hat
JW 642 se yon lipase potansyèl ak selektif lipase (MAGL) inibitè (IC = 3.7 nM). Montre&gt; 1000-pliye selektivite pou MAGL sou amidehydrolase asid gra (IC = 20.6 μM). Monoacylglycerol lipase (MAGL) isa serin idrolase responsab pou idrolyiz la nan 2-AG nan asid arachidonik ak gliserin, konsa endike fonksyon byolojik li yo. Efè toksikolojik ka lakòz tankou anba a: Methyl Acetate - Done toksisite: Oral LD50 (rat):&gt; 5,000 mg / kg; Oral LD50 (lapen): 3,705 mg / kg; Po LD50 (lapen):&gt; 5,000 mg / kg; Rale TCLO (imen): 15,000 mg / m3; Methyl Acetate - Done Iritasyon: Po (lapen): 500 mg (24h) twò grav; Je (lapen): 100 mg (24h) modere.
eng
JW 642 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor (IC = 3.7 nM). Displays &gt;1000-fold selectivity for MAGL over fatty acid amidehydrolase (IC = 20.6 μM). Monoacylglycerol lipase (MAGL) isa serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. Toxicological Effects may be caused like below: Methyl Acetate – Toxicity Data: Oral LD50 (rat): &gt;5,000 mg/kg; Oral LD50 (rabbit): 3,705 mg/kg; Skin LD50(rabbit): &gt;5,000 mg/kg; Inhalation TCLO (human): 15,000 mg/m3; Methyl Acetate – Irritation Data: Skin (rabbit): 500 mg (24h) mild; Eyes (rabbit):100 mg (24h)moderate.