Cadaverine is an organic compound with the formula (CH2)5(NH2)2. Classified as diamine, it is a colorless liquid with an unpleasant odor. It is produced by the putrefaction of animal tissue. Production Cadaverine is produced by decarboxylation of lysine. It can be synthesized by many methods including the hydrogenation of glutaronitrile and the reactions of 1,5-dichloropentane. History Putrescine and cadaverine were first described in 1885 by the Berlin physician Ludwig Brieger (1849–1919). Receptors In zebrafish, the trace amine-associated receptor 13c (or TAAR13c) has been identified as a high-affinity receptor for cadaverine. In humans, molecular modelling and docking experiments have shown that cadaverine fits into the binding pocket of the human TAAR6 and TAAR8. Clinical significance Elevated levels of cadaverine have been found in the urine of some patients with defects in lysine metabolism. The od
Cadaverine es un compuesto orgánico con la fórmula (CH2)5(NH2)2. Clasificado como diamina, es un líquido incoloro con un olor desagradable. Se produce por putrefacción de tejido animal. Producción Cadaverine se produce por decarboxilación de lysine. Se puede sintetizar por muchos métodos incluyendo la hidrogenación de glutaronitrile y las reacciones de 1,5-dichloropentane. Historia Putrescine y cadaverine fueron descritos por primera vez en 1885 por el médico berlinés Ludwig Brieger (1849-1919). Receptores En el pez zebrafish, el receptor asociado a amino de rastro 13c (o TAAR13c) ha sido identificado como un receptor de alta afinidad para cadaverine. En humanos, los experimentos de modelado molecular y de docking han demostrado que cadaverine se ajusta al vínculo del bolsillo humano y TAAR68.