hat
Estrogen yo pwodwi pa konvèsyon nan androjèn nan aktivite a nan anzim nan aromatase. Poud Letrozol kri bloke pwodiksyon de estrogen nan fason sa a pa konpetitif, revèsib obligatwa nan imaj la nan inite sitokrom P450 li yo. Aksyon an se espesifik, ak kri poud letrozol pa diminye pwodiksyon mineralo- oswa kortikoterapi. Nan contrast, aksyon an anti-jenerasyon nan tamoksifèn, pi gwo terapi medikal la anvan yo rive nan aromataz inibitè, se akòz entèfere li yo ak reseptè a estwojèn, olye ke envantè pwodiksyon monn fi.
eng
Estrogens are produced by the conversion of androgens through the activity of the aromatase enzyme. Raw Letrozole powder blocks production of estrogens in this way by competitive, reversible binding to the heme of its cytochrome P450 unit. The action is specific, and Raw Letrozole powder does not reduce production of mineralo- or corticosteroids. In contrast, the antiestrogenic action of tamoxifen, the major medical therapy prior to the arrival of aromatase inhibitors, is due to its interfering with the estrogen receptor, rather than inhibiting estrogen production.