hat
J147 poud lan ap travay pa diminye aktivite a nan synthase nan ATP nan mitokondri la. Sa a pwoteje selil neronal soti nan anpil nan toksisite nan sèvo laj ki gen rapò ak. Rechèch endike rezon ki fè konpoze sa a pwodui efè neroprotective sa a se paske nan jwe nan excitotoxicity wòl nan domaj selil newòn.
eng
CAD31 is an Alzheimer’s disease (AD) drug candidate that was selected on the basis of its ability to stimulate the replication of human embryonic stem cell-derived neural precursor cells as well as in APPswe/PS1ΔE9 AD mice. To move CAD-31 toward the clinic, experiments were undertaken to determine its neuroprotective and pharmacological properties, as well as to assay its therapeutic efficacy in a rigorous mouse model of AD.