hat
Te sentèz la pwodui chimik nan testostewòn soti nan kolestewòl reyalize nan mwa Out ane sa a pa Butenandt ak Hanisch. Se sèlman yon semèn pita, gwoup la Ciba nan Zurich, Leopold Ruzicka (1887-1976) ak A. Wettstein, pibliye sentèz yo nan testostewòn.Sa yo endepandan sentetik pati nan testostewòn ki sòti nan yon baz kolestewòl touche tou de Butenandt ak Ruzicka jwenti a 1939 Nobel Prize nan Chemistry.Testosterone te idantifye kòm 17β-hydroxyandrost-4-en-3-yon sèl (C19H28O2), yon alkòl solid polycyclic ak yon gwoup hydroxyl nan atòm nan kabòn 17yèm. Sa a tou te fè li evidan ke modifikasyon adisyonèl sou testostewòn nan sentèz ta ka fèt, sa vle di, esterifikasyon ak alkylasyon.
eng
The chemical synthesis of testosterone from cholesterol was achieved in August that year by Butenandt and Hanisch. Only a week later, the Ciba group in Zurich, Leopold Ruzicka (1887–1976) and A. Wettstein, published their synthesis of testosterone.These independent partial syntheses of testosterone from a cholesterol base earned both Butenandt and Ruzicka the joint 1939 Nobel Prize in Chemistry.Testosterone was identified as 17β-hydroxyandrost-4-en-3-one (C19H28O2), a solid polycyclic alcohol with a hydroxyl group at the 17th carbon atom. This also made it obvious that additional modifications on the synthesized testosterone could be made, i.e., esterification and alkylation.