hat
Monomethyl auristatin E (MMAE), yon auristatin trè ki pisan, rete yon sijè cho nan syans ADC. MMAE se yon ajan antimitotik ki inibit divizyon selil pa bloke polymerisation nan tubin, ki reprezante kòm anpil jan 100- 1000-pliye pi pisan pase medikaman dwòg kimoterapi tankou vinblastine16,17. The
eng
Monomethyl auristatin E(MMAE),a highly potent auristatin, remains a hot topic in ADC studies. MMAE is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin, representing as much as 100- to 1000-fold more potent than standard chemotherapeutic drugs such as vinblastine16,17. The