hat
Nou te jwenn ke devlopman nan obezite te makonnen ak Aparisyon nan yon defisi gradyèl vin pi grav defisi nan sèvo. Menm jan chanjman ki fèt nan homeostasis rekonpans induit pa kokayin oswa ewoyin konsidere kòm yon deklanche kritik nan tranzisyon an soti nan aksidantèl ak konpulsif pran dwòg. An konsekans, nou detekte konpulsif tankou konpòtman manje nan rat obèz, men se pa mèg, ki mezire kòm konsomasyon manje gou ki te rezistan a dezòd pa yon estimilis avèr kondane. Striatal Dopamine reseptè D2 (D2R) yo te downregulated nan rat obèz, menm jan ak rapò anvan yo nan dwòg moun dwòg. Anplis, lentivirus-mediated knockdown nan striatal D2R rapidman akselere devlopman nan defisi dejwe-tankou rekonpans ak aparisyon nan konpulsif tankou manje k ap chèche nan rat ak aksè pwolonje nan manje ki gen anpil grès. Done sa yo demontre ke overconsumption nan manje gou gou ki deklannche dejwe-tankou repons neuroadaptive nan sikwi rekonpans sèvo ak kondui devlopman nan konpulsif manje. Komen mekanik hedonic ka Se poutèt sa underlie obezite ak dejwe dwòg.
eng
We found that development of obesity was coupled with the emergence of a progressively worsening brain reward deficit. Similar changes in reward homeostasis induced by cocaine or heroin is considered a critical trigger in the transition from casual to compulsive drug-taking. Accordingly, we detected compulsive-like feeding behavior in obese but not lean rats, measured as palatable food consumption that was resistant to disruption by an aversive conditioned stimulus. Striatal dopamine D2 receptors (D2R) were downregulated in obese rats, similar to previous reports in human drug addicts. Moreover, lentivirus-mediated knockdown of striatal D2R rapidly accelerated the development of addiction-like reward deficits and the onset of compulsive-like food seeking in rats with extended access to palatable high-fat food. These data demonstrate that overconsumption of palatable food triggers addiction-like neuroadaptive responses in brain reward circuitries and drives the development of compulsive eating. Common hedonic mechanisms may therefore underlie obesity and drug addiction.