hat
URB597, konnen tou kòm KDS-4103, se yon inibitè trè pisan ak selektif nan idrataz amid gra-asid (FAAH), yon anzim katalize idrolyse entrazellilè nan anandamid la endocannabinoid, ak valè nan 50 konsantrasyon anpèchman IC50 nan 4.6 nM ak 0.5 nM nan membranes nan sèvo rat ak mikrosom nan fwa respektivman. URB597 ekspozisyon anksiolytik, depresè, antinociceptive ak analgesic efè nan vivo san yo pa evoke lòt sentòm ki asosye avèk konpoze cannabinoid ki tankou.
eng
URB597, also known as KDS-4103, is a highly potent and selective inhibitor of fatty-acid amide hydrolase (FAAH), an enzyme catalyzing the intracellular hydrolysis of the endocannabinoid anandamide, with values of 50% inhibition concentration IC50 of 4.6 nM and 0.5 nM in rat brain membranes and human liver microsomes respectively. URB597 exhibits anxiolytic, antidepressant, antinociceptive and analgesic effects in vivo without evoking other symptoms associated with cannabinoid-like compounds.