hat
Pf 750 se yon pisan, tan-depandan, irevokabl asid gra amid idrolase (FAAH) inhibitor (IC50 = 16.2 nM) ki montre pa gen okenn aktivite nan yon seri de lòt idrolasen serin. Li selektivman inibit FAAH nan sistèm nève santral la. ak valè IC50 0.6 ak 0.016 μM lè preincubated ak FAm rekòman imen pou 5 ak kilomèt minit, respektivman. Asid asid grate (FAAH) se anzim ki responsab pou idrolyiz ak inaktivasyon
eng
PF 750 is a potent, time-dependent,irreversible fatty acid amide hydrolase (FAAH) inhibitor (IC50 = 16.2 nM) that displays no activity at a range of other serine hydrolases. It selectively inhibits FAAH within the central nervous system. with IC50 values 0.6 and 0.016 μM when preincubated with recombinant human FAAH for 5 and 60 minutes, respectively. Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation