hat
Bèt yo miltiselilè, Caenorhabditis èlègan, se ideyal kòm yon sistèm nan adrès kesyon ki anwo yo. Ka eksperimantal evolisyon dwe fasil pou fèt nan vè sa yo, ak C. èlègan ki te karakterize kòm yon lame pou plizyè moun bakteri patojèn espès (sa vle di, Staphylococcus aureus ak anterokok fekali), ki ka fasil kiltive, konsève, ak evolye. Bay anpil pou kantite resous molekilè ki disponib pou C. èlègan ak ajan patojèn moun, nan dezyèm / twazyèm ane a nan pwojè a, elèv la ka gen opòtinite pou egzaminen fondman yo molekilè nan evolye vè k'ap manje kadav rezistans lame ajan patojèn diferan. Elèv la ap resevwa fò fòmasyon nan byoloji evolisyonè ak mikrobyoloji, evolisyon eksperimantal, teknik molekilè (qPCR, pus), konsepsyon eksperimantal, ak analiz estatistik.
eng
The multicellular animals, Caenorhabditis elegans, are ideal as a system to address the above questions. Experimental evolution can be easily conducted in these worms, and C. elegans has been characterized as a host for multiple human pathogenic bacteria species (i.e., Staphylococcus aureus and Enterococcus faecalis), which can be easily cultured, maintained, and evolved. Given the wealth of molecular resources available for C. elegans and human pathogens, in the second/third year of the project, the student may have the opportunity to examine the molecular underpinnings of evolved worm host resistance to different pathogens. The student will receive strong training in evolutionary biology and microbiology, experimental evolution, molecular techniques (qPCR, microarrays), experimental design, and statistical analysis.