hat
Te Sereyal dyetetik fib byen etabli benefis swen sante an tèm de diminye kolestewòl sewòm ak kardyovaskulèr yo epi li redwi risk pou kansè nan kolon (Aune et al, BMJ, 2011; 343: d6617doi: 10.1136/bmj.d6617). Fòmil yo nan efè sa yo mal konprann, men li posib ke fèmantasyon pre-byotik nan kolon an yon mekanis asistan. Previous syans kolaborasyon ant laboratwa aplikan an? S yo te montre aktivite ki pi gwo eleman nan fib dyetetik nan grenn jaden ble, arabinoxylan (AX), li te pre-byotik ki se ki gen rapò ak mas (Hughes et al, J agrik Manje Chem 2007). Bous a prezan pral eksplore relasyon sa yo nan plis detay lè l sèvi avèk liy transjenik ble deja pwodwi nan Rothamsted Rechèch kòm byen ke lòt aksyon ble jenetik.
eng
Cereal dietary fibre has well-established health benefits in terms of reducing serum cholesterol and CVD and reducing the incidence of colon cancer (Aune et al, BMJ, 2011; 343:d6617doi:10.1136/bmj.d6617). The mechanisms of these effects are poorly understood but it is likely that pre-biotic fermentation in the colon is a contributory mechanism. Previous collaborative studies between the applicants laboratories have shown that the major dietary fibre component in wheat grain, arabinoxylan (AX), has pre-biotic activity which is related to mass (Hughes et al, J Agric Food Chem 2007). The present studentship will explore these relationships in more detail using transgenic wheat lines already generated at Rothamsted Research as well as other genetic wheat stocks.