permeability whereas VEGFC reduces it and they have differential effects on the glycocalyx.