hat
Flibansetrin hcl gen gwo afinite pou reseptè serotonin nan sèvo a: li aji kòm yon agonist sou 5-HT1A ak yon antagonist sou 5-HT2A. Nan vivo, flibanserin mare egalman a 5-HT1A ak 5-HT2A reseptè. Sepandan, anba pi wo nivo nan sèvo 5-HT (sètadi, anba estrès), Flipanserin Hydrochloride ka okipe 5-HT2A reseptè nan pi wo pwopòsyon pase 5-HT (1A) reseptè. Li ka tou modera antagonize D4 (dopamine) reseptè ak 5-HT2B ak 5-HTB2C. Aksyon li yo sou reseptè nerotransmete ka kontribye nan rediksyon nan nivo serotonin ak ogmantasyon nan dopamine ak norepinephrine nivo, tout nan yo ki ka jwe yon pati nan pwosesis rekonpans.
eng
Flibansetrin hcl has high affinity for serotonin receptors in the brain: it acts as an agonist on 5-HT1A and an antagonist on 5-HT2A. In vivo, flibanserin binds equally to 5-HT1A and 5-HT2A receptors. However, under higher levels of brain 5-HT (i.e., under stress), Flibanserin Hydrochloride may occupy 5-HT2A receptors in higher proportion than 5-HT(1A) receptors. It may also moderately antagonize D4 (dopamine) receptors and 5-HT2B and 5-HTB2C. Its action on neurotransmitter receptors may contribute to reduction in serotonin levels and increase in dopamine and norepinephrine levels, all of which may play part in reward processing.